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Journal Articles

Abstract LB258: ZDHHC20 is a potential target for overcoming ABCB1-mediated multidrug resisance (MDR) in cancer

Ning Ji, Xin Peng, Yi-nan Liu, Yuqi Yang, Zhe-Sheng Chen, Dexin Kong, Yueguo Li
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB258.
https://doi.org/10.1158/1538-7445.AM2024-LB258
Published: 05 April 2024
View article titled, Abstract LB258: ZDHHC20 is a potential target for overcoming ABCB1-mediated multidrug resisance (MDR) in cancer
Journal Articles

Abstract 7193: ABCB1-mediated chemotherapeutic drug resistance is reversed by a potent p53-MDM2 inhibitor NVP-HDM201

Harsh Patel, Chaoyun Cai, Zhuoxun Wu, Qiuxu Teng, Hanli Li, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7193.
https://doi.org/10.1158/1538-7445.AM2024-7193
Published: 22 March 2024
View article titled, Abstract 7193: ABCB1-mediated chemotherapeutic drug resistance is reversed by a potent p53-MDM2 inhibitor NVP-HDM201
Journal Articles

Abstract 2843: RN486, a Bruton’s tyrosine kinase inhibitor, reverses multidrug resistance in ABCG2-overexpressing cancer cells

Xing-Duo Dong, Qisi Lu, Yi-Dong Li, Qiu-Xu Teng, Zi-Ning Lei, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2843.
https://doi.org/10.1158/1538-7445.AM2023-2843
Published: 04 April 2023
View article titled, Abstract 2843: RN486, a Bruton’s tyrosine kinase inhibitor, reverses multidrug resistance in ABCG2-overexpressing cancer cells
Journal Articles

Abstract 409: Reversal of ABCG2-mediated multidrug resistance by tepotinib in vitro and in vivo

Zhuoxun Wu, Qiu-Xu Teng, Yuqi Yang, Nikita Acharekar, Jing-Quan Wang, Min He, Sabesan Yoganathan, Jun Lin, Jian Wang, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 409.
https://doi.org/10.1158/1538-7445.AM2022-409
Published: 15 June 2022
View article titled, Abstract 409: Reversal of ABCG2-mediated multidrug resistance by tepotinib <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Abstract 407: OTS964, a TOPK inhibitor, is susceptible to ABCG2-mediated drug resistance

Yuqi Yang, Zhuo-Xun Wu, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 407.
https://doi.org/10.1158/1538-7445.AM2022-407
Published: 15 June 2022
View article titled, Abstract 407: OTS964, a TOPK inhibitor, is susceptible to ABCG2-mediated drug resistance
Journal Articles

Abstract 1095: Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model

Qiu-Xu Teng, Zi-Ning Lei, Wei Zhang, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Dong-Hua Yang, John Wurpel, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1095.
https://doi.org/10.1158/1538-7445.AM2022-1095
Published: 15 June 2022
View article titled, Abstract 1095: Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model
Journal Articles

Abstract 360: Methyl-cantharidimide (MCA) can induce apoptosis by activating UNC5B-Netrin-1-DAPK pathway in hepatocellular carcinoma

Yi-Dong Li, Yong Mao, Xing-Duo Dong, Zi-Ning Lei, Yuqi Yang, Lizhu Lin, Dong-Hua Yang, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 360.
https://doi.org/10.1158/1538-7445.AM2022-360
Published: 15 June 2022
View article titled, Abstract 360: Methyl-cantharidimide (MCA) can induce apoptosis by activating UNC5B-Netrin-1-DAPK pathway in hepatocellular carcinoma
Journal Articles

Abstract 5264: Selective toxicity of MX-106-4C, a survivin inhibitor, in P-glycoprotein-mediated multidrug resistant colon cancer

Zi-Ning Lei, Zhongzhi Wu, Qiu-Xu Teng, Min Xiao, Wei Li, John N. Wurpel, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5264.
https://doi.org/10.1158/1538-7445.AM2020-5264
Published: 15 August 2020
View article titled, Abstract 5264: Selective toxicity of MX-106-4C, a survivin inhibitor, in P-glycoprotein-mediated multidrug resistant colon cancer
Journal Articles

Abstract 3010: VKNG 1 reverses multidrug resistance by inhibiting ABCG2 mediated drug transport in vitro and in vivo

Silpa Narayanan, Nehaben A. Gujarati, Qiuxu Teng, Jingquan Wang, Chao-Yun Cai, Yuqi Yang, Anirudh Jaganna Chintalapati, Vijaya L. Korlipara, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3010.
https://doi.org/10.1158/1538-7445.AM2020-3010
Published: 15 August 2020
View article titled, Abstract 3010: VKNG 1 reverses multidrug resistance by inhibiting ABCG2 mediated drug transport in vitro and in vivo
Journal Articles

Abstract 3006: Anticancer and multidrug resistance-reversing activities of novel antimicrobial peptides

Qiu-Xu Teng, Zi-Ning Lei, Xiaofang Luo, Jing-Quan Wang, Zuodong Qin, John N. Wurpel, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3006.
https://doi.org/10.1158/1538-7445.AM2020-3006
Published: 15 August 2020
View article titled, Abstract 3006: Anticancer and multidrug resistance-reversing activities of novel antimicrobial peptides
Journal Articles

