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Zachary A. Cooper
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Journal Articles

Abstract 5466: Functional status of tumor-associated macrophages impacts clinical outcome of durvalumab in patients with advanced NSCLC as revealed by proteomics mass spectrometry

Anna Margaret Hansen, Vivian Ying Wang, Andrew Chambers, David Chain, Jaime Rodriguez Canales, Jorge Blando, Steve Sweet, Zachary A. Cooper, Ashok Gupta, Carl Barrett, Yeoun Jin Kim, Ikbel Achour
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5466.
https://doi.org/10.1158/1538-7445.AM2023-5466
Published: 04 April 2023
View article titled, Abstract 5466: Functional status of tumor-associated macrophages impacts clinical outcome of durvalumab in patients with advanced NSCLC as revealed by proteomics mass spectrometry
Journal Articles

Abstract 2947: Preclinical evaluation of a novel B7-H4 targeted antibody-drug conjugate AZD8205 as a single agent and in combination with novel PARP inhibitor and checkpoint blockade

Alex Cazes, Krista Kinneer, Bilal Omar, Jon Chesebrough, Judith Anderton, Jixin Wang, Anna D. Staniszewska, Steven Arbitman, Kalyani Daita, Himanshi Desai, Yoshimi Johnson, Raymond Rothstein, Marco Gymnopoulos, Giulia Fabbri, Zachary A. Cooper, Mark Albertella, Scott A. Hammond, Sabina Cosulich, Nadia Luheshi, Puja Sapra
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2947.
https://doi.org/10.1158/1538-7445.AM2023-2947
Published: 04 April 2023
View article titled, Abstract 2947: Preclinical evaluation of a novel B7-H4 targeted antibody-drug conjugate AZD8205 as a single agent and in combination with novel PARP inhibitor and checkpoint blockade
Journal Articles

Abstract 452: Development and implementation of image analysis-based Quantitative Continuous Score (QCS) for B7-H4 IHC to understand AZD8205 pharmacodynamics

Philipp Wortmann, Tze Heng Tan, Susanne Haneder, Andrea Ennio Storti, Ansh Kapil, Jon Chesebrough, Daniel Sutton, Michal Sulikowski, Arthur Lewis, Sofia Koch, Steve Sweet, Zifeng Song, David Chain, Yeoun Jin Kim, Nadia Luheshi, Krista Kinneer, Zachary A. Cooper, Marlon Rebelatto, Günter Schmidt, Hadassah Sade, J. Carl Barrett
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 452.
https://doi.org/10.1158/1538-7445.AM2022-452
Published: 15 June 2022
View article titled, Abstract 452: Development and implementation of image analysis-based Quantitative Continuous Score (QCS) for B7-H4 IHC to understand AZD8205 pharmacodynamics
Journal Articles

Abstract 1765: Discovery and first disclosure of AZD8205, a B7-H4-targeted antibody-drug conjugate utilizing a novel topoisomerase I linker-warhead

Krista Kinneer, Niall J. Dickinson, Luke Masterson, Thais Cailleau, Ian Hutchinson, Balakumar Vijayakrishnan, Nazzareno Dimasi, R. James Christie, Mary McFarlane, Kathryn Ball, Arthur Lewis, Sofia Koch, Lee Brown, Yue Huang, Anton I. Rosenbaum, Jiaqi Yuan, Si Mou, Noel R. Monks, Jon Chesebrough, Ravinder Tammali, Judith Anderton, Darrin Sabol, Frances Anne Tosto, Philipp Wortmann, Zachary A. Cooper, Pauline Ryan, John Hood, Carlos Fernandez Teruel, Carlos Serra Traynor, Andy Pike, Michael Davies, Elisabetta Leo, Kimberly Cook, Nadia Luheshi, Philip W. Howard, Puja Sapra
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1765.
https://doi.org/10.1158/1538-7445.AM2022-1765
Published: 15 June 2022
View article titled, Abstract 1765: Discovery and first disclosure of AZD8205, a B7-H4-targeted antibody-drug conjugate utilizing a novel topoisomerase I linker-warhead
Journal Articles

Abstract CT163: CD73 inhibitor oleclumab plus osimertinib for advanced EGFRm NSCLC: First report of a Phase 1b/2 study

Dong-Wan Kim, Sang-We Kim, D. Ross Camidge, Naiyer A. Rizvi, Kristen A. Marrone, Xiuning Le, Collin Blakely, Keunchil Park, Gee-Chen Chang, Sandip Pravin Patel, Zachary A. Cooper, Rakesh Kumar, Ramin Samadani, Rebecca McCombs, Michael Pluta, Kevin Yufeng Wu, Suresh Ramalingam
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT163.
https://doi.org/10.1158/1538-7445.AM2021-CT163
Published: 01 July 2021
View article titled, Abstract CT163: CD73 inhibitor oleclumab plus osimertinib for advanced EGFRm NSCLC: First report of a Phase 1b/2 study
Journal Articles

