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Abstract 3947: Glutaminolysis inhibitors benzo[d][1,2]selenazol -3(2H)-one dimers completely disrupt mitochondrial function and showed early promise as effective antitumor agents with little general toxicity

Benfang Helen Ruan, Yan Yu, Zhao Chen, Yanhong Jin, Jinzhang Fang, Han Zhao, Jennifer Ruan

Cancer Res (2018) 78 (13_Supplement): 3947.

https://doi.org/10.1158/1538-7445.AM2018-3947

Published: 01 July 2018

View articletitled, Abstract 3947: Glutaminolysis inhibitors benzo[d][1,2]selenazol -3(2H)-one dimers completely disrupt mitochondrial function and showed early promise as effective antitumor agents with little general toxicity

Journal Articles

Abstract 3607: An evaluation of NGS to identify gene fusions using RNA from FFPE solid tumor samples

Julianna Tdr Parks, Luo Byron, Brian Crain, Snedecor June, Zhao Chen, Tingting Du, Gabriel L. Sica, Taofee K. Owonikoko, Stewart G. Neill, Scott Newman, Debra F. Saxe, Jennifer S. LoCoco, Han-Yu Chuang, Charles Lin, Kathryn M. Stephens, Michael R. Rossi, Matthew C. Friedenberg

Cancer Res (2016) 76 (14_Supplement): 3607.

https://doi.org/10.1158/1538-7445.AM2016-3607

Published: 15 July 2016

View articletitled, Abstract 3607: An evaluation of NGS to identify gene fusions using RNA from FFPE solid tumor samples

Journal Articles

Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers

Aaron N. Hata, Alan Yeo, Anthony C. Faber, Eugene Lifshits, Zhao Chen, Katherine A. Cheng, Zandra Walton, Kristopher A. Sarosiek, Anthony Letai, Rebecca S. Heist, Mari Mino-Kenudson, Kwok-Kin Wong, Jeffrey A. Engelman

Cancer Res (2014) 74 (11): 3146–3156.

https://doi.org/10.1158/0008-5472.CAN-13-3728

Published: 29 May 2014

View articletitled, Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers

Includes: Supplementary data

Journal Articles

Abstract 1137: Expression of specific apoptotic mediators predicts sensitivity to combined MEK and PI3K inhibition in KRAS mutant non-small cell lung cancer according to TP53 mutational status.

Aaron Hata, Anthony Faber, Alan Yeo, Zhao Chen, Kwok-Kin Wong, Jeffrey Engelman

Cancer Res (2013) 73 (8_Supplement): 1137.

https://doi.org/10.1158/1538-7445.AM2013-1137

Published: 15 April 2013

View articletitled, Abstract 1137: Expression of specific apoptotic mediators predicts sensitivity to combined MEK and PI3K inhibition in KRAS mutant non-small cell lung cancer according to TP53 mutational status.

Journal Articles

Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.

Takeshi Shimamura, Zhao Chen, Margaret Soucheray, Julian Carretero, Eiki Kikuchi, Jeremy H. Tchaicha, Yandhi Gao, Katherine A. Cheng, Travis J. Cohoon, Jun Qi, Esra A. Akbay, Alec C. Kimmelman, Andrew L. Kung, James E. Bradner, Kwok Kin Wong

Cancer Res (2013) 73 (8_Supplement): 1126.

https://doi.org/10.1158/1538-7445.AM2013-1126

Published: 15 April 2013

View articletitled, Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.

Journal Articles

Abstract 2007: Differential roles of BCL-XL and BCL-2 in protecting mitochondria against oxidative stress in CML cells

Hui Zhang, Weiqin Lu, Terrence Liu, Gang Chen, Zhao Chen, Dunyaporn Trachootham, Ralph B. Arlinghaus, Peng Huang

Cancer Res (2012) 72 (8_Supplement): 2007.

https://doi.org/10.1158/1538-7445.AM2012-2007

Published: 15 April 2012

View articletitled, Abstract 2007: Differential roles of BCL-XL and BCL-2 in protecting mitochondria against oxidative stress in CML cells

Journal Articles

Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers

Hiromichi Ebi, Ryan B. Corcoran, Anurag Singh, Zhao Chen, Youngchul Song, Eugene Lifshits, David P. Ryan, Jeffrey A. Meyerhardt, Cyril Benes, Jeffrey Settleman, Lewis C. Cantley, Kwok-Kin Wong, Jeffrey A. Engelman

Cancer Res (2011) 71 (8_Supplement): 956.

https://doi.org/10.1158/1538-7445.AM2011-956

Published: 15 April 2011

View articletitled, Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers

Journal Articles

Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene

Cancer Res (2010) 70 (23): 9827–9836.

https://doi.org/10.1158/0008-5472.CAN-10-1671

Published: 06 December 2010

View articletitled, Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene

Includes: Supplementary data

Journal Articles

Abstract 3228: Dual HER2 and EGFR inhibitor BIBW2992 have dramatic activity in a HER2 wild type/EGFR L858R murine lung cancer model

Danan Li, Zhao Chen, Liang Chen, Mei-chih Liang, Zandra Walton, Benjamin Sanofsky, Pasi Janne, Kwok-Kin Wong

Cancer Res (2010) 70 (8_Supplement): 3228.

https://doi.org/10.1158/1538-7445.AM10-3228

Published: 15 April 2010

View articletitled, Abstract 3228: Dual HER2 and EGFR inhibitor BIBW2992 have dramatic activity in a HER2 wild type/EGFR L858R murine lung cancer model

Journal Articles

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Helene Pelicano, Weiqin Lu, Yan Zhou, Wan Zhang, Zhao Chen, Yumin Hu, Peng Huang

Cancer Res (2009) 69 (6): 2375–2383.

https://doi.org/10.1158/0008-5472.CAN-08-3359

Published: 17 March 2009

View articletitled, Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Includes: Supplementary data

Journal Articles

Mitochondrial dysfunction leads to NADPH oxidase (NOX) activation and sensitization of cancer cells to NOX inhibitor

Weiqin Lu, Zhao Chen, Helene pelicano, Li Feng, Peng Huang

Cancer Res (2008) 68 (9_Supplement): 4343.

