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glioblastoma

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Journal Articles
Cancer Res (2022) 82 (23_Supplement_2): B009.
Published: 01 December 2022
...Maureen Malloy; Sweta Sudhir; Harmon Khela; Maria Fagundo-Lugo; Bachchu Lal; Joseph Bressler; John Laterra; Hernando Lopez Bertoni Gliomas are the most common primary brain cancer and glioblastoma (GBM) represents the most aggressive and lethal subtype. The high GBM morbidity and mortality are due...
Journal Articles
Cancer Res CAN-22-0677.
Published: 21 November 2022
.... Poliani; Rosa Maria Moresco; Annapaola Andolfo; Rossella Galli Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (22): 4234–4246.
Published: 15 November 2022
.... Simultaneously, MSH2 identifies DNA adducts induced by temozolomide (TMZ) and triggers apoptosis and autophagy in tumor cells. Previous work has revealed that reduced MSH2 expression is often observed in patients with glioblastoma (GBM) who relapse after chemotherapy. Elucidation of the mechanism behind TMZ...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (22): 4274–4287.
Published: 15 November 2022
... In multiple types of cancer, an increased frequency in myeloid-derived suppressor cells (MDSC) is associated with worse outcomes and poor therapeutic response. In the glioblastoma (GBM) microenvironment, monocytic (m) MDSCs represent the predominant subset. However, the molecular basis of mMDSC enrichment...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (21): 4044–4057.
Published: 02 November 2022
... for cancer therapeutics. Pairs of paralog genes are among the most straightforward potential synthetic–lethal interactions by virtue of their redundant functions. Here, we demonstrate a paralog-based synthetic lethality by targeting vaccinia-related kinase 1 (VRK1) in glioblastoma (GBM) deficient of VRK2...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (19): 3573–3587.
Published: 04 October 2022
...Yongxu Li; Tiepeng Wang; Quan Wan; Qing Wang; Zhenzhong Chen; Yuan Gao; Yuchen Ye; Jiusheng Lin; Bihuan Zhao; Huaile Wang; Jinming Yang; Kai Zhao; Na Lu Glioblastoma (GBM) is the most common type of primary adult brain tumor. Glioma stem cell (GSC) residence and temozolomide (TMZ) resistance in GBM...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (19): 3622–3633.
Published: 04 October 2022
...Friederike Hesse; Alan J. Wright; Vencel Somai; Flaviu Bulat; Felix Kreis; Kevin M. Brindle Early detection of tumor cell death in glioblastoma following treatment with chemoradiation has the potential to distinguish between true disease progression and pseudoprogression. Tumor cell death can...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (18): 3321–3334.
Published: 16 September 2022
...; Qianghu Wang; Jianghong Man; Chaojun Li; Weiwei Tao; Sameer Agnihotri; Xu Qian; Yu Shi; Yongping You; Nu Zhang; Jeremy N. Rich; Xiuxing Wang Glioblastoma (GBM) is a complex ecosystem that includes a heterogeneous tumor population and the tumor-immune microenvironment (TIME), prominently containing tumor...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (18): 3359–3374.
Published: 16 September 2022
...Jingshu Xiao; Jiaming Liang; Junjie Fan; Panpan Hou; Xiaodong Li; Haipeng Zhang; Kai Li; Lang Bu; Ping Li; Miao He; Yongheng Zhong; Liping Guo; Penghui Jia; Qiaoqiao Xiao; Junyu Wu; Hong Peng; Chunmei Li; Fan Xing; Deyin Guo Glioblastoma (GBM) is among the most aggressive human cancers. Although...
Includes: Supplementary data
Images
<em>VRK2</em>-methylated <span class="search-highlight">glioblastoma</span> and neuroblastoma cell lines ...
Published: 02 November 2022
Figure 1. VRK2-methylated glioblastoma and neuroblastoma cell lines are sensitive to VRK1 loss. A, Scatter plot depicting VRK2 expression and VRK1 CRISPR knockdown sensitivity score in 783 cancer cell lines. Color coded by primary lineage. B, Scatter plot depicting VRK2 expression and VRK2 promoter methylation in 902 cancer cell lines. Color coded by primary lineage. C, Scatter plot depicting VRK2 expression and VRK2 methylation for 530 low grade glioma (LGG; peach) and 116 glioblastoma (GBM; purple) tumors. D, Scatter plots with VRK2 expression and MGMT methylation for GBM and LGG tumors as in ( C ), color coded by IDH mutation status. Figure 1. VRK2-methylated glioblastoma and neuroblastoma cell lines are sensitive to VRK1 loss. A, Scatter plot depicting VRK2 expression and VRK1 CRISPR knockdown sensitivity score in 783 cancer cell lines. Color coded by primary lineage. B, Scatter plot depicting VRK2 expression and VRK2 promoter methylation in 902 cancer cell lines. Color coded by primary lineage. C, Scatter plot depicting VRK2 Expression and VRK2 Methylation for 530 low grade glioma (LGG; peach) and 116 glioblastoma (GBM; purple) tumors. D, Scatter plots with VRK2 expression and MGMT methylation for GBM and LGG tumors as in (C), color coded by IDH mutation status. More
Journal Articles
Cancer Res (2022) 82 (23): 4301–4302.
