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Journal Articles

Abstract 4756: Targeting DNA topoisomerase II to manage acquired resistance to third generation EGFR tyrosine kinase inhibitors in the treatment of EGFR mutant NSCLC

Zhen Chen, Karin A. Vallega, Dongsheng Wang, Zihan Quan, Songqing Fan, Qiming Wang, Ticiana A. Leal, Suresh S. Ramalingam, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4756.
https://doi.org/10.1158/1538-7445.AM2024-4756
Published: 22 March 2024
View article titled, Abstract 4756: Targeting DNA topoisomerase II to manage acquired resistance to third generation EGFR tyrosine kinase inhibitors in the treatment of EGFR mutant NSCLC
Journal Articles

Abstract 5339: Establishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation in vivo

Suman Zhao, Shujin Zhang, Zhen Chen, Liya Yang, Mari Kuraguchi, Jiangfeng Yuan, Heiling Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5339.
https://doi.org/10.1158/1538-7445.AM2024-5339
Published: 22 March 2024
View article titled, Abstract 5339: Establishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation <em>in vivo</em>
Journal Articles

Abstract 113: Generation and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model

Linlin Wang, Lei Zhao, Meiqi Zhang, Zhi Zhang, Zhen Chen, Mari Kuraguchi, Jingjing Lian, Jiansu Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 113.
https://doi.org/10.1158/1538-7445.AM2024-113
Published: 22 March 2024
View article titled, Abstract 113: Generation and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model
Journal Articles

Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response

Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Ximing Tang, Sen Pathak, Maria G. Raso, Jared Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2585.
https://doi.org/10.1158/1538-7445.AM2023-2585
Published: 04 April 2023
View article titled, Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response
Journal Articles

Targeting c-Myc to Overcome Acquired Resistance of EGFR Mutant NSCLC Cells to the Third-Generation EGFR Tyrosine Kinase Inhibitor, Osimertinib

Lei Zhu, Zhen Chen, Hongjing Zang, Songqing Fan, Jiajia Gu, Guojing Zhang, Kevin D.-Y. Sun, Qiming Wang, Yong He, Taofeek K. Owonikoko, Suresh S. Ramalingam, Shi-Yong Sun
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4822–4834.
https://doi.org/10.1158/0008-5472.CAN-21-0556
Published: 15 September 2021
View article titled, Targeting c-Myc to Overcome Acquired Resistance of EGFR Mutant NSCLC Cells to the Third-Generation EGFR Tyrosine Kinase Inhibitor, Osimertinib
Open the PDF for Targeting c-Myc to Overcome Acquired Resistance of EGFR Mutant NSCLC Cells to the Third-Generation EGFR Tyrosine Kinase Inhibitor, Osimertinib in another window
Includes: Supplementary data
Journal Articles

A Notch-Dependent Inflammatory Feedback Circuit between Macrophages and Cancer Cells Regulates Pancreatic Cancer Metastasis

Yawen Geng, Jie Fan, Lianyu Chen, Chenyue Zhang, Chao Qu, Ling Qian, Kun Chen, Zhiqiang Meng, Zhen Chen, Peng Wang
Journal: Cancer Research
Cancer Res (2021) 81 (1): 64–76.
https://doi.org/10.1158/0008-5472.CAN-20-0256
Published: 04 January 2021
View article titled, A Notch-Dependent Inflammatory Feedback Circuit between Macrophages and Cancer Cells Regulates Pancreatic Cancer Metastasis
Open the PDF for A Notch-Dependent Inflammatory Feedback Circuit between Macrophages and Cancer Cells Regulates Pancreatic Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract CT406: Patients with cancer appear more vulnerable to SARS-COV-2: A multi-center study during the COVID-19 outbreak

Meng-Yuan Dai, Dian-bo Liu, Miao Liu, Fu-Xiang Zhou, Gui-Ling Li, Zhen Chen, Zhi-An Zhang, Hua-You Md, Meng Wu, Qi-Chao Zheng, Yong Xiong, Hui-Hua Xiong, Chun Wang, Chang-Chun Chen, Fei Xiong, Yan Zhang, Ya-Qin Peng, Si-Ping Ge, Bo Zhen, Ting-Ting Yu, Ling Wang, Hua Wang, Yu Liu, Ye-Shan Chen, Jun-Hua Mei, Xiao-Jia Gao, Zhu-Yan Li, Li-Juan Gan, Can He, Zhen Li, Yu-Ying Shi, Yu-Wen Qi, Jing Yang, Daniel G. Tenen, Li Chai, Lorelei Ann Mucci, Mauricio Santillana, Hongbing Cai
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT406.
https://doi.org/10.1158/1538-7445.AM2020-CT406
Published: 15 August 2020
View article titled, Abstract CT406: Patients with cancer appear more vulnerable to SARS-COV-2: A multi-center study during the COVID-19 outbreak
Journal Articles

Abstract 4686: Core transcriptional regulatory circuitry FOXA1-MAX-SP1 promotes malignancy of hepatocellular carcinoma

Li Peng, Xiaoqing Yuan, Zhen Chen, Chaoyang Zhang, Duanqing Tian, Dong Yin, De-Chen Lin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4686.
https://doi.org/10.1158/1538-7445.AM2020-4686
Published: 15 August 2020
View article titled, Abstract 4686: Core transcriptional regulatory circuitry FOXA1-MAX-SP1 promotes malignancy of hepatocellular carcinoma
Journal Articles

