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angiogenesis

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Journal Articles
Cancer Res (2022) 82 (23_Supplement_2): B031.
Published: 01 December 2022
...Hailong Zhang Tumor-associated angiogenesis plays a crucial role in the progression of tumor, especially in highly vascularized cancer, such as Liver hepatocellular carcinoma (LIHC), ovarian cancer, lung cancer, human head and neck cancers. Clinical research has shown that LIHC cells upregulate...
Journal Articles
Cancer Res (2022) 82 (22): 4299.
Published: 15 November 2022
... Jiang, Ming Liu, Dandan Yu, Yu Zhang, Shuo Fang, Yan Li, Ying-Hui Zhu, and Yunfei Yuan did not respond. References 1. Yan Q , Jiang L , Liu M , Yu D , Zhang Y , Li Y , . ANGPTL1 interacts with integrin α1β1 to suppress HCC angiogenesis...
Journal Articles
Cancer Res (2022) 82 (20): 3734–3750.
Published: 17 October 2022
... and upregulates OPN and SERPINE1 in pericytes, resulting in enhanced angiogenesis and lung cancer growth. This novel axis of CD248–Wnt signaling–angiogenic factors in pericytes provides a potential target for lung cancer therapy. Significance: These findings demonstrate that CD248 maintains pericyte function...
Includes: Supplementary data
Images
Mechanisms linking obesity with cancer initiation and progression.  A,  Inc...
Published: 02 December 2022
Figure 1. Mechanisms linking obesity with cancer initiation and progression. A, Increased energy intake, decreased energy expenditure, genetic background (leptin abnormality), and lifestyle changes lead to hypertrophy and hyperplasia of AT, angiogenesis, and inflammation, which can result in obe... More
Images
Role of macrophages in cancer progression.  A,  The cross-talk between canc...
Published: 02 December 2022
Figure 2. Role of macrophages in cancer progression. A, The cross-talk between cancer cells and macrophages initiates macrophage recruitment in the tumor microenvironment through various receptor–ligand signaling pathways. B, TAMs can directly lead to tumor progression by activating pathways s... More
Journal Articles
Cancer Res (2022) 82 (23_Supplement_1): B010.
Published: 01 December 2022
... of anti-VEGF therapy and DNA damaging agents, such as Bevacizumab + FOLFOX, has become the first-line therapy in managing colorectal cancer progression. To mimic the first-line therapy, we have conjugated the angiogenesis inhibitory and the DNA damaging moieties to form a bifunctional hybrid molecule...
Journal Articles
Cancer Res (2022) 82 (23_Supplement_1): B028.
Published: 01 December 2022
... dynamic pathway changes in normalized enrichment score (NES) for DNA repair (NES -2.3; p-adj=.008), IL6/JAK/STAT3 (NES -2.1, p-adj=.02), and IFN-α response (NES -2.0, p-adj=.03). For non-responders, relative increases in NES were observed for angiogenesis (NES 2.1, p-adj=.02) and IL-2/STAT5 (NES 2.0, p...
Journal Articles
Cancer Res (2022) 82 (23): 4303–4312.
Published: 02 December 2022
...Figure 1. Mechanisms linking obesity with cancer initiation and progression. A, Increased energy intake, decreased energy expenditure, genetic background (leptin abnormality), and lifestyle changes lead to hypertrophy and hyperplasia of AT, angiogenesis, and inflammation, which can result...
Images
Reduced lung tumor growth and <span class="search-highlight">angiogenesis</span> of transplanted LLC tumors in ...
