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Abstract LB217: ROBO1 promotes homing, dissemination, and survival of multiple myeloma within the bone marrow microenvironment

Giada Bianchi, Peter G. Czarnecki, Matthew Ho, Aldo M. Roccaro, Antonio Sacco, Yawara Kawano, Annamaria Gulla, Anil Aktas Samur, Tianzeng Cheng, Kenneth Wen, Yu-Tzu Tai, Maria Moscvin, Xinchen Wu, Gulden Camci-Unal, Matteo Claudio Da VIa, Niccolo Bolli, Ruben D. Carrasco, Irene M. Ghobrial, Kenneth C. Anderson

Cancer Res (2021) 81 (13_Supplement): LB217.

DOI: https://doi.org/10.1158/1538-7445.AM2021-LB217

Published: 01 July 2021

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Journal Articles

Abstract 2240: Genomic profiling of smoldering multiple myeloma classifies distinct molecular groups

Shankara Anand, Mark Bustoros, François Aguet, Romanos Sklavenitis-Pistofidis, Robert Redd, Benny Zhitomirsky, Andrew J. Dunford, Yu-Tzu Tai, Selina J. Chavda, Cody Boehner, Carl J. Neuse, Tineke Casneuf, Lorenzo Trippa, Chip Stewart, Kwee Yong, Irene Ghobrial, Gad Getz

Cancer Res (2021) 81 (13_Supplement): 2240.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2240

Published: 01 July 2021

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Journal Articles

Abstract 642: TRAF2 mediates sensitivity to immunomodulatory drugs via NF-κB and ERK signaling in myeloma cells

Jiye Liu, Teru Hideshima, Lijie Xing, Su Wang, Wenrong Zhou, Daisuke Ogiya, Kenneth Wen, Yu-Tzu Tai, Yong Cang, Kenneth C. Anderson

Cancer Res (2020) 80 (16_Supplement): 642.

DOI: https://doi.org/10.1158/1538-7445.AM2020-642

Published: 15 August 2020

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Journal Articles

Abstract 383: APOBEC3B is induced by activation of DNA repair pathway and modulates the survival and treatment response in human multiple myeloma

Lijie Xing, Jiye Liu, Liang Lin, Shih-Feng Cho, Kenneth Wen, Tengteng Yu, Gang An, Ligui Qiu, Kenneth Anderson, Yu-Tzu Tai

Cancer Res (2019) 79 (13_Supplement): 383.

DOI: https://doi.org/10.1158/1538-7445.AM2019-383

Published: 01 July 2019

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Journal Articles

Abstract 567: The lysosomal transporter SLC46A3 is a potential predictive biomarker for antibody-drug conjugates bearing the non-cleavable warheads SG3376 and DM1

Krista Kinneer, Yu-Tzu Tai, Sriram Sridhar, John Meekin, Sandrina Phipps, Ben Ruddle, Ryan Fleming, Nazzareno Dimasi, Ronald Herbst, Arnaud Tiberghien, Luke Masterson, Philip Howard, Kenneth Anderson, David Tice

Cancer Res (2018) 78 (13_Supplement): 567.

DOI: https://doi.org/10.1158/1538-7445.AM2018-567

Published: 01 July 2018

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Journal Articles

Abstract 3832: A proliferation-inducing ligand (APRIL) directly impacts immune regulatory subsets to regulate suppressive multiple myeloma bone marrow microenvironment

Yu-Tzu Tai, Liang Lin, Liji Xing, Liji Xing, Kenneth Wen, Nikhil Munshi, Paul Richardson, Kenneth Anderson

Cancer Res (2018) 78 (13_Supplement): 3832.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3832

Published: 01 July 2018

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Journal Articles

Abstract 3283: APRIL/BCMA activation promotes human multiple myeloma progression and further induces immunosuppressive bone marrow microenvironment

Yu-Tzu Tai, Chirag Acharya, Gang An, Michele Moschetta, Mike Y. Zhong, Xiaoyan Feng, Michele Cea, Antonia Cagnetta, Kenneth Wen, Hans van Eenennaam, Andrea van Elsas, Nikhil Munshi, Kenneth Anderson

Cancer Res (2016) 76 (14_Supplement): 3283.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3283

