... unknown. Nonsteroidal anti-inflammatory drugs (NSAIDs), like sulindac, inhibit cyclooxygenase-1 and cyclooxygenase-2 and modulate the secretion of pro-inflammatory cytokines. The purpose of this study was to investigate the mechanisms underlying the anticancer effects of sulindac in our E0771 mouse model...

... stimulating tumor proliferation, enhancing angiogenesis and suppressing immune function in the TME^{1, 2}. PGE2 is also a mediator of adaptive resistance to immune checkpoint inhibitor therapy via the upregulation of cyclooxygenase-2 (COX-2). While the role of PGE2 signaling in cancer is clear, how...

... pathology . Trends Endocrinol Metab 2004 ; 15 : 398 – 404 . 3. Vane J , Bakhle Y , Botting R . Cyclooxygenases 1 and 2 . Annu Rev Pharmacol Toxicol 1998 ; 38 : 97 – 120 . 4. Wang M-T , Honn KV , Nie D . Cyclooxygenases , prostanoids...

...-Bostwick CA , Jenkins G , Knox AJ , Pang L . A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis . FASEB J 2014 ; 28 : 3183 – 96 . 17. Lee JM , Lee JS , Kim H , Kim K , Park...

... located in human tissues although they are predominantly abundant in close proximity to vessels ( 2 ), epithelia, fibroblasts ( 3 ), and nerves ( 4 ). MCs store many small secretory granules, whose content allows the classification of MCs in two major types: MC_(T) and MC_(TC...

... Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment shape the fate of cancer both, at primary and metastatic sites ( 1 ). Among stromal cells, cancer-associated fibroblasts (CAF) are known to affect tumor growth ( 2, 3 ). Although most studies suggest a tumor...

...' tumour . J Pediatr Urol   2020 ; 16 : 376 . 189. Maturu   P , Jones   D , Ruteshouser   EC , Hu   Q , Reynolds   JM , Hicks   J , et al   Role of cyclooxygenase-2 pathway in creating an immunosuppressive microenvironment and in initiation and progression of Wilms' tumor...

...Rong Bu; Sandeep K. Parvathareddy; Abdul K. Siraj; Padmanaban Annaiyappanaidu; Kaleem Iqbal; Maha Al Rasheed; Wael Haqawi; Khawla S. Al-Kuraya The cyclooxygenase-2 (COX-2) - prostaglandin E2 (PGE2) pathway has been implicated in carcinogenesis with BRAF mutation shown to promote PGE2 synthesis...

... the similar structure with dyclonine and induce cell death in BSO-resistant cancer cells both in vitro and in vivo. Microarray analysis of tumor xenograft tissue showed cyclooxygenase-2 expression as a potential biomarker for the efficacy of such combination therapy. Moreover, OXY-mediated ALDH inhibition...

... peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link . Cardiovasc Res   2009 ; 83 : 419 – 20 . 31. Chistiakov   DA , Bobryshev   YV , Orekhov   AN .  Macrophage-mediated cholesterol handling in atherosclerosis . J Cell Mol Med   2016 ; 20 : 17 – 28 . 32...

.... While E-FABP deficiency did not affect the expression of Acsl, Crsl1, Pparβ, cyclooxygenase 2 (Cox2), dynamin-related protein 1 (Drp 1), dominant optic atrophy 1 (Opa 1; Supplementary Fig. S5D–S5I), Cpt1b and uncoupling protein 2 (Ucp2) expression were dramatically reduced in E-FABP^−/− T...

... , Barrera-Saldaña   HA , et al   Acetylsalicylic acid inhibits hepatitis C virus RNA and protein expression through cyclooxygenase 2 signaling pathways . Hepatology   2008 ; 47 : 1462 – 72 . 75. Rivas-Estilla   AM , Bryan-Marrugo   OL , Trujillo-Murillo   K , Pérez-Ibave   D...

...), ERK ( 45 ), EGFR and glycogen synthase kinase-3β (thus the stability of β-catenin; ref. 42 ) was negatively affected by POX expression. Cyclooxygenase-2, which is frequently upregulated in colorectal cancer and often contributes to cancer development ( 49 ), was also downregulated...

... advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. References 1. Dannenberg   AJ , Subbaramaiah   K .  Targeting cyclooxygenase-2 in human neoplasia: rationale and promise . Cancer Cell   2003 ; 4 : 431 – 6 . 2. Kalinski   P .  Regulation of immune...

... and clinical intervention studies indicate strong cancer preventive efficacy of cyclooxygenase (COX)-2 inhibitors. Their use for chemoprevention is limited due to increased cardiovascular (CV) toxicities. Selective COX-2 inhibition diverts arachidonic acid to the 5-lipoxygenase (5-LOX) pathway resulting...

... of less than 50% ( 2 ). Significant gaps in understanding the biology of disease continue to be the main reason behind the paucity of effective therapeutic interventions. The challenges in effectively treating HNSCC are attributed to its extreme heterogeneity as far as anatomic locations and genetic...

... results of the experiment described in Fig. 7B because the authors were unable to provide the original research records related to the figure. References 1. Zhu   J , Huang   JW , Tseng   PH , Yang   YT , Fowble   J , Shiau   CW , et al   From the cyclooxygenase-2 inhibitor...

... , Zhang   SL , He   CY , Zhuang   QY , Han   PY , Jiang   SW , et al   Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1 . Theranostics   2017 ; 7 : 1389 – 406 . 7. Xie   Q...

... the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates anti-tumor immune responses . J Clin Invest   2021 ; 131 : 140752 . 19. Lyons   TR , Borges   VF , Betts   CB , Guo   Q , Kapoor   P , Martinson   HA , et al   Cyclooxygenase-2-dependent lymphangiogenesis...

... endothelial growth factors and cyclooxygenase-2 in prostate cancer . Transl Res   2016 ; 175 : 116 – 28 . 20. Rinn   JL , Kertesz   M , Wang   JK , Squazzo   SL , Xiao   X , Brugmann   SA , et al   Functional demarcation of active and silent chromatin domains in human HOX loci...