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colorectal-carcinoma

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Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1705.
Published: 15 June 2022
.... For instance, half of microsatellite instability-high (MSI-H) colorectal carcinoma (CRC) patients do not respond to ICB immunotherapy. There is still a crucial need to identify and develop biomarkers predictive of outcome to ICB therapy. Tertiary lymphoid structures (TLS) have been observed in a variety...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 760.
Published: 15 June 2022
..., Vaclav Liska, Pavel Vodicka. Concordance of DNA copy number profiles between primary and metastatic colorectal carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 760...
Journal Articles
Cancer Res (2022) 82 (11): 2196.
Published: 06 June 2022
... , Liu T , . Porphyromonas gingivalis promotes colorectal carcinoma by activating the hematopoietic NLRP3 inflammasome . Cancer Res 2021 ; 81 : 2745 – 59 . ...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2550.
Published: 15 June 2022
...Daniela Castaldo; Sara Santagata; Giuseppina Rea; Maria Napolitano; Crescenzo D'Alterio; Rita Guarino; Vittorio Albino; Andrea Belli; Carmen Cutolo; Francesco Izzo; Stefania Scala Background: Hepatocellular carcinoma (HCC) and colorectal cancer liver metastasis (CRLM) represent the two most...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2051.
Published: 15 June 2022
... Kress, Claudine Vermot-Desroches, Lionel Chalus, Jeremy Forget, Benoît Pinteur, Paul Bravetti, Charles Dumontet, Antoîne Italiano. Antitumor activity of a novel allogeneic colorectal cancer vaccine in C57BL/6 mice bearing MC38 anti-PD1 resistant colon carcinoma syngeneic model with TME [abstract...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5252.
Published: 15 June 2022
... pathological findings of HE staining. Citation Format: Yuhan Rong, Yuma Takeda, Naoki Okubo, Akihiro Suzuki, Motohiko Tokuhisa, Noritoshi Kobayashi, Atsushi Ishibe, Ikuma Kato, Shoji Yamanaka, Satoshi Fujii, Itaru Endo, Yasushi Ichikawa. In colorectal cancer (CRC), neuroendocrine carcinoma (NEC...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6247.
Published: 15 June 2022
... was compared to AS-10 in the cell lines of pancreatic carcinoma (MiaPaCa2), lung carcinoma (H460), colorectal adenocarcinoma (HT29), colorectal carcinoma (HCT116), and FOLFOX resistant HT29 and HCT116 cells. Based on the IC50 values observed from these initial studies, only ASA-7, an open-chain...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2515.
Published: 15 June 2022
... microenvironment. Up to 50% of colorectal carcinoma patients develop LM during their disease and this is associated with a poor prognosis. Our laboratory previously identified a sexual dimorphism in the regulation of the immune microenvironment (IME) of LM and showed that estrogen could promote the accumulation...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6209.
Published: 15 June 2022
...Marie Flechner; Juergen Loskutov; Ulrike Pfohl; Katja Osman; Christian R. Regenbrecht; Katja Uhlig; Lena Wedeken Colorectal carcinomas (CRC) are one of the most common malignant tumors. Due to its heterogeneity and high probability to metastasize, the disease is often incurable and novel, improved...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB045.
Published: 15 June 2022
...-catenin pathway. Administration of ST316 to HCT116 human colorectal carcinoma cells, which carry a degradation-escape, gain-of-function mutation in β-catenin, dramatically reduced nuclear β-catenin localization. Furthermore, ST316-mediated loss of nuclear β-catenin was associated with a significant...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2420.
Published: 15 June 2022
... record. Atopic diseases such as asthma and eczema are characterized by an overabundance of IgE, a protein regulated by the IL4 pathway. Using Vanderbilt University Medical Center’s SD Discover program, we obtained de-identified records for patients diagnosed with at least stage II colorectal carcinoma...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): CT041.
Published: 15 June 2022
... responses were observed in 2 (colorectal carcinoma and renal cell carcinoma). Stable disease, defined as first scan at 6 weeks, was observed in 22; 9 (41%) demonstrated tumor volume reduction, 2 (9%) demonstrated SD for > 6 months, and 1 has an ongoing SD at 8 months. At doses above 0.1 mg/kg...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1924.
Published: 15 June 2022
... carcinoma, colorectal carcinoma, hepatocellular carcinoma, gastrointestinal carcinoma, melanoma, breast cancer, and sarcoma. A set of 196 patients was left out of the study for validation. Clinical data including patient, treatment, and cancer metadata were collected at baseline for all patients, as well...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3531.
Published: 15 June 2022
...Bin-Jin Hwang; Li-Chung Tsao; Chaitanya Acharya; Timothy Trotter; Pankaj Agarwal; Tao Wang; Junping Wei; Xiao-Yi Yang; Gang-jun Lei; Takuya Osada; Herbert Kim Lyerly; Michael A. Morse; Zachary Hartman Background: The majority of colorectal carcinomas (CRCs) are insensitive to anti-PD-1/PD-L1 immune...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1718.
Published: 15 June 2022
... interest in the potential of irradiation in colorectal cancer, not only as an adjuvant and palliative treatment, but also as an immune stimulant. Materials and Methods: CT26 murine colorectal carcinoma cells were subcutaneously implanted on the flank of BALB/c mice. Tumors were exposed to sham, single...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1210.
Published: 15 June 2022
... matched metastatic sites and two colorectal carcinomas with matched liver metastatic tissues. This analysis demonstrated that the breast metastatic tumors selected for subclones that were lacking ERBB2 amplification in the primary site. Furthermore, the liver metastasis had deletions of chromosomes 18, 19...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1694.
Published: 15 June 2022
... and progression in several cancer models, including colorectal carcinoma and melanoma. cfDNA may stem from a combination of apoptosis, necrosis, and cellular secretions. However, the source and mechanism of cfDNA release in cancer cells are still unclear. Indeed, while some data state that cfDNA is derived from...
Journal Articles
Cancer Res (2021) 81 (13_Supplement): 3172.
Published: 01 July 2021
... characteristic of the functional organization of this continuously evolving ecosystem is spatial intratumoral heterogeneity (ITH), a key determinant of disease progression landmarks in multiple carcinomas that include colorectal cancer. To optimize diagnosis, prognosis, therapeutic strategies and to identify...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): CT176.
Published: 15 June 2022
... in the indications, triple negative breast cancer, gastric cancer, colorectal carcinoma, hepatocellular carcinoma, ovarian cancer or osteosarcoma. Results: To date, 4 patients have been treated, including 2 patients with ovarian cancer and 2 with CRC at 4 dose levels. No dose limiting toxicities have been observed...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3708.
Published: 15 June 2022
... infiltrated syngeneic murine colorectal carcinoma model MC38. Besides its direct inhibitory effects on cancer cells, OMX-0407 repolarizes the tumor microenvironment (TME) by strongly decreasing regulatory T cells (T-regs) and M2-polarized macrophages in the tumor bed, while not affecting the peripheral T cell...