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Journal Articles

Abstract CT053: Exploration of potential biomarkers correlated with efficacy of ociperlimab (anti-TIGIT) plus tislelizumab (anti-PD-1) in 1L PD-L1+ non-small cell lung cancer (NSCLC)

Se Hyun Kim, Jiayuan Zhang, Wei Tan, Han Yan, Tian Tian, Hao Zheng, Ziqi Zhou, Ruihua Wang, Yun Zhang, Zhirong Shen, Hye Ryun Kim, Diansheng Zhong, Shun Lu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT053.
https://doi.org/10.1158/1538-7445.AM2024-CT053
Published: 05 April 2024
View article titled, Abstract CT053: Exploration of potential biomarkers correlated with efficacy of ociperlimab (anti-TIGIT) plus tislelizumab (anti-PD-1) in 1L PD-L1+ non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 550: Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets

Yun Zhang, Rachel Israel, Bryce Vandenburg, Shari Barnett, Jean-Jack Riethoven, Jennifer L. Clarke, Michelle P. Lee, Kiran Lagisetty, Jules Lin, Rishindra Reddy, Andrew Chang, Laura A. Kresty
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 550.
https://doi.org/10.1158/1538-7445.AM2024-550
Published: 22 March 2024
View article titled, Abstract 550: Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets
Journal Articles

Abstract 3138: Discovery of AT65474, a highly selective anti-CLDN6  ADC with a proprietary payload

Chen Zhong, You Xue Wu, Xi Yun Zhang, Yin Wen Cheng, Qian Wang, Ping Du, Shao Jun Liu, Bin Zou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3138.
https://doi.org/10.1158/1538-7445.AM2024-3138
Published: 22 March 2024
View article titled, Abstract 3138: Discovery of AT65474, a highly selective anti-CLDN6  ADC with a proprietary payload
Journal Articles

Abstract 3137: Development of AT2604, a highly efficacious  ADC targeting alkaline phosphatases ALPP  and ALPPL2​

Bryan K. Yeung, Xiao Hui Koh, Wei Li Ling, Weiqi Tan, You Xue Wu, Xi Yun Zhang, Hong Yee Tan, Shao Jun Liu, Chen Zhong, Bin Zou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3137.
https://doi.org/10.1158/1538-7445.AM2024-3137
Published: 22 March 2024
View article titled, Abstract 3137: Development of AT2604, a highly efficacious  ADC targeting alkaline phosphatases ALPP  and ALPPL2​
Journal Articles

Abstract 1858: Discovery of AT86474, a highly efficacious anti-ROR1 ADC utilizing a proprietary payload

Ban Xiong Tan, Xi Yun Zhang, You Xue Wu, Yin Wen Cheng, Shao Jun Liu, Ping Du, Chen Zhong, Bin Zou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1858.
https://doi.org/10.1158/1538-7445.AM2024-1858
Published: 22 March 2024
View article titled, Abstract 1858: Discovery of AT86474, a highly efficacious anti-ROR1 ADC utilizing a proprietary payload
Journal Articles

Abstract 4041: Translational assessment of triple combination with Tislelizumab (anti-PD-1), LBL-007 (anti-LAG-3) and < for Surzebiclimab (anti-TIM-3) highlights its strong anti-tumor activity and < for clinical potential in solid tumors such as HNSCC

Hengrui Zhu, Jinhui Zhang, Han Yan, Xiao Ding, Juan Yang, Yu Jiang, Minjuan Deng, Haoxuan Song, Fangfang Ping, Fuyun Sun, Xiaoyu Li, Lijie Zhang, Bin Jiang, Weiwei Song, Zhirong Shen, Wei Jin, Jiyuan Zhang, Yun Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4041.
https://doi.org/10.1158/1538-7445.AM2024-4041
Published: 22 March 2024
View article titled, Abstract 4041: Translational assessment of triple combination with Tislelizumab (anti-PD-1), LBL-007 (anti-LAG-3) and &lt; for Surzebiclimab (anti-TIM-3) highlights its strong anti-tumor activity and &lt; for clinical potential in solid tumors such as HNSCC
Journal Articles

Development of a Rare Earth Nanoprobe Enables In Vivo Real-Time Detection of Sentinel Lymph Node Metastasis of Breast Cancer Using NIR-IIb Imaging

