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Journal Articles

Abstract 1979: Preclinical characterization of NVL-330, a selective and brain penetrant HER2 tyrosine kinase inhibitor with broad activity on HER2 oncogenic alterations

Free
Yuting Sun, Kristin L. Andrews, Anupong Tangpeerachaikul, Tuan M. Nguyen, Baudouin Gerard, Nancy E. Kohl, Joshua C. Horan, Henry E. Pelish
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1979.
https://doi.org/10.1158/1538-7445.AM2024-1979
Published: 22 March 2024
View articletitled, Abstract 1979: Preclinical characterization of NVL-330, a selective and brain penetrant HER2 tyrosine kinase inhibitor with broad activity on HER2 oncogenic alterations
Journal Articles

Abstract 6140: Caspase-3 mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer

Free
Qiuyun Luo, Zengfei Xia, Jing Yang, Wentao Pan, Fan Luo, Jiaxin Cao, Yuting Sun, Liqiong Yang, Lin Zhang, Miaozhen Qiu, Dajun Yang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6140.
https://doi.org/10.1158/1538-7445.AM2023-6140
Published: 04 April 2023
View articletitled, Abstract 6140: Caspase-3 mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer
Journal Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Free
Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K. Mandal, Timothy McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (21): 4840–4853.
https://doi.org/10.1158/0008-5472.CAN-20-1634
Published: 03 November 2020
View articletitled, Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Open the PDF for Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib in another window
Includes: Supplementary data
Journal Articles

Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer

Free
Gloria V. Echeverria, Zhongqi Ge, Sahil Seth, Emily Powell, Xiaomei Zhang, Sabrina Jeter-Jones, Xinhui Zhou, Yan Jiang, Aaron McCoy, Shirong Cai, Yizheng Tu, Michael Peoples, Yuting Sun, Huan Qiu, Christopher Bristow, Alessandro Carugo, Jiansu Shao, Stacy L. Moulder, William F. Symmans, Timothy P. Heffernan, Jeffrey T. Chang, Helen M. Piwnica-Worms
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2901.
https://doi.org/10.1158/1538-7445.AM2019-2901
Published: 01 July 2019
View articletitled, Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer
Journal Articles

Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors

Free
Maria Emilia Di Francesco, Joseph R. Marszalek, Timothy McAfoos, Christopher L. Carroll, Zhijun Kang, Gang Liu, Jay P. Theroff, Jennifer P. Bardenhager, Madhavi L. Bandi, Jennifer R. Molina, Sonal Gera, Marina Protopopova, Yuting Sun, Mary K. Geck Do, Ningping Feng, Jason P. Gay, Florian Muller, Marina Konopleva, Funda Meric-Bernstam, Carlo Toniatti, Timothy P. Heffernan, Giulio F. Draetta, Philip Jones
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1655.
https://doi.org/10.1158/1538-7445.AM2018-1655
Published: 01 July 2018
View articletitled, Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors
Journal Articles

Abstract LB-367: [18F]FAZA PET imaging reveals precise pharmacodynamics in vivo of the novel chemotherapeutic IACS-010759

Free
Seth T. Gammon, Federica Pisaneschi, Madhavi Bandi, Melinda Smith, Yi Rao, Vashisht G. Yennu Nanda, Yuting Sun, Michael Davies, Emilia Di Francesco, Joseph Marszalek, David Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-367.
https://doi.org/10.1158/1538-7445.AM2018-LB-367
Published: 01 July 2018
View articletitled, Abstract LB-367: [18F]FAZA PET imaging reveals precise pharmacodynamics in vivo of the novel chemotherapeutic IACS-010759
Journal Articles

Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells

Free
Joseph R. Marszalek, Sahil Seth, Denise Corti, Qi Zhang, Gloria V. Echeverria, Lina Han, Yuting Sun, Jennifer Molina, Sonal Gera, Edward Chang, Tin O. Khor, Mikhila Mahendra, Ningping Feng, Jason P. Gay, Timothy McAfoos, Virginia Giuliani, Xi Shi, Sabrina Jeter-Jones, Sarah Loponte, Chieh-Yuan Li, Christopher A. Bristow, Maria Emilia Di Francesco, Helen Piwnica-Worms, Marina Konopleva, Alessandro Carugo, Andrea Viale, Philip Jones, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2856.
https://doi.org/10.1158/1538-7445.AM2018-2856
Published: 01 July 2018
View articletitled, Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells
Journal Articles

