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Abstract 5533: YIV-906 could modulate nuclear factor of activated T-cells (NFAT) activity of T cells for immune checkpoint blockade therapy and CAR T-cell therapy

Wing Lam, Shwu-Huey Liu, Peikwen Cheng, Yung-Chi Cheng

Cancer Res (2022) 82 (12_Supplement): 5533.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5533

Published: 15 June 2022

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Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration

Wing Lam, Xiaochen Yang, Zaoli Jiang, Xue han, Fulan Guan, Rong Hu, Chang-Hua Xu, Wei Cai, William Cheng, Shwu-Huey Liu, Yuping Cai, Nicholas Rattray, Caroline Johnson, Lieping Chen, Yung-chi Cheng

Cancer Res (2019) 79 (13_Supplement): 2252.

DOI: https://doi.org/10.1158/1538-7445.AM2019-2252

Published: 01 July 2019

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Abstract 2724: YIV906 (PHY906) enhanced the antitumor activity of immune checkpoint blockade therapy: Anti-PD1 against liver cancer

Wing Lam, XiaoChen Yang, Zaoli Jiang, Xue Han, Fulan Guan, William Cheng, Shwu-Huey Liu, Lieping Chen, Yung-Chi Cheng

Cancer Res (2018) 78 (13_Supplement): 2724.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2724

Published: 01 July 2018

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Abstract #1776: Novel inhibitory effects against translation by tylophorine analog, DCB-3503

Ying Wang, Wenli Gao, Annie Pei-Chun Chen, Yung-Chi Cheng

Cancer Res (2009) 69 (9_Supplement): 1776.

Published: 01 May 2009

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The impact of hypoxia on the expression of Phosphoglycerate Kinase (PGK) and the Cytotoxicity of L-OddC (Troxacitabine) and dFdC (Gemcitabine) in H460 Cells, in vitro and in vivo.

Wing Lam, Scott Bussom, Yung-Chi Cheng

Cancer Res (2008) 68 (9_Supplement): 3338.

Published: 01 May 2008

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Journal Articles

Phase I/II multicenter study of phy906/capecitabine in hepatocellular carcinoma

Yun Yen, Samuel So, Michal Rose, Wasif Saif, Edward Chu, Li-Tzong Cheng, Shwu-Huey Liu, Angeline Foo, Robert Tilton, Yung-Chi Cheng

Cancer Res (2008) 68 (9_Supplement): 4466.

Published: 01 May 2008

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A novel herb-drug interaction: Irinotecan can significantly change the pharmacokinetics and pharmacodynamics of PHY906, a Chinese medicine formulation for cancer therapy

Min Ye, Zaoli Jiang, Wing Lam, Ginger Dutschman, Scott Bussom, Pei-chun Chen, Shwu-Huey Liu, Yung-Chi Cheng

Cancer Res (2008) 68 (9_Supplement): 635.

Published: 01 May 2008

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Journal Articles

PHY906 in hepatocellular carcinoma

Shwu-Huey Liu, Zaoli Jiang, Angeline Foo, Wing Lam, Min Ye, Yashang Lee, Duncan Liang, Susan Grill, Yun Yen, Michal Rose, Samuel So, Wasif Saif, Edward Chu, Robert Tilton, Yung-Chi Cheng

Cancer Res (2007) 67 (9_Supplement): 1841.

Published: 01 May 2007

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The impact of hypoxia treatment on the expression of PGK and the cytotoxicity of L-OddC (Troxacitabine) and dFdC (Gemcitabine)

Wing Lam, Scott Bussom, Chung-Hang Leung, Yung-Chi Cheng

Cancer Res (2007) 67 (9_Supplement): 4044.

Published: 01 May 2007

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Journal Articles

Eriocalyxin B selectively inhibits NF-κB activity by targeting multiple steps of the NF-κB activation pathway

Chung-Hang Leung, Susan P. Grill, Wing Lam, Han-Dong Sun, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 325.

Published: 15 April 2006

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ATP and CPT could inhibit the religation action of Topoisomerase I facilitated by poly(ADP-ribose) polymerase-1 and NAD in the presence of camptothecin

Shin-Young Park, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 313.

Published: 15 April 2006

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Alteration of UMP/CMP Kinase (GeneID: 51727, mRNA: AF087865) Amount is Not Solely Responsible for the Phosphorylation of Cellular Pyrimidine Nucleoside Monophosphates and Their Analog Monophosphates in Human RKO Cells

Rong Hu, Wing Lam, Susan P. Grill, Jieh-Yuan Liou, Chih-Hung Hsu, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 313.

Published: 15 April 2006

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PHY906 as a broad-spectrum enhancer in cancer therapy: Clinical and preclinical results in hepatocellular carcinoma

Shwu-Huey Liu, Angeline Foo, Zaoli Jiang, Rajendra Marathe, Jing Guan, Tah-Mun Su, Robert Tilton, Yun Yen, Michal Rose, Samuel So, Edward Chu, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 506–507.

Published: 15 April 2006

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Dipropyloxy baicalein, a biochemical modulator in facilitating the oral uptake of drugs

Shwu-Huey Liu, Yashang Lee, Zaoli Jiang, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 506.