Yuan-Yuan Zhu, Liang Song, Yong-Qu Zhang, Wan-Ling Liu, Wei-Ling Chen, Wen-Liang Gao, Li-Xin Zhang, Jia-Zheng Wang, Zi-He Ming, Yun Zhang, Guo-Jun Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (20): 3428–3441.
https://doi.org/10.1158/0008-5472.CAN-22-3432
Published: 13 October 2023
View article titled, Development of a Rare Earth Nanoprobe Enables <em>In Vivo</em> Real-Time Detection of Sentinel Lymph Node Metastasis of Breast Cancer Using NIR-IIb Imaging
Open the PDF for Development of a Rare Earth Nanoprobe Enables <em>In Vivo</em> Real-Time Detection of Sentinel Lymph Node Metastasis of Breast Cancer Using NIR-IIb Imaging in another window
Includes: Supplementary data
Journal Articles

Abstract LB289: Longitudinal ctDNA levels and clinical outcomes of first-line (1L) tislelizumab (TIS) + chemotherapy (chemo) treatment for advanced non-small cell lung cancer (NSCLC) in the RATIONALE-304 and 307 studies

Shun Lu, Jie Wang, Meili Sun, Jun Zhao, Chunhong Hu, Mengzhao Wang, Jianying Zhou, Yong Song, Qinghua Zhou, Jiayuan Zhang, Yang Shi, Ruiqi Huang, Xikun Wu, Wanyu He, Xiaofei Qu, Yun Zhang, Zhirong Shen, Yan Yu
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB289.
https://doi.org/10.1158/1538-7445.AM2023-LB289
Published: 14 April 2023
View article titled, Abstract LB289: Longitudinal ctDNA levels and clinical outcomes of first-line (1L) tislelizumab (TIS) + chemotherapy (chemo) treatment for advanced non-small cell lung cancer (NSCLC) in the RATIONALE-304 and 307 studies
Journal Articles

Abstract CT077: Association of tumor mutational burden (TMB) and clinical outcomes with tislelizumab versus chemotherapy in esophageal cell carcinoma (ESCC) from RATIONALE-302

Lin Shen, Yongqian Shu, Kuaile Zhao, Taroh Satoh, Zhendong Chen, Eric Van Cutsem, Guohua Yu, Jun Wu, Chih-Hung Hsu, Sung Bae Kim, Wenting Du, Yang Shi, Ruiqi Huang, Qiao Li, Jingwen Shi, Yun Zhang, Kato Ken
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT077.
https://doi.org/10.1158/1538-7445.AM2023-CT077
Published: 14 April 2023
View article titled, Abstract CT077: Association of tumor mutational burden (TMB) and clinical outcomes with tislelizumab versus chemotherapy in esophageal cell carcinoma (ESCC) from RATIONALE-302
Journal Articles

Abstract 1883: A novel T cell engager targeting BCMA and GPRC5D showed promising preclinical activity with low toxic risk for multiple myeloma treatment

Yayuan Fu, Shumei You, Menghao Wei, Bowei Yin, Qi Deng, Xiaokang Qin, Yun Zhang, Yanqiu Wang, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1883.
https://doi.org/10.1158/1538-7445.AM2023-1883
Published: 04 April 2023
View article titled, Abstract 1883: A novel T cell engager targeting BCMA and GPRC5D showed promising preclinical activity with low toxic risk for multiple myeloma treatment
Journal Articles

Abstract 1745: Targeting therapeutic resistance of esophageal adenocarcinoma through modulating the epithelial-to-mesenchymal transition via NFκB-mediated signaling

Yun Zhang, Katherine M. Weh, Connor L. Howard, Jean-Jack Riethoven, Jennifer L. Clarke, Michelle P. Lee, Kiran H. Lagisetty, Jules Lin, Rishindra M. Reddy, Andrew C. Chang, Amy B. Howell, Laura A. Kresty
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1745.
https://doi.org/10.1158/1538-7445.AM2023-1745
Published: 04 April 2023
View article titled, Abstract 1745: Targeting therapeutic resistance of esophageal adenocarcinoma through modulating the epithelial-to-mesenchymal transition via NFκB-mediated signaling
Journal Articles

Abstract 6141: Mechanisms by which Mito-lonidamine inhibits EGFR mutant lung cancer

Katherine M. Weh, Connor Howard, Yun Zhang, Jean-Jack Riethoven, Jennifer Clarke, Gang Cheng, Balaraman Kalyanaraman, Ming You, Laura Kresty
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6141.
https://doi.org/10.1158/1538-7445.AM2023-6141
Published: 04 April 2023
View article titled, Abstract 6141: Mechanisms by which Mito-lonidamine inhibits <em>EGFR</em> mutant lung cancer
Journal Articles

Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile

Yingying Hu, Yayuan Fu, Lei Liu, Wenjing Li, Liting Xue, Zhiyong Yu, Yun Zhang, Meijuan Gao, Yixin Tan, Fudong Wang, Yadan Wu, Jie Li, Zhenzhen Li, Feng Zhou, Wenqing Yang, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6357.
https://doi.org/10.1158/1538-7445.AM2023-6357
Published: 04 April 2023
View article titled, Abstract 6357: Generation of a mutant SIRPa fusion protein with highly-improved affinity and favorable safety profile
Journal Articles

Abstract 1882: SCR-9171, a MUC17-targeted bispecific T cell engager molecule for gastrointestinal cancer

Guangcun Cheng, Yayuan Fu, Hua Zheng, ng Li, Xiaolei He, Xi Jiao, Shuhui Luan, Shuai Wang, Lei Jiang, Wenjing Li, Yun Zhang, Lei Liu, Renhong Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1882.
https://doi.org/10.1158/1538-7445.AM2023-1882
Published: 04 April 2023
View article titled, Abstract 1882: SCR-9171, a MUC17-targeted bispecific T cell engager molecule for gastrointestinal cancer
Journal Articles

Abstract A042: Differences in gain-of-function and inhibitory effects amongst p53 mutants in vivo

Shunbin Xiong, Dhruv Chachad, Yun Zhang, Jovanka Gencel-Augusto, Mario Sirito, Vinod Pant, Peirong Yang, Chang Sun, Guillermina Lozano
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): A042.
https://doi.org/10.1158/1538-7445.METASTASIS22-A042
Published: 15 January 2023
View article titled, Abstract A042: Differences in gain-of-function and inhibitory effects amongst p53 mutants <em>in vivo</em>
Journal Articles

Abstract A026: Epigenetic factor competition reshapes the EMT landscape

M. Ali Al-Radhawi, Shubham Tripath, Yun Zhang, Eduardo Sontag, Herbert Levine
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): A026.
https://doi.org/10.1158/1538-7445.CancEpi22-A026
Published: 01 December 2022
View article titled, Abstract A026: Epigenetic factor competition reshapes the EMT landscape
Journal Articles

Abstract 5741: Characterizing isoform switching events in esophageal adenocarcinoma

Yun Zhang, Katherine M. Weh, Connor L. Howard, Jean-Jack Riethoven, Jennifer L. Clarke, Kiran H. Lagisetty, Jules Lin, Rishindra M. Reddy, Andrew C. Chang, David G. Beer, Laura A. Kresty
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5741.
https://doi.org/10.1158/1538-7445.AM2022-5741
Published: 15 June 2022
View article titled, Abstract 5741: Characterizing isoform switching events in esophageal adenocarcinoma
Journal Articles

Abstract 5421: Prediction of intratumoral TIGIT receptor occupancy after the treatment with anti-TIGIT antibodies

Dmitry Shchelokov, Oleg Demin, Jr, Oleg Demin, Ahsan Rizwan, Yun Zhang, Wei Tan, Srikumar Sahasranaman, Nageshwar Budha
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5421.
https://doi.org/10.1158/1538-7445.AM2022-5421
Published: 15 June 2022
View article titled, Abstract 5421: Prediction of intratumoral TIGIT receptor occupancy after the treatment with anti-TIGIT antibodies
Journal Articles

Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors

Cuiqing Yang, Xiaohui Shao, Feng Zhou, Lei Zhou, Qi Deng, Yun Zhang, Guangcun Cheng, Yingying Hu, Huaiyuan Ma, Yadan Wu, Shuai Wang, Jie Zang, Lei Liu, Wenqing Yang, Yang Liu, Chunlei Xia, Jianzhong Hu, Ande Luo, Yayuan Fu, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6343.
https://doi.org/10.1158/1538-7445.AM2022-6343
Published: 15 June 2022
View article titled, Abstract 6343: A multispecific T cell engager binding to both membrane proximal and membrane distal epitopes of MSLN with low affinity CD3 for the treatment of AML and solid tumors
Journal Articles

Abstract LB514: CD8 T cells and macrophage abundances associated with clinical benefit of tislelizumab in various tumor types

Wei Shen, Tengfei Liu, Yang Shi, Jingwen Shi, Dan Wang, Liang Liang, Silu Yang, Xiaopeng Ma, Wei Jin, Pei Zhang, Ruiqi Huang, Yun Zhang, Zhirong Shen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB514.
https://doi.org/10.1158/1538-7445.AM2022-LB514
Published: 15 June 2022
View article titled, Abstract LB514: CD8 T cells and macrophage abundances associated with clinical benefit of tislelizumab in various tumor types