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Abstract 3599: Helical stapled peptides derived from DIRAS3 block KRAS dimerization and downstream MEK/ERK signaling in pancreatic and ovarian carcinomas

Joshua P. Gray, Gamze E. Bildik, Margie N. Sutton, Yong Zhou, Steven Millward, John F. Hancock, Zhen Lu, Robert C. Bast

Cancer Res (2022) 82 (12_Supplement): 3599.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3599

Published: 15 June 2022

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Abstract 83: Structural and biochemical properties of DIRAS3 N-terminal extension that permit its function as a tumor suppressor of oncogenic K-RAS

Xiaowen Liang, Kwangkook Lee, Sung Y. Jung, Gamze Bildik, Weiqun Mao, Joshua P. Gray, Steven W. Millward, Zhen Lu, Robert C. Bast

Cancer Res (2021) 81 (13_Supplement): 83.

DOI: https://doi.org/10.1158/1538-7445.AM2021-83

Published: 01 July 2021

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Journal Articles

Abstract 1999: DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas

Gamze Bildik, Joshua P. Gray, Weiqun Mao, Robert C. Bast, Zhen Lu

Cancer Res (2021) 81 (13_Supplement): 1999.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1999

Published: 01 July 2021

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Abstract 4083: Crizotinib improves the therapeutic efficacy of olaparib in ovarian cancer

Janice M. Santiago-O'Farrill, Alicia M. Blessing, Sarah E. Becker, Zhen Lu, Robert C. Bast

Cancer Res (2020) 80 (16_Supplement): 4083.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4083

Published: 15 August 2020

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Abstract 5210: Novel SIK2 inhibitors sensitize ovarian and breast cancer to PARP inhibitors

Zhen Lu, Weiqun Mso, Janice M. Santiago-O'Farrill, Hailing Yang, Lan Pang, Ahmed A. Ahmed, Hariprasad Vankayalapati, Robert C. Bast, Jr

Cancer Res (2020) 80 (16_Supplement): 5210.

DOI: https://doi.org/10.1158/1538-7445.AM2020-5210

Published: 15 August 2020

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Abstract 912: Macrophage inhibitory factor (MIF), osteopontin (OPN) and anti-interleukin-8 (IL-8) autoantibodies (AAb) complement CA125 for detection of early-stage ovarian cancer

Jing Guo, Wei-lei Yang, Joseph Celestino, Karen Lu, Anna E. Lokshin, Zhen Lu, Robert C. Bast

Cancer Res (2019) 79 (13_Supplement): 912.

DOI: https://doi.org/10.1158/1538-7445.AM2019-912

Published: 01 July 2019

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Abstract 3816: Corilagin could help to overcome PARP inhibitor resistance by inhibiting ERK signaling pathways

Baoxin Luan, Hongbo Zhao, Robert C. Bast, Jr., Zhen Lu, Yinhua Yu

Cancer Res (2019) 79 (13_Supplement): 3816.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3816

Published: 01 July 2019

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Abstract 4768: PARP inhibitor-induced autophagy provides an adaptive mechanism of drug resistance in preclinical models of ovarian cancer

Janice M. Santiago-O'Farrill, Saravut J. Weroha, Xiaonan Hou, Lan Pang, Philip Rask, Zhen Lu, Robert C. Bast

Cancer Res (2019) 79 (13_Supplement): 4768.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4768

Published: 01 July 2019

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Abstract 4263: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to ALK inhibition

Alicia M. Blessing, Weiqun Mao, Lan Pang, Philip Rask, Zhen Lu, Robert C. Bast

Cancer Res (2019) 79 (13_Supplement): 4263.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4263

Published: 01 July 2019

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Abstract LB-176: HE4 antigen-autoantibody complexes complement CA125 for detecting early stage ovarian cancer and can be elevated with CA125 in preclinical ovarian cancer

Wei-Lei Yang, Zhen Lu, Karen H. Lu, Usha Menon, Makoto Kobayashi, Samir Hanash, Steven Skates, Robert C. Bast

Cancer Res (2018) 78 (13_Supplement): LB-176.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-176

Published: 01 July 2018

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Abstract 1325: DIRAS3 (ARHI) is required for amino acid-mediated autophagy and nutrient deprivation in dormant ovarian cancers

Margie Nicole Sutton, Gilbert Y. Huang, Jinhua Zhou, Zhen Lu, Robert C. Bast

Cancer Res (2018) 78 (13_Supplement): 1325.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1325

Published: 01 July 2018

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Abstract 324: SIK2 inhibitors regulate DNA repair pathway and sensitize ovarian cancer to PARP1 inhibitors

Zhen Lu, Wequn Mao, Lan Pang, Janice M. Santiago-O'Farrill, Haling Yang, Ahmed Ahmed, Hariprasad Vankayalapati, Robert C. Bast

Cancer Res (2018) 78 (13_Supplement): 324.

DOI: https://doi.org/10.1158/1538-7445.AM2018-324

Published: 01 July 2018

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Abstract 3564: Silencing pfkfb2 enhances paclitaxel sensitivity by modulating metabolism of p53 wt ovarian and breast cancer cells and xenografts

Hailing Yang, Shu Zhang, Weiqun Mao, Ahmed A. Ahmed, Nicholas B. Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K. Sood, Xiao-Feng Le, Zhen Lu, Robert C. Bast

Cancer Res (2017) 77 (13_Supplement): 3564.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3564

Published: 01 July 2017

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Abstract 1864: Feasibility of magnetic relaxometry for early ovarian cancer detection: preliminary evaluation of sensitivity and specificity in cell culture and in mice

Kelsey Mathieu, Zhen Lu, Hailing Yang, Lan Pang, Adam Kulp, John Hazle, Robert C. Bast