Published: 15 July 2016

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Journal Articles

Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma

Jian-Jun Zhao, Zhang-Bo Chu, Yu Hu, Jianhong Lin, Zhongqiu Wang, Meng Jiang, Ming Chen, Xujun Wang, Yue Kang, Yangsheng Zhou, Triona Ni Chonghaile, Melanie E. Johncilla, Yu-Tzu Tai, Jin Q. Cheng, Antony Letai, Nikhil C. Munshi, Kenneth C. Anderson, Ruben D. Carrasco

Cancer Res (2015) 75 (20): 4384–4397.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-0457

Published: 14 October 2015

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Includes: Supplementary data

Journal Articles

Abstract 394: A novel anti-a proliferation-inducing ligand hAPRIL.01A monoclonal antibody targets multiple myeloma cells in the bone marrow microenvironment

Yu-Tzu Tai, Chirag Acharya, Gang An, Mike Y. Zhong, Xiaoyan Feng, Hua Jiang, Hans van Eenennaam, Andrea van Elsas, Nikhil C. Munshi, Kenneth C. Anderson

Cancer Res (2015) 75 (15_Supplement): 394.

DOI: https://doi.org/10.1158/1538-7445.AM2015-394

Published: 01 August 2015

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Journal Articles

Abstract 644: Novel anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity via enhanced effector function and direct tumor cell killing

Yu-Tzu Tai, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Patrick A. Mayes, Jenny Craigen, Louise Gliddon, James Smothers, Amanda L. Christie, Andrew L. Kung, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson

Cancer Res (2014) 74 (19_Supplement): 644.

DOI: https://doi.org/10.1158/1538-7445.AM2014-644

Published: 01 October 2014

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Journal Articles

Abstract LB-38: Zebrafish embryos provide a permissive environment for the growth and dissemination of primary human myeloma and its precursor cells

Dongdong MA, Arinze Nwokeji, Jianhong Lin, Yu-Tzu Tai, Nikhil Munshi, Robert I. Handin

Cancer Res (2014) 74 (19_Supplement): LB-38.

DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-38

Published: 01 October 2014

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Journal Articles

Abstract 972: B-cell maturation antigen (BCMA) activation in human multiple myeloma cells promotes myeloma cell growth and survival in the bone marrow microenvironment via upregulated MCL-1 and NFκB signaling

Yu-Tzu Tai, Chirag Acharya, Mike Y. Zhong, Michele Cea, Antonia Cagnetta, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson

Cancer Res (2014) 74 (19_Supplement): 972.

DOI: https://doi.org/10.1158/1538-7445.AM2014-972

Published: 01 October 2014

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Journal Articles

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition

Naoya Mimura, Teru Hideshima, Toshiyasu Shimomura, Rikio Suzuki, Hiroto Ohguchi, Ola Rizq, Shohei Kikuchi, Yasuhiro Yoshida, Francesca Cottini, Jana Jakubikova, Diana Cirstea, Gullu Gorgun, Jiro Minami, Yu-Tzu Tai, Paul G. Richardson, Teruhiro Utsugi, Atsushi Iwama, Kenneth C. Anderson

Cancer Res (2014) 74 (16): 4458–4469.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-3652

Published: 13 August 2014

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Includes: Supplementary data

Journal Articles

miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway

Cancer Res (2014) 74 (6): 1801–1813.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-3311-T

Published: 13 March 2014

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Includes: Supplementary data

Journal Articles

Abstract 2142: The nuclear export protein CRM1 (XPO1) regulates multiple myeloma cell growth, osteoclastogenesis, and myeloma-induced osteolysis.

Cancer Res (2013) 73 (8_Supplement): 2142.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2142

Published: 15 April 2013

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Journal Articles

Abstract 2934: Targeting Bruton's tyrosine kinase with PCI-32765 blocks growth and survival of multiple myeloma and Waldenström macroglobulinemia via potent inhibition of osteoclastogenesis, cytokines/chemokine secretion, and myeloma stem-like cells in the bone marrow microenvironment

Cancer Res (2012) 72 (8_Supplement): 2934.

