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philadelphia-chromosome

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Journal Articles
Cancer Res (2020) 80 (16_Supplement): 3893.
Published: 15 August 2020
...Yang Y. Ding; Kellyn Madden; Joseph P. Loftus; Hannah Kim; Chia-hui Chen; Sarah K. Tasian; Kai Tan Philadelphia chromosome-like B-acute lymphoblastic leukemia (Ph-like ALL) is a common leukemia subtype associated with high relapse rates and poor overall survival. Ph-like ALL has a kinase-activated...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2919.
Published: 15 June 2022
...Yonglan Liu; Hyunbum Jang; Mingzhen Zhang; Chung-Jung Tsai; Ryan Maloney; Ruth Nussinov Philadelphia chromosomes 9 and 22 encode BCR and ABL1 genes, respectively. Translocation mutation of two chromosomes generates the fused BCR-ABL1 gene. The resulting fused gene encodes the chimeric BCR-ABL...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5882.
Published: 15 June 2022
...Nikolai A. Podoltsev; Rong Wang; Joseph L. Wiemels; Libby M. Morimoto; Catherine Metayer; Xiaomei Ma Background: Philadelphia chromosome negative myeloproliferative neoplasms (MPN) have driver mutations that are acquired early in life, but median age at diagnosis for MPN is 65-69 years...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): CT027.
Published: 15 June 2022
... characteristics were similar in the evaluable pts vs the ITT population. Most common (≥5%) ALL subtypes were BCR-ABL1-positive (14%), low hypodiploidy (12%), Philadelphia chromosome (Ph)-like (11%), KMT2A-rearranged (9%), and DUX4-rearranged (6%); 29% (26/91) of pts could not be subtyped due to low blast counts...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3324.
Published: 15 June 2022
... lymphoblastic leukemia (B-ALL) is a malignancy caused by accumulation of immature B cells. Advances in the field, especially in genomic studies and new treatment development, significantly improved the prognosis of B-ALL over the last decades. However, the B-ALL subtype harboring Philadelphia chromosome t(9;22...
Journal Articles
Cancer Res (2019) 79 (13_Supplement): 398.
Published: 01 July 2019
...Ruibao Ren; Xinhua Xiao; Jianming Zhang; Bo Jiao The Philadelphia chromosome (Ph) translocation, which leads to creation of a fusion gene product BCR-ABL, is found in chronic myelogenous leukemia (CML) and 20% of adult and 2-5% pediatric acute B-lymphoblastic leukemia (B-ALL). The selective ABL...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2169.
Published: 15 June 2022
...; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2169. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LE03-01.
Published: 15 June 2022
... to uncover selection advantages of cancer aneuploidy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LE03-01. ©2022 American Association for Cancer Research 2022 American...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 705.
Published: 15 June 2022
... Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 705. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2299.
Published: 15 June 2022
... stability [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2299. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2492.
Published: 15 June 2022
... Schweinitz, Christian Vokuhl, Torsten Pietsch. Identification of RBMS1 in the amplified region 2q24 as a major driver of cellular growth in childhood hepatoblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): SY22-02.
Published: 15 June 2022
... Discher. Aneuploidy and 3D tissue rigidity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr SY22-02. ©2022 American Association for Cancer Research 2022...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1589.
Published: 15 June 2022
..., a seminal event in cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1589. ©2022 American Association for Cancer Research 2022 American Association...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2172.
Published: 15 June 2022
... Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2172. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2164.
Published: 15 June 2022
... Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2164. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5692.
Published: 15 June 2022
..., Tomi Jun, Nan Sun, Jie He, Kuan-lin Huang. Tissue specificity of chromosome aneuploidy correlates with BRCA-associated cancer risk [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3743.
Published: 15 June 2022
... Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3743. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1514.
Published: 15 June 2022
..., Alexander Shoushtari. Examining the impact of chromosomal instability on mucosal melanoma tumor infiltrate and responses to PD-1 based therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2497.
Published: 15 June 2022
... of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2497. ©2022 American Association for Cancer Research 2022 American Association for Cancer Research ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB202.
Published: 15 June 2022
... against chromosomally unstable cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB202. ©2022 American Association for Cancer Research 2022 American Association...