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Zeev Estrov
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Journal Articles

Abstract 5033: Clonal origin of therapy-related myeloid neoplasms

Koichi Takahashi, Feng Wang, Hagop Kantarjian, Doss Denaha, Erika Thompson, Curtis Gumbs, Keyur Patel, Sattva Neelapu, Yan Wang, Zachary Bohannan, Courtney DiNardo, Farhad Ravandi, Zeev Estrov, Simona Colla, Jianhua Zhang, Xifeng Wu, Guillermo Garcia-Manero, Andrew Futreal
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5033.
https://doi.org/10.1158/1538-7445.AM2016-5033
Published: 15 July 2016
View article titled, Abstract 5033: Clonal origin of therapy-related myeloid neoplasms
Journal Articles

Bone Marrow Stroma–Secreted Cytokines Protect JAK2V617F-Mutated Cells from the Effects of a JAK2 Inhibitor

Taghi Manshouri, Zeev Estrov, Alfonso Quintás-Cardama, Jan Burger, Ying Zhang, Ana Livun, Liza Knez, David Harris, Chad J. Creighton, Hagop M. Kantarjian, Srdan Verstovsek
Journal: Cancer Research
Cancer Res (2011) 71 (11): 3831–3840.
https://doi.org/10.1158/0008-5472.CAN-10-4002
Published: 31 May 2011
View article titled, Bone Marrow Stroma–Secreted Cytokines Protect JAK2<sup>V617F</sup>-Mutated Cells from the Effects of a JAK2 Inhibitor
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Includes: Supplementary data
Journal Articles

Kit Inhibitor APcK110 Induces Apoptosis and Inhibits Proliferation of Acute Myeloid Leukemia Cells

Stefan Faderl, Ashutosh Pal, William Bornmann, Maher Albitar, David Maxwell, Quin Van, Zhenghong Peng, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Hagop M. Kantarjian, Zeev Estrov
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3910–3917.
https://doi.org/10.1158/0008-5472.CAN-08-0034
Published: 30 April 2009
View article titled, Kit Inhibitor APcK110 Induces Apoptosis and Inhibits Proliferation of Acute Myeloid Leukemia Cells
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Journal Articles

Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)

Marina Konopleva, Julie Watt, Rooha Contractor, Twee Tsao, David Harris, Zeev Estrov, William Bornmann, Hagop Kantarjian, Jean Viallet, Ismael Samudio, Michael Andreeff
Journal: Cancer Research
Cancer Res (2008) 68 (9): 3413–3420.
https://doi.org/10.1158/0008-5472.CAN-07-1919
Published: 01 May 2008
View article titled, Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)
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Includes: Supplementary data
Journal Articles

Phosphatase-stable peptidomimetic prodrug inhibitors of signal transducer and activator of transcription 3

Pijus Mandal, Zhiyong Ren, Inbal Hallevi, Warren Liao, Xiaomin Chen, Zeev Estrov, John McMurray
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1306.
Published: 01 May 2008
View article titled, Phosphatase-stable peptidomimetic prodrug inhibitors of signal transducer and activator of transcription 3
Journal Articles

Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia

Michael Andreeff, Weiguo Zhang, Yue-xi Shi, Teresa McQueen, Zeev Estrov, Xiaoyang Ling, Alfonso Quintas-Cardama, Donald Small, Marina Konopleva, Jorge Cortes
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2331.
Published: 01 May 2008
View article titled, Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia
Journal Articles

WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in Acute Myelogenous Leukemia Cells

Alessandra Ferrajoli, Stefan Faderl, Quin Van, Patricia Koch, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Yongtao Wang, Hagop M. Kantarjian, Waldemar Priebe, Zeev Estrov
Journal: Cancer Research
Cancer Res (2007) 67 (23): 11291–11299.
https://doi.org/10.1158/0008-5472.CAN-07-0593
Published: 03 December 2007
View article titled, WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in Acute Myelogenous Leukemia Cells
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Journal Articles

Structure-based drug design of c-kit inhibitors for use in the treatment of several types of cancer

