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Journal Articles

R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts

Zhiyan Silvia Liu, Sayantani Sinha, Maxwell Bannister, Axia Song, Erica Arriaga-Gomez, Alexander J. McKeeken, Elizabeth A. Bonner, Benjamin K. Hanson, Martina Sarchi, Kouhei Takashima, Dawei Zong, Victor M. Corral, Evan Nguyen, Jennifer Yoo, Wannasiri Chiraphapphaiboon, Cassandra Leibson, Matthew C. McMahon, Sumit Rai, Elizabeth M. Swisher, Zohar Sachs, Srinivas Chatla, Derek L. Stirewalt, H. Joachim Deeg, Tomasz Skorski, Eirini P. Papapetrou, Matthew J. Walter, Timothy A. Graubert, Sergei Doulatov, Stanley C. Lee, Hai Dang Nguyen
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-3239
Published: 15 November 2023
View article titled, R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts
Open the PDF for R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts in another window
Includes: Supplementary data
Journal Articles

Abstract 2582: Dose-dependent NRASG12V-mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line

Morito Kurata, Marie L. Antony, Klara E. Noble, Susan K. Rathe, Haruka Hirakouchi, Kouhei Yamamoto, Masanobu Kitagawa, Zohar Sachs, David A. Largaespada
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2582.
https://doi.org/10.1158/1538-7445.AM2020-2582
Published: 15 August 2020
View article titled, Abstract 2582: Dose-dependent <em>NRAS<sup>G12V</sup></em>-mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line
Journal Articles

Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia

Karen Sachs, Aaron L. Sarver, Klara E. Noble-Orcutt, Rebecca S. LaRue, Marie Lue Antony, Daniel Chang, Yoonkyu Lee, Connor M. Navis, Alexandria L. Hillesheim, Ian R. Nykaza, Ngoc A. Ha, Conner J. Hansen, Fatma K. Karadag, Rachel J. Bergerson, Michael R. Verneris, Matthew M. Meredith, Matthew L. Schomaker, Michael A. Linden, Chad L. Myers, David A. Largaespada, Zohar Sachs
Journal: Cancer Research
Cancer Res (2020) 80 (3): 458–470.
https://doi.org/10.1158/0008-5472.CAN-18-2932
Published: 03 February 2020
View article titled, Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia
Open the PDF for Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML

Rebecca S. LaRue, Klara E. Noble-Orcutt, Conner Hansen, Ngoc Ha, David A. Largaespada, Zohar Sachs
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3339.
https://doi.org/10.1158/1538-7445.AM2016-3339
Published: 15 July 2016
View article titled, Abstract 3339: Single-cell analysis reveals molecular mechanisms of NRAS-mediated leukemia stem cell self-renewal in a murine model of AML
Journal Articles

Abstract 4176: Activated NRAS mediates self-renewal capacity in AML

Zohar Sachs, Susan K. Rathe, Ernesto Diaz-Flores, Miechaleen D. Diers, Kevin Shannon, David A. Largaespada
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4176.
https://doi.org/10.1158/1538-7445.AM2012-4176
Published: 15 April 2012
View article titled, Abstract 4176: Activated NRAS mediates self-renewal capacity in AML