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Journal Articles

Abstract 4676: 11α-O-2-methylbutanoyl-12β-O-tigloyl-tenacigenin B (MT2) is a novel paclitaxel chemosensitizer to inhibit growth in Taxol non-resistant and Taxol resistant cancers

Ka Ming Cheng, Gui yun Wu, Kowk Kuen Cheung, Xiao-Ling Shen, Ying-Jie Hu, Ki Lui
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4676.
https://doi.org/10.1158/1538-7445.AM2024-4676
Published: 22 March 2024
View article titled, Abstract 4676: 11α-O-2-methylbutanoyl-12β-O-tigloyl-tenacigenin B (MT2) is a novel paclitaxel chemosensitizer to inhibit growth in Taxol non-resistant and Taxol resistant cancers
Journal Articles

Abstract 2716: Further development of microRNA-34a therapeutics to target castration-resistant prostate cancer

Wen (Jess) Li, Xiaozhuo Liu, Ahmed M. Abdelaal, Sudarsan Kasireddy, Yafei Su, Yun Wu, Andrea L. Kasinski, Dean G. Tang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2716.
https://doi.org/10.1158/1538-7445.AM2023-2716
Published: 04 April 2023
View article titled, Abstract 2716: Further development of microRNA-34a therapeutics to target castration-resistant prostate cancer
Journal Articles

Abstract 5042: Reconstructing the spatial evolution of cancer through subclone detection on copy number profiles in tumor sequencing data

Chi-Yun Wu, Paul R. Hess, Anuja Sathe, Jiazhen Rong, Billy T. Lau, Susan M. Grimes, Hanlee P. Ji, Nancy R. Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5042.
https://doi.org/10.1158/1538-7445.AM2022-5042
Published: 15 June 2022
View article titled, Abstract 5042: Reconstructing the spatial evolution of cancer through subclone detection on copy number profiles in tumor sequencing data
Journal Articles

Abstract 6051: Longitudinal single-cell sequencing of high-risk neuroblastoma tumors reveals intrinsic and extrinsic mechanisms of therapy resistance

Yasin Uzun, Liron D. Grossmann, Chia-Hui Chen, Anusha Thadi, Chi-Yun Wu, Peng Gao, Dinh Diep, Lea Surrey, Daniel Martinez, Tasleema Patel, Qi Qiu, Sarah Johnson, Wenbao Yu, Shane Drabings, Changya Chen, Yuxuan Hu, Gregory Chen, Derek A. Oldridge, Kun Zhang, Hao Wu, Kathrin Bernt, Nancy Zhang, John M. Maris, Kai Tan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6051.
https://doi.org/10.1158/1538-7445.AM2022-6051
Published: 15 June 2022
View article titled, Abstract 6051: Longitudinal single-cell sequencing of high-risk neuroblastoma tumors reveals intrinsic and extrinsic mechanisms of therapy resistance
Journal Articles

Abstract 1860: NP-ALT, a liposomal:peptide drug, blocks p27Kip1 phosphorylation to cause cell death in CDK4i-resistant breast cancer

Stacy Wister Blain, Arianna Chand, Lina Pedraza-Ortiz, Allison VanInwegen, Lingyu Yan, Yun Wu, Grace Chen, Irina Jilishitz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1860.
https://doi.org/10.1158/1538-7445.AM2022-1860
Published: 15 June 2022
View article titled, Abstract 1860: NP-ALT, a liposomal:peptide drug, blocks p27Kip1 phosphorylation to cause cell death in CDK4i-resistant breast cancer
Journal Articles

Abstract 5564: QLS31901, a novel bifunctional anti-PD-L1/TGF-β fusion protein for treatment of solid tumors

Jiahua Jiang, Cuicui Han, Qi Chen, Yun Wu, Xiaodan Yan, Ping Cao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5564.
https://doi.org/10.1158/1538-7445.AM2022-5564
Published: 15 June 2022
View article titled, Abstract 5564: QLS31901, a novel bifunctional anti-PD-L1/TGF-β fusion protein for treatment of solid tumors
Journal Articles

Abstract 5551: QLS31905, an anti-claudin 18.2/CD3 bispecific antibody for claudin 18.2-positive gastric cancer

Jiahua Jiang, Meimei Si, Xiao Luo, Yun Wu, Yongjun Li, Xiaodan Yan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5551.
https://doi.org/10.1158/1538-7445.AM2022-5551
Published: 15 June 2022
View article titled, Abstract 5551: QLS31905, an anti-claudin 18.2/CD3 bispecific antibody for claudin 18.2-positive gastric cancer
Journal Articles