David Maxwell, Ashutosh Pal, Zhenghong Peng, Alexandr Shavrin, Stefan Faderl, Davis Harris, Quin Van, Liu Zhiming, Srdan Verstovsek, Taghi Manshouri, Alessandra Ferrajoli, Hagop Kantarjian, Zeev Estrov, Eylem Ozturk, Angelo Sanguino, Gabriel Lopez-Berestein, William Bornmann
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3959.
Published: 01 May 2007
View article titled, Structure-based drug design of c-kit inhibitors for use in the treatment of several types of cancer
Journal Articles

Mechanism of apoptosis induction by chemical inhibitors of bcl-2 in acute leukemia cells

Marina Konopleva, Rooha Contractor, Peter P. Ruvolo, Xingming Deng, Ismael J. Samudio, Yue-Xi Shi, Teresa McQueen, Rui-Yu Wang, Wendy D. Schober, Xiaoyang Ling, Frank C. Marini, David Harris, Zeev Estrov, James McCubrey, W. Stratford May, Michael Andreeff
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1142–1143.
Published: 15 April 2006
View article titled, Mechanism of apoptosis induction by chemical inhibitors of bcl-2 in acute leukemia cells
Journal Articles

Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia

Zhihong Zeng, Ismael J. Samudio, Weiguo Zhang, Zeev Estrov, Hélène Pelicano, David Harris, Olga Frolova, Numsen Hail, Jr., Wenjing Chen, Steven M. Kornblau, Peng Huang, Yiling Lu, Gordon B. Mills, Michael Andreeff, Marina Konopleva
Journal: Cancer Research
Cancer Res (2006) 66 (7): 3737–3746.
https://doi.org/10.1158/0008-5472.CAN-05-1278
Published: 03 April 2006
View article titled, Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia
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Journal Articles

A Novel Ring-Substituted Diindolylmethane,1,1-Bis[3′-(5-Methoxyindolyl)]-1-(p-t-Butylphenyl) Methane, Inhibits Extracellular Signal-Regulated Kinase Activation and Induces Apoptosis in Acute Myelogenous Leukemia

Rooha Contractor, Ismael J. Samudio, Zeev Estrov, David Harris, James A. McCubrey, Stephen H. Safe, Michael Andreeff, Marina Konopleva
Journal: Cancer Research
Cancer Res (2005) 65 (7): 2890–2898.
https://doi.org/10.1158/0008-5472.CAN-04-3781
Published: 01 April 2005
View article titled, A Novel Ring-Substituted Diindolylmethane,1,1-Bis[3′-(5-Methoxyindolyl)]-1-(<em>p-t</em>-Butylphenyl) Methane, Inhibits Extracellular Signal-Regulated Kinase Activation and Induces Apoptosis in Acute Myelogenous Leukemia
Open the PDF for A Novel Ring-Substituted Diindolylmethane,1,1-Bis[3′-(5-Methoxyindolyl)]-1-(<em>p-t</em>-Butylphenyl) Methane, Inhibits Extracellular Signal-Regulated Kinase Activation and Induces Apoptosis in Acute Myelogenous Leukemia in another window
Journal Articles

The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Caspase-Dependent and -Independent Apoptosis in Acute Myelogenous Leukemia

Marina Konopleva, Twee Tsao, Zeev Estrov, Ruey-min Lee, Rui-Yu Wang, C. Ellen Jackson, Teresa McQueen, Giuseppe Monaco, Mark Munsell, John Belmont, Hagop Kantarjian, Michael B. Sporn, Michael Andreeff
Journal: Cancer Research
Cancer Res (2004) 64 (21): 7927–7935.
https://doi.org/10.1158/0008-5472.CAN-03-2402
Published: 01 November 2004
View article titled, The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Caspase-Dependent and -Independent Apoptosis in Acute Myelogenous Leukemia
Open the PDF for The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Caspase-Dependent and -Independent Apoptosis in Acute Myelogenous Leukemia in another window
Journal Articles

Inhibition of AKT signaling by a small molecule KP372-1 induces apoptosis in AML

Zhihong Zeng, Marina Konopleva, Zeev Estrov, Wei Hu, Daphne Carlson-Bremer, David Harris, Bing Z. Carter, Michele Milella, Yiling Lu, Gordon B. Mills, Michael Andreeff
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 919.
Published: 01 April 2004
View article titled, Inhibition of AKT signaling by a small molecule KP372-1 induces apoptosis in AML
Journal Articles

