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Journal Articles

Abstract LB074: Targeting chromatin remodeling disrupts immune suppression by pathologically activated neutrophils in cancer

Free
Fan Yang, Yi Bao, Lanbo Xiao, Yuanyuan Qiao, Yizhi Cao, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB074.
https://doi.org/10.1158/1538-7445.AM2025-LB074
Published: 25 April 2025
View articletitled, Abstract LB074: Targeting chromatin remodeling disrupts immune suppression by pathologically activated neutrophils in cancer
Journal Articles

Abstract LB162: Clinically relevant humanized mouse models of metastatic prostate cancer facilitate therapeutic evaluation

Free
Raymond J. Kostlan, John T. Phoenix, Audris Budreika, Marina G. Ferrari, Neetika Khurana, Jae Eun Choi, Kristin Juckette, Somnath Mahapatra, Brooke L. McCollum, Russell Moskal, Rahul Mannan, Yuanyuan Qiao, Donald J. Vander Griend, Arul M. Chinnaiyan, Steven Kregel
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB162.
https://doi.org/10.1158/1538-7445.AM2025-LB162
Published: 25 April 2025
View articletitled, Abstract LB162: Clinically relevant humanized mouse models of metastatic prostate cancer facilitate therapeutic evaluation
Journal Articles

Abstract 2818: Targeting PIKfyve sensitizes gastroenteropancreatic neuroendocrine tumor to mTOR inhibition by disrupting ferritinophagy and lipid homeostasis

Free
Yizhi Cao, Yitong Yin, Caleb Cheng, Shannon VanAkon, Sarah Nicole Yee, Jacinda Jiali Liu, Yang Zheng, Andrej Coleski, Radha Paturu, Somnath Mahapatra, Fan Yang, Rupam Bhattacharyya, Rahul Mannan, Yuanyuan Qiao, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2818.
https://doi.org/10.1158/1538-7445.AM2025-2818
Published: 21 April 2025
View articletitled, Abstract 2818: Targeting PIKfyve sensitizes gastroenteropancreatic neuroendocrine tumor to mTOR inhibition by disrupting ferritinophagy and lipid homeostasis
Journal Articles

Abstract 406: Targeting NSD2 aberrations in hematological malignancies with a potent and selective NSD2 PROTAC degrader

Free
Yihan Liu, Abhijit Parolia, Lianchao Liu, Tongchen He, Yuanyuan Qiao, Sanjana Eyunni, Jie Luo, Zhen Wang, Arul Chinnaiyan, Ke Ding
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 406.
https://doi.org/10.1158/1538-7445.AM2025-406
Published: 21 April 2025
View articletitled, Abstract 406: Targeting NSD2 aberrations in hematological malignancies with a potent and selective NSD2 PROTAC degrader
Journal Articles

Abstract 3936: CDK12 tumor suppressor function and therapeutic targeting in newly developed mouse models of serous ovarian cancer

Free
Jean Ching-Yi Tien, Yali Zhai, Rong Wu, Yuping Zhang, Yu Chang, Yunhui Cheng, Abigail J. Todd, Christina Wheeler, Shuqin Li, Rahul Mannan, Caleb Cheng, Somnath Somnath Mahapatra, Xuhong Cao, Yuanyuan Qiao, Lanbo Xiao, Marcin Cieslik, Ding Ke, Kathleen R. Cho, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3936.
https://doi.org/10.1158/1538-7445.AM2025-3936
Published: 21 April 2025
View articletitled, Abstract 3936: CDK12 tumor suppressor function and therapeutic targeting in newly developed mouse models of serous ovarian cancer
Journal Articles

Abstract 6667: Dual inhibition of PIKfyve and KRAS/MAPK targets metabolic vulnerabilities of pancreatic ductal adenocarcinoma

Free
Jasmine P. Wisniewski, Caleb Cheng, Sydney Peters, Rüya Pakkan, Pietro Morlacchi, Jennifer P. Morton, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6667.
https://doi.org/10.1158/1538-7445.AM2025-6667
Published: 21 April 2025
View articletitled, Abstract 6667: Dual inhibition of PIKfyve and KRAS/MAPK targets metabolic vulnerabilities of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 5384: Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