Abstract 1695: Activation of B cells by CD73 blocking antibodies

James Hair, Fabien Garcon, Michelle Hsueh, Laura Dallaway, Elena Bibikova, Maria Letizia Giardino Torchia, Gordon Moody, Alwin Schuller, Simon J. Dovedi, Zachary A. Cooper, Kris Sachsenmeier, Rakesh Kumar, Jim Eyles, Robert W. Wilkinson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1695.
https://doi.org/10.1158/1538-7445.AM2021-1695
Published: 01 July 2021
View article titled, Abstract 1695: Activation of B cells by CD73 blocking antibodies
Journal Articles

Abstract 1584: Efficacy and pharmacodynamic effect of anti-CD73/PD-L1 monoclonal antibodies in combination with chemotherapy: Observations from mouse tumor models

Jim Eyles, Amanda Watkins, Kristina Ilieva, Stef Mullins, Jude Anderton, Elena Galvani, Fabien Garcon, Kelli Ryan, Brajesh P. Kaistha, Andreas Dannhorn, Stephanie Ling, Tim Slidel, Gozde Kar, Alwin Schuller, Zachary A. Cooper, Kris Sachsenmeier, Nadia Luheshi, Rakesh Kumar, Robert W. Wilkinson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1584.
https://doi.org/10.1158/1538-7445.AM2021-1584
Published: 01 July 2021
View article titled, Abstract 1584: Efficacy and pharmacodynamic effect of anti-CD73/PD-L1 monoclonal antibodies in combination with chemotherapy: Observations from mouse tumor models
Journal Articles

Abstract 1493: Therapeutic efficacy and tolerability of combined immune checkpoint blockade in metastatic melanoma patients is influenced by the gut microbiome

Vancheswaran Gopalakrishnan, Miles Andrews, Wei-Shen Chen, Christine Spencer, Luis Vence, Alexandre Reuben, Zachary A. Cooper, Peter A. Prieto, Michael T. Tetzlaff, MA Abdul Wadud Khan, Alexander Lazar, Courtney W. Hudgens, Lauren E. Haydu, Hussein A. Tawbi, Patrick Hwu, Wen-Jen Hwu, Rodabe N. Amaria, Elizabeth M. Burton, Scottt E. Woodman, Adi Diab, Sapna P. Patel, Isabella C. Glitza, Jianhua Zhang, Joseph Petrosino, Robert R. Jenq, Michael A. Davies, Jeffrey E. Gershenwald, Padmanee Sharma, James P. Allison, Andrew Futreal, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1493.
https://doi.org/10.1158/1538-7445.AM2019-1493
Published: 01 July 2019
View article titled, Abstract 1493: Therapeutic efficacy and tolerability of combined immune checkpoint blockade in metastatic melanoma patients is influenced by the gut microbiome
Journal Articles

Abstract CT091: Safety and pharmacodynamic activity of MEDI9197, a TLR 7/8 agonist, administered intratumorally in subjects with solid tumors

Shilpa Gupta, Juneko Grilley-Olson, David Hong, Aurélien Marabelle, Pamela Munster, Rahul Aggarwal, Sandrine Aspeslagh, Robert G. Dixon, Manish Patel, Vivek Subbiah, Chris Morehouse, Yuling Wu, Jiping Zha, Leo Tseng, Zachary A. Cooper, Shannon Morris, Joshua Brody
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT091.
https://doi.org/10.1158/1538-7445.AM2017-CT091
Published: 01 July 2017
View article titled, Abstract CT091: Safety and pharmacodynamic activity of MEDI9197, a TLR 7/8 agonist, administered intratumorally in subjects with solid tumors
Journal Articles

Abstract 2392: Genomic and immune heterogeneity in synchronous melanoma metastases is associated with differential tumor growth and response to therapy

Alexandre Reuben, Christine N. Spencer, Peter A. Prieto, John P. Miller, Xizeng Mao, Wei-Shen Chen, Hannah Cheung, Hong Jiang, Cara Haymaker, Mariana Petaccia De Macedo, Haven R. Garber, Pei-Ling Chen, Vancheswaran Gopalakrishnan, Jacob Austin-Breneman, Courtney W. Hudgens, Jason Roszik, Patrick Hwu, Scott E. Woodman, Lynda Chin, Michael A. Davies, Rodabe N. Amaria, Sapna P. Patel, Alexander J. Lazar, Michael T. Tetzlaff, Karen C. Dwyer, Ignacio I. Wistuba, Padmanee Sharma, James P. Allison, Jianhua Zhang, Andrew Futreal, Zachary A. Cooper, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2392.
https://doi.org/10.1158/1538-7445.AM2016-2392
Published: 15 July 2016
View article titled, Abstract 2392: Genomic and immune heterogeneity in synchronous melanoma metastases is associated with differential tumor growth and response to therapy
Journal Articles

