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Journal Articles

Abstract CT205: Updated clinical results, recommended phase 2 dose (RP2D) determination and translational study results for START-001: A phase 1/2 trial of invikafusp alfa, a first-in-class TCR b chain-targeted bispecific antibody in patients with anti-PD(L)1-resistant, antigen-rich solid tumors

Ryan J. Sullivan, Claire F. Friedman, Nick Tschernia, Mercedes Herrera Juarez, Jeffrey Schlom, Yo-Ting Tsai, Renee N. Donahue, Guru P. Sonpavde, Aparna Parikh, Aurelien Marabelle, Shannon McCue, Karunya Srinivasan, Jacques Moisan, Madan Katragadda, Raj Chopra, Kevin Chin, Andrew Bayliffe, Zhen Su, Ke Liu, James L. Gulley, Lillian L. Siu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT205.
https://doi.org/10.1158/1538-7445.AM2025-CT205
Published: 25 April 2025
View articletitled, Abstract CT205: Updated clinical results, recommended phase 2 dose (RP2D) determination and translational study results for START-001: A phase 1/2 trial of invikafusp alfa, a first-in-class TCR b chain-targeted bispecific antibody in patients with anti-PD(L)1-resistant, antigen-rich solid tumors
Journal Articles

Abstract 1425: Epigenetic modulation synergizes with a novel TCR β chain directed antibody-fusion molecule to suppress checkpoint-refractory tumors irrespective of MHC I status

Katherine E. Lothstein, Asma S. Khelifa, Masaya Miyamoto, Christine M. Minnar, Lisa Poppe, Nicholas Roller, Andrew Bayliffe, Ke Liu, Jacques Moisan, Madan Katragadda, Zhen Su, Jeffrey Schlom, Sofia R. Gameiro
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1425.
https://doi.org/10.1158/1538-7445.AM2024-1425
Published: 22 March 2024
View articletitled, Abstract 1425: Epigenetic modulation synergizes with a novel TCR β chain directed antibody-fusion molecule to suppress checkpoint-refractory tumors irrespective of MHC I status
Journal Articles

Abstract 2357: T cell receptor beta chain-directed Tri-specific antibody molecules retarget V-beta T cell subsets to tumors to promote potent and durable antitumor activity

Madan Katragadda, Jacques Moisan, Gurkan Guntas, Manuel Sequeria, Roya Servattalab, Jessica Lowry, Robert Ruidera, Kent Nybakken, Erik Gerson, Ke Liu, Kevin Chin, Zhen Su, Andrew Bayliffe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2357.
https://doi.org/10.1158/1538-7445.AM2024-2357
Published: 22 March 2024
View articletitled, Abstract 2357: T cell receptor beta chain-directed Tri-specific antibody molecules retarget V-beta T cell subsets to tumors to promote potent and durable antitumor activity
Journal Articles

Abstract LB338: A novel class of T cell-activators targeting germline encoded TCRβ chains promotes antitumor activity in PD1-refractory models through expansion of a clonally enriched effector memory T cell subset

Jacques Moisan, Madan Katraggada, Jonathan Hsu, Jessica Lowry, Wei Huang, Jian Tang, Roya Servattalab, Gurkan Guntas, Raj Chopra, Zhen Su, Andrew Bayliffe
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB338.
https://doi.org/10.1158/1538-7445.AM2023-LB338
Published: 14 April 2023
View articletitled, Abstract LB338: A novel class of T cell-activators targeting germline encoded TCRβ chains promotes antitumor activity in PD1-refractory models through expansion of a clonally enriched effector memory T cell subset
Journal Articles

Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions

Zhen Su, Fusheng Wei, Carole Frye, Kyun-mi Bae, Siqing Wang, Vicky Kelley, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4996.
Published: 01 May 2008
View articletitled, Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions
Journal Articles

Expression of pluripotent stem cell genes by prostate tumor-initiating cells

Johannes Vieweg, Siqing Wang, Kyung-Mi Bae, Karrune Woan, Charles J. Rosser Rosser, Philipp Dahm, Vicky Kelley, Marda Jorgensen, Dennis Steindler, Zhen Su
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2037.
Published: 01 May 2008
View articletitled, Expression of pluripotent stem cell genes by prostate tumor-initiating cells
Journal Articles

VEGFR1+CD11b+ myeloid cells in cancer patients with metastatic renal cell carcinoma: link to tumor-induced immune suppression and angiogenesis

Sergei Kusmartsev, Hubert Kubler, Eugeniy Eruslanov, Zhen Su, Philipp Dahm, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2552.
Published: 01 May 2007
View articletitled, VEGFR1+CD11b+ myeloid cells in cancer patients with metastatic renal cell carcinoma: link to tumor-induced immune suppression and angiogenesis
Journal Articles

