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hypoxia

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Journal Articles
Cancer Res (2022) 82 (12_Supplement): 74.
Published: 15 June 2022
...Yi-Chien Wu; Steve Seung-Young Lee Tumor hypoxia arises from the abnormal vasculature in tumors which limit the oxygen supply to the rapidly growing cancer cells. To acclimate to this deprived microenvironment, cancer cells upregulate hypoxia-inducible factor 1-alpha (HIF-1) signaling pathway...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB217.
Published: 15 June 2022
...Nazli Jafarzadeh; Pankaj Gaur; Dareen Sarhan; Nour Shobaki; Wael Traboulsi; Zainab Ramlaoui; Vivek Verma; Seema Gupta; Samir N. Khleif Growing evidence suggests that hypoxia is one of the most important phenomena of solid tumors that supports tumor progression as well as therapeutic resistance...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6236.
Published: 15 June 2022
...Vicky Smith; Debayan Mukherjee; Anna Maria Tsakiroglou; Alexander Baker; Hitesh Mistry; Ananya Choudhury; Peter Hoskin; Tim Illidge; Catharine West Introduction: Hypoxia and an immunosuppressive tumor microenvironment (TME) are both independent negative prognostic factors that contribute...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 121.
Published: 15 June 2022
... cancer (PCa). PCa cells characteristically store lipids, especially cholesterol. Furthermore, hypoxia and lipid metabolism are both associated with decreased responses to immune system and resistance to cancer treatments. Aim of this study was to investigate the impact of hypoxia on cell proliferation...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1587.
Published: 15 June 2022
...Olivia Lombardi; Ran Li; Lisa Browning; Peter J. Ratcliffe; David R. Mole Kidney cancer is the seventh most common malignancy in the Western world and 80% of these are clear cell renal cell cancers (ccRCC). ccRCC arises following inactivation of the VHL gene, which negatively regulates HIF (hypoxia...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 117.
Published: 15 June 2022
...Ji Zhang; Dan Cojocari; Pedro Boasquevisque; Mark Zaidi; Trevor McKee; Nikolina Radulovich; Ming-Sound Tsao; David Hedley; Marianne Koritzinsky; Bradley Wouters Hypoxia is present in most solid tumours and has been clinically correlated with poor prognosis, aggressive disease, and resistance...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 118.
Published: 15 June 2022
... cellular response to hypoxia is largely driven by hypoxia inducible factors (HIFs) that stimulate transcription of genes related to angiogenesis, cancer stem cells, cell survival, and glucose and iron metabolism. There is growing evidence that several factors, in addition to HIFs, contribute to the tumor...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1040.
Published: 15 June 2022
... nature of HNSCC, this carcinoma results in higher resistance to chemoradiotherapy. Recent evidence highlight the importance of the hypoxic microenvironment in contributing to cisplatin resistance. Therefore, the aim of this study was to investigate the role played by hypoxia-induced protein carbonic...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 119.
Published: 15 June 2022
...Olivia Lombardi; Ran Li; Silvia Halim; Peter J. Ratcliffe; David R. Mole Low levels of tissue oxygen, or intra-tumor hypoxia, is a common feature of many solid cancers in which dysregulated cell proliferation often outstrips the ability to develop new functional blood vessels. Furthermore, hypoxia...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5680.
Published: 15 June 2022
... expression of ATAD2 both in stomach adenocarcinoma and metastatic stomach tissue samples. Survival analysis indicates that upregulated ATAD2 expression drastically affects the survival of stomach cancer patients. Since H. pylori infection, and hypoxia are the major contributing factors for stomach...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3766.
Published: 15 June 2022
...Jessica D. Kindrick; Peter J. Ratcliffe; WIlliam Doug Figg; David R. Mole Low oxygen availability (hypoxia) is a common feature of many solid tumors and is associated with poor prognosis and resistance to therapy. The main regulator of cellular responses to hypoxia is the transcription factor HIF...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5678.
Published: 15 June 2022
...Conrado Guerrero Quiles; Julia Gonzalez Abalos; Jonathan Humphries; Martin Humphries; Ananya CHOUDHURY; Catharine West Background: Hypoxia is a common feature of cancer that promotes hallmarks such as cell migration and sustained proliferation. Hypoxia also has a strong link with extracellular...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5679.
Published: 15 June 2022
...Raefa Abou Khouzam; Nagwa Ahmed Zeinelabdin; Mohak Sharda; Husam Nawafleh; Ayda shah Mahmood; Munazza Samar Khan; Goutham Hassan Venkatesh; Salem Chouaib; Shyama Prasad Rao Hypoxia afflicts the microenvironment of solid tumors fueling tumor malignancy. Using an 8-gene in vitro hypoxia signature, we...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 122.
Published: 15 June 2022
... treatment response, castration-resistant prostate cancer nearly always develops and remains driven primarily by the androgen axis. We investigated how changes in oxygenation affect androgen synthesis. Our study indicates that when chronic hypoxia is coupled to reoxygenation, prostate cancer cells...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5006.
Published: 15 June 2022
...Neha Bahadur Merchant; Santosh Kumar Behera; Afroz Alam; Ganji Purnachandra Nagaraju; Riyaz Basha Hypoxia-inducible factor 1-alpha (HIF-1α) is a heterodimeric transcription factor, which is elevated during hypoxic conditions in several malignancies. HIF-1α is known to stimulate hypoxia-responsive...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 263.
Published: 15 June 2022
...Corbin C. Jensen; Noel A. Warfel One of the leading factors in prostate cancer mortality is the onset of metastatic events. This is seen by the drastic decline in survival rates following tumor escape from the primary site. A key promoter of metastasis is tumor hypoxia, or low oxygen concentration...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3835.
Published: 15 June 2022
... was to determine if integrin-kindlin-2 adhesion complexes (kindlin-2:α6β1) were responsive to hypoxia, a physiologically relevant and altered microenvironment in PCa progression. Five different endpoints were tested including the biochemical analysis of kindlin-2 complexes, qRT-PCR, immunoblotting...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 4231.
Published: 15 June 2022
... poor vascularity, and is highly hypoxic. We previously showed that the hypoxia-activated prodrug TH-302 (Evofosfamide) reduces intratumoral hypoxia through a tissue remodeling process, initiates tumor vasculature reorganization, and sensitizes aggressive, spontaneous murine models of prostate cancer...
Journal Articles
Cancer Res (2022) 82 (10_Supplement): A027.
Published: 15 May 2022
...Mina Dinh; Bezhou Feng; Jeff Maltas; Emily Dolson; Masahiro Hitomi; Steph Owen; Jacob Scott Hypoxia and the development of spatially heterogeneous hypoxic and/or necrotic regions in non-small cell lung cancer (NSCLC) and other solid tumors is associated with chemotherapy and radiation resistance...
Journal Articles
Cancer Res canres.4256.2021.
Published: 10 May 2022
... initial treatment response, castration-resistant prostate cancer nearly always develops and remains driven primarily by the androgen axis. Here we investigated how changes in oxygenation affect androgen synthesis. In prostate cancer cells, chronic hypoxia coupled to reoxygenation resulted in efficient...
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