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oral-contraceptives

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Journal Articles
Cancer Res (2022) 82 (4_Supplement): P2-11-18.
Published: 15 February 2022
... Introduction: The increased risk of breast cancer is the most controversial and most feared adverse effect of combined oral contraceptives (COC) by women. The mechanisms by which COC would act on the breast parenchyma leading to its increased incidence, are not yet well known. Objectives...
Journal Articles
Series: Author Choice
Cancer Res (2021) 81 (4): 1153–1162.
Published: 15 February 2021
...Torgny Karlsson; Therese Johansson; Julia Höglund; Weronica E. Ek; Åsa Johansson Oral contraceptive use has been suggested to influence the risk of breast, ovarian, and endometrial cancer. The purpose of this study is to clarify the time-dependent effects between long-term oral contraceptive use...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2248.
Published: 15 June 2022
..., menopausal status, race/ethnicity, education level, first-degree family history of ovarian cancer, endometriosis, smoking, body mass index, parity, incomplete pregnancy, tubal ligation, use of combined oral contraceptives, depot-medroxyprogesterone acetate, estrogen (ET), and combined estrogen-progestin...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2253.
Published: 15 June 2022
... multivariable logistic regression, adjusted for matching factors, tubal ligation, oral contraceptive use, and parity, to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of ovarian cancer risk per 1 standard deviation increase in probit-transformed metabolite levels. We used Metabolite Set...
Journal Articles
Cancer Res (2022) 82 (4_Supplement): P3-12-28.
Published: 15 February 2022
... the variables individually. The risk of ER+ BC was inversely related to parity (OR = 0.78 95% CI, 0.63-0.95), having breastfed (OR = 0.47 95% CI, 0.26-0.87) and the use of oral contraceptives (OR = 0.56 95% CI, 0.32 -0.99). Although an increased risk for ER- and TN tumors was observed with the use of oral...
Journal Articles
Cancer Res (2022) 82 (4_Supplement): P2-09-04.
Published: 15 February 2022
...% identified as Near East/Middle Eastern. The baseline characteristics of our cohort can be seen in Table 1. Ovarian malignancy was incidentally detected on pathology evaluation in 1.5% of patients who elected rrBSO. The odds of rrBSO were lower among those who had used oral contraceptives for more than one...
Journal Articles
Cancer Res (2022) 82 (4_Supplement): P3-13-03.
Published: 15 February 2022
... by Northwestern’s Institutional Review Board (NU15B07). We isolated organoids from these tissues, and cryopreserved them for future use. We selected organoids of premenopausal women, age-matched (28-46) without oral contraceptive usage within 3 years: BRCA1mut/+ (n=12) and BRCA1 normal (n=4). Organoids were...
Journal Articles
Cancer Res (2020) 80 (16_Supplement): 5760.
Published: 15 August 2020
...Lauren A. King; Kara A. Michels; Barry I. Graubard; Britton Trabert Importance: Since the 1960s, an increase in the use of oral contraceptives (OC) and other hormonal contraceptives has mirrored a decreased incidence of ovarian and endometrial cancers in the US. With improved access and increased...
Images
Time-dependent HR of <span class="search-highlight">oral</span> <span class="search-highlight">contraceptives</span> during use ( A, C,  and  E ) and a...
Published: 15 February 2021
Figure 3. Time-dependent HR of oral contraceptives during use ( A, C, and E ) and after discontinued use ( B, D and E ) for breast cancer ( A and B ), ovarian cancer ( C and D ), and endometrial cancer ( E and F ). The solid, black line, and gray area indicates the time-independent HR wi... More
Images
Incidence rates of cancers and the pattern of <span class="search-highlight">oral</span> <span class="search-highlight">contraceptive</span> use in UKB...
