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Journal Articles

The genetic, pharmacogenomic, and immune landscapes associated with protein expression across human cancers

Chengxuan Chen, Yuan Liu, Qiang Li, Zhao Zhang, Mei Luo, Yaoming Liu, Leng Han
Journal: Cancer Research
Cancer Res CAN-23-0758.
https://doi.org/10.1158/0008-5472.CAN-23-0758
Published: 07 August 2023
View article titled, The genetic, pharmacogenomic, and immune landscapes associated with protein expression across human cancers
Open the PDF for The genetic, pharmacogenomic, and immune landscapes associated with protein expression across human cancers in another window
Includes: Supplementary data
Journal Articles

Abstract LB340: Spur cell-delivered peptide antigen generates T cell immunity to eradicate mouse KRASG12D spontaneous lung cancer

Shuang Qu, Jiafan Wang, Meng Jia, Hongwei Liang, Yuan Liu, Ke Zen
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB340.
https://doi.org/10.1158/1538-7445.AM2023-LB340
Published: 14 April 2023
View article titled, Abstract LB340: Spur cell-delivered peptide antigen generates T cell immunity to eradicate mouse KRAS<sup>G12D</sup> spontaneous lung cancer
Journal Articles

Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1

Yuan Liu, Mads B. Larsen, Bo Lin, Jason R. Kennerdell, Irene Alfaras, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1805.
https://doi.org/10.1158/1538-7445.AM2023-1805
Published: 04 April 2023
View article titled, Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1
Journal Articles

Abstract 6438: Next-generation pan-cancer immunotherapy with patient-derived APC

Zhen Bian, Lei Shi, Yuan Liu, harry Stylli
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6438.
https://doi.org/10.1158/1538-7445.AM2023-6438
Published: 04 April 2023
View article titled, Abstract 6438: Next-generation pan-cancer immunotherapy with patient-derived APC
Journal Articles

Abstract 1620: Identification of a molecular degrader targeting the AR-V7 splice variant

Yuan Liu, Bo Lin, Mads B. Larsen, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1620.
https://doi.org/10.1158/1538-7445.AM2023-1620
Published: 04 April 2023
View article titled, Abstract 1620: Identification of a molecular degrader targeting the AR-V7 splice variant
Journal Articles

Abstract 1619: Generation of a novel estrogen receptor degrader

Yuan Liu, Jason R. Kennerdell, Bo Lin, Mads B. Larsen, Irene Alfaras, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1619.
https://doi.org/10.1158/1538-7445.AM2023-1619
Published: 04 April 2023
View article titled, Abstract 1619: Generation of a novel estrogen receptor degrader
Journal Articles

Abstract 2720: Enhancing oral delivery of plant-derived vesicles

Yuan Liu, Adrian Lankenau-Ahumada, Emine Bayraktar, Paul Schwartz, Mamur Chowdhury, Sixiang Shi, Manu M. Sebastian, Htet Khant, Natalia De Val, Zuliang Jie, Nicholas B. Jennings, Cristian Rodriguez-Aguayo, Jody Swain, Elaine Stur, Lingegowda S. Mangala, Yutuan Wu, Supriya Nagaraju, Brooke Erimas, Chun Li, Gabriel Lopez-Berestein, Janet Braam, Anil K. Sood
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2720.
https://doi.org/10.1158/1538-7445.AM2023-2720
Published: 04 April 2023
View article titled, Abstract 2720: Enhancing oral delivery of plant-derived vesicles
Journal Articles

Abstract 2337: Overcome solid tumor immunosuppression for T cells-mediated cancer elimination

Lei Shi, Zhen Bian, Jane Zen, Harry Stylli, Yuan Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2337.
https://doi.org/10.1158/1538-7445.AM2023-2337
Published: 04 April 2023
View article titled, Abstract 2337: Overcome solid tumor immunosuppression for T cells-mediated cancer elimination
Journal Articles

Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping

Carsten Denkert, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Erik S. Knudsen, Seock-Ah Im, Angela DeMichele, Agnieszka Witkiewicz, Laura Van ’t Veer, Sung-Bae Kim, Harry D. Bear, Nicole McCarthy, Karen Gelmon, Frederik Marmé, José Ángel García-Sáenz, Nicholas Turner, Federico Rojo, Martin Filipits, Lesley-Ann Martin, Peter A. Fasching, Christian Schem, Catherine M. Kelly, Toralf Reimer, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Yuan Liu, Karsten Weber, Sivaramakrishna Rachakonda, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): HER2-06.
https://doi.org/10.1158/1538-7445.SABCS22-HER2-06
Published: 01 March 2023
View article titled, Abstract HER2-06: HER2-06 Outcome analysis of HER2-zero or HER2-low hormone receptor-positive (HR+) breast cancer patients - characterization of the molecular phenotype in combination with molecular subtyping
Journal Articles

Abstract P5-02-22: Circulating Tumor DNA Genotyping of Intrinsic and Acquired Gene Alterations in Patients With Advanced Breast Cancer Receiving the Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib: Biomarker Results from POLARIS

Debu Tripathy, Joanne L. Blum, Shibing Deng, Steven L. McCune, Kamal Patel, Yao Wang, Shailendra Lakhanpal, Meghan S. Karuturi, Zhe Zhang, Chetan Deshpande, Monica Z. Montelongo, Eric Gauthier, Yuan Liu, Gabrielle B. Rocque, Aditya Bardia
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P5-02-22.
https://doi.org/10.1158/1538-7445.SABCS22-P5-02-22
Published: 01 March 2023
View article titled, Abstract P5-02-22: Circulating Tumor DNA Genotyping of Intrinsic and Acquired Gene Alterations in Patients With Advanced Breast Cancer Receiving the Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib: Biomarker Results from POLARIS
Journal Articles

Abstract P5-02-17: Prognostic and predictive role of RBsig and CCNE1/RB1 gene-expression signatures in patients with advanced breast cancer treated with palbociclib in combination with endocrine therapy in the PALOMA-2 and 3 trials

Luca Malorni, Matteo Benelli, Yuan Liu, Shibing Deng, Zhe Zhang, Cristina Guarducci, Angela Leo, Agostina Nardone, Francesca Galardi, Emanuela Risi, Erica Moretti, Dario Romagnoli, Chiara Biagioni, Marta Paoli, Laura Biganzoli, Ilenia Migliaccio
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P5-02-17.
https://doi.org/10.1158/1538-7445.SABCS22-P5-02-17
Published: 01 March 2023
View article titled, Abstract P5-02-17: Prognostic and predictive role of RBsig and CCNE1/RB1 gene-expression signatures in patients with advanced breast cancer treated with palbociclib in combination with endocrine therapy in the PALOMA-2 and 3 trials
Journal Articles

Abstract GS3-06: GS3-06 Palbociclib After CDK4/6i and Endocrine Therapy (PACE): A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab for Endocrine Pre-treated ER+/HER2- Metastatic Breast Cancer

Erica L. Mayer, Yue Ren, Nikhil Wagle, Reshma Mahtani, Cynthia Ma, Angela DeMichele, Massimo Cristofanilli, Jane Meisel, Kathy D. Miller, Trevor Jolly, Elizabeth Riley, Rubina Qamar, Priyanka Sharma, Sonya Reid, Natalie Sinclair, Meredith Faggen, Caroline Block, Naomi Ko, Ann Partridge, Wendy Y. Chen, Michelle K. DeMeo, Victoria Attaya, Amanda Okpoebo, Yuan Liu, Eric Gauthier, Harold Burstein, Meredith Regan, Sara Tolaney
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): GS3-06.
https://doi.org/10.1158/1538-7445.SABCS22-GS3-06
Published: 01 March 2023
View article titled, Abstract GS3-06: GS3-06 Palbociclib After CDK4/6i and Endocrine Therapy (PACE): A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab for Endocrine Pre-treated ER+/HER2- Metastatic Breast Cancer
Journal Articles

Abstract PD17-06: Immunohistochemical markers and determinants of clinical response in the Penelope-B trial