Published: 15 April 2006

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Journal Articles

Potent inhibitory effect of a tylophorine analog DCB-3503 against NF-κB and its rapid induction of proteasomal degradation

Wenli Gao, Elizabeth Gullen, Her-Shyong Shiah, Wing Lam, Conrad Kaczmarek, David Baker, Zhinan Yin, Jin-Young Choi, Joseph Craft, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 1096.

Published: 15 April 2006

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Journal Articles

The effect of hypoxia treatment on the expression of phosphoglycerate kinase and apurine endonuclease-1 and its impact on the cytotoxicity of troxacitabine and gemcitabine

Wing Lam, Chung-Hang Leung, Yung-Chi Cheng

Cancer Res (2006) 66 (8_Supplement): 907.

Published: 15 April 2006

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Poly(ADP-Ribose) Polymerase-1 Could Facilitate the Religation of Topoisomerase I-linked DNA Inhibited by Camptothecin

Shin-Young Park, Yung-Chi Cheng

Cancer Res (2005) 65 (9): 3894–3902.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-4014

Published: 02 May 2005

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Journal Articles

Human apurinic/apyrimidinic endonuclease (APE1) protein level is associated with the cytotoxicity of L-OddC but not Gemcitabine

Wing Lam, Chung-Hang Leung, Shin-Young Park, Yung-Chi Cheng

Cancer Res (2005) 65 (9_Supplement): 1182.

Published: 01 May 2005

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Journal Articles

Cellular expression and localization of DNA exonucleases, Trex, and their response to chemotherapeutic compounds in different tumor cell lines

Chuan-Jen C. J. Wang, Guangwei Yang, Hua-Mei Chang, Wing Lam, Chih-Hung Hsu, Yung-Chi Cheng

Cancer Res (2005) 65 (9_Supplement): 418.

Published: 01 May 2005

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Journal Articles

Reexpression of uridine monophosphate kinase activity restores sensitivity to pulse 5FU resistant colorectal cancer cells

Rita Humeniuk Polaczek, Lata G. Menon, Richard Gorlick, Rebecca Sowers, Wojciech Rode, Giuseppe Pizzorno, Yung-Chi Cheng, Joseph R. Bertino, Debabrata Banerjee

Cancer Res (2005) 65 (9_Supplement): 776.

Published: 01 May 2005

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NARROW

Abstract 5533: YIV-906 could modulate nuclear factor of activated T-cells (NFAT) activity of T cells for immune checkpoint blockade therapy and CAR T-cell therapy

Abstract 2252: YIV-906 (PHY906) enhanced the anti-tumor activity of immune checkpoint blockade therapy (Anti-PD1) against liver cancer by changing the tumor micro-environment associated with M1 macrophages infiltration

Abstract 2724: YIV906 (PHY906) enhanced the antitumor activity of immune checkpoint blockade therapy: Anti-PD1 against liver cancer

Abstract #1776: Novel inhibitory effects against translation by tylophorine analog, DCB-3503

The impact of hypoxia on the expression of Phosphoglycerate Kinase (PGK) and the Cytotoxicity of L-OddC (Troxacitabine) and dFdC (Gemcitabine) in H460 Cells, in vitro and in vivo.

Phase I/II multicenter study of phy906/capecitabine in hepatocellular carcinoma

A novel herb-drug interaction: Irinotecan can significantly change the pharmacokinetics and pharmacodynamics of PHY906, a Chinese medicine formulation for cancer therapy

PHY906 in hepatocellular carcinoma

The impact of hypoxia treatment on the expression of PGK and the cytotoxicity of L-OddC (Troxacitabine) and dFdC (Gemcitabine)

Eriocalyxin B selectively inhibits NF-κB activity by targeting multiple steps of the NF-κB activation pathway

ATP and CPT could inhibit the religation action of Topoisomerase I facilitated by poly(ADP-ribose) polymerase-1 and NAD in the presence of camptothecin

Alteration of UMP/CMP Kinase (GeneID: 51727, mRNA: AF087865) Amount is Not Solely Responsible for the Phosphorylation of Cellular Pyrimidine Nucleoside Monophosphates and Their Analog Monophosphates in Human RKO Cells

PHY906 as a broad-spectrum enhancer in cancer therapy: Clinical and preclinical results in hepatocellular carcinoma

Dipropyloxy baicalein, a biochemical modulator in facilitating the oral uptake of drugs

Potent inhibitory effect of a tylophorine analog DCB-3503 against NF-κB and its rapid induction of proteasomal degradation

The effect of hypoxia treatment on the expression of phosphoglycerate kinase and apurine endonuclease-1 and its impact on the cytotoxicity of troxacitabine and gemcitabine

Poly(ADP-Ribose) Polymerase-1 Could Facilitate the Religation of Topoisomerase I-linked DNA Inhibited by Camptothecin

Human apurinic/apyrimidinic endonuclease (APE1) protein level is associated with the cytotoxicity of L-OddC but not Gemcitabine

Cellular expression and localization of DNA exonucleases, Trex, and their response to chemotherapeutic compounds in different tumor cell lines

Reexpression of uridine monophosphate kinase activity restores sensitivity to pulse 5FU resistant colorectal cancer cells

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