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Journal Articles

Abstract 6191: A novel anti-IL33 antibody that neutralized Th1-type and Th2-type pro-inflammation responses induced by IL-33/ST2 axis pathway

Xuesai Zhang, Qingrou Li, Cui Liu, Le Zhao, Lujie Wang, Lan Deng, Wei Xu, Hongli song, Zhenping Zhu, Haomin Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6191.
https://doi.org/10.1158/1538-7445.AM2022-6191
Published: 15 June 2022
View article titled, Abstract 6191: A novel anti-IL33 antibody that neutralized Th1-type and Th2-type pro-inflammation responses induced by IL-33/ST2 axis pathway
Journal Articles

Abstract 5287: Aggregation of HER2 receptors on the tumor cell surface induced by a novel anti-HER2 bispecific antibody led to enhanced tumor cell growth inhibition

Lan Deng, Jie Zhao, Xiaoqing Meng, Aotian Xiao, Zhenping Zhu, Haomin Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5287.
https://doi.org/10.1158/1538-7445.AM2022-5287
Published: 15 June 2022
View article titled, Abstract 5287: Aggregation of HER2 receptors on the tumor cell surface induced by a novel anti-HER2 bispecific antibody led to enhanced tumor cell growth inhibition
Journal Articles

Abstract 355: A novel anti-HER2 antibody that displays superior synergetic effects in Trastuzumab mediated HER2-overexpressing tumor arrest

Haomin Huang, xuesai zhang, jianhe Chen, Le Zhao, qingrou Li, zhenping zhu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 355.
https://doi.org/10.1158/1538-7445.AM2019-355
Published: 01 July 2019
View article titled, Abstract 355: A novel anti-HER2 antibody that displays superior synergetic effects in Trastuzumab mediated HER2-overexpressing tumor arrest
Journal Articles

Abstract 572: A novel anti-PDL1 x anti-VEGFR2 bispecific antibody for enhanced antitumor immunity

Dan Lu, Zhanna Polonskaya, Haifan Zhang, Xenia Luna, Stella Martomo, Zhikai Zhang, Zhaojing Zhong, Yan Wu, Jeegar Patel, James Tonra, Larry Witte, Sam Waksal, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 572.
https://doi.org/10.1158/1538-7445.AM2016-572
Published: 15 July 2016
View article titled, Abstract 572: A novel anti-PDL1 x anti-VEGFR2 bispecific antibody for enhanced antitumor immunity
Journal Articles

Abstract 4997: Novel anti-PD-L1/IL-15 bifunctional immunotherapeutics potentiates antitumor immunity

Yan Wu, Zhaojing Zhong, Stella Martomo, Dan Lu, Haifan Zhang, Zhanna Polonskaya, Xenia Luna, Zhikai Zhang, Zhun Wang, Leo Liu, Jeegar Patel, James Tonra, Henry Li, Larry Witte, Sam Waksal, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4997.
https://doi.org/10.1158/1538-7445.AM2016-4997
Published: 15 July 2016
View article titled, Abstract 4997: Novel anti-PD-L1/IL-15 bifunctional immunotherapeutics potentiates antitumor immunity
Journal Articles

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

Chris Folkins, Yuval Shaked, Shan Man, Terence Tang, Christina R. Lee, Zhenping Zhu, Robert M. Hoffman, Robert S. Kerbel
Journal: Cancer Research
Cancer Res (2009) 69 (18): 7243–7251.
https://doi.org/10.1158/0008-5472.CAN-09-0167
Published: 14 September 2009
View article titled, Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1
Open the PDF for Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1 in another window
Includes: Supplementary data
Journal Articles

Abstract #5659: Anti-TGF beta receptor II antibody abrogates FoxP3+/TGF \#946; RII + Treg cells and enhances antitumor immunity against tumor growth and metastasis

Kyla Carroll, Zhaojing Zhong, Desiree Policarpio, Michael Gregory, Rajiv Bassi, Xenia Jimenez, Kris Persaud, Paul Balderes, Dale Ludwig, Larry Witte, Zhenping Zhu, Yan Wu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5659.
Published: 01 May 2009
View article titled, Abstract #5659: Anti-TGF beta receptor II antibody abrogates FoxP3+/TGF \#946; RII + Treg cells and enhances antitumor immunity against tumor growth and metastasis
Journal Articles

Abstract #844: Anti-TGF beta receptor II antibody suppresses tumor growth and metastasis through inhibiting TGF beta autocrine stimulation of tumor cells and myeloid cells

