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Zhihong Lai
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Journal Articles

Biological characterization of GSK1070916: A potent and selective inhibitor of Aurora B/C kinase

Mary Ann Hardwicke, Qiaoyin Liao, Kate Oleykowski, Ramona Plant, Jamin Wang, Kelly Anderson, Jingsong Yang, Zhihong Lai, Domingos Silva, Jerry Adams, Robert Copeland, Denis Patrick
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5650.
Published: 01 May 2008
View article titled, Biological characterization of GSK1070916: A potent and selective inhibitor of Aurora B/C kinase
Journal Articles

Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B kinase with an extremely slow off-rate.

Jingsong Yang, Kelly Anderson, Mary Ann Hardwicke, Domingos Silva, Ken Newlander, Octerloney McDonald, Jerry Adams, Denis Patrick, Peter Tummino, Robert Copeland, Zhihong Lai
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5649.
Published: 01 May 2008
View article titled, Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B kinase with an extremely slow off-rate.
Journal Articles

Investigation of 7-azaindoles as developable kinase inhibitors: identification of GSK1070916 as a highly potent and selective inhibitor of Aurora B kinase

Domingos Silva, Ken Newlander, Nicholas Adams, Joelle Burgess, Amita Chaudhari, Carla Donatelli, David Drewry, Toshihiro Hamajima, Cynthia Parrish, Martha Sarpong, Stanley Schmidt, Jun Tang, Dashyant Dhanak, Jerry Adams, Kelly Anderson, Zhihong Lai, Jingsong Yang, Octerloney McDonald, Mary Hardwicke, Denis Patrick
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1296.
Published: 01 May 2008
View article titled, Investigation of 7-azaindoles as developable kinase inhibitors: identification of GSK1070916 as a highly potent and selective inhibitor of Aurora B kinase
Journal Articles

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Nelson Rhodes, Dirk A. Heerding, Derek R. Duckett, Derek J. Eberwein, Victoria B. Knick, Timothy J. Lansing, Randy T. McConnell, Tona M. Gilmer, Shu-Yun Zhang, Kimberly Robell, Jason A. Kahana, Robert S. Geske, Elena V. Kleymenova, Anthony E. Choudhry, Zhihong Lai, Jack D. Leber, Elisabeth A. Minthorn, Susan L. Strum, Edgar R. Wood, Pearl S. Huang, Robert A. Copeland, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2366–2374.
https://doi.org/10.1158/0008-5472.CAN-07-5783
Published: 01 April 2008
View article titled, Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Open the PDF for Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity in another window
Includes: Supplementary data
Journal Articles

GSK690693, a pan-AKT kinase inhibitor has potent anti-tumor activity and shows additive effect with lapatinib.

Nelson Rhodes, Victoria Knick, Randy McConnell, Timothy Lansing, David Rusnak, Derek Duckett, Tona Gilmer, Jason Kahana, Kimerly Robell, Jack Leber, Anthony Choudhry, Zhihong Lai, Edgar Wood, Susan Strum, Dirk Heerding, Pearl Huang, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 279.
Published: 01 May 2007
View article titled, GSK690693, a pan-AKT kinase inhibitor has potent anti-tumor activity and shows additive effect with lapatinib.
Journal Articles

Identification of a novel inhibitor of AKT kinase, GSK690693.

Dirk Heerding, Nelson Rhodes, Jack Leber, Anthony Choudhry, Tammy Clark, Nestor Concha, Derek Duckett, Derek Eberwein, Robert Geske, Tona Gilmer, Pearl Huang, Jason Kahana, Richard Keenan, Elena Kleymenova, Victoria Knick, Louis Lafrance, Zhihong Lai, Timothy Lansing, Mei Li, Elisabeth Minthorn, Kimberly Robell, David Rusnak, Igor Safonov, Edgar Wood, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): ND-2.
Published: 01 May 2007
View article titled, Identification of a novel inhibitor of AKT kinase, GSK690693.