Abstract 2831: Collateral lethality: A new target for personalized oncology

Free
Yu-Hsi Lin, Naima Hammoudi, Nikunj Satani, Jeffrey Ackroyd, Sunada Khadka, Dimitra Georgiou, Joe Marszalek, Yuting Sun, Marina Protopopova, Maria E. Di Francesco, Barbara Czako, Alan Y. Wang, Ronald A. DePinho, Florian L. Muller
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2831.
https://doi.org/10.1158/1538-7445.AM2018-2831
Published: 01 July 2018
View articletitled, Abstract 2831: Collateral lethality: A new target for personalized oncology
Journal Articles

Abstract 212: High-resolution barcoding in patient-derived xenografts of triple-negative breast cancer reveals reversible chemoresistance conferred by non-mutational mechanisms

Free
Gloria Vittone Echeverria, Sahil Seth, Zhongqi Ge, Alessandro Carugo, Christopher Bristow, Prabjhot Mundi, Sabrina Jeter-Jones, Xiaomei Zhang, Xinhui Zhou, Aaron McCoy, Shirong Cai, Yizheng Tu, Yuting Sun, Joseph Marszalek, Andrea Califano, William F. Symmans, Stacy L. Moulder, Jeffery T. Chang, Timothy P. Heffernan, Helen Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 212.
https://doi.org/10.1158/1538-7445.AM2018-212
Published: 01 July 2018
View articletitled, Abstract 212: High-resolution barcoding in patient-derived xenografts of triple-negative breast cancer reveals reversible chemoresistance conferred by non-mutational mechanisms
Journal Articles

Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors

Free
Jennifer Molina, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Christopher Carroll, Edward Chang, Jason Cross, Naval Daver, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Jing Han, Judy Hirst, Sha Huang, Yongying Jiang, Zhijun Kang, Marina Konopleva, Gang Liu, Helen Ma, Polina Matre, Timothy McAfoos, Funda Meric-Bernstam, Pietro Morlacchi, Florian Muller, Marina Protopopova, Melinda Smith, Sonal Sonal, Yuting Sun, Jay Theroff, Andrea Viale, Quanyun Xu, Carlo Toniatti, Giulio Draetta, Philip Jones, M. Emilia Di Francesco, Joseph R. Marszalek
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4971.
https://doi.org/10.1158/1538-7445.AM2017-4971
Published: 01 July 2017
View articletitled, Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors
Journal Articles

Abstract 3016: Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient models

Free
Virginia Giuliani, Bhavatarini Vangamudi, Erika Suzuki, Meredith Miller, Chiu-Yi Liu, Alessandro Carugo, Christopher Bristow, Guang Gao, Jing Han, Yuting Sun, Ningping Feng, Edward Chang, Joseph Marszalek, Jeffrey Kovacs, Maria Emilia Di Francesco, Carlo Toniatti, Timothy Heffernan, Philip Jones, Giulio Draetta
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3016.
https://doi.org/10.1158/1538-7445.AM2017-3016
Published: 01 July 2017
View articletitled, Abstract 3016: Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient models
Journal Articles

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription

Free
Matthew Wong, Andrew E.L. Tee, Giorgio Milazzo, Jessica L. Bell, Rebecca C. Poulos, Bernard Atmadibrata, Yuting Sun, Duohui Jing, Nicholas Ho, Dora Ling, Pei Yan Liu, Xu Dong Zhang, Stefan Hüttelmaier, Jason W.H. Wong, Jenny Wang, Patsie Polly, Giovanni Perini, Christopher J. Scarlett, Tao Liu
Journal: Cancer Research
Cancer Res (2017) 77 (9): 2522–2533.
https://doi.org/10.1158/0008-5472.CAN-16-1663
Published: 30 April 2017
View articletitled, The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription
Open the PDF for The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription in another window
Includes: Supplementary data
Journal Articles

Abstract 1023: Functional genomics reveals dependency on 6-phosphogluconate dehydrogenase in OXPHOS-deficient tumors