Zhaojing Zhong, Desiree Policarpio, Kyla Carroll, Michael Gregory, Rajiv Bassi, Marie Prewette, Su Wang, Jim Tonra, Xenia Jimenez, Jackie Doody, Kris Persaud, Paul Balderes, Dale Ludwig, Larry Witte, Zhenping Zhu, Yan Wu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 844.
Published: 01 May 2009
View article titled, Abstract #844: Anti-TGF beta receptor II antibody suppresses tumor growth and metastasis through inhibiting TGF beta autocrine stimulation of tumor cells and myeloid cells
Journal Articles

Abstract #2811: Ability of EGFR and IGF-IR antibodies to reduce HIF-1\#945; activity and VEGF production in tumors does not correlate with monotherapy efficacy, but may prevent escape from VEGFR2 targeted therapy

Dhanvanthri Deevi, Huiling Li, Erik Corcoran, Dale Ludwig, Zhenping Zhu, David Surguladze, Larry Witte, James Tonra
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2811.
Published: 01 May 2009
View article titled, Abstract #2811: Ability of EGFR and IGF-IR antibodies to reduce HIF-1\#945; activity and VEGF production in tumors does not correlate with monotherapy efficacy, but may prevent escape from VEGFR2 targeted therapy
Journal Articles

Elucidation of the antagonistic mechanisms of various anti-FLT3 antibodies via binding epitope dissection

Brent Williams, Gayani Fernando, Haifan Zhang, Xenia Jimenez, Dan Lu, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4110.
Published: 01 May 2007
View article titled, Elucidation of the antagonistic mechanisms of various anti-FLT3 antibodies via binding epitope dissection
Journal Articles

An Antibody directed against platelet-derived growth factor β receptor suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody

juqun shen, Marie Vil, Haifan Zhang, James Tonra, Nick Loizos, Paul Balderes, Marie Prewett, Chris Damoci, Anthony Kayas, Xenia Jimenez, Michelle Iacolina, Heather Griffith, Dale Ludwig, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4790.
Published: 01 May 2007
View article titled, An Antibody directed against platelet-derived growth factor β receptor suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody
Journal Articles

Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member

Jennifer M. O'Toole, Karen E. Rabenau, Kerri Burns, Dan Lu, Venkat Mangalampalli, Paul Balderes, Nicole Covino, Rajiv Bassi, Marie Prewett, Kimberly J. Gottfredsen, Megan N. Thobe, Yuan Cheng, Yiwen Li, Daniel J. Hicklin, Zhenping Zhu, Susan E. Waltz, Michael J. Hayman, Dale L. Ludwig, Daniel S. Pereira
Journal: Cancer Research
Cancer Res (2006) 66 (18): 9162–9170.
https://doi.org/10.1158/0008-5472.CAN-06-0283
Published: 18 September 2006
View article titled, Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member
Open the PDF for Therapeutic Implications of a Human Neutralizing Antibody to the Macrophage-Stimulating Protein Receptor Tyrosine Kinase (RON), a c-MET Family Member in another window
Includes: Supplementary data
Journal Articles

Therapeutic implications of a human neutralizing antibody to the Macrophage-Stimulating Protein receptor tyrosine kinase (RON) that inhibits cancer cell signaling, migration and tumorigenesis

Jennifer M. O’Toole, Karen E. Rabenau, Kerri Burns, Yuan Cheng, Dan Lu, Venkat R. M. Mangalampalli, Paul Balderes, Marie C. Prewett, Zhenping Zhu, Dale L. Ludwig, Larry Witte, Daniel S. Pereira
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 876.
Published: 15 April 2006
View article titled, Therapeutic implications of a human neutralizing antibody to the Macrophage-Stimulating Protein receptor tyrosine kinase (RON) that inhibits cancer cell signaling, migration and tumorigenesis
Journal Articles

Suppression of leukemia growth in vivo by a novel anti-FLT3 antibody-auristatin conjugate

Yiwen Li, Hongli Li, Mei-Nai Wang, Rajiv Bassi, Venkat Mangalampalli, Dale L. Ludwig, Paul Balderes, Larry Witte, Zhenping Zhu, Damon Meyer, Angelyn Larkin, Peter Senter, Peter Bohlen, Daniel J. Hicklin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1455.
Published: 01 May 2005
View article titled, Suppression of leukemia growth in vivo by a novel anti-FLT3 antibody-auristatin conjugate
Journal Articles

