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multidrug-resistance

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Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5338.
Published: 15 June 2022
... mechanisms, one of which is the P-glycoprotein (P-gp, encoded by the ABCB1 gene) mediated multidrug resistance. Tumor cells with high P-gp protein expression extrude P-gp substrate drugs from intracellular space and reduce drug efficacy. Since Paclitaxel and some PARP inhibitors such as Olaparib are P-gp...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 409.
Published: 15 June 2022
...Zhuoxun Wu; Qiu-Xu Teng; Yuqi Yang; Nikita Acharekar; Jing-Quan Wang; Min He; Sabesan Yoganathan; Jun Lin; Jian Wang; Zhe-Sheng Chen ABCG2/BCRP transporter-mediated Multidrug resistance (MDR) in cancers has been considered as one of the obstacles to the cancer chemotherapy. Our recent study...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5484.
Published: 15 June 2022
... is less toxic to animals and the maximum tolerated dose is approximately 3 times higher than irofulven (mg/kg basis). CAP-0121 also retains activity against multidrug resistant cell lines including MRP1 and MDR1 expressing variants. As a result CAP-0121 is capable of inducing tumor remission in MDR...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3246.
Published: 15 June 2022
... and activator of transcription 3 (STAT3) thereby increasing the expression of the drug efflux pump, multidrug resistance protein 1 (MDR1). ATP-binding cassette (ABC) transporters, such as MDR1, are well established to contribute to drug resistance through exporting drugs from the cell. Furthermore, tumor...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1095.
Published: 15 June 2022
.... This was confirmed by the abolishment of drug resistance in NCI-H460/TPT10 cells after ABCG2 knockout. Moreover, the involvement of functional ABCG2 as a drug efflux pump conferring multidrug resistance (MDR) was indicated by low intracellular accumulation of TPT in NCI-H460/TPT10 cells, and the reversal effects...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 301.
Published: 15 June 2022
... selectively recognize and bind to PSMA membrane. The functionalities of this strategy were analyzed by targeting A10-TQ-PBM-NP in DTX-resistant cells (C4-2B-R and LNCaP-R), which overexpresses PSMA protein and multidrug resistance (MDR) gene ABCB1, and validated through flow cytometry, immunofluorescence, qRT...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6328.
Published: 15 June 2022
... and tumorigenesis. GPR56 is also upregulated in CRC and increased expression levels correlate with poor patient survival. We recently showed GPR56 can promote tumor growth and drug resistance of CRC cells through upregulation of multidrug resistance proteins. These findings identify GPR56 as a potential therapeutic...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5368.
Published: 15 June 2022
... from erlotinib treatment, as measured by proliferation (ki67), migration (podoplanin) and resistance (Multidrug Resistance 1; MDR1) markers. However, while TCFs increase O-GlcNAcylation in cancer cells, a type of dynamic O-glycosylation, TAFs decrease O-GlcNAcylation in a subpopulation of cells...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 407.
Published: 15 June 2022
...Yuqi Yang; Zhuo-Xun Wu; Jing-Quan Wang; Qiu-Xu Teng; Zi-Ning Lei; Sabrina Lusvarghi; Suresh V. Ambudkar; Ning Ji; Zhe-Sheng Chen The overexpression of ATP-binding cassette (ABC) transporters has known to be one of the most important mechanisms responsible for the development of multidrug resistance...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5399.
Published: 15 June 2022
... efflux pumps responsible for multidrug resistance to enhance DOX efficacy in breast cancer gene 1 (BRCA1) mutant and non-mutant TNBC. Methods: The cytotoxicity of DOX, oHA and their combinations in free solution or in nanoparticles was evaluated by clonogenic assay in human MDA-MB-231-luc-D3H2LN and MDA...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5306.
Published: 15 June 2022
...) in malignant ascites following peritoneal metastasis. Treatment of OVCAR8, A2780 and A1847 cells with LMW HA (50-200 ng/ml) induced IRAK1 phosphorylation at 80 ng/ml that was further enhanced at 200 ng/ml. In addition, LMW HA induced stemness and multidrug resistance genes. With additional studies using...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 191.
Published: 15 June 2022
... and phenotypic profiles of these models we analyzed Next Generation Sequencing data and phenotypic cell killing using a panel of FDA-approved agents. Our results showed that mRNA expression of several known cancer stem cell markers were upregulated in our PDCs in addition to multidrug resistance (MDR) genes...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6066.
Published: 15 June 2022
...Kangyu Lin; John Paul Shen Cancer stem cells (CSCs) are a small subpopulation of cells with capabilities of self-renewal and differentiation potential and have been suggested to play a critical role in tumor-initiation, metastasis, and multidrug resistance. The marker genes used to identify CSCs...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3357.
Published: 15 June 2022
... protein targets, including ones responsible for multidrug- resistance in liver cancer, like YB-1. Methods: The RCSB protein data bank (PDB) was used to retrieve the crystal structure of YB-1, while the DrugBank database was used to obtain a list of experimental and approved drugs. A multiple sequence...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6073.
Published: 15 June 2022
... to multiple tumor malignancies, such as recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Doublecortin-like kinase 1 (DCLK1) was recently identified as CSC marker is upregulated in several solid tumors, which distinguishes between cancer and normal stem cell. However...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2155.
Published: 15 June 2022
... response. To further validate our promising GEMM results in more clinically relevant human-derived models, we used patient-derived xenografts lines we established from multidrug-resistant, metastatic PCa (Lawrence et al, European Urology, 2018). PMR-116 treatment decreased tumour volume in all PDX tested...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 4048.
Published: 15 June 2022
.... Our studies have identified that Annamycin (ANN), a potent topoisomerase II poison that displays organotropism imitating that of metastatic CRC. ANN is an analog of doxorubicin (Dox) that shows unique properties. Notably, ANN is active against multidrug-resistant tumors and undergoes efficient uptake...
Journal Articles
Cancer Res (2022) 82 (10_Supplement): A038.
Published: 15 May 2022
... treatments such as chemotherapy influence mutation rate, and mutation rate of drug and multidrug resistance cancer cell is higher than newly diagnosed cancer cells. Further, mutation rate is defined differently in different literature, some papers measure the mutation rate in a population or a gene, some...
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 1108.
Published: 01 July 2021
...Haiyun Zhang; Xuan Wang; Xiaozhuo Chen Cancer is the second leading cause of death in the US. Multidrug resistance (MDR) and the resulting ineffectiveness of the drug treatment are responsible for most relapses of cancer and cancer-related death. One major mechanism of MDR is the efflux of multiple...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1004.
Published: 15 June 2022
... has been reported to induce a drug-resistant phenotype across the tumor by transporting ABC multidrug transporters and mediators of EMT. Multiple studies have established that pituitary-, or tumor- or tumor microenvironment-derived growth hormone (GH) promotes EMT and drug resistance in cancer...