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Journal Articles

Abstract CT238: Associations of ctDNA levels during neoadjuvant treatment with pathological response in patients with resectable NSCLC from the phase 3 AEGEAN trial

Davina Gale, Zhou Zhu, Zhongwu Lai, Martin Reck, David Harpole, Janis M. Taube, Tetsuya Mitsudomi, Maximilian Hochmair, Thomas Winder, László Urbán, Jeronimo Rodriguez-Cid, Quincy Chu, Jamie Chaft, Ross Stewart, Darren Hodgson, Gary J. Doherty, John V. Heymach
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT238.
https://doi.org/10.1158/1538-7445.AM2024-CT238
Published: 05 April 2024
View article titled, Abstract CT238: Associations of ctDNA levels during neoadjuvant treatment with pathological response in patients with resectable NSCLC from the phase 3 AEGEAN trial
Journal Articles

Abstract 936: Targeted proteomics and next-generation sequencing (NGS) for biomarker discovery in metastatic colorectal cancer (mCRC)

William J. Kelly, Barrett Nuttall, Marlon Rebelatto, Marcus Schick, Armin Meier, Steve Sweet, Beom-Jun Kim, David Chain, Yeoun Jin Kim, Zhongwu Lai, Ying Wang, Todd H. Creasy, Ramya Gurrapu, Sakshi Gulati, Alice Barkell, Brian Dougherty, Danielle Carroll, Fabiola Cecchi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 936.
https://doi.org/10.1158/1538-7445.AM2024-936
Published: 22 March 2024
View article titled, Abstract 936: Targeted proteomics and next-generation sequencing (NGS) for biomarker discovery in metastatic colorectal cancer (mCRC)
Journal Articles

Abstract 2299: Misclassification of clonal hematopoietic mutations as tumor-derived confound accurate ctDNA-response assessment in patients with metastatic non-small-cell lung cancer: analyses from the phase 3 MYSTIC trial

Chris Abbosh, Michael Kuziora, Daniel Stetson, Zhongwu Lai, Yashaswi Shrestha, Paul Labrousse, Xiaojin Shi, Helen Mann, Diana Merino Vega, Matthew D. Hellmann, Solange Peters, J. Carl Barrett, Darren Hodgson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2299.
https://doi.org/10.1158/1538-7445.AM2023-2299
Published: 04 April 2023
View article titled, Abstract 2299: Misclassification of clonal hematopoietic mutations as tumor-derived confound accurate ctDNA-response assessment in patients with metastatic non-small-cell lung cancer: analyses from the phase 3 MYSTIC trial
Journal Articles

Abstract 6553: The development of homologous recombination repair deficiency (HRD) score methodology using WES data and its application in patient-derived xenograft models

Jixin Wang, Krista Kinneer, Wenyan Zhong, Zhongwu Lai
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6553.
https://doi.org/10.1158/1538-7445.AM2023-6553
Published: 04 April 2023
View article titled, Abstract 6553: The development of homologous recombination repair deficiency (HRD) score methodology using WES data and its application in patient-derived xenograft models
Journal Articles

Abstract 5360: Improved identification of CHIP mutations from cell-free DNA without matched normal samples using machine learning

Gustavo Arango-Argoty, Gerald Sun, Aleksandra Markovets, Carl Barrett, Zhongwu Lai, Etai Jacob
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5360.
https://doi.org/10.1158/1538-7445.AM2023-5360
Published: 04 April 2023
View article titled, Abstract 5360: Improved identification of CHIP mutations from cell-free DNA without matched normal samples using machine learning
Journal Articles

Abstract CT024: Durvalumab (D) + platinum-etoposide (EP) in 1L extensive-stage small-cell lung cancer (ES-SCLC): Exploratory analysis of SCLC molecular subtypes in CASPIAN

