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Journal Articles

VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer

Tenzin Passang, Shuhua Wang, Hanwen Zhang, Fanyuan Zeng, Po-Chih Hsu, Wenxi Wang, Jian-Ming Li, Yuan Liu, Sruthi Ravindranathan, Gregory B. Lesinski, Edmund K. Waller
Journal: Cancer Research
Cancer Res (2024) 84 (18): 2954–2967.
https://doi.org/10.1158/0008-5472.CAN-23-3628
Published: 16 September 2024
View article titled, VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer
Open the PDF for VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO1-15-10: Lower pre-treatment B-cell gene expression signatures correspond with improved overall survival with palbociclib + endocrine therapy in HR+/HER2- metastatic breast cancer: a biomarker analysis from the GEICAM/2013-02 PEARL trial

Yash Agrawal, Aranzazu Fernandez-Martinez, Miguel Gil-Gil, Christoph Zielinski, Manuel Ruíz- Borrego, Eva Ciruelos, Montserrat Muñoz, Mireia Margelí, Begoña Bermejo, Antonio Antón, Zsuzsanna Kahan, Tibor Csöszi, José L Alonso-Romero, Jose Angel García-Sáenz, Pedro Sánchez-Rovira, Elena Álvarez, J. Ignacio Chacón, Santiago González-Santiago, César A Rodríguez, Sonia Servitja, Adam D. Pfefferle, Jesús Herranz, Yuan Liu, Lisa A. Carey, Isabel Romero - Camarero, Rosalía Caballero, Charles M. Perou, Miguel Martín
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-15-10.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-15-10
Published: 02 May 2024
View article titled, Abstract PO1-15-10: Lower pre-treatment B-cell gene expression signatures correspond with improved overall survival with palbociclib + endocrine therapy in HR+/HER2- metastatic breast cancer: a biomarker analysis from the GEICAM/2013-02 PEARL trial
Journal Articles

Abstract PO1-01-13: Clinical characterization, prognostic and predictive values of HER2-low in early breast cancer in the PALLAS trial

Guilherme Nader-Marta, Christian F. Singer, Dominik Hlauschek, Angela DeMichele, Paolo Tarantino, Georg Pfeiler, Miguel Martín, Justin Balko, Zbigniew Nowecki, Marija Balic, Adam Brufsky, Arlene Chan, Patrick G. Morris, Tufia Haddad, Sibylle Loibl, Yuan Liu, Lidija Sölkner, Christian Fesl, Erica Mayer, Michael Gnant
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-01-13.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-01-13
Published: 02 May 2024
View article titled, Abstract PO1-01-13: Clinical characterization, prognostic and predictive values of HER2-low in early breast cancer in the PALLAS trial
Journal Articles

Abstract PS12-02: Exploration of ctDNA Dynamics in the PACE Trial: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab for HR+/HER2- Metastatic Breast Cancer

Rinath Jeselsohn, Jingxin Fu, Yue Ren, Reshma Mahtani, Cynthia Ma, Angela DeMichele, Massimo Cristofanilli, Jane Meisel, Kathy Miller, Yara Abdou, Elizabeth Riley, Rubina Qamar, Priyanka Sharma, Sonya Reid, Naomi Ko, Yuan Liu, Harold Burstein, Michelle DeMeo, Sara Tolaney, Erica Mayer
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS12-02.
https://doi.org/10.1158/1538-7445.SABCS23-PS12-02
Published: 02 May 2024
View article titled, Abstract PS12-02: Exploration of ctDNA Dynamics in the PACE Trial: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab for HR+/HER2- Metastatic Breast Cancer
Journal Articles

Abstract GS03-07: Protocol-defined biomarker analysis in the PALLAS (AFT-05) adjuvant trial: Genomic subtype derived from RNA sequencing of HR+/HER2- early breast cancer

Daniel Stover, Dominik Hlauschek, Erica Mayer, W. Fraser Symmans, Mark Watson, Iros Barozzi, Martin Filipits, Karla Ballman, Meritxell Bellet- Ezquerra, Justin Balko, Gabor Rubovszky, Nicholas Zdenkowski, Adam Brufsky, Guenther Steger, Claudine Isaacs, Sibylle Loibl, Fernando Henao, Meredith Regan, Yuan Liu, Christian Fesl, Patrick O'Brien, Angela DeMichele, Michael Gnant, Otto Metzger
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): GS03-07.
https://doi.org/10.1158/1538-7445.SABCS23-GS03-07
Published: 02 May 2024
View article titled, Abstract GS03-07: Protocol-defined biomarker analysis in the PALLAS (AFT-05) adjuvant trial: Genomic subtype derived from RNA sequencing of HR+/HER2- early breast cancer
Journal Articles

