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Yves Pommier
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Journal Articles

Abstract 6404: NOTCH1 drives immunogenicity through STING and improves survival with immune checkpoint blockade in small cell lung cancer

Free
Yoo Sun Kim, Barzin Y. Nabet, Briana N. Cortez, Nai-Yun Sun, Robin Sebastian, Christophe E. Redon, Anagh Ray, Sivasish Sindiri, Min-Jung Lee, Shraddha Rastogi, Nahoko Sato, Jane Trepel, Noemi Kedei, Thorkell Andresson, Sudipto Das, Suresh Kumar, Alan E. Bers, Hongliang Zhang, Alberto Chiappori, Priyanka Gopal, Mohamed E. Abazeed, Haobin Chen, Mirit I. Aladjem, Yves Pommier, Moises J. Velez, David S. Shames, Nitin Roper
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6404.
https://doi.org/10.1158/1538-7445.AM2025-6404
Published: 21 April 2025
View articletitled, Abstract 6404: NOTCH1 drives immunogenicity through STING and improves survival with immune checkpoint blockade in small cell lung cancer
Journal Articles

Abstract 2835: Lamin AC deficiency promotes genomic instability through increased R-loop accumulation

Free
Christopher William Schultz, Sourav Saha, Anjali Dhall, Yang Zhang, Parth Desai, Lorinc Pongor, David A. Scheiblin, Valentin Magidson, Yilun Sun, Christophe Redon, Suresh Kumar, Manan Krishnamurthy, Henrique B. Dias, Vasilisa Askenova, Elizabeth Giordanio, Nobuyuki Takahashi, Michael Nirula, Yasuhiro Arakawa, Ukhyun Jo, Beverly A. Teacher, Mirit I. Aladjem, Stephen Lockett, Marry Dasso, Yves Pommier, Ajit K. Sharma, Anish Thomas
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2835.
https://doi.org/10.1158/1538-7445.AM2025-2835
Published: 21 April 2025
View articletitled, Abstract 2835: Lamin AC deficiency promotes genomic instability through increased R-loop accumulation
Journal Articles

Abstract 5127: Metastatic organotropism in small cell lung cancer

Free
Manan Krishnamurthy, Anjali Dhall, Christopher W. Schultz, Michelle Baird, Parth A. Desai, Jacob Odell, Sarthak Sahoo, Nobu Takahashi, Michael Nirula, Sophie Zhuang, Yue Huang, Brett Schroeder, Yang Zhang, Christophe Redon, Christina Robinson, Lai Thang, Lilia Ileva, Nimit L. Patel, Joseph D. Kalen, Alice-Anaïs Varlet, Noam Zuela-Sopilniak, Ankita Jha, Darawalee W. Zong, Donna Butcher, Tamara Morgan, Alyah Afzal, Raj Chari, Karim Baktiar, Suresh Kumar, Lorinc Pongor, Simone Difilippantonio, Mirit I. Aladjem, Yves Pommier, Mohit K. Jolly, Jan Lammerding, Ajit K. Sharma, Anish Thomas
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5127.
https://doi.org/10.1158/1538-7445.AM2025-5127
Published: 21 April 2025
View articletitled, Abstract 5127: Metastatic organotropism in small cell lung cancer
Journal Articles

Abstract 3581: IGFR1 and MEK inhibition synergize to mediate anti-tumor activity in adrenocortical carcinoma

Free
Suresh Kumar, Nai-Yun Sun, Yasuhiro Arakawa, Diana Varghese, Chuong D. Hoang, Jonathan M. Hernandez, Yves Pommier, Craig Thomas, Jaydira Del Rivero, Nitin Roper
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3581.
https://doi.org/10.1158/1538-7445.AM2024-3581
Published: 22 March 2024
View articletitled, Abstract 3581: IGFR1 and MEK inhibition synergize to mediate anti-tumor activity in adrenocortical carcinoma
Journal Articles

Abstract 6573: Targeting DLK1, a Notch ligand, with an antibody-drug conjugate in adrenocortical carcinoma

Free
Nai-Yun Sun, Suresh Kumar, Amber Weiner, Yoo Sun Kim, Arnulfo Mendoza, Rosa Nguyen, Reona Okada, Yves Pommier, Dan Martinez, Jennifer Pogoriler, Sharon Diskin, John Maris, Jaydira Del Rivero, Nitin Roper
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6573.
https://doi.org/10.1158/1538-7445.AM2024-6573
Published: 22 March 2024
View articletitled, Abstract 6573: Targeting DLK1, a Notch ligand, with an antibody-drug conjugate in adrenocortical carcinoma
Journal Articles

Abstract 7175: Web-based cross-database exploration of molecular pharmacology data from cancer cell lines and patient genomics

