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Journal Articles

Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states

Yuan Lin, Theresa A. Ramelot, Simge Senyuz, Attila Gursoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4388.
https://doi.org/10.1158/1538-7445.AM2024-4388
Published: 22 March 2024
View article titled, Abstract 4388: Tumor-associated RhoA mutants interact with effectors in both GDP- and GTP-bound states
Journal Articles

Abstract 1550: Identification of a novel squalene epoxidase function in breast cancer brain metastasis

Shu-Ping Wang, Jia-Yun Yeh, Yu-Ling (Pony) Lee, Kun-Yuan Lin, Chao-Di Chang, Chih-Chieh Yang, Shan-Yun Cheng, Ya-Wen Hung, Yu-Hsien Chang, Yao-Feng Li, Yung-Lung Yu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1550.
https://doi.org/10.1158/1538-7445.AM2024-1550
Published: 22 March 2024
View article titled, Abstract 1550: Identification of a novel squalene epoxidase function in breast cancer brain metastasis
Journal Articles

Abstract 2366: Balancing efficacy and toxicity of a fibroblast activation protein dependent tetravalent CD40 agonist antibody for cancer therapy

Simeng Chen, Yuan Lin, Xiaoru Zhou, Xing Sun, Changyong Yang, Cheng Liao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2366.
https://doi.org/10.1158/1538-7445.AM2024-2366
Published: 22 March 2024
View article titled, Abstract 2366: Balancing efficacy and toxicity of a fibroblast activation protein dependent tetravalent CD40 agonist antibody for cancer therapy
Journal Articles

Abstract 3384: Rapid and automated tumor cell phenotyping based on annexin-mediated enforce blebbing response

Wei Huang, Zheng Wang, Dennis Wai-Yin Au, Bingxian Tang, Baiqian Qi, William C. Cho, Yuan Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3384.
https://doi.org/10.1158/1538-7445.AM2024-3384
Published: 22 March 2024
View article titled, Abstract 3384: Rapid and automated tumor cell phenotyping based on annexin-mediated enforce blebbing response
Journal Articles

Abstract 1449: Targeting squalene epoxidase for breast cancer brain metastasis: The evaluation of a new therapeutic target for brain extravasation and colonization using animal models

Pony Yu-Ling Lee, Kun-Yuan Lin, Chao-Di Chang, Shan-Yun Cheng, Ya-Wen Hung, Chih-Chieh Yang, Yu-Hsien Chang, Chien-Chang Shen, Jia-Yun Yeh, Yung-Lung Yu, Shu-Ping Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1449.
https://doi.org/10.1158/1538-7445.AM2024-1449
Published: 22 March 2024
View article titled, Abstract 1449: Targeting squalene epoxidase for breast cancer brain metastasis: The evaluation of a new therapeutic target for brain extravasation and colonization using animal models
Journal Articles

Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression

Marvin A. Aberin, Yu-Ling (Pony) Lee, Xin-Guo Hsu, Chen-Yang Shen, Yao-Ming Chang, Kun-Yuan Lin, Chandan Guha, Shu-Ping Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3646.
https://doi.org/10.1158/1538-7445.AM2023-3646
Published: 04 April 2023
View article titled, Abstract 3646: New functional role of tamoxifen in breast cancer immunomodulation: role of RACK7 in activation of type I interferon signaling and CEACAM1/TIM-3-dependent immunosuppression
Journal Articles

Abstract 5953: Reshaping the tumor microenvironment: new application of tamoxifen in triple negative breast cancer immunomodulation

Pony Yu-Ling Lee, Marvin A. Aberin, Chien-Chang Shen, Kun-Yuan Lin, Chao Di Chang, Chih-Chieh Yang, Shan-Yun Cheng, Ya Wen Hung, Xin-Guo Hsu, Shu-Ping Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5953.
https://doi.org/10.1158/1538-7445.AM2023-5953
Published: 04 April 2023
View article titled, Abstract 5953: Reshaping the tumor microenvironment: new application of tamoxifen in triple negative breast cancer immunomodulation
Journal Articles

Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression

Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2520–2537.
https://doi.org/10.1158/0008-5472.CAN-22-0668
Published: 18 July 2022
View article titled, Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression
Open the PDF for Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 6002: Invasiveness-dependent mechanical plasticity of cancer cells

Xingyu Xia, Zishen Yan, William C. Cho, Yuan Lin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6002.
https://doi.org/10.1158/1538-7445.AM2022-6002
Published: 15 June 2022
View article titled, Abstract 6002: Invasiveness-dependent mechanical plasticity of cancer cells
Journal Articles

Abstract LB198: Inhibition of the RAC Activator VAV3 by the small molecule IODVA1 impedes RAC signaling & overcomes resistance to tyrosine kinase inhibition in lymphoblastic leukemia

Nicolas N. Nassar, Shailaja Hegde, Kark Wunderlich, Yuan Lin, Reza Ahmadian, William Seibel, Yi Zheng, Benjamin E. Mizukawa, Lisa Privette Vinnedge, Jose A. Cancelas
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB198.
https://doi.org/10.1158/1538-7445.AM2021-LB198
Published: 01 July 2021
View article titled, Abstract LB198: Inhibition of the RAC Activator VAV3 by the small molecule IODVA1 impedes RAC signaling & overcomes resistance to tyrosine kinase inhibition in lymphoblastic leukemia
Journal Articles

