... Zhou, Xuejie Tang, Yi Yang, Li Luo, Yu Ding. Gene profile analysis of breast cancer lung metastasis, liver metastasis, brain metastasis and primary tumor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res...

...Eva C. González Díaz; Michelle Tai; Callan E. Monette; Joy Wu; Fan Yang Bone is one of the most common sites of cancer metastasis, affecting more than 70% of patients with advanced breast cancer and prostate cancer. Despite its prevalence, there are still no effective treatments for bone metastasis...

... is therapeutically active against metastatic breast cancers harboring activating HER2 mutations, but responses are variable and often not durable. Here we demonstrate that recurrent HER2 mutations have differential effects on endocrine therapy responsiveness, metastasis, and pan-HER TKI therapeutic sensitivity...

... can drive their nuclear export, which may be involved in cancer metastasis. However, the mechanism underlying circRNA nuclear export and its role in lymph node (LN) metastasis of bladder cancer remain unclear. Here, we identify an intron-retained circRNA, circNCOR1, that is significantly downregulated...

... with few effective treatments. Here we show that the mitochondrial calcium uniporter (MCU) promotes PDAC cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program. The cystine transporter SLC7A11 was identified as a druggable target downstream...

...Arkadi Hesin; Santosh Kumar; Valid Gahramanov; Maria Becker; Maria Vilenchik; Ilya Alexandrov; Julia Yaglom; Michael Sherman Imaging in monitoring metastasis in mouse models have low sensitivity and is not quantitative. Cell DNA barcoding, demonstrating high sensitivity and resolution, allows...

...Lin Yan; Sneha Sundaram; Bret M. Rust; Matthew J. Picklo; Michael R. Bukowski Metastasis, the spread of malignant cells from a primary tumor to distant organs, is the most devastating aspect of cancer. To understand the metabolism of metastases, we compared the metabolomes of pulmonary metastases...

...Benjamin G. Kaplan; Richard S. Huang; Lucas Dennis; Lee A. Albacker; Garrett M. Frampton; Ethan S. Sokol; Smruthy Sivakumar Introduction NSCLCs are frequently identified at a later stage, with 30-40% of cases presenting with metastasis at the time of diagnosis. Metastatic progression is a major...

... Greig, James M. Wilson. Optimizing adeno-associated viral vector-mediated delivery of trastuzumab to the central nervous system for the treatment of Her2 positive brain metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia...

...Yuki Kimura; Hideyuki Ohzawa; Yuki Kaneko; Kohei Tamura; Yurie Futoh; Kazuya Takahashi; Akira Saito; Mineyuki Tojo; Hideyo Miyato; Joji Kitayama Background: Mesothelial cells play tumor-promoting roles in the development of peritoneal metastasis (PM) through mesothelial-mesenchymal transition (MMT...

... reservoirs in models of breast cancer metastasis. We discovered that DTCs laid preferentially dormant in the liver, and spatially distinct liver sub-microenvironments allow coexistence of dormant DTCs and rare growing metastases even within the same tissue. To explore whether the distinct fates of DTCs...

... and metastasis, including widespread changes in DNA methylation and histone modifications. To better understand the role of altered DNA methylation in NSCLC metastasis to the brain, we measured DNA methylation during disease progression for 12 patients, globally profiling the methylation status of normal lung...

...Zhenzhen Zhang; Solange Bassale; Sonali Jindal; Emily Guinto; Alison Fraser; Tomi Mori; Ken R. Smith; Pepper Schedin Introduction: A diagnosis of breast cancer after childbirth increases risk for metastasis and death in patients diagnosed at ≤45 years of age [1]. Data to delineate if a postpartum...

...) showed markedly different phenotype by exhibiting less aggressive features in vitro and significantly slower tumor growth and metastasis in vivo. The tumor tissue of the C12 showed significant alteration in immune microenvironment as higher number of recruited immune cells including T and B cells. RNA...

.... To investigate the effects of NME7_AB on cancer growth and metastasis, we generated populations of cancer cells that had been cultured in a serum-free media to which was added a recombinant NME7_AB. The parent cells, the NME7_AB grown progeny, or mixed populations were implanted...

... disease, providing evidence that our current therapies are ineffective and new treatments are desperately needed. Pre-clinical models to study metastasis of human soft tissue sarcomas are limited. We have developed a system that allows for the formation of distinct soft tissue sarcoma subtypes from...

...Mabel G. Perez-Oquendo; Roxsan Manshouri; Don Gibbons Lung cancer is the leading cause of cancer-related death worldwide due to the ability of cancer cells to metastasize. Therefore, it is essential to expand our current knowledge of the biological processes that contribute to metastasis to guide...

... increased incidence of thyroid cancer. Although indolent, a subset of PTMC could potentially develop distant metastasis (DM). This study aimed to evaluate the clinico-pathological features and molecular characteristics of PTMC and identify the risk factors for DM in PTMC patients from Middle Eastern...

...Feng Hu; Ki On Fong; May P.L Cheung; Jessica A.J Liu; Rui Liang; Tsz Wai Li; Rakesh Sharma; Philip P.C Ip; Xintao Yang; Martin Cheung The ability of melanoma to acquire metastasis through the induction of angiogenesis is one of the major causes of skin cancer death. Here, we find that high...

...Yu Zhang; Ching Ngar Wong; Lanqi Gong; Xin-yuan Guan; Beibei Ru; Beilei Liu Cancer metastasis remains the key barrier for patient’s cure. Tumor metastasis initiating from a single disseminated cell into the invasive nodule in the foreign microenvironment is poorly understand. In this study, we...