Abstract 72: PARK2 enhances chemosensitivity of antimicrotubule drugs in breast cancer via promoting degradation of BCL-2

Hengxing Chen, Yun Li, Yu Li, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Daning Lu, Xue Hong, H. Phillip Koeffler, Wenjing Wu, Kaishun Hu, Dong Yin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 72.
https://doi.org/10.1158/1538-7445.AM2020-72
Published: 15 August 2020
View article titled, Abstract 72: PARK2 enhances chemosensitivity of antimicrotubule drugs in breast cancer via promoting degradation of BCL-2
Journal Articles

Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance

Hongxi Wu, Linjun You, Yan Li, Zhili Zhao, Guangjiang Shi, Zhen Chen, Zhuo Wang, Xianjing Li, Shijia Du, Wanli Ye, Xiaofang Gao, Jingjing Duan, Yan Cheng, Weiyan Tao, Jinsong Bian, Jin-Rong Zhou, Qingyi Zhu, Yong Yang
Journal: Cancer Research
Cancer Res (2020) 80 (13): 2927–2939.
https://doi.org/10.1158/0008-5472.CAN-19-2549
Published: 02 July 2020
View article titled, Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance
Open the PDF for Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance in another window
Includes: Supplementary data
Journal Articles

Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR

Xiao-Lin Luo, Cheng-Cheng Deng, Xiao-Dong Su, Fang Wang, Zhen Chen, Xing-Ping Wu, Shao-Bo Liang, Ji-Hong Liu, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2018) 78 (13): 3532–3543.
https://doi.org/10.1158/0008-5472.CAN-18-0134
Published: 01 July 2018
View article titled, Loss of MED12 Induces Tumor Dormancy in Human Epithelial Ovarian Cancer via Downregulation of EGFR
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Includes: Supplementary data
Journal Articles

Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer

Xiaokun Wang, Dongjuan Qiao, Likun Chen, Liyan Huang, Meng Xu, Zhen Chen, Fang Wang, Zhesheng Chen, Musheng Zeng, Li-Wu Fu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3180.
https://doi.org/10.1158/1538-7445.AM2017-3180
Published: 01 July 2017
View article titled, Abstract 3180: Chemotherapeutical agent triggers transient resistance of cancer cells by promoting ABCB1 intercellular transfer
Journal Articles

miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4

Hsin-Yi Chen, Yu-Min Lin, Hsiang-Ching Chung, Yaw-Dong Lang, Ching-Jung Lin, John Huang, Wei-Chi Wang, Feng-Mao Lin, Zhen Chen, Hsien-Da Huang, John Y.-J. Shyy, Jin-Tung Liang, Ruey-Hwa Chen
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3631–3641.
https://doi.org/10.1158/0008-5472.CAN-12-0667
Published: 15 July 2012
View article titled, miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4
Open the PDF for miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4 in another window
Includes: Supplementary data
Journal Articles

Comprehensive Pathway-Based Association Study of DNA Repair Gene Variants and the Risk of Nasopharyngeal Carcinoma

Hai-De Qin, Yin Yao Shugart, Jin-Xin Bei, Qing-Hua Pan, Lina Chen, Qi-Sheng Feng, Li-Zhen Chen, Wei Huang, Jian Jun Liu, Timothy J. Jorgensen, Yi-Xin Zeng, Wei-Hua Jia
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3000–3008.
https://doi.org/10.1158/0008-5472.CAN-10-0469
Published: 13 April 2011
View article titled, Comprehensive Pathway-Based Association Study of DNA Repair Gene Variants and the Risk of Nasopharyngeal Carcinoma
Open the PDF for Comprehensive Pathway-Based Association Study of DNA Repair Gene Variants and the Risk of Nasopharyngeal Carcinoma in another window
Includes: Supplementary data
Journal Articles

Identification of Cancer Stem Cell–Like Side Population Cells in Human Nasopharyngeal Carcinoma Cell Line

Jing Wang, Li-Ping Guo, Li-Zhen Chen, Yi-Xin Zeng, Shih Hsin Lu
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3716–3724.
https://doi.org/10.1158/0008-5472.CAN-06-4343
Published: 17 April 2007
View article titled, Identification of Cancer Stem Cell–Like Side Population Cells in Human Nasopharyngeal Carcinoma Cell Line
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Includes: Supplementary data
Journal Articles

A Functional Variant in the Transcriptional Regulatory Region of Gene LOC344967 Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma

Ri-Cheng Jiang, Hai-De Qin, Mu-Sheng Zeng, Wei Huang, Bing-Jian Feng, Feng Zhang, Han-Kui Chen, Wei-Hua Jia, Li-Zhen Chen, Qi-Sheng Feng, Ru-Hua Zhang, Xing-Juan Yu, Mei-Zhen Zheng, Yi-Xin Zeng
Journal: Cancer Research
Cancer Res (2006) 66 (2): 693–700.
https://doi.org/10.1158/0008-5472.CAN-05-2166
Published: 19 January 2006
View article titled, A Functional Variant in the Transcriptional Regulatory Region of Gene <em>LOC344967</em> Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma
Open the PDF for A Functional Variant in the Transcriptional Regulatory Region of Gene <em>LOC344967</em> Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma in another window