Abstract P5-16-18: Developing IpY: A novel inhibitor for the treatment of ER+ CDK4i-resistant breast cancer

Grace Chen, Stacy W Blain, Irina Jilishitz, Allison Vanlnwegen, Lingyue Yan, Yun Wu
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-16-18.
https://doi.org/10.1158/1538-7445.SABCS21-P5-16-18
Published: 15 February 2022
View article titled, Abstract P5-16-18: Developing IpY: A novel inhibitor for the treatment of ER+ CDK4i-resistant breast cancer
Journal Articles

Abstract LB115: Blocking p27Kip1phosphorylation with a liposomal:peptide drug induces Reactive Oxygen Species,necroptosis and tumor regression in breast cancer cells

Stacy Wister Blain, Irina Jilishitz, Jason L. Quinones, Priyank Patel, Grace Chen, Jared Pavetsky, Allison VanInwegen VanInwegen, Scott Schoninger, Manasi P. Jogalekar, Vladislav Tsiperson, Lingyue Yan, Yun Wu, Susan R. Gottesman, Jonathan Somma
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB115.
https://doi.org/10.1158/1538-7445.AM2021-LB115
Published: 01 July 2021
View article titled, Abstract LB115: Blocking p27Kip1phosphorylation with a liposomal:peptide drug induces Reactive Oxygen Species,necroptosis and tumor regression in breast cancer cells
Journal Articles

Abstract LB-218: High-dimensional modeling of single-cell-based CD8+ T cell exhaustion predicts response to immune checkpoint blockade

Guangxu Jin, Gang Xue, Rui-Sheng Wang, Ling-Yun Wu, Lance Miller, Yong Lu, Wei Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-218.
https://doi.org/10.1158/1538-7445.AM2019-LB-218
Published: 01 July 2019
View article titled, Abstract LB-218: High-dimensional modeling of single-cell-based CD8<sup>+</sup> T cell exhaustion predicts response to immune checkpoint blockade
Journal Articles

Abstract 1983: Cancer exosomes immunosuppressive activity in the absence of contaminating soluble factors is multifactorial

Shin La Shu, Junko Matsuzaki, Cheryl Allen, Yunchen Yang, Edward Hurley, Kunle Odunsi, Yun Wu, Marc S. Ernstoff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1983.
https://doi.org/10.1158/1538-7445.AM2019-1983
Published: 01 July 2019
View article titled, Abstract 1983: Cancer exosomes immunosuppressive activity in the absence of contaminating soluble factors is multifactorial
Journal Articles

Abstract 1678: Integrated genomics and histology based studies of triple negative breast cancer identify ICOS as potential target for therapeutic intervention

Heather A. Hirsch, Tong Zi, Rachel Fontana, Yun Wu, Jason Reeves, Alexander Needham, Edward Stack, David Lee, Emma Lees, Deborah A. Law, Elizabeth Trehu, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1678.
https://doi.org/10.1158/1538-7445.AM2018-1678
Published: 01 July 2018
View article titled, Abstract 1678: Integrated genomics and histology based studies of triple negative breast cancer identify ICOS as potential target for therapeutic intervention
Journal Articles

Abstract 5172: A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

Emily Powell, Jiansu Shao, Hector Picon, Christopher Bristow, Zhongqi Ge, Caitlin Grzeskowiak, Michael Peoples, Frederick Robinson, Sabrina Jeter-Jones, Christopher Schlosberg, Fei Yang, Yun Wu, Ignacio Wistuba, Stacy Moulder, Fraser Symmans, Kenneth Scott, John Edwards, Han Liang, Timothy Heffernan, Helen Piwnica-Worms
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5172.
https://doi.org/10.1158/1538-7445.AM2018-5172
Published: 01 July 2018
View article titled, Abstract 5172: A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis
Journal Articles

Abstract 5087: Human melanoma exosomes induce metabolic reprogramming in human adult dermal fibroblasts

Shin La Shu, Cheryl L. Allen, Yunchen Yang, Orla Maguire, Hans Minderman, Arindam Sen, Michael J. Ciesielski, Katherine A. Collins, Peter J. Bush, Martin Morgan, Yun Wu, Richard B. Bankert, Marc S. Ernstoff
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5087.
https://doi.org/10.1158/1538-7445.AM2018-5087
Published: 01 July 2018
View article titled, Abstract 5087: Human melanoma exosomes induce metabolic reprogramming in human adult dermal fibroblasts
Journal Articles

