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Zahid H. Siddik
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Journal Articles

Abstract 1073: Preclinical tissue biodistribution and plasma pharmacokinetic studies with oxaliTEX, a novel platinum(IV)-based oxaliplatin prodrug

Guangan He, Gregory Thiabaud, Kathyrin A. Shelton, Luke J. Segura, Jonathan L. Sessler, Rick A. Finch, Zahid H. Siddik, Jonathan F. Arambula
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1073.
https://doi.org/10.1158/1538-7445.AM2021-1073
Published: 01 July 2021
View articletitled, Abstract 1073: Preclinical tissue biodistribution and plasma pharmacokinetic studies with oxaliTEX, a novel platinum(IV)-based oxaliplatin prodrug
Journal Articles

Abstract 1962: Dianhydrogalactitol (VAL-083) has a distinct mechanism of action that suggests combination with PARP inhibitors as an effective therapeutic strategy

Jeffrey A. Bacha, Guangan He, Anne Steino, Dennis M. Brown, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1962.
https://doi.org/10.1158/1538-7445.AM2018-1962
Published: 01 July 2018
View articletitled, Abstract 1962: Dianhydrogalactitol (VAL-083) has a distinct mechanism of action that suggests combination with PARP inhibitors as an effective therapeutic strategy
Journal Articles

Abstract 2157: Enhanced in vitro activity of dianhydrogalactitol (VAL-083) in combination with platinum drugs: Impact of p53 and platinum-resistance

Anne Steino, Guanghan He, Michelle Martinez-Rivera, Jeffrey A. Bacha, Dennis M. Brown, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2157.
https://doi.org/10.1158/1538-7445.AM2016-2157
Published: 15 July 2016
View articletitled, Abstract 2157: Enhanced in vitro activity of dianhydrogalactitol (VAL-083) in combination with platinum drugs: Impact of p53 and platinum-resistance
Journal Articles

Abstract 751: In vitro activity of dianhydrogalactitol alone or with platinum drugs in the treatment of non-small cell lung cancer

Anne Steino, Guangan He, Jeffrey A. Bacha, Sarath Kanekal, Dennis M. Brown, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 751.
https://doi.org/10.1158/1538-7445.AM2015-751
Published: 01 August 2015
View articletitled, Abstract 751: In vitro activity of dianhydrogalactitol alone or with platinum drugs in the treatment of non-small cell lung cancer
Journal Articles

Abstract CT201: Phase I study of 5-azacytidine and oxaliplatin in patients with advanced cancers relapsed or refractory to platinum compounds

Apostolia M. Tsimberidou, Kirk Culotta, Ignacio Wistuba, Siqing Fu, Aung Naing, Gerald Falchook, Sarina Piha-Paul, Ralph Zinner, Jaime Rodriguez-Canales, Guangan He, Zahid H. Siddik, Jaroslav Jelinek, Woonbok Chung, Yang Ye, Rabih Said, Kenneth Hess, David J. Stewart, Razelle Kurzrock, Jean-Pierre Issa
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT201.
https://doi.org/10.1158/1538-7445.AM2014-CT201
Published: 01 October 2014
View articletitled, Abstract CT201: Phase I study of 5-azacytidine and oxaliplatin in patients with advanced cancers relapsed or refractory to platinum compounds
Journal Articles

Abstract 5361: DNA damage by platinum-based drugs induces p21-dependent recruitment of PCNA as a homotrimer into the inhibited G1-phase CDK complex

Guangan He, Jian Kuang, John Koomen, Ryuji Kobayashi, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5361.
https://doi.org/10.1158/1538-7445.AM2011-5361
Published: 15 April 2011
View articletitled, Abstract 5361: DNA damage by platinum-based drugs induces p21-dependent recruitment of PCNA as a homotrimer into the inhibited G1-phase CDK complex
Journal Articles

Abstract 2507: Defective Chk2 expression in cisplatin-resistant ovarian tumor cells impedes wild-type p53 function

Ismail M. Meraz, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2507.
https://doi.org/10.1158/1538-7445.AM10-2507
Published: 15 April 2010
View articletitled, Abstract 2507: Defective Chk2 expression in cisplatin-resistant ovarian tumor cells impedes wild-type p53 function
Journal Articles

Abstract 3513: The underlying basis for divergent cell cycle kinetics following checkpoint activation by cisplatin and a platinum (IV) analog

Guangan He, Jian Kuang, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3513.
https://doi.org/10.1158/1538-7445.AM10-3513
Published: 15 April 2010
View articletitled, Abstract 3513: The underlying basis for divergent cell cycle kinetics following checkpoint activation by cisplatin and a platinum (IV) analog
Journal Articles

Epidermal Growth Factor Receptor (EGFR) Ubiquitination as a Mechanism of Acquired Resistance Escaping Treatment by the Anti-EGFR Monoclonal Antibody Cetuximab

Yang Lu, Xinqun Li, Ke Liang, Rodney Luwor, Zahid H. Siddik, Gordon B. Mills, John Mendelsohn, Zhen Fan
Journal: Cancer Research
Cancer Res (2007) 67 (17): 8240–8247.
https://doi.org/10.1158/0008-5472.CAN-07-0589
Published: 05 September 2007
View articletitled, Epidermal Growth Factor Receptor (EGFR) Ubiquitination as a Mechanism of Acquired Resistance Escaping Treatment by the Anti-EGFR Monoclonal Antibody Cetuximab
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Journal Articles

Circumvention of drug resistance in human tumors harboring wild-type p53.