Free
Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher Bristow, Norma Rogers, Chang Edward, Mary Geck Do, Yongying Jiang, Pietro Morlacchi, Florian Muller, Faika Mseeh, Barbara Czako, Wylie Palmer, Carlo Toniatti, Philip Jones, Giulio Draetta, Timothy Heffernan, Joseph Marszalek
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1023.
https://doi.org/10.1158/1538-7445.AM2016-1023
Published: 15 July 2016
View articletitled, Abstract 1023: Functional genomics reveals dependency on 6-phosphogluconate dehydrogenase in OXPHOS-deficient tumors
Journal Articles

Abstract 3837: Passenger deletion of ENO1 as a collateral lethality target in cancer

Free
Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Joe Marszalek, Yuting Sun, Marina Protopopova, Maria E. Di Francesco, Barbara Czako, Alan Wang, Ronald A. DePinho, Florian L. Muller
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3837.
https://doi.org/10.1158/1538-7445.AM2016-3837
Published: 15 July 2016
View articletitled, Abstract 3837: Passenger deletion of ENO1 as a collateral lethality target in cancer
Journal Articles

Abstract LB-149: LYAR promotes cell proliferation by repressing CHAC1 expression in neuroblastoma

Free
Yuting Sun, Bernard Atmadibrata, Bing Liu, Tao Liu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-149.
https://doi.org/10.1158/1538-7445.AM2016-LB-149
Published: 15 July 2016
View articletitled, Abstract LB-149: LYAR promotes cell proliferation by repressing CHAC1 expression in neuroblastoma
Journal Articles

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Free
Yuting Sun, Jessica L. Bell, Daniel Carter, Samuele Gherardi, Rebecca C. Poulos, Giorgio Milazzo, Jason W.H. Wong, Rima Al-Awar, Andrew E. Tee, Pei Y. Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M. Shohet, Ygal Haupt, Johannes H. Schulte, Peter J. Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Karen L. MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M. Marshall, Antony Braithwaite, Tao Liu
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5143–5154.
https://doi.org/10.1158/0008-5472.CAN-15-0423
Published: 30 November 2015
View articletitled, WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Open the PDF for WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor

Free
Marina Protopopova, Madhavi Bandi, Jennifer Bardenhagen, Christophor Bristow, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Florian Muller, Timothy Lofton, Timothy McAfoos, Jay Theroff, Yuting Sun, Yuanqiang Wu, Melinda Smith, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti, M. Emilia Di Francesco, Joseph R. Marszalek
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4455.
https://doi.org/10.1158/1538-7445.AM2015-4455
Published: 01 August 2015
View articletitled, Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor
Journal Articles

Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities

Free
Marina Protopopova, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Florian Muller, Timothy Lofton, Timothy McAfoos, Yuting Sun, Melinda Smith, Jay Theroff, Yuanqiang Wu, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti, M. Emilia Di Francesco, Joseph R. Marszalek
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4380.
https://doi.org/10.1158/1538-7445.AM2015-4380
Published: 01 August 2015
View articletitled, Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities
Journal Articles

Abstract 1378: The histone methyltransferase adaptor WDR5 is a novel cofactor in neuroblastoma

Free
Yuting Sun, Pei Yan Liu, Daniel Carter, Nicolas Sokolowski, Karen L. MacKenzie, Glenn M. Marshall, Tao Liu
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1378.
https://doi.org/10.1158/1538-7445.AM2014-1378
Published: 01 October 2014
View articletitled, Abstract 1378: The histone methyltransferase adaptor WDR5 is a novel cofactor in neuroblastoma
Journal Articles

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy

Free
Yuting Sun, Bu-Er Wang, Kevin G. Leong, Peng Yue, Li Li, Suchit Jhunjhunwala, Darrell Chen, Kyounghee Seo, Zora Modrusan, Wei-Qiang Gao, Jeffrey Settleman, Leisa Johnson
Journal: Cancer Research
Cancer Res (2012) 72 (2): 527–536.
https://doi.org/10.1158/0008-5472.CAN-11-3004
Published: 16 January 2012
View articletitled, Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy
Open the PDF for Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy in another window
Includes: Supplementary data