Published: 17 October 2022
Figure 1. Reduced lung tumor growth and angiogenesis of transplanted LLC tumors in Cd248LacZ/LacZ mice. A, LLC-derived lung tumors in Cd248+/+, Cd248+/LacZ, and Cd248LacZ/LacZ mice. Matrigel-embedded LLC cells (2 × 105) were inoculated into the left lung of mice. Tumors (14 days) were processed for hematoxylin and eosin staining. Black arrows, largest diameters; green arrows, smallest diameters. Scale bar, 1 mm. B, The LLC-derived lung tumor volume decreased in Cd248LacZ/LacZ mice (n = 9). C, The tumor weight (the tumor-bearing left lung/tumor-free right lung ratio) decreased in Cd248LacZ/LacZ mice (n = 9). Control, Matrigel. D, CD31+ blood vessel densities decreased in Cd248LacZ/LacZ mice. The vessel density was quantified as the CD31+ area per medium power field (MPF, 200×) using ImageJ. Yellow circles, large-diameter (≥50 μm) vessels (histograms in Supplementary Fig. S1B). Scale bar, 50 μm. E, Comparison of NG2 and β-gal expression in LLC-derived tumors in mice by IF microscopy. Cell nuclei were stained with DAPI. Scale bar, 20 μm. F, Flow cytometry (diagrams in Supplementary Fig. S1H) showed a reduction in both NG2+ and NG2+β-gal+ cell numbers in LLC tumors (14 days) from Cd248LacZ/LacZ mice (n = 3). G, Bioluminescence images of luciferase-expressing CL1–1-derived tumor xenografts (14 days) in the lungs of NOD/SCID Cd248+/+, Cd248+/LacZ, and Cd248LacZ/LacZ mice (n = 5). H, Bioluminescence total flux (photons per second per centimeter squared per steradian [p/s/cm2/sr]) showed a significant reduction in CL1–1-derived tumors in Cd248LacZ/LacZ mice (n = 5). Ctrl, Cd248 +/+ mice injected with PBS. I, Flow cytometry showed a decrease in NG2+ cell numbers in Cd248LacZ/LacZ mice (n = 3). J, IF microscopy showed decreased CD31+ blood vessel densities in CL1-1–derived tumors in Cd248 LacZ/LacZ mice (n = 5). Yellow circles, large-diameter (≥ 50 μm) vessels (histograms in Supplementary Fig. S3D). Scale bar, 50 μm. Data ( B , C , D , F , I, and J ) represent mean plus SD. ns, nonsignificant; *, P < 0.05; **, P < 0.01; ***, P < 0.001. Figure 1. Reduced lung tumor growth and angiogenesis of transplanted LLC tumors in Cd248 LacZ/LacZ mice. A, LLC-derived lung tumors in Cd248+/+, Cd248+/LacZ, and Cd248LacZ/LacZ mice. Matrigel-embedded LLC cells (2 × 105) were inoculated into the left lung of mice. Tumors (14 days) were processed for hematoxylin–eosin (H&E) staining. Black arrows, largest diameters; green arrows, smallest diameters. Scale bar, 1 mm. B, The LLC-derived lung tumor volume decreased in Cd248LacZ/LacZ mice (n = 9). C, The tumor weight (the tumor-bearing left lung/tumor-free right lung ratio) decreased in Cd248LacZ/LacZ mice (n = 9). Control, Matrigel. D, CD31+ blood vessel densities decreased in Cd248LacZ/LacZ mice. The vessel density was quantified as the CD31+ area per medium-power field (MPF, 200 ×) using ImageJ. Yellow circles: large-diameter (≥ 50 μmol/L) vessels (histograms in Supplementary Fig. S1B). Scale bar, 50 μmol/L. E, Comparison of NG2 and β-gal expression in LLC-derived tumors in mice by IF microscopy. Cell nuclei were stained with DAPI. Scale bar, 20 μm. F, Flow cytometry (diagrams in Supplementary Fig. S1H) showed a reduction in both NG2+ and NG2+β-gal+ cell numbers in LLC tumors (14 days) from Cd248LacZ/LacZ mice (n = 3). G, Bioluminescence images of luciferase-expressing CL1–1-derived tumor xenografts (14 days) in the lungs of NOD/SCID Cd248+/+, Cd248+/LacZ, and Cd248LacZ/LacZ mice (n = 5). H, Bioluminescence total flux (photons per second per centimeter squared per steradian [p/s/cm2/sr]) showed a significant reduction in CL1–1-derived tumors in Cd248LacZ/LacZ mice (n = 5). Ctrl, Cd248 +/+ mice injected with PBS. I, Flow cytometry showed a decrease in NG2+ cell numbers in Cd248LacZ/LacZ mice (n = 3). J, IF microscopy showed decreased CD31+ blood vessel densities in CL1-1–derived tumors in Cd248 LacZ/LacZ mice (n = 5). Yellow circles: large-diameter (≥ 50 μmol/L) vessels (histograms in Supplementary Fig. S3D). Scale bar, 50 μmol/L. Data (B, C, D, F, I, and J) represent mean plus standard deviation (SD). More
Journal Articles
Cancer Res (2022) 82 (22_Supplement): C069.