Published: 02 December 2022
.... Nat Cancer 2022;3:1228-46 . Despite advances in other tumor entities, immunotherapies have a limited effect in glioblastoma (GBM). A potential role of myeloid-derived suppressor cells (MDSC) in promoting treatment resistance suggests MDSCs as next-generation immunotherapy targets. MDSCs...
Images
<em>VRK2</em>-methylated context is maintained in patient-relevant ...
Published: 02 November 2022
Figure 6. VRK2-methylated context is maintained in patient-relevant glioblastoma models. A, Immunoblots from 9 GBM CSC models. B, Select CSC models were cultured in CSC or non-CSC medium and immunoblotted for VRK1 and VRK2 protein. C, Seven-day growth curves of the 3832 model with shRNA knockdown induced by doxycycline of the indicated genes (left), and data from day 6 quantified (right). ****, P < 0.001, one-way ANOVA and Dunnett post hoc multiple comparison test. D, Data as in C for the DI318 model. E and F, Immunoblots ( E ) and mRNA levels ( F ) for VRK1 at 3 days after doxycycline. Figure 6. VRK2-methylated context is maintained in patient-relevant glioblastoma models. A, Immunoblots from 9 GBM CSC models. B, Select CSC models were cultured in CSC or non-CSC medium and immunoblotted for VRK1 and VRK2 protein. C, 7-day growth curves of the 3832 model with shRNA knockdown induced by doxycycline of the indicated genes (left), data from day 6 quantified (right) ****, P < 0.001, one-way ANOVA and Dunnett's post hoc multiple comparison test. D, Data as in (C) for the DI318 model. E, Immunoblots and (F) mRNA levels for VRK1 at 3 days after doxycycline. More
Journal Articles
Cancer Res (2022) 82 (22_Supplement): A021.
Published: 15 November 2022
...Vincent J. Picozzi; Teresa Macarulla; Philip Agop Philip; Carlos Roberto Becerra; Tomislav Dragovich Background: Tumor Treating Fields (TTFields) therapy is a loco-regional antimitotic treatment approved for glioblastoma and malignant pleural mesothelioma. TTFields (150 kHz), with/without...
Journal Articles
Cancer Res (2022) 82 (22_Supplement): B009.
Published: 15 November 2022
...Jenna Duttenhefner; Katie M. Reindl GSTP1 belongs to a large family of detoxification enzymes essential for cellular homeostasis in healthy cells. GSTP1 is overexpressed in many cancers and is associated with poor survival in PDAC patients. Studies in glioblastoma and breast cancer have suggested...
Journal Articles
Cancer Res CAN-22-0074.
Published: 02 December 2022
...), and Glioblastoma 12 (GBM) (10 datasets, 121 patients) (Fig. 1C). Less frequent tumor types included acute T cell 13 leukemia, renal cell carcinoma, and certain childhood tumors like medulloblastoma. The 14 majority of the datasets were generated from single cell suspensions with no prior enrichment 15 (Unbiased...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (23): 4414–4428.
Published: 02 December 2022
... to metabolic and vascular remodeling of the adult heart . Circulation 2018 ; 137 : 2592 – 608 . 18. Zhu TS , Costello MA , Talsma CE , Flack CG , Crowley JG , Hamm LL , . Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (23): 4474–4484.
Published: 02 December 2022
... chemotherapy formulations exist as rigid wafers, microparticles, or soft hydrogels ( 35 ). The biodegradable Gliadel wafer for the treatment of glioblastoma is the prime example (Eisai Inc.), and its use increases patient survival by 2.3 months ( 36 ). However, this rigid polymeric wafer releases over 50...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 908.
Published: 15 June 2022
...Jiri Sana; Frantisek Siegl; Marek Vecera; Pavel Fadrus; Jaroslav Juracek; Petra Pokorna; Karolina Trachtova; Tomas Kazda; Ondrej Slaby Introduction: Glioblastoma (GBM) is the most common malignancy affecting the CNS. Despite radical therapy, recurrence of GBM is a frequent and relatively early...
Journal Articles
Cancer Res (2022) 82 (23): 4325–4339.
Published: 02 December 2022
... , Cheng XR , . Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma . ACS Med Chem Lett 2013 ; 4 : 1102 – 7 . ...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (13): 2388–2402.
Published: 05 July 2022
... isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDHWT GBM growth. Through a metabolic synthetic lethal screen, we report here that α-ketoglutarate (AKG) kills IDHWT GBM cells when BCAT1 protein is lost, which is reversed...
Includes: Supplementary data