Published: 01 May 2008

View articletitled, Mitochondrial dysfunction leads to NADPH oxidase (NOX) activation and sensitization of cancer cells to NOX inhibitor

Journal Articles

CXCL14: A new molecular link between ROS and malignant behavior in breast cancer cells

Helene Pelicano, Weigin lu, Zhao Chen, Yumin Hu, Peng Huang

Cancer Res (2007) 67 (9_Supplement): LB-271.

Published: 01 May 2007

View articletitled, CXCL14: A new molecular link between ROS and malignant behavior in breast cancer cells

Journal Articles

A novel mechanism of 3-Bromopyruvate-induced cell death through targeting Hexokinase II

Zhao Chen, Rui-Hua Xu, Geetha Achanta, Peng Huang

Cancer Res (2007) 67 (9_Supplement): 5617.

Published: 01 May 2007

View articletitled, A novel mechanism of 3-Bromopyruvate-induced cell death through targeting Hexokinase II

Journal Articles

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

Dunyaporn Trachootham, Hui Zhang, Zhao Chen, Li Feng, Min Du, Helene Pelicano, Michael Keating, Peng Huang

Cancer Res (2007) 67 (9_Supplement): 1842.

Published: 01 May 2007

View articletitled, PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

Journal Articles

Mitochondrial respiratory defects lead to significant alterations in cellular redox states and drug sensitivity

Weiqin Lu, Helene Pelicano, zhao chen, li feng, Peng Huang

Cancer Res (2007) 67 (9_Supplement): LB-115.

Published: 01 May 2007

View articletitled, Mitochondrial respiratory defects lead to significant alterations in cellular redox states and drug sensitivity

Journal Articles

Inducible expression of dominant negative DNA polymerase gamma(POLGdn) in human cells: characterizations and applications

Weiqin Lu, Li Feng, Helene Pelicano, Zhao Chen, Geetha Achanta, Hui Zhang, Peng Huang

Cancer Res (2006) 66 (8_Supplement): 25.

Published: 15 April 2006

View articletitled, Inducible expression of dominant negative DNA polymerase gamma(POLGdn) in human cells: characterizations and applications

Journal Articles

Critical role of hexokinase II in 3-Bromopyruvate-induced cell death: A potential target for cancer therapeutics

Zhao Chen, Ruihua Xu, Geetha Achanta, Hui Zhang, Peng Huang

Cancer Res (2006) 66 (8_Supplement): 1103.

Published: 15 April 2006

View articletitled, Critical role of hexokinase II in 3-Bromopyruvate-induced cell death: A potential target for cancer therapeutics

Journal Articles

OSW-1 induces calcium-dependent apoptosis: Involvement of mitochondria and endoplasmic reticulum

Celia Garcia-Prieto, Geetha Achanta, Yan Zhou, Weiqin Lu, Zhao Chen, Yumin Hu, Zhendong Jin, Peng Huang

Cancer Res (2006) 66 (8_Supplement): 1105.

Published: 15 April 2006

View articletitled, OSW-1 induces calcium-dependent apoptosis: Involvement of mitochondria and endoplasmic reticulum

Journal Articles

Ethnic and geographic differences in mammographic density and their association with breast cancer incidence.

Gertraud Maskarinec, Zhao Chen, Chisato Nagata, Inger Torhild Gram

Cancer Res (2006) 66 (8_Supplement): 1259–1260.

Published: 15 April 2006

View articletitled, Ethnic and geographic differences in mammographic density and their association with breast cancer incidence.

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Abstract 3947: Glutaminolysis inhibitors benzo[d][1,2]selenazol -3(2H)-one dimers completely disrupt mitochondrial function and showed early promise as effective antitumor agents with little general toxicity

Abstract 3607: An evaluation of NGS to identify gene fusions using RNA from FFPE solid tumor samples

Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers

Abstract 1137: Expression of specific apoptotic mediators predicts sensitivity to combined MEK and PI3K inhibition in KRAS mutant non-small cell lung cancer according to TP53 mutational status.

Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.

Abstract 2007: Differential roles of BCL-XL and BCL-2 in protecting mitochondria against oxidative stress in CML cells

Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers

Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene

Abstract 3228: Dual HER2 and EGFR inhibitor BIBW2992 have dramatic activity in a HER2 wild type/EGFR L858R murine lung cancer model

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Mitochondrial dysfunction leads to NADPH oxidase (NOX) activation and sensitization of cancer cells to NOX inhibitor

CXCL14: A new molecular link between ROS and malignant behavior in breast cancer cells

A novel mechanism of 3-Bromopyruvate-induced cell death through targeting Hexokinase II

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

Mitochondrial respiratory defects lead to significant alterations in cellular redox states and drug sensitivity

Inducible expression of dominant negative DNA polymerase gamma(POLGdn) in human cells: characterizations and applications

Critical role of hexokinase II in 3-Bromopyruvate-induced cell death: A potential target for cancer therapeutics

OSW-1 induces calcium-dependent apoptosis: Involvement of mitochondria and endoplasmic reticulum

Ethnic and geographic differences in mammographic density and their association with breast cancer incidence.

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