Published: 15 November 2022
... angiogenesis in PDAC. Endothelial cells and fibroblasts self-assemble into a 3D vascular network when incorporated into the microdevices. In the absence of tumor cells, mature vascular networks formed on day 4 of culture. Interestingly, vascular networks formed faster in the presence of PDAC tumor cells...
Journal Articles
Cancer Res (2022) 82 (22_Supplement): PR002.
Published: 15 November 2022
... significantly enriched biological processes were: angiogenesis/blood vessel and vasculature development (qv=1.34e-07, normalized enrichment score [NES]=1.89), positive regulation of cell migration and locomotion (qv=1.34e-07, NES=1.91), and humoral immune response (qv= 9.8e-07, NES=-2.06). Among the top 5...
Journal Articles
Cancer Res (2022) 82 (22_Supplement): C042.
Published: 15 November 2022
...Mario A. Shields; Anastasia E. Metropulos; Christina Spaulding; Thao ND Pham; Hidayatullah G. Munshi G protein-coupled receptor (GPCR) signaling regulates many aspects of tumor biology, including inflammation, angiogenesis, and metastasis. However, the tumor-specific functions of G proteins...
Journal Articles
Cancer Res (2022) 82 (22_Supplement): PR010.
Published: 15 November 2022
..., phagocytosis-associated gene sets were enriched in C1QC+ TAMs, while angiogenesis-associated gene sets were enriched in SPP1+ TAMs. Comparison of naïve and chemotherapy treated primary PDAC samples revealed that classical and basal-like cancer cells exhibited similar transcriptional responses to chemotherapy...
Journal Articles
Cancer Res (2022) 82 (23): 4414–4428.
Published: 02 December 2022
... into a transcriptional activator upon binding of a Notch receptor ICD ( 12 ). Sustained endothelial Notch1 signaling is associated with increased myeloid cell infiltration and metastasis ( 11 ). The Notch pathway in ECs is a major regulator of angiogenesis, angiocrine functions, and tumor cell transmigration ( 11, 13–18...
Includes: Supplementary data
Journal Articles
Cancer Res OF1–OF14.
Published: 30 November 2022
... proliferation and apoptosis are at equilibrium in the metastatic tumor. Support for this latter state came from experiments showing that despite being mitotically active, the tumor mass could not progress due to failure in angiogenesis (28, 29), and that some micrometastases failed to progress...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (23): 4313–4321.
Published: 02 December 2022
... ). Further studies into the differential effects of physioxia on ASCs by Chen and colleagues ( 40 ) revealed positive effects of physioxia on their proliferation, migration, angiogenesis, and survival. Data from studies involving four human MSC lines showed the beneficial impact of physiologic O2...
Journal Articles
Cancer Res CAN-22-1477.
Published: 30 November 2022
... can be secreted to intercept IGFR ligands, thereby inhibiting the activation of IGFR and interfering with the IGF-IR pathway (Fig. S7D) impacting cell growth, survival, and differentiation. Besides modulating these pathways, it was shown that the c-terminus of IGFBP5 is able to inhibit angiogenesis...
Includes: Supplementary data
Journal Articles
Cancer Res OF1–OF10.
Published: 30 November 2022
... tumor growth by promoting angiogenesis (21), immune suppression, and metastasis (18, 22). A recent investigation into the stem cell dynamics within mosaic mouse intestinal crypts attempted to quantify the competitive advantage of distinct MT clonal populations (oncogenic Kras MT, Apc p53-MT...
Journal Articles
Cancer Res CAN-22-0677.
Published: 21 November 2022
... impaired the growth of MES GCL/GSC-derived orthotopic xenografts, as assessed by 7 Tesla T2-weighted (T2w) MRI-based volumetric longitudinal analysis (Fig. 3D-E and Supplementary Fig. S7D). Since tumor neo-angiogenesis is regulated by core fucosylation (39), we analyzed FUT8-silenced xenografts by IHC...
Includes: Supplementary data
Journal Articles
Cancer Res (2022) 82 (22): 4124–4125.
Published: 15 November 2022
... incidence and mortality ( 5 ). Other epidemiologic and animal studies have demonstrated that physical exercise can inhibit several cancer hallmarks, such as sustained proliferative signaling, evasion of growth suppression, replicative immortality, increased angiogenesis, and resistance to cell death ( 3...