Free
Caleb Cheng, Jasmine Wisniewski, Sydney Peters, Rüya Pakkan, Jennifer P. Morton, Pietro Morlacchi, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5384.
https://doi.org/10.1158/1538-7445.AM2025-5384
Published: 21 April 2025
View articletitled, Abstract 5384: Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Journal Articles

Abstract 4158: PIKfyve inhibition drives lipogenic adaptation and reveals metabolic vulnerabilities in PDAC

Free
Ruya Pakkan, Caleb Cheng, Jasmine Wisniewski, Sydney Peters, Pietro Morlacchi, Li Zhang, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4158.
https://doi.org/10.1158/1538-7445.AM2025-4158
Published: 21 April 2025
View articletitled, Abstract 4158: PIKfyve inhibition drives lipogenic adaptation and reveals metabolic vulnerabilities in PDAC
Journal Articles

Abstract C033: Targeting PIKfyve-driven lipid metabolism in pancreatic cancer

Free
Caleb Cheng, Jasmine P Wisniewski, Sydney Peters, Jing Hu, Rahul Mannan, Bailey Jackson, Rüya Pakkan, Pietro Morlacchi, Brian Magnuson, Tongchen He, Rupam Bhattacharyya, Yuanyuan Qiao, Costas A Lyssiotis, Arul M Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C033.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C033
Published: 15 September 2024
View articletitled, Abstract C033: Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Journal Articles

Abstract 6602: Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

Free
Lanbo Xiao, Tongchen He, Olaf Klingbeil, Young Eleanor, Xiaoli Wu, Yuanyuan Qiao, Abhijit Parolia, Sanjana Eyunni, Rahul Mannan, Somnath Mahapatra, NamHoon Kim, Heng Zheng, Fengyun Su, Xuhong Cao, Susanta Samajdar, Murali Ramachandra, Christopher R. Vakoc, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6602.
https://doi.org/10.1158/1538-7445.AM2024-6602
Published: 22 March 2024
View articletitled, Abstract 6602: Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
Journal Articles

Abstract 3300: Dual inhibition of PIKfyve and KRAS/MAPK as a potential for therapeutic strategy for pancreatic ductal adenocarcinoma

Free
Jasmine P. Wisniewski, Caleb Cheng, Bailey Jackson, Ahmet Korkaya, Sydney Peters, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3300.
https://doi.org/10.1158/1538-7445.AM2024-3300
Published: 22 March 2024
View articletitled, Abstract 3300: Dual inhibition of PIKfyve and KRAS/MAPK as a potential for therapeutic strategy for pancreatic ductal adenocarcinoma
Journal Articles

Abstract 3299: Harnessing PIKfyve as a therapeutic vulnerability in neuroendocrine prostate cancer

Free
Yang Zheng, Kyle Garcia Rogers, Arya Gopal Kamat, Sarah Nicole Yee, Rahul Mannan, Xia Jiang, Rowena Kannaiyan, Xuhong Cao, Yuzhuo Wang, Yuanyuan Qiao, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3299.
https://doi.org/10.1158/1538-7445.AM2024-3299
Published: 22 March 2024
View articletitled, Abstract 3299: Harnessing PIKfyve as a therapeutic vulnerability in neuroendocrine prostate cancer
Journal Articles

Abstract 7479: Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy

Free
Parth Borker, Yi Bao, Yuanyuan Qiao, Arul Chinnaiyan, Jae Eun Choi, Yuping Zhang, Rahul Mannan, Caleb Cheng, Tongchen He, Yang Zheng, Jiali Yu, Mahnoor Gondal, Gabriel Cruz, Sara Sara Grove, Xuhong Cao, Fengyun Su, Rui Wang, Yu Chang, Ilona Kryczek, Marcin Cieslik, Michael D. Green, Weiping Zou
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7479.
https://doi.org/10.1158/1538-7445.AM2024-7479
Published: 22 March 2024
View articletitled, Abstract 7479: Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy
Journal Articles