Cancer Res (2017) 77 (13_Supplement): 1864.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1864

Published: 01 July 2017

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Abstract 3317: Autophagy protects ovarian cancer cells from olaparib-induced toxicity

Janice M. Santiago-O'Farrill, Safia Essien, Mary Figueroa, Lan Pang, Ravi Amaravadi, Zhen Lu, Robert C. Bast

Cancer Res (2017) 77 (13_Supplement): 3317.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3317

Published: 01 July 2017

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Abstract 3313: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to Crizotinib

Alicia M. Blessing, Yan Wang, Weiqun Mao, Lan Pang, Zhen Lu, Robert C. Bast

Cancer Res (2017) 77 (13_Supplement): 3313.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3313

Published: 01 July 2017

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Journal Articles

Abstract 887: Magnetic relaxometry detection of stealth, antibody-targeted micellar iron oxide nanoparticles in-vivo

Rebeca Romero Aburto, Konstantin Sokolov, Adam M. Kulp, Erika C. Vreeland, Zhen Lu, Robert C. Bast, John D. Hazle, Kelsey B. Mathieu

Cancer Res (2017) 77 (13_Supplement): 887.

DOI: https://doi.org/10.1158/1538-7445.AM2017-887

Published: 01 July 2017

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Abstract 888: Volumetric reconstruction of targeted nanoparticles for superparamagnetic relaxometry

Sara L. Thrower, Kelsey Mathieu, Wolfgang Stefan, R. Romero Aburto, Zhen Lu, Robert C. Bast, Javad Sovizi, David Fuentes, John D. Hazle

Cancer Res (2017) 77 (13_Supplement): 888.

DOI: https://doi.org/10.1158/1538-7445.AM2017-888

Published: 01 July 2017

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Journal Articles

Abstract LB-296: Discovery of ARN-3261 as a potent, selective, orally available SIK2 inhibitor for treating ovarian, endometrial, primary peritoneal, fallopian tube, and triple negative breast cancers

Hariprasad Vankayalapati, Venkatakrishnareddy Yerramreddy, Jinhua Zhou, Jeffrey A. Handler, Rajendra P. Appalaneni, Ramamohan R. Kancherla, Roy J. Wu, Hiroshi Takemori, Angelique Whitehurst, Amir Anthony Jazaeri, Robert L. Coleman, Zhen Lu, Robert C. Bast

Cancer Res (2017) 77 (13_Supplement): LB-296.

DOI: https://doi.org/10.1158/1538-7445.AM2017-LB-296

Published: 01 July 2017

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Journal Articles

Abstract 1151: IL-8, VEGF and IGF-1 play the important role in ARHI mediated-tumor dormancy in ovarian cancer

Zhen Lu, Aaron Orozco, Weiqun Mao, Yan Wang, Margie Nicole Sutton, Hailing Yang, Douglas A. Levine, Robert C. Bast, Jr

Cancer Res (2016) 76 (14_Supplement): 1151.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1151

Published: 15 July 2016

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NARROW

Abstract 3599: Helical stapled peptides derived from DIRAS3 block KRAS dimerization and downstream MEK/ERK signaling in pancreatic and ovarian carcinomas

Abstract 83: Structural and biochemical properties of DIRAS3 N-terminal extension that permit its function as a tumor suppressor of oncogenic K-RAS

Abstract 1999: DIRAS3 induces autophagy and enhances sensitivity to anti-autophagic therapy in KRAS-driven pancreatic and ovarian carcinomas

Abstract 4083: Crizotinib improves the therapeutic efficacy of olaparib in ovarian cancer

Abstract 5210: Novel SIK2 inhibitors sensitize ovarian and breast cancer to PARP inhibitors

Abstract 912: Macrophage inhibitory factor (MIF), osteopontin (OPN) and anti-interleukin-8 (IL-8) autoantibodies (AAb) complement CA125 for detection of early-stage ovarian cancer

Abstract 3816: Corilagin could help to overcome PARP inhibitor resistance by inhibiting ERK signaling pathways

Abstract 4768: PARP inhibitor-induced autophagy provides an adaptive mechanism of drug resistance in preclinical models of ovarian cancer

Abstract 4263: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to ALK inhibition

Abstract LB-176: HE4 antigen-autoantibody complexes complement CA125 for detecting early stage ovarian cancer and can be elevated with CA125 in preclinical ovarian cancer

Abstract 1325: DIRAS3 (ARHI) is required for amino acid-mediated autophagy and nutrient deprivation in dormant ovarian cancers

Abstract 324: SIK2 inhibitors regulate DNA repair pathway and sensitize ovarian cancer to PARP1 inhibitors

Abstract 3564: Silencing pfkfb2 enhances paclitaxel sensitivity by modulating metabolism of p53 wt ovarian and breast cancer cells and xenografts

Abstract 1864: Feasibility of magnetic relaxometry for early ovarian cancer detection: preliminary evaluation of sensitivity and specificity in cell culture and in mice

Abstract 3317: Autophagy protects ovarian cancer cells from olaparib-induced toxicity

Abstract 3313: Autophagic ovarian cancer cells exhibit substantially enhanced sensitivity to Crizotinib

Abstract 887: Magnetic relaxometry detection of stealth, antibody-targeted micellar iron oxide nanoparticles in-vivo

Abstract 888: Volumetric reconstruction of targeted nanoparticles for superparamagnetic relaxometry

Abstract LB-296: Discovery of ARN-3261 as a potent, selective, orally available SIK2 inhibitor for treating ovarian, endometrial, primary peritoneal, fallopian tube, and triple negative breast cancers

Abstract 1151: IL-8, VEGF and IGF-1 play the important role in ARHI mediated-tumor dormancy in ovarian cancer

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