Published: 15 February 2021
Figure 1. Incidence rates of cancers and the pattern of oral contraceptive use in UKB. Age specific incidence rates for breast ( A ), ovarian ( B ), and endometrial cancer ( C ) in the UKB females (light gray), as compared with all women in UK (dark gray). UKB female incidence rate is estimated fr... More
Images
ORs and 95% CIs for duration of <span class="search-highlight">oral</span> <span class="search-highlight">contraceptive</span> use subgroups compared w...
Published: 15 February 2021
Figure 2. ORs and 95% CIs for duration of oral contraceptive use subgroups compared with never users. All estimates are adjusted for covariates included in the full model (model 4): age, year of birth, smoking, BMI, and TDI, number of live births, age at menarche, hormone replacement therapy, as w... More
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 878.
Published: 01 July 2021
...Yue Yin Xia; Jan Lubinski; Barry Rosen; Pal Moller; Andrea Eisen; Peter Ainsworth; Leigha Senter; Louise Bordeleau; Susan L. Neuhausen; Christian F. Singer; Jennifer Brooks; Ping Sun; Steven A. Narod; Joanne Kotsopoulos Background: Oral contraceptive use is associated with a significantly reduced...
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 794.
Published: 01 July 2021
...Minh Tung Phung; Celeste Leigh Pearce; Rafael Meza; Jihyoun Jeon Background: Ovarian cancer incidence rates in the U.S. decreased since the early 1970s, which was largely attributed to increasing parity among birth cohorts through 1935 and the introduction of combined oral contraceptives (COCs...
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 876.
Published: 01 July 2021
... evaluated for IHC-based TP53 and ER. For each risk factor, joint effects of TP53 and ER were evaluated by allowing for an interaction between the two markers. Results: When classifying TP53 status using the RNA signature, the effects of several hormone-related factors (oral contraceptive use, menopausal...
Images
Splines describing associations of cancer risks in middle-aged women with t...
Published: 15 April 2021
Figure 3. Splines describing associations of cancer risks in middle-aged women with the age at menarche (years). Nonlinear associations of selected site-specific cancer risks with the age at menarche among middle-aged women drawn from nine cohorts: colon cancer ( A ), lung cancer ( B ), and breast... More
Images
Splines describing associations of cancer risks in middle-aged women with t...
Published: 15 April 2021
Figure 2. Splines describing associations of cancer risks in middle-aged women with the age at menarche (years). Nonlinear associations of selected site-specific cancer risks with the age at menarche among middle-aged women drawn from nine cohorts: endometrial cancer ( A ), liver cancer ( B ), mel... More
Images
Summary estimates for multivariable-adjusted relative risks of 19 site-spec...
Published: 15 April 2021
Figure 4. Summary estimates for multivariable-adjusted relative risks of 19 site-specific cancers for each additional year in the age at menarche among middle-aged women drawn from nine cohorts. This forest plot describes summary estimates for multivariable-adjusted relative risks of site-specific... More
Journal Articles
Cancer Res (2021) 81 (15): 4155–4162.
Published: 01 August 2021
... at menarche, menopausal status, parity, menopausal hormone therapy use, oral contraceptive use, history of benign breast disease, family history of breast cancer, and prediagnosis BMI. We also included disease stage, ER status, and self-reported radiotherapy, chemotherapy, and hormonal therapy. Model 3...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (21): 5377–5395.
Published: 01 November 2021
... factors for cervical cancer include HIV infection, smoking, ethnicity, sexual life, oral contraceptive intake, and obesity ( Fig. 1 ; Supplementary Table S1). It was reported that HPV infection was detected at higher rates in women who were HIV-positive than in those who were HIV-negative...
Includes: Supplementary data
Journal Articles
Cancer Res (2019) 79 (13_Supplement): 641.
Published: 01 July 2019
...Jennifer M. Mongiovi; Janine M. Joseph; Albina N. Minlikeeva; Ahmad AlSulimani; Hani Almohanna; Kirsten B. Moysich Objectives: While oral contraceptives (OC) use is associated with lower risk of ovarian cancer compared to non-users, its role in the etiology of aggressive and highly fatal...