Antibody against mouse platelet-derived growth factor β receptor suppresses growth of human ovarian tumor xenografts

Juqun Shen, Marie Vil, James Tonra, Haifan Zhang, Dhanvanthri Deevi, Bridget Finnerty, Paul Balderes, Venkat Mangalampalli, Anthony Kayas, Xenia Jimenez, Michelle Iacolina, Julie Yuen, Heather Griffith, Nick Loizos, Dale Ludwig, Larry Witte, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 127.
Published: 01 May 2005
View article titled, Antibody against mouse platelet-derived growth factor β receptor suppresses growth of human ovarian tumor xenografts
Journal Articles

Cell-based selection of internalizing antagonistic fully human antibodies directed against FLT3 for suppression of leukemia cell growth

Brent R. Williams, Amanda Atkins, Haifan Zhang, Dan Lu, Xenia Jimenez, Hongli Li, Mei-Nai Wang, Dale Ludwig, Paul Balderes, Larry Witte, Yiwen Li, Zhenping Zhu
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 129.
Published: 01 May 2005
View article titled, Cell-based selection of internalizing antagonistic fully human antibodies directed against FLT3 for suppression of leukemia cell growth
Journal Articles

Therapeutic implications of an antibody to the human macrophage-stimulating protein receptor tyrosine kinase (RON)

Daniel S. Pereira, Jennifer M. O’Toole, Karen E. Rabenau, Dan Lu, Venkat Mangalampalli, Henry Koo, Anthony Kayas, Julie P. Yuen, Paul Balderes, Nicole Covino, Rajiv Bassi, Andrea Hooper, Philipp Steiner, Xenia Jimenez, Zhenping Zhu, Dale L. Ludwig, Daniel J. Hicklin, Larry Witte
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 130–131.
Published: 01 May 2005
View article titled, Therapeutic implications of an antibody to the human macrophage-stimulating protein receptor tyrosine kinase (RON)
Journal Articles

Generation of Intracellular antibody directed against the non-Receptor Tyrosine Kinase Etk

Laura Brennan, Michelle Iacolina, Yaron Hadari, Jacqueline Doody, Zhenping Zhu, Keren Paz
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 133.
Published: 01 May 2005
View article titled, Generation of Intracellular antibody directed against the non-Receptor Tyrosine Kinase Etk
Journal Articles

Fetal Stromal–Dependent Paracrine and Intracrine Vascular Endothelial Growth Factor-A/Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Proliferation and Motility of Human Primary Myeloma Cells

Loïc Vincent, David K. Jin, Matthias A. Karajannis, Koji Shido, Andrea T. Hooper, William K. Rashbaum, Bronislaw Pytowski, Yan Wu, Daniel J. Hicklin, Zhenping Zhu, Peter Bohlen, Ruben Niesvizky, Shahin Rafii
Journal: Cancer Research
Cancer Res (2005) 65 (8): 3185–3192.
https://doi.org/10.1158/0008-5472.CAN-04-3598
Published: 15 April 2005
View article titled, Fetal Stromal–Dependent Paracrine and Intracrine Vascular Endothelial Growth Factor-A/Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Proliferation and Motility of Human Primary Myeloma Cells
Open the PDF for Fetal Stromal–Dependent Paracrine and Intracrine Vascular Endothelial Growth Factor-A/Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Proliferation and Motility of Human Primary Myeloma Cells in another window
Journal Articles

Inhibitory Anti-FLT3 Antibodies Are Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity and Reducing Engraftment of Acute Myelogenous Leukemia Blasts in Nonobese Diabetic/Severe Combined Immunodeficient Mice

Obdulio Piloto, Mark Levis, David Huso, Yiwen Li, Hongli Li, Mei-Nai Wang, Rajiv Bassi, Paul Balderes, Dale L. Ludwig, Larry Witte, Zhenping Zhu, Daniel J. Hicklin, Donald Small
Journal: Cancer Research
Cancer Res (2005) 65 (4): 1514–1522.
https://doi.org/10.1158/0008-5472.CAN-04-3081
Published: 25 February 2005
View article titled, Inhibitory Anti-FLT3 Antibodies Are Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity and Reducing Engraftment of Acute Myelogenous Leukemia Blasts in Nonobese Diabetic/Severe Combined Immunodeficient Mice
Open the PDF for Inhibitory Anti-FLT3 Antibodies Are Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity and Reducing Engraftment of Acute Myelogenous Leukemia Blasts in Nonobese Diabetic/Severe Combined Immunodeficient Mice in another window