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computerized-simulation-synergism-and-antagonism

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Journal Articles
Cancer Res (2022) 82 (8): 1448–1460.
Published: 15 April 2022
... 2018 ; 42 : 102 – 10 . 188. Tang J , Wennerberg K , Aittokallio T . What is synergy? The Saariselka agreement revisited . Front Pharmacol 2015 ; 6 : 181 . 189. Chou TC . Theoretical basis, experimental design, and computerized simulation of synergism...
Journal Articles
Cancer Res (2022) 82 (4): 721–733.
Published: 17 December 2021
... expression library of human ORFs . Nat Methods 2011 ; 8 : 659 – 61 . 25. Chou TC . Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev 2006 ; 58 : 621 – 81 . 26. Wisitpitthaya S...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (19): 4964–4980.
Published: 01 October 2021
...   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 48. Menezes   WP , Silva   VAO , Gomes   INF , Rosa   MN , Spina   MLC , Carloni   AC , et al   Loss...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (13): 3539–3553.
Published: 01 July 2021
... Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-resistant non-small-cell lung cancer cells . Mol Ther Nucleic Acids   2018 ; 11 : 455 – 67 . 36. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies...
Includes: Supplementary data
Journal Articles
Cancer Res (2021) 81 (5): 1398–1412.
Published: 01 March 2021
..., experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 26. Ianevski   A , Giri   AK , Aittokallio   T .  SynergyFinder 2.0: visual analytics of multi-drug combination synergies . Nucleic Acids Res...
Includes: Supplementary data
Journal Articles
Journal Articles
Cancer Res (2021) 81 (6): 1457–1471.
Published: 15 March 2021
... loss of heterozygosity is common in the cell lines but uncommon in primary tumors . BMC Genomics   2011 ; 12 : 443 . 31. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621...
Includes: Supplementary data
Journal Articles
Cancer Res (2020) 80 (10): 2031–2044.
Published: 15 May 2020
... . 21. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 22. Chou   TC .  Drug combination studies and their synergy quantification using the Chou-Talalay...
Includes: Supplementary data
Journal Articles
Cancer Res (2020) 80 (4): 663–674.
Published: 14 February 2020
... Keyserlingk   NG , Elbling   L , et al   Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24) . Biochem Pharmacol   2006 ; 71 : 426 – 40 . 18. Chou   T-C .  Theoretical basis, experimental design, and computerized simulation...
Includes: Supplementary data
Journal Articles
Series: Author Choice
Cancer Res (2019) 79 (21): 5612–5625.
Published: 01 November 2019
... sensitivity . Nature   2012 ; 483 : 603 – 7 . 39. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 40. Chou   TC .  Drug combination studies and their synergy...
Includes: Supplementary data
Journal Articles
Cancer Res (2018) 78 (9): 2419–2431.
Published: 30 April 2018
... . 10. Chou   T-C .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 11. Cavalli   F , Hansen   HH , Kaye   SB , European Society for Medical Oncology . Textbook...
Includes: Supplementary data
Journal Articles
Cancer Res (2018) 78 (20): 5754–5766.
Published: 15 October 2018
... Biol   1976 ; 59 : 253 – 76 . 42. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 43. Weisenberger   DJ , Campan   M , Long   TI , Kim   M...
Includes: Supplementary data
Journal Articles
Cancer Res (2018) 78 (15): 4344–4359.
Published: 31 July 2018
..., and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 6. Das   TK , Dana   D , Paroly   SS , Perumal   SK , Singh   S , Jhun   H , et al   Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote...
Includes: Supplementary data
Journal Articles
Cancer Res (2008) 68 (9_Supplement): 4183.
Published: 01 May 2008
... or sigmoidicity) and Dm (potency or ED50) values from each drug and their combinations allow computerized simulation of synergism or antagonism at all doses and effect levels at different time points for therapeutic efficacy and for toxicity. The isobolograms at different effect levels...
Journal Articles
Cancer Res (2017) 77 (24): 7120–7130.
Published: 14 December 2017
... Biol   2008 ; 35 : 1 – 2 . 30. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 31. Yokoyama   Y , Dhanabal   M , Griffioen   AW , Sukhatme   VP...
Includes: Supplementary data
Journal Articles
Cancer Res (2017) 77 (20): 5503–5517.
Published: 15 October 2017
... , Abrego   J , Haridas   D , Mishra   A , Souchek   J , et al   MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism . Oncotarget   2015 ; 6 : 19118 – 31 . 25. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism...
Includes: Supplementary data
Journal Articles
Cancer Res (2017) 77 (22): 6340–6352.
Published: 14 November 2017
... , Mintoff   C , Virassamy   B , et al   Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer . Nat Commun   2017 ; 8 : 606 . 20. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism...
Includes: Supplementary data
Journal Articles
Cancer Res (2016) 76 (14_Supplement): 2515.
Published: 15 July 2016
.... Effectiveness of different concentration of each single therapy and its combination with LGK974 was determined to create a drug-response-curve due to the computerized simulation of synergism and antagonism in drug combination studies (Chou, 2006). A reporter assay for canonical WNT/β-catenin signaling was used...
Journal Articles
Cancer Res (2017) 77 (9): 2488–2499.
Published: 30 April 2017
...-dependent kinase-1 (PDK1) inhibitors . J Med Chem   2011 ; 54 : 1871 – 95 . 26. Chou   TC .  Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 27. Chou   TC , Talalay   P...
Includes: Supplementary data
Journal Articles
Series: Author Choice
Cancer Res (2017) 77 (2): 459–469.
Published: 16 January 2017
..., experimental design, and computerized simulation of synergism and antagonism in drug combination studies . Pharmacol Rev   2006 ; 58 : 621 – 81 . 30. Chou   TC , Talalay   P .  Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors . Adv...
Includes: Supplementary data