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cancer-stem-cells

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Journal Articles
Cancer Res (2022) 82 (12_Supplement): 888.
Published: 15 June 2022
... (EMT). Recently, our lab found that eATP functions in promoting cancer cell growth, metastasis are similar to those of TGF-β, a well-known EMT and cancer stem cells (CSCs) inducer. Increasing reports state that the EMT and CSCs share some molecular links, but the detailed mechanisms and inductor...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3961.
Published: 15 June 2022
... underlying principle is unknown.Here, we report that one can predict a priori the resistance mechanism that will arise in individual SMO inhibitor (SMOi)-resistant SHH medulloblastoma (MB), based on different CSC phenotypes in each tumor. We show that the dependence of cancer stem cells (CSCs), not bulk...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2354.
Published: 15 June 2022
..., promotes BCBM of circulating tumor cells in vivo. We previously reported that tGLI1 enriches the breast cancer stem cell (BCSC) subpopulation, and that tGLI1-positive BCSCs strongly activate astrocytes, the most abundant glial cell type in the brain. The mechanisms by which tGLI1-activated astrocytes...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6066.
Published: 15 June 2022
...Kangyu Lin; John Paul Shen Cancer stem cells (CSCs) are a small subpopulation of cells with capabilities of self-renewal and differentiation potential and have been suggested to play a critical role in tumor-initiation, metastasis, and multidrug resistance. The marker genes used to identify CSCs...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 6068.
Published: 15 June 2022
... signaling to promote differentiation of cancer stem cells in treatment of colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6068. ©2022 American Association...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2.
Published: 15 June 2022
...Liankun Song; Merci Mino; Jana Yamak; Vyvyan Nguyen; Derron Lopez; Victor Pham; Ali Fazelpour; Vinh Le; Dongjun Fu; Matthew Tippin; Xiaolin Zi Prostate cancer stem cells (PCSC) are small tumor subpopulations capable of self-renewal and driving prostate cancer heterogeneity, which is critical...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 863.
Published: 15 June 2022
... a decrease in the GD2+ cancer stem cells (CSCs). Additionally, functional assays show a reduction growth and proliferation in 3D culture systems. Interestingly, there was no effect on proliferation in standard 2D culture conditions. GD2 was previously identified to be regulated by NFkB signaling. Because...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 889.
Published: 15 June 2022
...Na Li; Tejinder Pal; Shurui Cai; Ananya Banerjee; Xuetao Bai; Kousalya Lavudi; Qi-En Wang Tumors contain phenotypically and functionally heterogeneous cancer cells. Among them, a minority of cell subpopulation, termed cancer stem cells (CSCs), which possess the self-renewal capacity and are able...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 5335.
Published: 15 June 2022
... treatment. If we could overcome the initial resistance, we could prevent cancer cells from developing various types of acquired resistance. We are now focusing on YAP1 and cancer stem cells, which have been also reported as acquired resistance mechanisms in various types of cancers. Methods: PC-9 cells...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 3119.
Published: 15 June 2022
...Monika Pizon; Dorothea Schott; Ulrich Pachmann; Rainer Schobert; Katharina Pachmann Background: Circulating cancer stem cells (cCSCs) are a small aggressive subset of circulating tumor cells with cancer stem cells features: resistance to diverse cancer treatments and the capacity for generating new...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB024.
Published: 15 June 2022
...Xuanhua Peter Xie; Mungunsarnai Ganbold; Alicia Pedraza; Luis Parada A number of studies have described an essential role of cancer stem cells (CSC) in glioblastoma (GBM) progression and recurrence based on isolation by candidate markers. However, a systematic evaluation of the proposed CSC...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): LB540.
Published: 15 June 2022
... has the full Thy-1 protein and the GPI anchor. The cell lines were grown on non-adherent plates to allow formation of spheroids. Spheroid formation is dependent on the number of cancer stem cells. The size and number of spheroids were measured using microscopy. Spheroids were defined as an aggregate...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 92.
Published: 15 June 2022
... are associated with a worse bone, brain, and lung MFS compared to tumors with low co-activation. Ectopic co-overexpression of tGLI1 and GP130 upregulates mRNA expression of stemness genes, Nanog, Sox2, and Oct4, leading to the subsequent promotion of the breast cancer stem cell (CSC) subpopulation in vitro...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 890.
Published: 15 June 2022
... have enrichment of cancer stem cells (CSCs) with enhanced pro-survival and self-renewal capacity, suggesting a potential vulnerable population for effective targeted therapies with less toxicity. APOBEC3 proteins are a family of primate-specific DNA deaminases that catalyze cytidine to uracil (C-to-U...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 891.
Published: 15 June 2022
... studies suggest that ovarian cancer stem cells (OCSCs) contribute to tumor relapse and chemotherapy resistance. Recent studies demonstrate that OCa cells express estrogen receptor beta (ERβ), which functions as a tumor suppressor. However, the status of ERβ expression in OCSCs and the therapeutic utility...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 892.
Published: 15 June 2022
..., Yuichiro Doki, Hidetoshi Eguchi, Norikatsu Miyoshi. Single-cell RNA sequencing of patient-derived organoid reveals treatment-induced tumor resistance through cancer stem cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 893.
Published: 15 June 2022
...Khoa Nguyen; Minh Tran; Thomas Cheng; Kurtis Willingham; Reza Izadpanah; Matthew Burow Introduction: Treatment resistance and tumor recurrence of Glioblastoma (GBM) have been associated with cancer stem cells (CSCs), a subpopulation of cancer cells defined by capabilities of sphere-formation in 3D...
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 1039.
Published: 15 June 2022
... genes SOX2 and c-MYC, which are associated with breast cancer stem cell formation as well as tumor recurrence and metastasis. In this study, we aimed to further characterize the effects of the TrkA-JAK2/STAT3 pathway crosstalk on breast cancer stem cells. Our data showed that overexpression of TrkA...
Journal Articles
Cancer Res (2022) 82 (11): 2124–2140.
Published: 06 June 2022
...Hui Wang; Haibo Xu; Wei Chen; Mei Cheng; Li Zou; Qin Yang; Chi Bun Chan; Hao Zhu; Ceshi Chen; Jianyun Nie; Baowei Jiao Cancer stem cells (CSC) are supported by the tumor microenvironment, and non-CSCs can regain CSC phenotypes in certain niches, leading to limited clinical benefits of CSC-targeted...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (12_Supplement): 2046.
Published: 15 June 2022
...You Qin; Kexing Lyu; Sifei Yu; Ming Lin; Max Wicha; Alfred E. Chang; Qiao Li We have reported that cancer stem cell (CSC) vaccination induces CSC-specific T and B cell responses associated with therapeutic efficacy which can be enhanced by anti-PD-L1 administration. Tumor cells have been recognized...