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packing-density

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Finite difference simulations of regularly <span class="search-highlight">packed</span> cells with varying cell d...
Published: 04 October 2022
Figure 2. Finite difference simulations of regularly packed cells with varying cell diameter (d) and volume fraction (vin) using 70 ms (PGSE) and 10 ms (OGSE) diffusion times. A and B, ADC is fitted from signals with both diffusion times. C and D, The diffusion time dependence using the difference in ADC ( C ) and the iAUC ( D ) change the sensitivity landscape. Where ADC is mostly sensitive to volume fraction at small restriction sizes, such as axons (1–5 μm) or glia (5–10 μm), ΔADC and iAUC filter out these components to give contrast driven by size-selective cellular density. iAUC provides more selective sensitivity to cancer cells approximately 10–20 μm than ΔADC. Figure 2. Finite difference simulations of regularly packed cells with varying cell diameter (d) and volume fraction (vin) using 70 ms (PGSE) and 10 ms (OGSE) diffusion times. A and B, ADC is fitted from signals with both diffusion times. The diffusion time dependence using (C) the difference in ADC and (D) the iAUC change the sensitivity landscape. Where ADC is mostly sensitive to volume fraction at small restriction sizes, such as axons (1–5 μm) or glia (5–10 μm), ∆ADC and iAUC filter out these components to give contrast driven by size-selective cellular density. iAUC provides more selective sensitivity to cancer cells approximately 10–20 μm than ∆ADC. More
Journal Articles
Cancer Res CAN-22-0677.
Published: 21 November 2022
... was calculated using the ELDA software (httpsbioinf.wehi.edu.au/software/elda/; RRID:SCR_018933). Long-term population analysis To monitor the effect of gene silencing on GSC self-renewal, a long-term population analysis was performed by plating cells at 8x103 cells/cm2 density. The resulting neurospheres were...
Includes: Supplementary data
Journal Articles
Cancer Res CAN-22-1533.
Published: 22 November 2022
... repeat genotyping (Labcorp), except for LNCaP95 which lack a reference STR profile, and confirmed to be negative for mycoplasma contamination using MycoAlertTM PLUS Assay (Lonza). Measurements of drug sensitivity and drug combination synergy Cells were plated in 96- or 384-well plates at a density...
Includes: Multimedia, Supplementary data
Journal Articles
Cancer Res (2022) 82 (19): 3603–3613.
Published: 04 October 2022
...-selective cellular density. iAUC provides more selective sensitivity to cancer cells approximately 10–20 μm than ΔADC. Figure 2. Finite difference simulations of regularly packed cells with varying cell diameter (d) and volume fraction (vin) using 70 ms (PGSE) and 10 ms (OGSE) diffusion times. A and B...
Includes: Supplementary data
Journal Articles
Cancer Res CAN-22-1601.
Published: 20 October 2022
... selectively retrieve genetic information to drive differentiation 102 in a linear stepwise manner. This morphogenesis portrayal cannot explain 103 [11] the massive individual variability in blood vessel path and density, and 104 the structural diversity in innervation between twins, in spite...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (4_Supplement): P5-05-05.
Published: 15 February 2022
... with increased expression in the contralateral unaffected breast of women with ER- BC (PMID: 28263391). MCF-10A cells exposed to lipids in vitro display profound changes in gene expression, chromatin packing density, chromatin accessibility and histone posttranslational modifications (PTMs). In addition...
Journal Articles
Cancer Res (2022) 82 (19): 3516–3531.
Published: 04 October 2022
... as indicated. After 72-hour incubation, the model 550 microplate reader (Bio-Rad Laboratories) was used to measure the optical density (OD) values at 450 nm and the inhibition rate was calculated as [1− (ODdrug treated-ODblank)/(ODvehicle control-ODblank)] × 100...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (19): 3486–3498.
Published: 04 October 2022
... maintained in DMEM supplemented with 10% complete (nondialyzed) FBS (cFBS). For experimental purposes, cells were seeded and grown in DMEM supplemented with 10% dialyzed FBS (dFBS). Cells were seeded in at a packed-cell volume of 0.25 μL/mL and grown to approximately 70%–80% confluence. Comparable cell...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (18): 3394–3404.
