1-20 of 2440 Search Results for

hif-1α

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 120.
Published: 15 June 2022
...Shuai Zhao; Wafik S. El-Deiry HIF- is the main mediator of hypoxic response in cells and contributes to angiogenesis, metastasis and therapy resistance in cancer. The canonical pathway of HIF- degradation in normoxia is through the Von Hippel-Lindau (VHL) E3 ubiquitin ligase. We previously...
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 2014.
Published: 01 July 2021
...Shuai Zhao; Wafik S. El-Deiry The major adaptive response to hypoxia involves HIF- which is conventionally regulated by VHL E3 ligase. Our previous experiments suggested a stabilization of HIF- by CDK1 and CDK4/6 that is independent of VHL, hypoxia or p53, and that CDK4/6 inhibitors...
Journal Articles
Cancer Res (2022) 82 (22_Supplement): PR018.
Published: 15 November 2022
... and are enriched in hypoxic regions of PDAC tumors. Hypoxia leads to acquisition of an inflammatory gene expression signature in fibroblasts and synergizes with cancer cell-derived IL1 to promote an iCAF phenotype in a HIF- dependent fashion. Furthermore, we show in PDAC organoid co-culture models that HIF-...
Journal Articles
Cancer Res (2020) 80 (16_Supplement): 1482.
Published: 15 August 2020
... confirmed that PIM1 overexpression increases tumor angiogenesis. Gene expression analysis of PIM1 overexpressing cells showed that PIM kinases regulates the expression levels of many hypoxia inducible factor- (HIF-) target genes in normoxic conditions. In vitro, in vivo and kinase assays...
Journal Articles
Cancer Res (2020) 80 (16_Supplement): 2933.
Published: 15 August 2020
..., and was significantly associated with tall-cell variant (p <0.0001), extrathyroidal extension (p = 0.0003), lymph node metastasis (p < 0.0001) and stage IV tumors (p < 0.0001). A significant association was also noted with HIF- over-expression (p = 0.0492). Interestingly, KLF5 over-expressing tumors showed...
Journal Articles
Cancer Res (2020) 80 (16_Supplement): 3561.
Published: 15 August 2020
...Laura Cussonneau; Anne-Lise Dechaume; Pamela M. Murray; Henegama Liyanage; Tet-Woo Lee; Frederik Pruijn; Euphemia Y. Leung; Dean C. Singleton Increased expression of Hypoxia-Inducible Factor (HIF-) in breast tumours is associated with poor survival outcome. HIF- promotes phenotypic...
Journal Articles
Cancer Res (2020) 80 (16_Supplement): 3560.
Published: 15 August 2020
... the prevalence of CA is documented in a variety of cancer types, it remains unclear how CA is induced in tumor cells.This study aims to examine the role of intratumoral hypoxia in inducing CA via HIF-. Methods: We (a) exposed cultured breast, pancreatic, colorectal and prostate cancer cells to hypoxia...
Journal Articles
Cancer Res (2020) 80 (16_Supplement): 6178.
Published: 15 August 2020
... if given total 10Gy dose radiation. Moreover, we found the amount of cleaved PARP and phosphorylated γ-H2AX decreased in DAB2IP knocking down cells exposed to 2Gy dose radiation for 6h. In addition, loss of DAB2IP could promote HIF- expression in nucleus and activate the signal pathway by HIF-...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3209.
Published: 15 June 2022
... studies demonstrated that mTOR activates STAT3 to upregulate HIF- and its target proteins, VEGF-A and VEGF-C, key molecules involved in angiogenesis and lymphangiogenesis, respectively. Further, mTOR inhibitors suppress autocrine and paracrine growth stimulation of tumor and lymphatic endothelial cells...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5006.