DOI: https://doi.org/10.1158/1538-7445.AM2012-2934

Published: 15 April 2012

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Journal Articles

Abstract 400: Establishment and characterization of a novel IL6-dependent HLA-A2+ human myeloma cell line LNT1

Sun-Young Kong, Weihua Song, Xian-Feng Li, Sabikun Nahar, Paola Dal Cin, Cynthia J. McLaughlin, Ruben D. Carrasco, Catherine J. Wu, Lili Wang, Nikhil C. Munshi, Kenneth C. Anderson, Yu-Tzu Tai

Cancer Res (2010) 70 (8_Supplement): 400.

DOI: https://doi.org/10.1158/1538-7445.AM10-400

Published: 15 April 2010

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Journal Articles

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma

Jing Zhang, Martin Sattler, Giovanni Tonon, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc S. Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Teru Hideshima, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson, Klaus Podar

Cancer Res (2009) 69 (12): 5082–5090.

DOI: https://doi.org/10.1158/0008-5472.CAN-08-4603

Published: 15 June 2009

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Includes: Supplementary data

Journal Articles

Abstract #3185: Targeting angiogenesis via a c-Myc/ Hif-1\#945;- dependent pathway in MM

Klaus Podar, Jing Zhang, Giovanni Tonon, Martin Sattler, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Yu-Tzu Tai, Dharminder Chauhan, Kenneth Anderson

Cancer Res (2009) 69 (9_Supplement): 3185.

Published: 01 May 2009

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Journal Articles

Abstract #2236: Potential therapeutic role of the selective adhesion molecule inhibitor natalizumab (Tysabri) in Multiple Myeloma

Klaus Podar, Alexander Zimmerhackl, Dian Olson, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson

Cancer Res (2009) 69 (9_Supplement): 2236.

Published: 01 May 2009

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NARROW

Abstract LB217: ROBO1 promotes homing, dissemination, and survival of multiple myeloma within the bone marrow microenvironment

Abstract 2240: Genomic profiling of smoldering multiple myeloma classifies distinct molecular groups

Abstract 642: TRAF2 mediates sensitivity to immunomodulatory drugs via NF-κB and ERK signaling in myeloma cells

Abstract 383: APOBEC3B is induced by activation of DNA repair pathway and modulates the survival and treatment response in human multiple myeloma

Abstract 567: The lysosomal transporter SLC46A3 is a potential predictive biomarker for antibody-drug conjugates bearing the non-cleavable warheads SG3376 and DM1

Abstract 3832: A proliferation-inducing ligand (APRIL) directly impacts immune regulatory subsets to regulate suppressive multiple myeloma bone marrow microenvironment

Abstract 3283: APRIL/BCMA activation promotes human multiple myeloma progression and further induces immunosuppressive bone marrow microenvironment

Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma

Abstract 394: A novel anti-a proliferation-inducing ligand hAPRIL.01A monoclonal antibody targets multiple myeloma cells in the bone marrow microenvironment

Abstract 644: Novel anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity via enhanced effector function and direct tumor cell killing

Abstract LB-38: Zebrafish embryos provide a permissive environment for the growth and dissemination of primary human myeloma and its precursor cells

Abstract 972: B-cell maturation antigen (BCMA) activation in human multiple myeloma cells promotes myeloma cell growth and survival in the bone marrow microenvironment via upregulated MCL-1 and NFκB signaling

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition

miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway

Abstract 2142: The nuclear export protein CRM1 (XPO1) regulates multiple myeloma cell growth, osteoclastogenesis, and myeloma-induced osteolysis.

Abstract 2934: Targeting Bruton's tyrosine kinase with PCI-32765 blocks growth and survival of multiple myeloma and Waldenström macroglobulinemia via potent inhibition of osteoclastogenesis, cytokines/chemokine secretion, and myeloma stem-like cells in the bone marrow microenvironment

Abstract 400: Establishment and characterization of a novel IL6-dependent HLA-A2+ human myeloma cell line LNT1

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma

Abstract #3185: Targeting angiogenesis via a c-Myc/ Hif-1\#945;- dependent pathway in MM

Abstract #2236: Potential therapeutic role of the selective adhesion molecule inhibitor natalizumab (Tysabri) in Multiple Myeloma

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