Free
William C. Reinhold, Augustin Luna, Fathi Elloumi, Sudhir Varma, Daiki Taniyama, Makito Mizunuma, Jaydira del Rivero, Anish Thomas, Karyyne Reilly, Karel Pacak, Mirit Aladjem, Yves Pommier
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7175.
https://doi.org/10.1158/1538-7445.AM2024-7175
Published: 22 March 2024
View articletitled, Abstract 7175: Web-based cross-database exploration of molecular pharmacology data from cancer cell lines and patient genomics
Journal Articles

CellMinerCDB: NCATS Is a Web-Based Portal Integrating Public Cancer Cell Line Databases for Pharmacogenomic Explorations

Available to Purchase
William C. Reinhold, Kelli Wilson, Fathi Elloumi, Katie R. Bradwell, Michele Ceribelli, Sudhir Varma, Yanghsin Wang, Damien Duveau, Nikhil Menon, Jane Trepel, Xiaohu Zhang, Carleen Klumpp-Thomas, Samuel Micheal, Paul Shinn, Augustin Luna, Craig Thomas, Yves Pommier
Journal: Cancer Research
Cancer Res (2023) 83 (12): 1941–1952.
https://doi.org/10.1158/0008-5472.CAN-22-2996
Published: 15 June 2023
View articletitled, CellMinerCDB: NCATS Is a Web-Based Portal Integrating Public Cancer Cell Line Databases for Pharmacogenomic Explorations
Open the PDF for CellMinerCDB: NCATS Is a Web-Based Portal Integrating Public Cancer Cell Line Databases for Pharmacogenomic Explorations in another window
Includes: Supplementary data
Journal Articles

BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality

Free
Junko Murai, Yves Pommier
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1173–1174.
https://doi.org/10.1158/0008-5472.CAN-23-0628
Published: 14 April 2023
View articletitled, BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality
Open the PDF for BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality in another window
Journal Articles

Abstract CT268: Targeting replication stress and chemotherapy resistance with a combination of sacituzumab govitecan and berzosertib: A phase I clinical trial

Free
Melissa L. Abel, Nobukyuki Takahashi, Parth Desai, Cody Peer, Christophe Redon, Samantha Nichols, Rasa Vilimas, Min-Jung Lee, Sunmin Lee, Linda Sciuto, Danielle Pinkiert, Meenakshi Shelat, Chante Graham, Seth Steinberg, William D. Figg, Mirit Aladjem, Jane Trepel, Yves Pommier, Anish Thomas
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT268.
https://doi.org/10.1158/1538-7445.AM2023-CT268
Published: 14 April 2023
View articletitled, Abstract CT268: Targeting replication stress and chemotherapy resistance with a combination of sacituzumab govitecan and berzosertib: A phase I clinical trial
Journal Articles

Abstract LB301: Molecular pharmacology and broad synergy of the novel ATR inhibitor M1774 with DNA damaging anticancer agents

Free
Ukhyun Jo, Yasuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M Jenkins, Suresh Kumar, Frank T Zenke, Yves Pommier
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB301.
https://doi.org/10.1158/1538-7445.AM2023-LB301
Published: 14 April 2023
View articletitled, Abstract LB301: Molecular pharmacology and broad synergy of the novel ATR inhibitor M1774 with DNA damaging anticancer agents
Journal Articles

Abstract 2153: ATR inhibition augments the efficacy of the lurbinectedin in small cell lung cancer

Free
Christopher William Schultz, Yang Zhang, Haiqing Fu, Yasuhisa Murai, Darawalee Wangsa, Devon Atkinson, Liton Saha, Brian Elenbaas, Chien-Fei Lee, Astrid Zimmerman, Thomas Ried, Frank Zenke, Zoe Weaver, Rajaa Elmeskini, Yves Pommier, Anish Thomas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2153.
https://doi.org/10.1158/1538-7445.AM2022-2153
Published: 15 June 2022
View articletitled, Abstract 2153: ATR inhibition augments the efficacy of the lurbinectedin in small cell lung cancer
Journal Articles

Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

Free
Ukhyun Jo, Ilya Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, Se Hyun Kim, Vinodh N Rajapakse, Fathi Elloumi, Nobuyuki Takahashi, Christopher Schultz, Anish Thomas, Frank Zenke, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1055.
https://doi.org/10.1158/1538-7445.AM2021-1055
Published: 01 July 2021
View articletitled, Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents
Journal Articles

Abstract 1182: The NEDD8 inhibitor pevonedistat blocks the repair of topoisomerase I (TOP1)-induced replication damage and synergizes with TOP1 inhibitors