Published: 16 September 2022
...) ADC value in the tumor for the patient across all visits. The carrying capacity, θ, describes the maximum number of tumor cells that can physically fit within a voxel, which was determined by assuming a spherical packing density of 0.7405 and a nominal tumor cell radius of 10 μmol/L ( 30...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (14): 2576–2592.
Published: 18 July 2022
...) was used for analysis. The extracted peptides were dissolved with 25 μL of solvent A (0.1% formic acid in water), and loaded to a homemade trap column (100 μm × 2 cm) packed with C18 reverse-phase resin (particle size, 3 μm; pore size, 120 Å; SunChrom) at a maximum pressure of 220 bar with 12 μL of solvent...
Includes: Multimedia, Supplementary data
Journal Articles
Cancer Res (2022) 82 (10): 1909–1925.
Published: 16 May 2022
... was transferred to fresh tubes and stored on ice and the pelleted TiO2 was loaded into an empty PE-filtered top tip (Glygen) prewashed with ACN and packed by centrifugation at 1,500 × g for 3 minutes. After loading the remaining volume of the supernatant by centrifugation at 1,500 × g...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (10): 2003–2018.
Published: 16 May 2022
... (3450124; Bio-Rad) in XT MES running buffer (1610789; Bio-Rad) and transferred to polyvinylidene difluoride membranes (1620233; Bio-Rad) using the Trans-Blot Turbo Transfer Pack and System ( 11 ). Membranes were blocked with TBST buffer containing 5% skim milk for 1 hour and incubated overnight at 4°C...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (10): 2031–2044.
Published: 16 May 2022
... (Thermo Easy nLC1000; Thermo Fisher Scientific) using a precolumn (made in house, 6 cm of 10-µmol/L C18) and a self-pack 5-µmol/L tip analytical column (12 cm of 5-µmol/L C18; New Objective) over a 140-minute gradient before nanoelectrospray using a Q Exactive HF-X mass spectrometer (Thermo Fisher...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (24): 6106–6116.
Published: 15 December 2021
... in S phase that each genomic region is replicated ( 9 ), is found to be associated with mutation load. The RT of a region reflects a higher order of genomic organization as it correlates with basic chromosomal features such as the regional GC content, Giemsa banding, and gene density. In addition...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 2733.
Published: 01 July 2021
... and potential confounders. Results: During follow-up of 131,144 participants (3,648,371 person-years), we documented 3,203 incident CRC cases including 871 CRC cases with available data on immune cell densities in tumor tissue. The association of pack-years smoked with colorectal cancer incidence was stronger...
Journal Articles
Cancer Res (2021) 81 (20): 5147–5160.
Published: 15 October 2021
...+ clusters showed a packed morphology with a clear smooth peripheral edge in contrast to jagged cell–cell contact between mesothelial cells. The disc-like clusters often had an indentation at the center and appeared to penetrate the basal membrane underneath the mesothelium ( Fig. 3D , E , and G...
Journal Articles
Cancer Res (2021) 81 (20): 5296–5310.
Published: 15 October 2021
... bonds in the aliphatic chain. SFA have linear structure while cis unsaturated FA exhibit a bent shape due to the double bond. As such, saturated fats rich in linear SFA are tightly packed and therefore are solid (e.g., butter) whereas oils rich in bent UFA are loosely packed and are liquid...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (21): 5377–5395.
Published: 01 November 2021
... increased for heavy smokers who smoked more than 40 packs/year (OR 1.74, 95% CI 1.22–2.50), more than 40 years (OR 1.50, 95% CI 1.05–2.16), or more than 40 cigarettes/day (OR 1.92, 95% CI 1.04–3.54) in males. Similar findings were observed in heavy female smokers who have smoked for more than 20 years...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (19): 4949–4963.
Published: 01 October 2021
.... TRC culture was conducted according to our previously described methods ( 21–23 ). In brief, tumor cells were maintained in the conventional rigid plate. After 0.25% trypsin digestion, cells were detached and suspended in DMEM or RPMI1640 medium (10% FBS), and cell density was adjusted...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (18): 4874–4885.
Published: 15 September 2021
...-axis represented the log( \overline {| {{{\rm{G}}^{\rm{*}}}} |} $ ), because while collagen density saturates at 100%, fiber alignment and cross-linking could substantially increase \overline {| {{{\rm{G}}^{\rm{*}}}} |} $ even for small changes in total collagen. Figure 2. SHEAR validation...