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microtubule

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Journal Articles
Cancer Res (2022) 82 (12_Supplement): 965.
Published: 15 June 2022
... in chemo-sensitive ovarian cancer cell lines results in increased EMT markers as well as increased invasion and migration. Microtubules are a very common target of multiple cancer therapies. However, the impact of 5-Aza-dC and MCAM on the microtubule network and non-adherent cells has not been well studied...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3906.
Published: 15 June 2022
... of the biology of diseases. Previously, we have identified multiple cytoskeleton regulators, including actin-binding and microtubule-associated proteins as binding partners of mTORC2 in glioblastoma cells by affinity purification-mass spectrometry (AP-MS). In this work, we provided extensive characterization...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 959.
Published: 15 June 2022
... suggests that non-junctional Cx43 can regulate the cytoskeleton, including microtubule stability. The C-terminus of Cx43 encompasses a tubulin binding domain which, while implicated in Cx43 trafficking, remains functionally poorly understood. We have identified a tumorigenic role for non-junctional Cx43...
Journal Articles
Cancer Res (2022) 82 (4_Supplement): P5-13-04.
Published: 15 February 2022
... and both 2D and 3D proliferations assays were used for drug sensitivity profiling; live-cell imaging, high-resolution confocal microscopy and an ad-hoc computational algorithm were employed to study cell fate and microtubule conformational changes. Patient data were obtained from the Northwestern...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1551.
Published: 15 June 2022
... with transcriptome profiling of HGSC cells transfected with miR-625-3p mimics or control mimics identified SSX2IP as a direct target of miR-625-3p, suggesting that SSX2IP may play a role in conferring cisplatin/paclitaxel resistance in HGSC by mediating the effect of miR-625-3p. SSX2IP is a microtubule anchoring...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5644.
Published: 15 June 2022
.... The mitotic checkpoint prevents completion of mitosis until chromosomes have made bipolar kinetochore attachments to microtubules. Previous studies have shown that cells that experience a prolonged prometaphase(>1.5 h) following treatment with microtubule destabilizing drugs will arrest in G1 following...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2623.
Published: 15 June 2022
... Despite its widespread use, the majority of patients with gastric cancer (GC) will not respond to taxane chemotherapy due to resistance mechanisms. Recently, we reported the discovery of a novel truncated variant of the microtubule plus-end binding protein CLIP-170, hereafter CLIP-170S, whose expression...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2575.
Published: 15 June 2022
...Filippo Spriano; Luca Aresu; Luciano Cascione; Alberto J. Arribas; Nicole Forster-Gross; Felix Bachmann; Heidi Lane; Francesco Bertoni Background: Avanbulin (BAL27862) is a microtubule-targeting agent (MTA) that promotes tumor cell death by modulating the spindle assembly checkpoint. Preclinical...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 270.
Published: 15 June 2022
... of growth factors from the bone matrix that causes aggressive tumor growth and bone loss. A potentially important aspect of this process is vesicular trafficking on microtubules (MTs) which can affect the output of signaling pathways and secretory activity of metastatic bone cells. MTs are cytoskeletal...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2599.
Published: 15 June 2022
...Francis M. Barnieh; Goreti Ribeiro Morais; Paul M. Loadman; Robert A. Falconer Introduction: Vascular disrupting agents (VDA) are an important class of therapeutic that have yet to reach their clinical potential. Colchicine is representative of the class and is an effective disruptor of microtubule...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB202.
Published: 15 June 2022
... KIF18A is a mitotic kinesin that localizes to the plus-end tips of kinetochore microtubule (MT) spindle fibers during metaphase, where it regulates chromosome alignment, and promotes the viability of chromosomally unstable cancer cells. KIF18A is overexpressed in a subset of human cancers, and its...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6227.
Published: 15 June 2022
... prognosis. In previously reported work, NN2101-DM1, a fully human, anti-cKIT antibody-drug conjugate (ADC), was developed as a proof-of-concept (PoC) entity by conjugating the site-nonspecific and uncleavable linker SMCC with the microtubule inhibitory payload DM1. This linker-payload system is the same...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 346.
Published: 15 June 2022
...). The chemotherapy agents included inhibitors of epidermal growth factor receptor (osimertinib, afatinib), other tyrosine kinases (regorafenib, imatinib), sex steroid receptors (4-OH-tamoxifen, enzalutamide), and microtubule function (docetaxel). To improve solubility, a methylsulfonate salt of JKYN-1 was used...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): CT211.
Published: 15 June 2022
... monoclonal antibody linked to pAF-AS269, a potent microtubule inhibitor. Upon binding to PSMA on the surface of cancer cells, ARX517 is internalized and pAF-AS269 is released following lysosomal metabolism. Methods: This Phase 1, dose-escalation and dose-expansion study is evaluating the safety...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5284.
Published: 15 June 2022
... free expression system Xpress CF+™ enables incorporation of non-natural amino acids at precise positions in the SEED-antibody for site-specific linker-payload conjugation. The cytotoxic payload of M1231 (SC209) is a hemiasterlin-related microtubule inhibitor. The cleavable linker (ValCit-PABA...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3946.
Published: 15 June 2022
... pathway, not shared by AR-fl. Using fluorescently tagged-AR-fl or AR-V7 proteins in conjunction with live cell imaging, FRAP assays and pathway inhibitors, we showed that AR-V7 exhibits fast nuclear import kinetics partially mediated by the dimerization D-box domain, independently of microtubules...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3252.
Published: 15 June 2022
... temozolomide (TMZ) chemotherapy. How TTFields exert efficacy on cancer cells over normal cells, or interact with TMZ is unclear. Primary cilia are microtubule-based organelles triggered by extracellular ligands, mechanical and electrical field stimulation, and are capable of promoting cancer growth and TMZ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6206.
Published: 15 June 2022
... proliferating neovasculature of tumors lacks pericyte support and exhibits increased permeability thereby offering a unique, potentially selective target for anticancer therapy. Most vascular disrupting agents (VDAs) inhibit microtubule formation, causing rapid morphological changes in endothelia cells...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6384.
Published: 15 June 2022
... in residual tumor cells, and these changes reverted when residual tumors were allowed to regrow in the absence of treatment. We then administered chemotherapeutics to human TNBC cells, revealing that DNA-damaging chemotherapeutics increased mitochondrial elongation, but microtubule poisons increased...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1281.
Published: 15 June 2022
... composed of a B7-H4-directed human monoclonal antibody conjugated to the validated vedotin drug linker, which incorporates the microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable peptide linkage. This vedotin drug linker system has been clinically validated by multiple ADC...