Abstract 2983: A synthetic derivative of 1,2,3-triazole-pyrimidine hybrid reverses multidrug resistance mediated by MRP7

Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Bo Wang, Li-Ying Ma, Hong-Min Liu, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2983.
https://doi.org/10.1158/1538-7445.AM2020-2983
Published: 15 August 2020
View article titled, Abstract 2983: A synthetic derivative of 1,2,3-triazole-pyrimidine hybrid reverses multidrug resistance mediated by MRP7
Journal Articles

Abstract 3796: Selonsertib, an ASK1 inhibitor, antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance

Ning Ji, Yuqi Yang, Chao-Yun Cai, Zi-Ning Lei, Jing-Quan Wang, Pranav Gupta, Suneet Shukla, Suresh V. Ambudkar, Dexin Kong, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3796.
https://doi.org/10.1158/1538-7445.AM2019-3796
Published: 01 July 2019
View article titled, Abstract 3796: Selonsertib, an ASK1 inhibitor, antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance
Journal Articles

Abstract 4899: Establishment and characterization of SN-38 resistant metastatic colorectal cancer cells (SW620/SN100) reveals an ABCG2 (BCRP) transport mediated resistance

Anna Maria Barbuti, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4899.
https://doi.org/10.1158/1538-7445.AM2018-4899
Published: 01 July 2018
View article titled, Abstract 4899: Establishment and characterization of SN-38 resistant metastatic colorectal cancer cells (SW620/SN100) reveals an ABCG2 (BCRP) transport mediated resistance
Journal Articles

Abstract 1980: S116836 overcomes BCR-ABL T315I mutation mediated imatinib resistance in chronic myeloid leukemia

Pranav Gupta, Guannan Zhang, Anna Maria Barbuti, Ke Ding, Jingxuan Pan, Brian J. Druker, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1980.
https://doi.org/10.1158/1538-7445.AM2018-1980
Published: 01 July 2018
View article titled, Abstract 1980: S116836 overcomes BCR-ABL T315I mutation mediated imatinib resistance in chronic myeloid leukemia
Journal Articles

Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor

Pranav Gupta, Rishil Kathawala, Liuya Wei, Fang Wang, XiaoKun Wang, Brian J. Druker, Li-Wu FU, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4158.
https://doi.org/10.1158/1538-7445.AM2017-4158
Published: 01 July 2017
View article titled, Abstract 4158: Targeting the imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia through a novel BCR-ABL inhibitor
Journal Articles

Abstract 4063: Design and synthesis of indole derivatives as ABCG2 mediated resistance reversal agents

Chao-Yun Cai, Hong Zhai, Zi-Ning Lei, Bao-Li Chen, Zhao-Yi Du, Yun-Kai Zhang, Yi-Jun Wang, Bo Wang, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4063.
https://doi.org/10.1158/1538-7445.AM2017-4063
Published: 01 July 2017
View article titled, Abstract 4063: Design and synthesis of indole derivatives as ABCG2 mediated resistance reversal agents
Journal Articles

Abstract 1192: Regorafenib (Stivarga®) reverses BCRP-mediated multidrug resistance in vitro and in vivo

Yun-Kai Zhang, Yi-Jun Wang, Guan-Nan Zhang, Wen-Ji Zhang, Meng-Ning Wei, Zhi Shi, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1192.
https://doi.org/10.1158/1538-7445.AM2017-1192
Published: 01 July 2017
View article titled, Abstract 1192: Regorafenib (Stivarga®) reverses BCRP-mediated multidrug resistance <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Abstract 5876: Osimertinib (AZD9291), a mutant-selective EGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells

Xiao-Yu Zhang, Zi-Ning Lei, Yun-Kai Zhang, Yi-Jun Wang, Pranav Gupta, Leli Zeng, Megan Xu, Xiu-Qi Wang, Dong-Hua Yang, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5876.
https://doi.org/10.1158/1538-7445.AM2017-5876
Published: 01 July 2017
View article titled, Abstract 5876: Osimertinib (AZD9291), a mutant-selective EGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells
Journal Articles

Abstract 2144: Next generation inhibitors to reverse ABCB1 transport mediated multidrug resistance in cancer

Anna Maria Barbuti, Bhargav A. Patel, Tanaji T. Talele, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2144.
https://doi.org/10.1158/1538-7445.AM2016-2144
Published: 15 July 2016
View article titled, Abstract 2144: Next generation inhibitors to reverse ABCB1 transport mediated multidrug resistance in cancer
Journal Articles

Abstract 4684: Modulating the function of multidrug resistance ABCG2 transporter by tyrosine kinases receptor inhibitor cabozantinib

Guannan Zhang, Yun-Kai Zhang, Yi-Jun Wang, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4684.
https://doi.org/10.1158/1538-7445.AM2016-4684
Published: 15 July 2016
View article titled, Abstract 4684: Modulating the function of multidrug resistance ABCG2 transporter by tyrosine kinases receptor inhibitor cabozantinib