Abstract PO1-19-12: VERITAC-2: a phase 3 study of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, vs fulvestrant in ER–positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer

Mario Campone, Cynthia Ma, Michelino de Laurentiis, Hiroji Iwata, Sara Hurvitz, Seth Wander, Michael Danso, Dongrui Lu, Julia Perkins Smith, Yuan Liu, Lana Tran, Sibyl Anderson, Erika Hamilton
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-19-12.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-19-12
Published: 02 May 2024
View article titled, Abstract PO1-19-12: VERITAC-2: a phase 3 study of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, vs fulvestrant in ER–positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer
Journal Articles

Abstract PO2-20-03: VERITAC-3: A randomized phase 3 study, with a lead-in, of first-line vepdegestrant + palbociclib vs letrozole + palbociclib in estrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer

Seth Wander, Erika Hamilton, Mario Campone, Michael Danso, Sara Hurvitz, Hiroji Iwata, Colombe Chappey, Derek Yang, Julia Perkins Smith, Yuan Liu, Yuanyuan Zhang, Sibyl Anderson, Michelino de Laurentiis
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-20-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-20-03
Published: 02 May 2024
View article titled, Abstract PO2-20-03: VERITAC-3: A randomized phase 3 study, with a lead-in, of first-line vepdegestrant + palbociclib vs letrozole + palbociclib in estrogen receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer
Journal Articles

Abstract 3707: Characterization of estrogen receptor expression on CTCs during CDK4/6i treatment in HR+/HER2- metastatic breast cancer: Results from the PACE phase II study

Mara Serena Serafini, Carolina Reduzzi, Lorenzo Gerratana, Rinath Jeselsohn, Reshma L. Mahtani, Cynthia X. Ma, Angela DeMichele, Jane Lowe Meisel, Kathy D. Miller, Yara Abdou, Elizabeth C. Riley, Rubina Qamar, Priyanka Sharma, Sonya Reid, Harold J. Burstein, Sara M. Tolaney, Michelle K. DeMeo, Yuan Liu, Eric Gauthier, Yue Ren, Meredith M. Regan, Huiping Liu, Erica L. Mayer, Massimo Cristofanilli
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3707.
https://doi.org/10.1158/1538-7445.AM2024-3707
Published: 22 March 2024
View article titled, Abstract 3707: Characterization of estrogen receptor expression on CTCs during CDK4/6i treatment in HR+/HER2- metastatic breast cancer: Results from the PACE phase II study
Journal Articles

Abstract 7613: Association of KAT6A expression with clinical outcomes in previously treated HR-positive and HER2-negative metastatic breast cancer

Massimo Cristofanilli, Li Liu, Shibing Deng, Xin Huang, Fabrice André, Sibylle Loibl, Angela DeMichele, Eric Gauthier, Yuan Liu, Nicholas C. Turner
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7613.
https://doi.org/10.1158/1538-7445.AM2024-7613
Published: 22 March 2024
View article titled, Abstract 7613: Association of KAT6A expression with clinical outcomes in previously treated HR-positive and HER2-negative metastatic breast cancer
Journal Articles

Abstract 6596: BRMS1 downregulation alters the tumor microenvironment and induces immunotherapy resistance in lung adenocarcinoma

Manendra B. Lankadasari, Yuan Liu, Brooke Mastrogiacomo, Yingjie Zhu, Elizabeth G. Dunne, Cameron N. Fick, Choudhary Harsha, Jorge S. Reis-Filho, David R. Jones
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6596.
https://doi.org/10.1158/1538-7445.AM2024-6596
Published: 22 March 2024
View article titled, Abstract 6596: BRMS1 downregulation alters the tumor microenvironment and induces immunotherapy resistance in lung adenocarcinoma
Journal Articles

Abstract 2556: Longitudinal analyses of clinical sequencing data provide novel insights into the evolutionary dynamics of lung adenocarcinoma