Abstract 1301: Inter- and intra-tumoral immune and genomic heterogeneity in patients with metastatic melanoma

Alexandre Reuben, Zachary A. Cooper, Whijae Roh, Yu Cao, Jacob Austin-Breneman, Hong Jiang, Rodabe N. Amaria, Pei-Ling Chen, Michael T. Tetzlaff, Lynda Chin, Andrew Futreal, Michael A. Davies, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1301.
https://doi.org/10.1158/1538-7445.AM2015-1301
Published: 01 August 2015
View article titled, Abstract 1301: Inter- and intra-tumoral immune and genomic heterogeneity in patients with metastatic melanoma
Journal Articles

Abstract LB-239: The Hippo effector YAP promotes resistance to RAF and MEK targeted therapies

Luping Lin, Amit Sabnis, Elton Chan, Victor Olivas, Lindsay Cade, Evangelos Pazarentzos, Saurabh Asthana, Dana Neel, Jenny Jiacheng Yan, Xinyuan Lu, Luu Pham, Mingxue Wang, Niki Karachaliou, Maria G. Cao, Jose L. Manzano, Jose L. Ramirez, Jose M. Torres, Fiamma Buttitta, Charles M. Rudin, Eric A. Collisson, Alain Algazi, Eric Robinson, Iman Osman, Eva Munoz-Couselo, Javier Cortes, Dennie T. Frederick, Zachary A. Cooper, Martin McMahon, Antonio Marchetti, Rafael Rosell, Keith T. Flaherty, Jennifer A. Wargo, Trever G. Bivona
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-239.
https://doi.org/10.1158/1538-7445.AM2015-LB-239
Published: 01 August 2015
View article titled, Abstract LB-239: The Hippo effector YAP promotes resistance to RAF and MEK targeted therapies
Journal Articles

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma

Y.N. Vashisht Gopal, Helen Rizos, Guo Chen, Wanleng Deng, Dennie T. Frederick, Zachary A. Cooper, Richard A. Scolyer, Gulietta Pupo, Kakajan Komurov, Vasudha Sehgal, Jiexin Zhang, Lalit Patel, Cristiano G. Pereira, Bradley M. Broom, Gordon B. Mills, Prahlad Ram, Paul D. Smith, Jennifer A. Wargo, Georgina V. Long, Michael A. Davies
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7037–7047.
https://doi.org/10.1158/0008-5472.CAN-14-1392
Published: 30 November 2014
View article titled, Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Open the PDF for Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3703: PDGFRα up-regulation mediated by Sonic Hedgehog Pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation

Francesco Sabbatino, Yangyang Wang, Xinhui Wang, Keith T. Flaherty, David Pepin, Giosuè Scognamiglio, Ling Yu, Zachary A. Cooper, Stefano Pepe, John M. Kirkwood, Dennie T. Frederick, Jennifer A. Wargo, Soldano Ferrone, Cristina R. Ferrone
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3703.
https://doi.org/10.1158/1538-7445.AM2014-3703
Published: 01 October 2014
View article titled, Abstract 3703: PDGFRα up-regulation mediated by Sonic Hedgehog Pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation
Journal Articles

Abstract 2338: BRAF inhibition is associated with increased clonality of tumor infiltrating lymphocytes.

Zachary A. Cooper, Dennie T. Frederick, Ryan J. Sullivan, Donald P. Lawrence, Adriano Piris, Keith T. Flaherty, David A. Fisher, Jennifer A. Wargo
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2338.
https://doi.org/10.1158/1538-7445.AM2013-2338
Published: 15 April 2013
View article titled, Abstract 2338: BRAF inhibition is associated with increased clonality of tumor infiltrating lymphocytes.
Journal Articles

Abstract 1724: BRAF inhibition is enhanced by BH3-mimetic through BIM induction.

Dennie T. Frederick, Roberto A. Salas Fragomeni, Taylor Hoff, Zachary A. Cooper, James W. Mier, Jennifer A. Wargo, Ryan J. Sullivan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1724.
https://doi.org/10.1158/1538-7445.AM2013-1724
Published: 15 April 2013
View article titled, Abstract 1724: BRAF inhibition is enhanced by BH3-mimetic through BIM induction.
Journal Articles

Abstract 2476: Acetylated Survivin functions in DNA damage repair

Zachary A. Cooper, Matthew Riolo, Michael P. Holloway, Rachel A. Altura
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2476.
https://doi.org/10.1158/1538-7445.AM2011-2476
Published: 15 April 2011
View article titled, Abstract 2476: Acetylated Survivin functions in DNA damage repair