Mingchao Xie, Priti Chugh, Helen Broadhurst, Zhongwu Lai, David Whitston, Luis Paz-Ares, Carl Gay, Lauren Byers, Charles M. Rudin, Ross Stewart, J. Carl Barrett, Yashaswi Shrestha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT024.
https://doi.org/10.1158/1538-7445.AM2022-CT024
Published: 15 June 2022
View article titled, Abstract CT024: Durvalumab (D) + platinum-etoposide (EP) in 1L extensive-stage small-cell lung cancer (ES-SCLC): Exploratory analysis of SCLC molecular subtypes in CASPIAN
Journal Articles

Abstract CT217: POLO: Homologous recombination repair gene mutations (HRRm) in metastatic pancreatic cancer (mPaC) tumors

Zhongwu Lai, Talia Golan, Hedy L. Kindler, Brian Dougherty, Athena Matakidou, Liqin Dong, Gershon Locker, Elizabeth A. Harrington
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT217.
https://doi.org/10.1158/1538-7445.AM2020-CT217
Published: 15 August 2020
View article titled, Abstract CT217: POLO: Homologous recombination repair gene mutations (HRRm) in metastatic pancreatic cancer (mPaC) tumors
Journal Articles

Abstract 5427: Genomic prevalence analysis in TNBC patients in the Phase 2 VIOLETTE study

Joshua Armenia, Zhongwu Lai, Andrew Tutt, Emma Dean, Bienvenu Loembe, Hannah McGarvey, Sarah Edgington, J Carl Barrett, Andrew J. Pierce, Elizabeth A. Harrington, Natalia Lukashchuk
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5427.
https://doi.org/10.1158/1538-7445.AM2020-5427
Published: 15 August 2020
View article titled, Abstract 5427: Genomic prevalence analysis in TNBC patients in the Phase 2 VIOLETTE study
Journal Articles

Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response

Mark J. O'Connor, Cristina Cruz, Marta Castroviejo-Bermejo, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Zhongwu Lai, Josep Forment, Krishna Bulusu, Alba Llop-Guevara, Brian Dougherty, Cristina Saura, Rachel Brough, Chris J. Lord, Alejandra Bruna, Carlos Caldas, Stephen Fawell, J Carl Barrett, Susan E. Critchlow, Judith Balmaña, Elaine Cadogan, Violeta Serra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 932.
https://doi.org/10.1158/1538-7445.AM2019-932
Published: 01 July 2019
View article titled, Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response
Journal Articles

Abstract 2462: HemeBase: a comprehensive model-to-patient genomic map for AML and DLBCL

Kathleen A. Burke, Tyler Faits, Adriana E. Tron, Jay Mettetal, Andrew Bloecher, Zhongwu Lai, Jonathan Dry, Bolan Linghu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2462.
https://doi.org/10.1158/1538-7445.AM2019-2462
Published: 01 July 2019
View article titled, Abstract 2462: HemeBase: a comprehensive model-to-patient genomic map for AML and DLBCL
Journal Articles

Abstract 1747: Both somatic and germline BRCA mutations show high degree of bi-allelic loss in breast and ovarian cancers

Zhongwu Lai, Darren Hodgson, James Sun, Adrienne Johnson, Carl Barrett, Jonathan Dry
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1747.
https://doi.org/10.1158/1538-7445.AM2019-1747
Published: 01 July 2019
View article titled, Abstract 1747: Both somatic and germline BRCA mutations show high degree of bi-allelic loss in breast and ovarian cancers
Journal Articles

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer

Violeta Serra, Cristina Cruz, Zhongwu Lai, Marta Castroviejo-Bermejo, Marta Palafox, Urszula M. Polanska, Gemma N. Jones, Anderson Wang, Filippos Michopoulos, Rachel Brough, Brian Dougherty, Elaine Cadogan, Susan Critchlow, Alejandra Bruna, J. Carl Barrett, Cristina Saura, Christopher J. Lord, Carlos Caldas, Joaquin Arribas, Judith Balmaña, Mark J. O’Connor
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3503.
https://doi.org/10.1158/1538-7445.AM2019-3503
Published: 01 July 2019
View article titled, Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer
Journal Articles