Brooke Mastrogiacomo, Elizabeth G. Dunne, Cameron N. Fick, John Nguyen, Jairam Hathwar, Manendra Lankadasari, Yuan Liu, Soo-Ryum Yang, Jason Chang, Walid K. Chatila, Nikolaus Schultz, David R. Jones, Francisco Sanchez-Vega
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2556.
https://doi.org/10.1158/1538-7445.AM2024-2556
Published: 22 March 2024
View article titled, Abstract 2556: Longitudinal analyses of clinical sequencing data provide novel insights into the evolutionary dynamics of lung adenocarcinoma
Journal Articles

Abstract 6071: Identification of a molecular glue degrader targeting the full-length AR and AR-V7 splice variant

Yuan Liu, Mads B. Larsen, Bo Lin, Irene A. Cardenal, Jason Kennerdell, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6071.
https://doi.org/10.1158/1538-7445.AM2024-6071
Published: 22 March 2024
View article titled, Abstract 6071: Identification of a molecular glue degrader targeting the full-length AR and AR-V7 splice variant
Journal Articles

Abstract 6070: Identification of a molecular glue degrader that engages a cancer-specific E3 ligase

Yuan Liu, Mads Larsen, Bo Lin, Irene A. Cardenal, Jason R. Kennerdell, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6070.
https://doi.org/10.1158/1538-7445.AM2024-6070
Published: 22 March 2024
View article titled, Abstract 6070: Identification of a molecular glue degrader that engages a cancer-specific E3 ligase
Journal Articles

The Genetic, Pharmacogenomic, and Immune Landscapes Associated with Protein Expression across Human Cancers

Chengxuan Chen, Yuan Liu, Qiang Li, Zhao Zhang, Mei Luo, Yaoming Liu, Leng Han
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3673–3680.
https://doi.org/10.1158/0008-5472.CAN-23-0758
Published: 15 November 2023
View article titled, The Genetic, Pharmacogenomic, and Immune Landscapes Associated with Protein Expression across Human Cancers
Open the PDF for The Genetic, Pharmacogenomic, and Immune Landscapes Associated with Protein Expression across Human Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract LB340: Spur cell-delivered peptide antigen generates T cell immunity to eradicate mouse KRASG12D spontaneous lung cancer

Shuang Qu, Jiafan Wang, Meng Jia, Hongwei Liang, Yuan Liu, Ke Zen
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB340.
https://doi.org/10.1158/1538-7445.AM2023-LB340
Published: 14 April 2023
View article titled, Abstract LB340: Spur cell-delivered peptide antigen generates T cell immunity to eradicate mouse KRAS<sup>G12D</sup> spontaneous lung cancer
Journal Articles

Abstract 1620: Identification of a molecular degrader targeting the AR-V7 splice variant

Yuan Liu, Bo Lin, Mads B. Larsen, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1620.
https://doi.org/10.1158/1538-7445.AM2023-1620
Published: 04 April 2023
View article titled, Abstract 1620: Identification of a molecular degrader targeting the AR-V7 splice variant
Journal Articles

Abstract 1619: Generation of a novel estrogen receptor degrader

Yuan Liu, Jason R. Kennerdell, Bo Lin, Mads B. Larsen, Irene Alfaras, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1619.
https://doi.org/10.1158/1538-7445.AM2023-1619
Published: 04 April 2023
View article titled, Abstract 1619: Generation of a novel estrogen receptor degrader
Journal Articles

Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1

Yuan Liu, Mads B. Larsen, Bo Lin, Jason R. Kennerdell, Irene Alfaras, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, Bill B. Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1805.
https://doi.org/10.1158/1538-7445.AM2023-1805
Published: 04 April 2023
View article titled, Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1
Journal Articles

Abstract 6438: Next-generation pan-cancer immunotherapy with patient-derived APC

Zhen Bian, Lei Shi, Yuan Liu, harry Stylli
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6438.
https://doi.org/10.1158/1538-7445.AM2023-6438
Published: 04 April 2023
View article titled, Abstract 6438: Next-generation pan-cancer immunotherapy with patient-derived APC
Journal Articles

Abstract 2337: Overcome solid tumor immunosuppression for T cells-mediated cancer elimination

Lei Shi, Zhen Bian, Jane Zen, Harry Stylli, Yuan Liu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2337.
https://doi.org/10.1158/1538-7445.AM2023-2337
Published: 04 April 2023
View article titled, Abstract 2337: Overcome solid tumor immunosuppression for T cells-mediated cancer elimination