Erik S. Knudsen, Sivaramakrishna Rachakonda, Frederik Marmé, Miguel Martín, Michael Untch, Hervé R. Bonnefoi, Wolfgang D. Schmitt, Sung-Bae Kim, Harry D. Bear, Agnieszka Witkiewicz, Seock-Ah Im, Angela DeMichele, Laura Van’t Veer, Nicole McCarthy, Bruno V. Sinn, Karen Gelmon, José Ángel García-Sáenz, Catherine M. Kelly, Toralf Reimer, Nicholas Turner, Federico Rojo, Martin Filipits, Peter A. Fasching, Christian Schem, Lesley-Ann Martin, Yuan Liu, Masakazu Toi, Hope Rugo, Michael Gnant, Andreas Makris, Jenny Furlanetto, Karsten Weber, Carsten Denkert, Sibylle Loibl
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD17-06.
https://doi.org/10.1158/1538-7445.SABCS22-PD17-06
Published: 01 March 2023
View article titled, Abstract PD17-06: Immunohistochemical markers and determinants of clinical response in the Penelope-B trial
Journal Articles

Abstract PD17-05: Development and Validation of a Composite Biomarker Predictive of Palbociclib + Endocrine Treatment Benefit in Early Breast Cancer: PENELOPE-B and PALLAS Trials

Sibylle Loibl, Carsten Denkert, Yuan Liu, Erik S. Knudsen, Angela DeMichele, Zhe Zhang, Julia Teply-Szymanski, Martin Filipits, Peter A. Fasching, Michael Gnant, Shibing Deng, Marija Balic, Federico Rojo, Mark Watson, Chetan Deshpande, Nicholas Turner, Otto Metzger, Kathy Puyana Theall, Agnieszka Witkiewicz, Olga Valota, W. Fraser Symmans, Erica L. Mayer
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD17-05.
https://doi.org/10.1158/1538-7445.SABCS22-PD17-05
Published: 01 March 2023
View article titled, Abstract PD17-05: Development and Validation of a Composite Biomarker Predictive of Palbociclib + Endocrine Treatment Benefit in Early Breast Cancer: PENELOPE-B and PALLAS Trials
Journal Articles

Abstract 936: Developing a sex-biased model for LKB1-mutant lung adenocarcinoma

Yijian Fan, Rui Jin, Xiuju Liu, Yuan Liu, Chunzi Huang, Mellissa Gilbert-Ross, Adam Marcus, Wei Zhou
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 936.
https://doi.org/10.1158/1538-7445.AM2022-936
Published: 15 June 2022
View article titled, Abstract 936: Developing a sex-biased model for LKB1-mutant lung adenocarcinoma
Journal Articles

Abstract 4082: Expression of chimeric antigen receptor therapy targets in subpopulations detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity

Ying Jing, Yuan Liu, Qiang Li, Leng Han
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4082.
https://doi.org/10.1158/1538-7445.AM2022-4082
Published: 15 June 2022
View article titled, Abstract 4082: Expression of chimeric antigen receptor therapy targets in subpopulations detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity
Journal Articles

Abstract 3142: BRMS1 alters the tumor inflammatory signature and immune infiltration in lung adenocarcinoma

Manendra B. Lankadasari, Yuan Liu, Di He, Samhita Bapat, Brooke Mastrogiacomo, Harry B. Lengel, David R. Jones
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3142.
https://doi.org/10.1158/1538-7445.AM2022-3142
Published: 15 June 2022
View article titled, Abstract 3142: BRMS1 alters the tumor inflammatory signature and immune infiltration in lung adenocarcinoma
Journal Articles

Abstract 2439: Targeting c-fos to suppress metastasis inBRMS1v2germline mutantlung adenocarcinoma

Yuan Liu, David Jones
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2439.
https://doi.org/10.1158/1538-7445.AM2022-2439
Published: 15 June 2022
View article titled, Abstract 2439: Targeting c-fos to suppress metastasis in<em>BRMS1v2</em>germline mutantlung adenocarcinoma
Journal Articles

Abstract 695: Patient derived organoids model lung adenocarcinoma metastases

Yuan Liu, David Jones
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 695.
https://doi.org/10.1158/1538-7445.AM2022-695
Published: 15 June 2022
View article titled, Abstract 695: Patient derived organoids model lung adenocarcinoma metastases
Journal Articles

Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers

Zhao Zhang, Mei Luo, Qiang Li, Yuan Liu, Charles Lussier, Jian Zhang, Youqiong Ye, An-Yuan Guo, Leng Han
Journal: Cancer Research
Cancer Res (2022) 82 (5): 785–790.
https://doi.org/10.1158/0008-5472.CAN-21-2058
Published: 03 March 2022
View article titled, Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers
Open the PDF for Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers in another window
Includes: Supplementary data