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Zhengdong Liang
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Journal Articles

Abstract 2883: Cetuximab increases LGR5 expression and enhances efficacy of LGR5 antibody-drug conjugates in patient-derived models of colorectal cancer

Peyton High, Zhengdong Liang, Cara Guernsey-Biddle, Adela Aldana, Yukimatsu Toh, Qingyun Liu, Kendra S. Carmon
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2883.
https://doi.org/10.1158/1538-7445.AM2025-2883
Published: 21 April 2025
View articletitled, Abstract 2883: Cetuximab increases LGR5 expression and enhances efficacy of LGR5 antibody-drug conjugates in patient-derived models of colorectal cancer
Journal Articles

Abstract 2956: Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer

Yukimatsu Toh, Ling Wu, Jianghua Tu, Zhengdong Liang, Adela M. Aldana, Li Li, Jake J. Wen, Sheng Pan, Julie H. Rowe, Martha E. Hensel, Carolyn L. Hodo, Rick A. Finch, Kendra S. Carmon, Qingyun J. Liu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2956.
https://doi.org/10.1158/1538-7445.AM2025-2956
Published: 21 April 2025
View articletitled, Abstract 2956: Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
Journal Articles

Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer

Joan Jacob, Yasuaki Anami, Peyton C. High, Zhengdong Liang, Shraddha Subramanian, Sukhen C. Ghosh, Solmaz AghaAmiri, Cara Guernsey-Biddle, Ha Tran, Julie Rowe, Ali Azhdarinia, Kyoji Tsuchikama, Kendra S. Carmon
Journal: Cancer Research
Cancer Res (2025) 85 (5): 973–986.
https://doi.org/10.1158/0008-5472.CAN-24-0798
Published: 03 March 2025
View articletitled, Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer
Open the PDF for Antibody–Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4552: EGFR inhibitors increase LGR5 expression and enhance potency of LGR5 antibody-drug conjugates targeting colorectal cancer stem cells

Peyton C. High, Zhengdong Liang, Kendra S. Carmon
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4552.
https://doi.org/10.1158/1538-7445.AM2024-4552
Published: 22 March 2024
View articletitled, Abstract 4552: EGFR inhibitors increase LGR5 expression and enhance potency of LGR5 antibody-drug conjugates targeting colorectal cancer stem cells
Journal Articles

Abstract 6328: GPR56 as a therapeutic target for the development of antibody-drug conjugates for the treatment of colorectal cancer

Liezl E. Francisco, Treena Chatterjee, Zhengdong Liang, Sheng Zhang, Kendra Carmon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6328.
https://doi.org/10.1158/1538-7445.AM2022-6328
Published: 15 June 2022
View articletitled, Abstract 6328: GPR56 as a therapeutic target for the development of antibody-drug conjugates for the treatment of colorectal cancer
Journal Articles

Abstract 4251: Development and characterization of an epiregulin antibody-drug conjugate for targeting colorectal cancer cell plasticity

Joan Jacob, Zhengdong Liang, Kendra Carmon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4251.
https://doi.org/10.1158/1538-7445.AM2022-4251
Published: 15 June 2022
View articletitled, Abstract 4251: Development and characterization of an epiregulin antibody-drug conjugate for targeting colorectal cancer cell plasticity
Journal Articles

Abstract PO-115: Effects of mesothelin exert on tumor microenvironment in pancreatic ductal adenocarcinoma

Dongliang Liu, Ethan Poteet, Zhengdong Liang, Emily Laplante, Lisa Brubaker, Sadhna Dhingra, Aleksandar Milosavljevic, Changyi Chen, Qizhi Cathy Yao
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-115.
https://doi.org/10.1158/1538-7445.PANCA21-PO-115
Published: 15 November 2021
View articletitled, Abstract PO-115: Effects of mesothelin exert on tumor microenvironment in pancreatic ductal adenocarcinoma
Journal Articles

Abstract A90: Mesothelin confers tumor cell vulnerabilities for gefitinib treatment

Ethan Poteet, Zhengdong Liang, Youwen Wang, Changyi Chen, Qizhi Yao
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A90.
https://doi.org/10.1158/1538-7445.PANCA16-A90
Published: 14 December 2016
View articletitled, Abstract A90: Mesothelin confers tumor cell vulnerabilities for gefitinib treatment
Journal Articles

Abstract A48: Overexpression of Semaphorin-3E enhances pancreatic cancer cell proliferation ad is associated with patient poor survival

Lin-Kin Yong, Syeling Lai, Zhengdong Liang, Dali Li, Ethan Poteet, William Fisher, Qianxin Mo, Changyi Chen, Qizhi Yao
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): A48.
https://doi.org/10.1158/1538-7445.FBCR15-A48
Published: 07 April 2016
View articletitled, Abstract A48: Overexpression of Semaphorin-3E enhances pancreatic cancer cell proliferation ad is associated with patient poor survival
Journal Articles

Abstract 3574: Novel roles of an axon-guidance molecule, semaphorin 3E, in pancreatic cancer

Lin-Kin Yong, Dali Li, Ethan Poteet, Zhengdong Liang, William Fisher, Changyi Chen, Qizhi Cathy Yao
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3574.
https://doi.org/10.1158/1538-7445.AM2015-3574
Published: 01 August 2015
View articletitled, Abstract 3574: Novel roles of an axon-guidance molecule, semaphorin 3E, in pancreatic cancer
Journal Articles

Suppression of cancer cell proliferation and invasion by Big1, a novel retinoic acid receptor-beta2 induced gene through binding to and inhibition of RhoA

Zhengdong Liang, Sr., Tsung-Teh Wu, Sr., Reuben Lotan Lotan, Sr., Scott M. Lippman, Jr., Xiaochun Xu, Sr.
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 545.
Published: 01 May 2005
View articletitled, Suppression of cancer cell proliferation and invasion by Big1, a novel retinoic acid receptor-beta2 induced gene through binding to and inhibition of RhoA
Journal Articles

Identification of Benzo( a )pyrene Diol Epoxide-binding DNA Fragments Using DNA Immunoprecipitation Technique

Zhengdong Liang, Scott M. Lippman, Atsushi Kawabe, Yutaka Shimada, Xiao-chun Xu
Journal: Cancer Research
Cancer Res (2003) 63 (7): 1470–1474.
Published: 01 April 2003
View articletitled, Identification of Benzo( a )pyrene Diol Epoxide-binding DNA Fragments Using DNA Immunoprecipitation Technique
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