1-20 of 41312 Search Results for

invasion

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3872.
Published: 15 June 2022
... performed the NanoString nCounter® assay in mouse CAFs and normal lung fibroblasts (LFs). Among the miRNAs differentially expressed between CAFs and LFs, miR-200 family members were significantly downregulated in CAFs. Overexpression of miR-200 in CAFs suppressed the migration and invasion of lung cancer...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 767.
Published: 15 June 2022
... that are not adequately treated by current therapeutic modalities and invasion into surrounding tissue next to the thyroid worsens the prognosis. Utilizing the NYMC biobank of PTC patient samples, meta-analysis of RNASeq data was performed, ranking differentially expressed genes between invasive vs noninvasive and lymph...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1322.
Published: 15 June 2022
... overexpression in breast cancer may affect invasion. To investigate this, TK1 mRNA transcript levels were analyzed between normal and BRCA patient tissue samples. The wild-type breast cancer cell line HCC 1806 was used, as well as a TK1 knockdown (L133) which was produced using CRISPR-Cas9. Successful TK1...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3463.
Published: 15 June 2022
..., migration and cytoskeletal organization. Tg(fli1:EGFP) zebrafish model was used to examine the effects of NISCH agonists on PDAC cell growth and invasion. We found that NISCH was expressed in PDAC cell lines, and that out of the three tested agonists, rilmenidine most potently inhibited cancer cell...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5392.
Published: 15 June 2022
... transduction. Glioblastoma multiforme (GBM) is the most common central nervous system (CNS) tumor and associated with poor prognosis among adults due to rapid growth and aggressive invasion. However, the treatment efficacy of current standard therapy for GBM is remaining unsatisfied. Nevertheless, whether...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1561.
Published: 15 June 2022
... transcription factor. lnc-NR2F1 expression levels showed a positive correlation with ZEB1 mRNA levels and EMT scores in 13 mouse lung cancer cells or in lung adenocarcinoma data from TCGA. The migration and invasion of lung cancer cells were decreased after lnc-NR2F1 knockdown and increased after lnc-NR2F1...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3996.
Published: 15 June 2022
... proliferation assays, clonogenic- and wound healing assays were used to investigate function. Gelatin zymography assessed CSPG4/NG2 matrix metalloproteinase (MMP) cross-talk during invasion on mixed extracellular matrix- or collagen IV- coated transwells. Results: A novel 13bp frameshift deletion in exon 3...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3858.
Published: 15 June 2022
... to quantify the number of CRC cells that have invaded from the epithelial channel into the vascular channel over time. We determined that peristalsis-like motions in our organ-on-chip model enhanced the invasion capacity of CRC cells, mimicking intravasation. We subsequently examined the effluent media...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 274.
Published: 15 June 2022
...Valentino Ribecco; Matteo Tamborini; Elisabetta Stanzani; Marco Pizzocri; Milena Mattioli; Simone Olei; Maria Pia Tropeano; Federico Pessina; Michela Matteoli; Lorena Passoni To promote cell growth, invasion and therapy resistance, glioblastoma (GBM) makes use of different communication routes...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5993.
Published: 15 June 2022
... becomes extremely important for reduction of cancer mortality. Isorhapontigenin (ISO), a phytopolyphenol, is derivative stilbene isolated from the Chinese herb Gnetum cleistostachyum. It has been reported that ISO exhibits multiple anticancer activities in human high grade invasive bladder cancer cells...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB541.
Published: 15 June 2022
...Jiyoon Jung; sungae Koh; Kyunghee Lee; Jaeryong Kim Background: CCN growth factor family regulates a variety of biological events such as cell proliferation, cell invasion, cell differentiation, apoptosis, and growth inhibition. Cysteine-rich protein 61 (Cyr61) is one of six secreted proteins...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1552.
Published: 15 June 2022
..., and TUNEL apoptosis assays. Depletion of FER1L4 enhanced cell proliferation, migration, and invasion in a p73-dependent manner. Furthermore, RNA-In situ hybridization (RNA-ISH) analysis of non-metastatic and metastatic human colon cancer tissue samples was carried out to compare the levels of FER1L4 and p73...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 958.
Published: 15 June 2022
...’ for non-invasive cancer diagnosis. They have been reported to influence epithelial mesenchymal transition (EMT) in pathological states such as metastatic lung cancer. We successfully isolated exosomes from an Epidermal Growth Factor Receptor (EGFR) mutated cell line (HCC827) and from serum of different...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5474.
Published: 15 June 2022
... cells. Experimental methods: Proliferation ability, invasion capacity, matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP) major group’s gene expressions and protein levels, and the gelatinolytic activity of MMPs were analyzed after treatment of MCF-7 and MDA-MB-231...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 261.
Published: 15 June 2022
...Colewyn Knoblich; Khosrow Rezvani Colorectal cancer (CRC) is the third most diagnosed cancer and cause of cancer related mortality. CRC that metastasizes to distance sites results in poor prognosis, diminished survival, and reduced effectiveness of treatments. Perineural invasion (PNI...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6398.
Published: 15 June 2022
... in decreased invasion and Epithelial-mesenchymal transition (EMT). Interestingly knocking down of ARVs barring AR-V7, restored invasiveness suggesting the compensatory behavior of AR-V7. Conclusion: Our work demonstrates the presence of ARVs in BrCa with a particular focus on the AR-V7. The LBD truncated AR...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5722.
Published: 15 June 2022
... of CPFS73 inhibited migration and invasion as well as stem cell renewal phenotypes in vitro in triple negative breast cancer cells. In addition, genetic overexpression of CPSF73 promoted breast cancer stemness and knocking down of CPSF73 inhibited stem cell renewal property. Together, our findings indicate...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 786.
Published: 15 June 2022
..., but its role in muscle invasive bladder cancer (MIBC) remains unknown. We have previously found that in MIBC, loss of STAG2 protein expression is associated with better overall survival (n=169; p=0.049) and progression free survival (n=169; p=0.016). Based on these retrospective analyses, we hypothesized...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB015.
Published: 15 June 2022
... to, invasion of, proliferation within and exit from the CNS. mRNA expression of CCR7 in the T-ALL was confirmed by RT-PCR and protein expression on the cell surface was confirmed by flow cytometry. Chemotaxis and calcium mobilization of T-ALL in response to CCL19 was confirmed using transwell-migration assays...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2416.
Published: 15 June 2022
..., particularly in breast cancer. Interestingly, although Ras is rarely mutated in breast cancer, it is often upregulated due to amplification and overexpression of growth factor receptors. Here, we investigated the role of Ras in promoting the migration and invasion of breast cancer cells through mTORC2. We...