Abstract 498: ZL-1201, a differentiated CD47 therapeutic antibody with improved hematological safety profile

Bing Wan, Xu Fang, Shou Li, Wenhua Shi, Holly Li, David Bellovin, Lei Wang, Yusong Zhu, Yuan Lin, Shali Qi, Sophia Yin, Frank Tao, Lishan Kang, Omar Kabbarah, Haiying Zhou, Petter Veiby, James Yan, Karl Hsu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 498.
https://doi.org/10.1158/1538-7445.AM2021-498
Published: 01 July 2021
View article titled, Abstract 498: ZL-1201, a differentiated CD47 therapeutic antibody with improved hematological safety profile
Journal Articles

Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation

Nana Dang, Yuan Lin, Omer Rutgeerts, Xavier Sagaert, An D. Billiau, Mark Waer, Ben Sprangers
Journal: Cancer Research
Cancer Res (2019) 79 (10): 2709–2721.
https://doi.org/10.1158/0008-5472.CAN-18-3143
Published: 15 May 2019
View article titled, Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation
Open the PDF for Solid Tumor–Induced Immune Regulation Alters the GvHD/GvT Paradigm after Allogenic Bone Marrow Transplantation in another window
Includes: Supplementary data
Journal Articles

Abstract 3359: Elucidating the oncogenic mechanism of the TAZ-CAMTA1 and YAP-TFE3 fusion proteins

Nicole Merritt, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina Mitchell, Colleen Fullenkamp, Anne-Claude Gingras, Kieran Harvey, Munir Tanas
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3359.
https://doi.org/10.1158/1538-7445.AM2018-3359
Published: 01 July 2018
View article titled, Abstract 3359: Elucidating the oncogenic mechanism of the TAZ-CAMTA1 and YAP-TFE3 fusion proteins
Journal Articles

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

Rasha Abu Eid, Shamim Ahmad, Yuan Lin, Mason Webb, Zuzana Berrong, Rajeev Shrimali, Takumi Kumai, Sudha Ananth, Paulo C. Rodriguez, Esteban Celis, John Janik, Mikayel Mkrtichyan, Samir N. Khleif
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (15): 4135–4145.
https://doi.org/10.1158/0008-5472.CAN-16-1925
Published: 01 August 2017
View article titled, Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by <em>Ex Vivo</em> PI3K-δ Inhibition
Open the PDF for Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by <em>Ex Vivo</em> PI3K-δ Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 4581: A novel modular polymer platform for the treatment of oral and head and neck carcinoma

Yuan Lin, Sherven Sharma, Steven M. Dubinett, Ben Wu, Maie St. John
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4581.
https://doi.org/10.1158/1538-7445.AM2014-4581
Published: 01 October 2014
View article titled, Abstract 4581: A novel modular polymer platform for the treatment of oral and head and neck carcinoma
Journal Articles

Abstract 1141: p53-dependent regulation of epithelial-to-mescenchymal transition by nf-κb in head and neck squamous cell carcinoma

Yuan Lin, Jie Luo, Elliot Abemayor, Sherven Sharma, Steven Dubinett, Maie S. John
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1141.
https://doi.org/10.1158/1538-7445.AM2014-1141
Published: 01 October 2014
View article titled, Abstract 1141: p53-dependent regulation of epithelial-to-mescenchymal transition by nf-κb in head and neck squamous cell carcinoma
Journal Articles

ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway

Chen-Yuan Lin, Hung-Jen Chen, Cheng-Chung Huang, Liang-Chuan Lai, Tzu-Pin Lu, Guan-Chin Tseng, Ting-Ting Kuo, Qian-Yu Kuok, Jennifer L. Hsu, Shian-Ying Sung, Mien-Chie Hung, Yuh-Pyng Sher
Journal: Cancer Research
Cancer Res (2014) 74 (18): 5229–5243.
https://doi.org/10.1158/0008-5472.CAN-13-2995
Published: 14 September 2014
View article titled, ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Open the PDF for ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway in another window
Includes: Supplementary data
Journal Articles

Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation

Cleo Yi-Fang Lee, Yuan Lin, Scott V. Bratman, Weiguo Feng, Angera H. Kuo, Ferenc A. Scheeren, Jesse M. Engreitz, Sushama Varma, Robert B. West, Maximilian Diehn
Journal: Cancer Research
Cancer Res (2014) 74 (1): 341–352.
https://doi.org/10.1158/0008-5472.CAN-13-1055
Published: 05 January 2014
View article titled, Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation
Open the PDF for Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation in another window
Includes: Supplementary data
Journal Articles

Abstract 1490: p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and snail in head and neck squamous cell carcinoma (HNSCC).

Yuan Lin, Guangyu Wang, Jie Luo, Chi Lai, Elliot Abemayor, David Elashoff, Steve Dubinett, Maie A. St. John
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1490.
https://doi.org/10.1158/1538-7445.AM2013-1490
Published: 15 April 2013
View article titled, Abstract 1490: p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and snail in head and neck squamous cell carcinoma (HNSCC).
Journal Articles

Abstract 3374: Characterizing a new population of adult mouse submandibular gland stem cells

Nan Xiao, Yuan Lin, Maximilian Diehn, Quynh-Thu Le
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3374.
https://doi.org/10.1158/1538-7445.AM2012-3374
Published: 15 April 2012
View article titled, Abstract 3374: Characterizing a new population of adult mouse submandibular gland stem cells