Abstract 2348: Targeting the p27kip1/cdk4/cdk2/Rb axis in breast cancer using a peptidomimetic of Brk’s SH3 domain

Stacy W. Blain, Jason Quinones, Priyank Patel, Vladislav Tsiperson, Susan Gottesman, Jonathan Somma, Yun Wu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2348.
https://doi.org/10.1158/1538-7445.AM2017-2348
Published: 01 July 2017
View article titled, Abstract 2348: Targeting the p27kip1/cdk4/cdk2/Rb axis in breast cancer using a peptidomimetic of Brk’s SH3 domain
Journal Articles

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

Chia-Wei Li, Weiya Xia, Seung-Oe Lim, Jennifer L. Hsu, Longfei Huo, Yun Wu, Long-Yuan Li, Chien-Chen Lai, Shih-Shin Chang, Yi-Hsin Hsu, Hui-Lung Sun, Jongchan Kim, Hirohito Yamaguchi, Dung-Fang Lee, Hongmei Wang, Yan Wang, Chao-Kai Chou, Jung-Mao Hsu, Yun-Ju Lai, Adam M. LaBaff, Qingqing Ding, How-Wen Ko, Fuu-Jen Tsai, Chang-Hai Tsai, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1451–1462.
https://doi.org/10.1158/0008-5472.CAN-15-1941
Published: 14 March 2016
View article titled, AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation
Open the PDF for AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation in another window
Includes: Supplementary data
Journal Articles

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

Seung-Oe Lim, Chia-Wei Li, Weiya Xia, Heng-Huan Lee, Shih-Shin Chang, Jia Shen, Jennifer L. Hsu, Daniel Raftery, Danijel Djukovic, Haiwei Gu, Wei-Chao Chang, Hung-Ling Wang, Mong-Liang Chen, Longfei Huo, Chung-Hsuan Chen, Yun Wu, Aysegul Sahin, Samir M. Hanash, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (5): 1284–1296.
https://doi.org/10.1158/0008-5472.CAN-15-2478
Published: 29 February 2016
View article titled, EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
Open the PDF for EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape in another window
Includes: Supplementary data
Journal Articles

Abstract 4465: Sequential combination of docetaxel with a novel SHP-1 agonist enhanced anti-tumor effect in triple negative breast cancer cells

Ling-Min Tseng, Chun-Yu Liu, Shiu-Ping Yang, Wan-Lun Wang, Jung-Chen Su, Chia-Yun Wu, Chung-Wai Shiau, Kuen-Feng Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4465.
https://doi.org/10.1158/1538-7445.AM2015-4465
Published: 01 August 2015
View article titled, Abstract 4465: Sequential combination of docetaxel with a novel SHP-1 agonist enhanced anti-tumor effect in triple negative breast cancer cells
Journal Articles

Abstract P5-04-07: Multispectral imaging allows visualization and quantification of multiple immunologic cell types in breast tumor tissues

Elizabeth A Mittendorf, Chichung Wang, Peng Yau, Kristin Roman, Yun Wu, Gheath Alatrash, Clifford Hoyt
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-04-07.
https://doi.org/10.1158/1538-7445.SABCS14-P5-04-07
Published: 01 May 2015
View article titled, Abstract P5-04-07: Multispectral imaging allows visualization and quantification of multiple immunologic cell types in breast tumor tissues
Journal Articles

Abstract 3927: Obesity induces changes in adipokines profile and activates Akt/mTOR signaling accelerating breast carcinogenesis and tumor growth

Enrique Fuentes-Mattei, Guermarie Velazquez-Torres, Liem Phan, Fanmao Zhang, Ping-Chieh Chou, Ji-Hyun Shin, Hyun-Ho Choi, Jiun-Sheng Chen, Ruiying Zhao, Jian Chen, Chris Gully, Colin Carlock, Yuan Qi, Ya Zhang, Yun Wu, Francisco Esteva, Yongde Luo, Wallace L. McKeehan, Joe E. Ensor, Gabriel N. Hortobagyi, Lajos Pusztai Pusztai, W. Fraser Symmans, Mong-Hong Lee, Sai-Ching J. Yeung
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3927.
https://doi.org/10.1158/1538-7445.AM2014-3927
Published: 01 October 2014
View article titled, Abstract 3927: Obesity induces changes in adipokines profile and activates Akt/mTOR signaling accelerating breast carcinogenesis and tumor growth