Zahid H. Siddik, Guangan He, Masayuki Watanabe, Kalpana Mujoo, Abdul R. Khokhar, Jian Kuang
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1273.
Published: 15 April 2006
View articletitled, Circumvention of drug resistance in human tumors harboring wild-type p53.
Journal Articles

p27 changes its binding to the Cdk4 and Cdk2 complexes during DAP-induced G1-phase checkpoint response

Zahid H. Siddik, Guangan He, John Koomen, Ryuji Kobayashi, Zaifeng Huang, Abdul R. Khokhar, Jian Kuang
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 534.
Published: 01 May 2005
View articletitled, p27 changes its binding to the Cdk4 and Cdk2 complexes during DAP-induced G1-phase checkpoint response
Journal Articles

Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells

Imsook Song, Niramol Savaraj, Zahid H. Siddik, Peiman Liu, Yingjie Wei, C. J. Wu, M. Tien Kuo
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 347.
Published: 01 May 2005
View articletitled, Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells
Journal Articles

Molecular and proteomic analysis of Cdk4 and Cdk2 complexes following G1-phase checkpoint response to DNA damage.

Zahid H. Siddik, Guangan He, John Koomen, Ryuji Kobayashi, Zai-Feng Huang, Abdul R. Khokhar, Jian Kuang
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 539.
Published: 01 April 2004
View articletitled, Molecular and proteomic analysis of Cdk4 and Cdk2 complexes following G1-phase checkpoint response to DNA damage.
Journal Articles

Independent Pathways of p53 Induction by Cisplatin and X-Rays in a Cisplatin-resistant Ovarian Tumor Cell Line

Zahid H. Siddik, Betsy Mims, Guillermina Lozano, Gerald Thai
Journal: Cancer Research
Cancer Res (1998) 58 (4): 698–703.
Published: 01 February 1998
View articletitled, Independent Pathways of p53 Induction by Cisplatin and X-Rays in a Cisplatin-resistant Ovarian Tumor Cell Line
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Journal Articles

Axial Ligands and Alicyclic Ring Size Modulate the Activity and Biochemical Pharmacology of Ammine/Cycloalkylamine-Platinum(IV) Complexes in Tumor Cells Resistant to cis-Diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-Diaminocyclohexanetetrachloroplatinum(IV)

Motofumi Yoshida, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (1994) 54 (17): 4691–4697.
Published: 01 September 1994
View articletitled, Axial Ligands and Alicyclic Ring Size Modulate the Activity and Biochemical Pharmacology of Ammine/Cycloalkylamine-Platinum(IV) Complexes in Tumor Cells Resistant to cis-Diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-Diaminocyclohexanetetrachloroplatinum(IV)
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Journal Articles

Biochemical Pharmacology of Homologous Alicyclic Mixed Amine Platinum(II) Complexes in Sensitive and Resistant Tumor Cell Lines

Motofumi Yoshida, Abdul R. Khokhar, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (1994) 54 (13): 3468–3473.
Published: 01 July 1994
View articletitled, Biochemical Pharmacology of Homologous Alicyclic Mixed Amine Platinum(II) Complexes in Sensitive and Resistant Tumor Cell Lines
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Journal Articles

Modulation of Cytotoxicity and Cellular Pharmacology of 1,2-Diaminocyclohexane Platinum(IV) Complexes Mediated by Axial and Equatorial Ligands

Yuichiro Kido, Abdul R. Khokhar, Salaam Al-Baken, Zahid H. Siddik
Journal: Cancer Research
Cancer Res (1993) 53 (19): 4567–4572.
Published: 01 October 1993
View articletitled, Modulation of Cytotoxicity and Cellular Pharmacology of 1,2-Diaminocyclohexane Platinum(IV) Complexes Mediated by Axial and Equatorial Ligands
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Journal Articles

Enhanced Sensitivity of Human Colon Tumor Cell Lines in Vitro in Response to Thermochemoimmunotherapy

Jim Klostergaard, Elena Leroux, Zahid H. Siddik, Mojgan Khodadadian, Stephen P. Tomasovic
Journal: Cancer Research
Cancer Res (1992) 52 (19): 5271–5277.
Published: 01 October 1992
View articletitled, Enhanced Sensitivity of Human Colon Tumor Cell Lines in Vitro in Response to Thermochemoimmunotherapy
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Journal Articles

Increased Therapeutic Efficacy Induced by Tumor Necrosis Factor α Combined with Platinum Complexes and Whole-Body Hyperthermia in Rats

Shinji Ohno, Frederick R. Strebel, L. Clifton Stephens, Zahid H. Siddik, Masato Makino, Jim Klostergaard, Stephen P. Tomasovic, Abdul R. Khokhar, Joan M. C. Bull
Journal: Cancer Research
Cancer Res (1992) 52 (15): 4096–4101.
Published: 01 August 1992
View articletitled, Increased Therapeutic Efficacy Induced by Tumor Necrosis Factor α Combined with Platinum Complexes and Whole-Body Hyperthermia in Rats
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Journal Articles

Protective Effect of ICRF-187 against Normal Tissue Injury Induced by Adriamycin in Combination with Whole Body Hyperthermia

Hideo Baba, L. Clifton Stephens, Frederick R. Strebel, Zahid H. Siddik, Robert A. Newman, Shinji Ohno, Joan M. C. Bull
Journal: Cancer Research
Cancer Res (1991) 51 (13): 3568–3577.
Published: 01 July 1991
View articletitled, Protective Effect of ICRF-187 against Normal Tissue Injury Induced by Adriamycin in Combination with Whole Body Hyperthermia
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