Expression of a Truncated First Exon BCR Sequence in Chronic Myelogenous Leukemia Cells Blocks Cell Growth and Induces Cell Death

Yan Wang, Jiaxin Liu, Yun Wu, Weiping Luo, Sue-Hwa Lin, Hui Lin, Natalyn Hawk, Tong Sun, Jie Qiang Guo, Zeev Estrov, Moshe Talpaz, Richard Champlin, Ralph B. Arlinghaus
Journal: Cancer Research
Cancer Res (2001) 61 (1): 138–144.
Published: 01 January 2001
View article titled, Expression of a Truncated First Exon BCR Sequence in Chronic Myelogenous Leukemia Cells Blocks Cell Growth and Induces Cell Death
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Journal Articles

Autocrine Interleukin-1β Production in Leukemia: Evidence for the Involvement of Mutated RAS6

Darrin M. Beaupre, Moshe Talpaz, Frank C. Marini, III, Richard J. Cristiano, Jack A. Roth, Zeev Estrov, Maher Albitar, Melvin H. Freedman, Razelle Kurzrock
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2971–2980.
Published: 15 June 1999
View article titled, Autocrine Interleukin-1β Production in Leukemia: <subtitle>Evidence for the Involvement of Mutated <em>RAS</em>6</subtitle>
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Journal Articles

Leukemia Inhibitory Factor in Long-Term Adherent Layer Cultures: Increased Levels of Bioactive Protein in Leukemia and Modulation by IL-4, IL-1β, and TNF-α

Meir Wetzler, Zeev Estrov, Moshe Talpaz, K. Jin Kim, M. Alphonso, Ramaprasad Srinivasan, Razelle Kurzrock
Journal: Cancer Research
Cancer Res (1994) 54 (7): 1837–1842.
Published: 01 April 1994
View article titled, Leukemia Inhibitory Factor in Long-Term Adherent Layer Cultures: Increased Levels of Bioactive Protein in Leukemia and Modulation by IL-4, IL-1β, and TNF-α
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Journal Articles

Heterogeneity in Lineage Derivation of Philadelphia-positive Acute Lymphoblastic Leukemia Expressing p190BCR-ABL or p210BCR-ABL: Determination by Analysis of Individual Colonies with the Polymerase Chain Reaction

Zeev Estrov, Moshe Talpaz, Hagop M. Kantarjian, Theodore F. Zipf, Kenneth L. McClain, Razelle Kurzrock
Journal: Cancer Research
Cancer Res (1993) 53 (14): 3289–3293.
Published: 01 July 1993
View article titled, Heterogeneity in Lineage Derivation of Philadelphia-positive Acute Lymphoblastic Leukemia Expressing p190<sup>BCR-ABL</sup> or p210<sup>BCR-ABL</sup>: Determination by Analysis of Individual Colonies with the Polymerase Chain Reaction
Open the PDF for Heterogeneity in Lineage Derivation of Philadelphia-positive Acute Lymphoblastic Leukemia Expressing p190<sup>BCR-ABL</sup> or p210<sup>BCR-ABL</sup>: Determination by Analysis of Individual Colonies with the Polymerase Chain Reaction in another window
Journal Articles

Growth Requirements for Human Acute Lymphoblastic Leukemia Cells: Refinement of a Clonogenic Assay

Zeev Estrov, Melvin H. Freedman
Journal: Cancer Research
Cancer Res (1988) 48 (20): 5901–5907.
Published: 01 October 1988
View article titled, Growth Requirements for Human Acute Lymphoblastic Leukemia Cells: Refinement of a Clonogenic Assay
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Journal Articles

Characterization of Malignant Peripheral Blood Cells of Juvenile Chronic Myelogenous Leukemia

Zeev Estrov, Barry Zimmerman, Tom Grunberger, Judy Chao, Ikuko E. Teshima, Helen S. Chan, Melvin H. Freedman
Journal: Cancer Research
Cancer Res (1986) 46 (12_Part_1): 6456–6461.
Published: 01 December 1986
View article titled, Characterization of Malignant Peripheral Blood Cells of Juvenile Chronic Myelogenous Leukemia
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