Free
Yilun Sun, Andrea Baechler, Valentina Factor, Kanako Okamoto, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1182.
https://doi.org/10.1158/1538-7445.AM2021-1182
Published: 01 July 2021
View articletitled, Abstract 1182: The NEDD8 inhibitor pevonedistat blocks the repair of topoisomerase I (TOP1)-induced replication damage and synergizes with TOP1 inhibitors
Journal Articles

Abstract 203: SCLC-CellMiner: An extensive cell line genomic and pharmacology resource identifies a subgroup of small cell lung cancers sensitive to targeted therapies and immunotherapies

Free
Camille Tlemsani, Lorinc Pongor, Fathi Elloumi, Luc Girard, Kenneth Huffman, Nitin Roper, Sudhir Varma, Augustin Luna, Vinodh Rajapakse, Pascaline Boudou-Rouquette, Robin Sebastian, Kurt Kohn, Julia Krushkal, Mirit Aladjem, Beverly Teicher, Paul Meltzer, William Reinhold, John Minna, Anish Thomas, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 203.
https://doi.org/10.1158/1538-7445.AM2021-203
Published: 01 July 2021
View articletitled, Abstract 203: SCLC-CellMiner: An extensive cell line genomic and pharmacology resource identifies a subgroup of small cell lung cancers sensitive to targeted therapies and immunotherapies
Journal Articles

Abstract 212: Sarcoma-CellMiner: An extensive resource for patient-derived sarcoma cell line epigenetics, genomics and pharmacology

Free
Camille Tlemsani, Lorinc Pongor, Javed Khan, Fathi Elloumi, Sudhir Varma, Augustin Luna, Vinodh Rajapakse, Kurt Kohn, Julia Krushkal, Mirit Aladjem, Beverly Teicher, Paul Meltzer, William Reinhold, Christine Heske, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 212.
https://doi.org/10.1158/1538-7445.AM2021-212
Published: 01 July 2021
View articletitled, Abstract 212: Sarcoma-CellMiner: An extensive resource for patient-derived sarcoma cell line epigenetics, genomics and pharmacology
Journal Articles

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243

Available to Purchase
Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M. Jenkins, Shar-Yin N. Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier
Journal: Cancer Research
Cancer Res (2021) 81 (11): 3067–3078.
https://doi.org/10.1158/0008-5472.CAN-20-2694
Published: 01 June 2021
View articletitled, SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243
Open the PDF for SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243 in another window
Includes: Supplementary data
Journal Articles

Abstract 2090: Machine learning-derived gene signature predicts strong sensitivity of several solid tumors to the alkylating agent LP-184

Free
Umesh Kathad, Aditya Kulkarni, Jean Philippe Richard, Terri Lehman, Rama Modali, Kishor Bhatia, Panna Sharma, Fathi Elloumi, Yves Pommier, William C. Reinhold
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2090.
https://doi.org/10.1158/1538-7445.AM2020-2090
Published: 15 August 2020
View articletitled, Abstract 2090: Machine learning-derived gene signature predicts strong sensitivity of several solid tumors to the alkylating agent LP-184
Journal Articles

Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents

Free
Ukhyun Jo, Yasuhisa Murai, Junko Murai, Shar‐yin N Huang, Sirisha Chakka, Lu Chen, Ken Cheng, Yves Pommier
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-121.
https://doi.org/10.1158/1538-7445.AM2020-LB-121
Published: 15 August 2020
View articletitled, Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents
Journal Articles

Abstract 365: Indotecan (LMP400), indimitecan (LMP776) and LMP744, a new class of non-camptothecin topoisomerase I inhibitors selective for schlafen11-positive and BRCA-deficient cells that synergize with olaparib

Free
Laetitia Marzi, Ludmila Szabova, Zoe Weaver Ohler, Shyam Sharan, Mike Beshiri, Junko Murai, Kathy Kelly, Yves Pommier
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 365.
https://doi.org/10.1158/1538-7445.AM2019-365
Published: 01 July 2019
View articletitled, Abstract 365: Indotecan (LMP400), indimitecan (LMP776) and LMP744, a new class of non-camptothecin topoisomerase I inhibitors selective for schlafen11-positive and BRCA-deficient cells that synergize with olaparib
Journal Articles

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB

Available to Purchase
William C. Reinhold, Sudhir Varma, Margot Sunshine, Fathi Elloumi, Kwabena Ofori-Atta, Sunmin Lee, Jane B. Trepel, Paul S. Meltzer, James H. Doroshow, Yves Pommier
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3514–3524.
https://doi.org/10.1158/0008-5472.CAN-18-2047
Published: 01 July 2019
View articletitled, RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB
Open the PDF for RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB in another window
Includes: Supplementary data