Abstract 2087: Targeting lipid metabolism in pancreatic cancer

Free
Caleb Cheng, Jasmine P. Wisniewski, Ahmet Korkaya, Bailey Jackson, Rahul Mannan, Somnath Mahapatra, Nicholas Rossiter, Rupam Bhattacharyya, Pietro Morlacchi, Sydney Peters, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2087.
https://doi.org/10.1158/1538-7445.AM2024-2087
Published: 22 March 2024
View articletitled, Abstract 2087: Targeting lipid metabolism in pancreatic cancer
Journal Articles

Abstract 4323: Deletion of the lipid kinase PIKfyve in Kras-driven pancreatic genetically engineered mouse model

Free
Sarah N. Yee, Xia Jiang, Caleb Cheng, Ahmet Korkaya, Rahul Mannan, Rohit Mehra, Yuanyuan Qiao, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4323.
https://doi.org/10.1158/1538-7445.AM2024-4323
Published: 22 March 2024
View articletitled, Abstract 4323: Deletion of the lipid kinase PIKfyve in Kras-driven pancreatic genetically engineered mouse model
Journal Articles

Abstract 6048: Targeting AR positive prostate cancer cells by the novel P300/CBP oral available PROTAC degrader

Free
Jie luo, Abhijit Prolia, Yuanyuan Qiao, Jean Tian, Rahul Mannan, Somnath Mahapatra, Zhixiang Chen, Rithvik Seri, Shaomeng Wang, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6048.
https://doi.org/10.1158/1538-7445.AM2024-6048
Published: 22 March 2024
View articletitled, Abstract 6048: Targeting AR positive prostate cancer cells by the novel P300/CBP oral available PROTAC degrader
Journal Articles

Abstract 2898: Development of the lipid kinase PIKfyve PROTAC degrader against neuroendocrine prostate cancer

Free
Yuanyuan Qiao, Chungen Li, Yang Zheng, Xia Jiang, Sarah Nicole Yee, Caleb Cheng, Yi Bao, Yuping Zhang, Yuzhuo Wang, Zhen Wang, Ke Ding, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2898.
https://doi.org/10.1158/1538-7445.AM2024-2898
Published: 22 March 2024
View articletitled, Abstract 2898: Development of the lipid kinase PIKfyve PROTAC degrader against neuroendocrine prostate cancer
Journal Articles

Abstract 1634: Novel autophagy inhibitor ESK981 potentiates MEK inhibition cytotoxicity in pancreatic cancer

Free
Caleb Cheng, Jasmine Wisniewski, Bailey Jackson, Yi Bao, Yuanyuan Qiao, Costas A. Lyssiotis, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1634.
https://doi.org/10.1158/1538-7445.AM2023-1634
Published: 04 April 2023
View articletitled, Abstract 1634: Novel autophagy inhibitor ESK981 potentiates MEK inhibition cytotoxicity in pancreatic cancer
Journal Articles

Abstract 5502: Androgen blockade confers sensitivity to PIKfyve inhibition in prostate cancer

Free
Yuanyuan Qiao, Sarah Nicole Yee, Caleb Cheng, Yang Zheng, Jie Luo, Yi Bao, Xia Jiang, Xuhong Cao, Yuping Zhang, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5502.
https://doi.org/10.1158/1538-7445.AM2023-5502
Published: 04 April 2023
View articletitled, Abstract 5502: Androgen blockade confers sensitivity to PIKfyve inhibition in prostate cancer
Journal Articles

Abstract 1685: Overcoming acquired resistance to PROTAC degraders

Free
Tongchen He, Caleb Cheng, Abhijit Parolia, Alex Hopkins, Yuanyuan Qiao, Lanbo Xiao, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2023-1685
Published: 04 April 2023
View articletitled, Abstract 1685: Overcoming acquired resistance to PROTAC degraders