Abstract 5724: Homologous recombination repair gene mutations for DNA repair and immune oncology drug combinations

Jonathan R. Dry, Zhongwu Lai, Brian Dougherty, Carl Barrett, Steven Criscione
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5724.
https://doi.org/10.1158/1538-7445.AM2018-5724
Published: 01 July 2018
View article titled, Abstract 5724: Homologous recombination repair gene mutations for DNA repair and immune oncology drug combinations
Journal Articles

Abstract 5582: Use of circulating tumor DNA (ctDNA) to predict superiority of dosing schedules in early clinical development

Juliann Chmielecki, Zhongwu Lai, Kristy Potts, Kavita Garg, Mark Li, J Carl Barrett
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5582.
https://doi.org/10.1158/1538-7445.AM2018-5582
Published: 01 July 2018
View article titled, Abstract 5582: Use of circulating tumor DNA (ctDNA) to predict superiority of dosing schedules in early clinical development
Journal Articles

Abstract 2816: Patient derived ovarian cancer xenograft (OC-PDX) to study the response of the PARP inhibitor olaparib

Francesca Bizzaro, Alessia C. Marchetti, Alessandra Decio, Francesca Ricci, Mark J. O'Connor, Molly A. Taylor, Zhongwu Lai, Simon T. Barry, Maria R. Bani, Raffaella Giavazzi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2816.
https://doi.org/10.1158/1538-7445.AM2018-2816
Published: 01 July 2018
View article titled, Abstract 2816: Patient derived ovarian cancer xenograft (OC-PDX) to study the response of the PARP inhibitor olaparib
Journal Articles

Abstract 397: Whole genome copy number variation analysis using a SNP-focused targeted sequencing panel for tumor analysis

Jiashi Wang, Kristina Giorda, Zhongwu Lai, Daniel Stetson, Mirna Jarosz
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 397.
https://doi.org/10.1158/1538-7445.AM2017-397
Published: 01 July 2017
View article titled, Abstract 397: Whole genome copy number variation analysis using a SNP-focused targeted sequencing panel for tumor analysis
Journal Articles

Abstract 337: Genetic analysis of tumors from a phase II trial evaluating AZD1775, carboplatin and paclitaxel in patients with TP53-mutant ovarian cancer

Naomi Laing, Zhongwu Lai, J. Carl Barrett, Mark J. O’Connor, Amit M. Oza, David Lawrence
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 337.
https://doi.org/10.1158/1538-7445.AM2016-337
Published: 15 July 2016
View article titled, Abstract 337: Genetic analysis of tumors from a phase II trial evaluating AZD1775, carboplatin and paclitaxel in patients with TP53-mutant ovarian cancer
Journal Articles

Abstract 166: Optimizing the detection of subclonal somatic variants with VarDict

Zhongwu Lai, Brad Chapman, Miika Ahdesmäki, Oliver Hofmann, Justin Johnson, Jonathan Dry
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 166.
https://doi.org/10.1158/1538-7445.AM2016-166
Published: 15 July 2016
View article titled, Abstract 166: Optimizing the detection of subclonal somatic variants with VarDict
Journal Articles

Abstract 3168: Your targeted population might not be what you predict: Changes in tumor genetic landscapes post standard of care

Danielle Greenawalt, Austin Dulak, Manasa Ramakrishna, Zhongwu Lai, Justin Johnson, Hongyue Dai, Melissa Mitchell, Carl Barrett, Stephen Fawell, Jonathan Dry
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3168.
https://doi.org/10.1158/1538-7445.AM2016-3168
Published: 15 July 2016
View article titled, Abstract 3168: Your targeted population might not be what you predict: Changes in tumor genetic landscapes post standard of care
Journal Articles

Abstract 5268: Seq2C: from sequence to copy number for cancer samples

Zhongwu Lai, Aleksandra Markovets, Jonathan Dry
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5268.
https://doi.org/10.1158/1538-7445.AM2016-5268
Published: 15 July 2016
View article titled, Abstract 5268: Seq2C: from sequence to copy number for cancer samples