Published: 15 June 2022
...Neha Bahadur Merchant; Santosh Kumar Behera; Afroz Alam; Ganji Purnachandra Nagaraju; Riyaz Basha Hypoxia-inducible factor 1-alpha (HIF-) is a heterodimeric transcription factor, which is elevated during hypoxic conditions in several malignancies. HIF- is known to stimulate hypoxia-responsive...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2179.
Published: 15 June 2022
... to significant downregulation of HIF (Hypoxia Inducible Factor ) and its targets, which was confirmed by Western Blot analysis of Carbonic Anhydrase IX (CAIX) and Hexokinase II (HKII) in cell and tumor lysates. The opposite was observed following BCAT1 overexpression. BCAT1 knockdown also led to higher DNA...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB128.
Published: 15 June 2022
... in cellular Hexokinase II expression and downregulation of HIF- in HSV-P10 infected cells. Consistent with the function of HIF1 and hexokinase in driving glycolysis we also observed a significant reduction in glucose uptake and lactate release: implying a reduction in glycolysis in cells after being treated...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5398.
Published: 15 June 2022
... through a HIF- dependent mechanism. Furthermore, increased apelin expression resulted in upregulation of its G-protein coupled receptor, APJ which initiates its downstream signaling pathways, together referred to as apelinergic signaling, demonstrating an autocrine loop. Co-culture of hepatocytes...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2339.
Published: 15 June 2022
... restriction, modulates mitochondrial adaptation to low energy input. SIRT3 destabilizes HIF-, and then regulates glycoytic gene expression. The role of SIRT3 in epigenetic regulation has been reported. Using Differential Dependency Network analysis to compare the wiring of the SIRTs and key metabolism...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2366.
Published: 15 June 2022
...-kB, STAT3, HIF- from an oxidized to a reduced state, allowing TFs to bind DNA and activate various biological responses such as cell growth and inflammation. Ref-1 and its transcriptional targets are highly active in Pancreatic Ductal Adenocarcinoma (PDAC) which often presents with tumor metastasis...
Journal Articles
Cancer Res (2022) 82 (22): 4206–4218.
Published: 15 November 2022
... , Trinchieri G , Liu Y-J . Plasmacytoid dendritic cells in immunity . Nat Immunol 2004 ; 5 : 1219 – 26 . 25. Pang L , Ng KT-P , Liu J , Yeung W-HO , Zhu J , Chiu T-LS , . Plasmacytoid dendritic cells recruited by HIF-/eADO/ADORA1 signaling...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (17): 3102–3115.
Published: 02 September 2022
... . Gastroenterol. Hepatol (NY) 2014 ; 10 : 417 – 26 . 43. Feng J , Dai WQ , Mao Y , Wu L , Li J , Chen K , . Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-/PPAR-ϒ/PKM2-mediated glycolysis . J Exp Clin Cancer Res...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (5): 943.
Published: 03 March 2022
... are publishing this note to alert readers to a concern about this article ( 1 ). In Fig. 1B, the Western blot bands representing HIF-, HIF-2α, and actin were inadvertently also used in Fig. 1A of a 2012 Oncogene publication by the authors ( 2 ). The blots were presented to demonstrate knockdown efficiency...
Journal Articles
Cancer Res (2022) 82 (11): 2097–2109.
Published: 06 June 2022
...-deficient ccRCC with wild-type TET2 and increased the sensitivity to glycolysis inhibitors. Moreover, combined expression levels of the HNF4α–TET2-FBP1 axis served as a biomarker of prognosis in patients with ccRCC. This study reveals a unique function of TET2 in the suppression of tumor metabolism and HIF...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (13): 2388–2402.
Published: 05 July 2022
... with cell-permeable AKG for 24 hours (Supplementary Fig. S6A). To determine the role of HIF in BCAT1i/AKG-induced IDHWT GBM cell death, we performed clonogenic assays under 20% or 1% O2 and found that hypoxia had no obvious effect on viability of parental and BCAT1 KO#2 or KO#3 U251MG...
Includes: Supplementary data