Stimulation of potent antigen-specific T-cell responses using semiallogenic dendritic cells derived from human embryonic stem cells

Zhen Su, Fusheng Wei, Siqing Wang, Vicky Kelley, Philipp Dahm, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1846.
Published: 01 May 2007
View articletitled, Stimulation of potent antigen-specific T-cell responses using semiallogenic dendritic cells derived from human embryonic stem cells
Journal Articles

Immature myeloid cell (ImC)- mediated immunosuppression in advanced renal cell cancer (RCC)

Jens Dannull, Hubert R. Kuebler, Timothy T. Tseng, Aijing Zhang, Zhen Su, Philipp Dahm, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 909.
Published: 15 April 2006
View articletitled, Immature myeloid cell (ImC)- mediated immunosuppression in advanced renal cell cancer (RCC)
Journal Articles

Delivery of mRNA into human dendritic cells using novel transfer peptides leads to prolonged antigen expression and potent immune responses in vivo

Zhen Su, Quinton Cancel, Philip Dahm, Johannes Vieweg, Jens Dannull
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 996.
Published: 01 May 2005
View articletitled, Delivery of mRNA into human dendritic cells using novel transfer peptides leads to prolonged antigen expression and potent immune responses in vivo
Journal Articles

Reversal of immature myeloid cell-mediated immunosuppression

Curtis Bradney, Jens Dannull, Zhen Su, Aijing Zhang, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 569.
Published: 01 May 2005
View articletitled, Reversal of immature myeloid cell-mediated immunosuppression
Journal Articles

Vaccination of metastatic prostate cancer patients using mature dendritic cells transfected with mRNA encoding hTERT or an MHC class II targeted hTERT/LAMP fusion protein: Results From A Phase I clinical trial

Zhen Su, Benjamin K. Yang, Jens Dannull, Philipp Dahm, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 325.
Published: 01 April 2004
View articletitled, Vaccination of metastatic prostate cancer patients using mature dendritic cells transfected with mRNA encoding hTERT or an MHC class II targeted hTERT/LAMP fusion protein: Results From A Phase I clinical trial
Journal Articles

Enhancement of antitumor immunity following depletion of CD4+CD25+ regulatory T cells.

Jens Dannull, Benjamin K. Yang, Zhen Su, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 503.
Published: 01 April 2004
View articletitled, Enhancement of antitumor immunity following depletion of CD4+CD25+ regulatory T cells.
Journal Articles

Enhanced antigen presenting function of antigen-loaded dendritic cells following cotransfection with OX40 ligand mRNA.

Jens Dannull, Smita Nair, Zhen Su, Eli Gilboa, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 495.
Published: 01 April 2004
View articletitled, Enhanced antigen presenting function of antigen-loaded dendritic cells following cotransfection with OX40 ligand mRNA.
Journal Articles

Immunological and Clinical Responses in Metastatic Renal Cancer Patients Vaccinated with Tumor RNA-transfected Dendritic Cells

Zhen Su, Jens Dannull, Axel Heiser, Donna Yancey, Scott Pruitt, John Madden, Doris Coleman, Donna Niedzwiecki, Eli Gilboa, Johannes Vieweg
Journal: Cancer Research
Cancer Res (2003) 63 (9): 2127–2133.
Published: 01 May 2003
View articletitled, Immunological and Clinical Responses in Metastatic Renal Cancer Patients Vaccinated with Tumor RNA-transfected Dendritic Cells
Open the PDF for Immunological and Clinical Responses in Metastatic Renal Cancer Patients Vaccinated with Tumor RNA-transfected Dendritic Cells in another window
Journal Articles

Enhanced Induction of Telomerase-specific CD4+ T Cells Using Dendritic Cells Transfected with RNA Encoding a Chimeric Gene Product

Zhen Su, Johannes Vieweg, Alon Z. Weizer, Philipp Dahm, Donna Yancey, Vandana Turaga, John Higgins, David Boczkowski, Eli Gilboa, Jens Dannull
Journal: Cancer Research
Cancer Res (2002) 62 (17): 5041–5048.
Published: 01 September 2002
View articletitled, Enhanced Induction of Telomerase-specific CD4+ T Cells Using Dendritic Cells Transfected with RNA Encoding a Chimeric Gene Product
Open the PDF for Enhanced Induction of Telomerase-specific CD4+ T Cells Using Dendritic Cells Transfected with RNA Encoding a Chimeric Gene Product in another window