...; Paul Gougis; Chloé-Agathe Azencott; Fabien Reyal; Anne-Sophie Hamy Background: Breast cancer (BC) incidence increases with age, as well as the incidence of many other chronic diseases. Between 42 and 68% of BC patients suffer from other chronic conditions -comorbidities- at BC diagnosis. Comorbidities...

... of 1-2%. Ectopic mammary tissue may occur anywhere along the milk line, from the axilla to the groin. Thus, breast cancer present in the vulva may arise as a primary breast adenocarcinoma or distant metastasis. Differentiating the two can be clinically challenging but is critically important...

...Grace L. Wong; Sherona R. Sirkisoon; Noah R. Aguayo; Daniel L. Doheny; Dongqin Zhu; Angelina T. Regua; Austin Arrigo; Sara G. Manore; Calvin J. Wagner; Alexandra Thomas; Ravi Singh; Fei Xing; Guangxu Jin; Kounosuke Watabe; Hui-Wen Lo Breast cancer is the most frequently diagnosed cancer, and second...

...Michael K. McGrath; McKenzie L. Hagan; Timmothy Summers; Jesse Wayson; Carol Joseph; Amanda C. Barrett; John T. Barrett; Patricia V. Schoenlein Our long-term goal is to elucidate the role of JNK/Jun signaling in breast cancer cell autophagy induced by anti-estrogen treatment and/or chemotherapy...

...Charlotte L. Myers; Catherine Waldron; Kathleen Bennett; Caitriona Cahir COVID-19 has heightened social inequalities, particularly for those with non-communicable diseases (NCDs), such as cancer, and health services for NCDs have been significantly disrupted. Breast cancer (BC) is the most common...

...Ellen C. De Heer; Christos E. Zois; Esther Bridges; Mieke C. Zwager; Tineke van der Sluis; Bert van der Vegt; Carolien P. Schröder; Steven de Jong; Adrian L. Harris; Mathilde Jalving Background: Triple-negative breast cancer (TNBC) has a poor clinical prognosis and is characterized by a lack...

...Kate Ormiston; Kirti Kaul; Neelam Shinde; Allen Zhang; Morgan Bauer; Hee Kyung Kim; Ramesh K. Ganju; Sarmila Majumder; Bhuvaneswari Ramaswamy Purpose: Epidemiological data links lack of breastfeeding with increased risk of breast cancer, particularly triple negative breast cancer (TNBC...

...Bhuvaneswari Ramaswamy; Neelam Shinde; Gary K. Gray; Resham Mawalkar; Allen Zhang; Mustafa Basree; Xiaoli Zhang; Ramesh Ganju; Gina M. Sizemore; Joan S. Brugge; Sarmila Majumder Background: Triple negative breast cancer (TNBC) is associated with poor survival, particularly affecting African...

...Maria Eleni Syleouni; Nena Karavasiloglou; Laura Manduchi; Miriam Wanner; Dimitri Korol; Sabine Rohrmann In 2020 2.3 million women were diagnosed with breast cancer. About 7.4% of women who have been diagnosed with primary breast cancer will have a second primary breast cancer within 10 years...

...Sara G. Manore; Daniel L. Doheny; Dongqin Zhu; Grace L. Wong; Angelina T. Regua; Austin Arrigo; Calvin J. Wagner; Mariana Najjar; Hui-Wen Lo Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer-related deaths in women; 30% of primary breast cancer cases...

...Angelina T. Regua; Dongqin Zhu; Daniel L. Doheny; Grace L. Wong; Sara G. Manore; Calvin J. Wagner; Austin Arrigo; Mariana Najjar; Hui-Wen Lo Breast cancer is the most commonly diagnosed cancer in American women and accounts for ~15% of cancer-related deaths. Despite the current standard of care...

...Frank H. Lau; C. Ethan Byrne; Loren Brown; Jake Fontenot; Rafael P. Tiongco; Rakesh R. Gurrala; Jonathan Cuccia; Andrew DiNardo; Matthew Burow; Elizabeth C. Martin Breast cancer is a heterogeneous disease that accumulates signaling cues from cell intrinsic and extrinsic factors. Many of these cues...

... is therapeutically active against metastatic breast cancers harboring activating HER2 mutations, but responses are variable and often not durable. Here we demonstrate that recurrent HER2 mutations have differential effects on endocrine therapy responsiveness, metastasis, and pan-HER TKI therapeutic sensitivity...

...Diane M. Demas; Julie Collins; Ayesha N. Shajahan-Haq Breast cancer is the second most common cause of death from cancer in women in the United States after lung cancer. Estrogen receptor positive (ER+) breast cancer comprises 70% of all breast cancer cases. Antiestrogens and CDK4/6 inhibitors...

...Ruth Í. O'Connor; Amira F. Mahdi; Joanne Nolan; Catríona M. Dowling; Colum P. Dunne; Patrick A. Kiely Breast cancer is the most prevalent form of cancer worldwide, with surgery remaining a standard treatment. Although a treatable disease, with the survival rate improving due to enhancements...

... and therapy resistance. Spheroid culture is unique method for CSC enrichment. Patient-derived breast cancer cells (PDBCCs) has provided an invaluable tool in preclinical and translational research. The objective of this study is to characterize the immunophenotype and transcriptomes of PDBCCs grown...

...Minsu Park; Tae-Min Cho; Soeun Park; Jung Min Park; Juyeon Seo; Dongmi Ko; Seongjae Kim; So Ra Seuk; Yong Gu Kang; Kee Dal Nam; Yoon-Jae Kim; Ji Young Kim; Jae Hong Seo Purpose: Triple-negative breast cancer (TNBC) still relies on non-selective cytotoxic anticancer agents due to the absence...

...Khoa Nguyen; Madlin Alzoubi; Thomas Cheng; Katherine Hebert; Steven Elliott; Hassan Yousefi; Suresh Alahari; Matthew Burow; Bridgette Collins-Burow Breast cancer is the most common malignancy diagnosed in US women and is the second leading global cause of death for women. Triple Negative Breast...

... (NR2E1) in triple-negative breast cancer (TNBC) in order to evaluate its potential therapeutic value in a subtype of breast cancer that has proven particularly challenging to treat, primarily due to the lack of targeted modes of intervention. Unfortunately, breast cancer continues to be the second...

...Danielle S. Brasino; Sean D. Speese; Beverly M. Emerson Gut microbiota are recognized as an integral part in maintaining health, with disturbances in composition linked to disease states ranging from cancer to depression. Breast cancer patient microbiome analysis has demonstrated a correlation...