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Journal Articles

Abstract 4626: A machine learning model for predicting hyperprogressive disease risk in cancer immunotherapy: Integrating clinical and molecular data

Free
Haitao Wang, Lili Wang, Yu Zhang, Hongzheng Li, Nan Li, Qijie Jian, Yaxian Wang, Zhijian Song, Fei Pang, Kai Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4626.
https://doi.org/10.1158/1538-7445.AM2025-4626
Published: 21 April 2025
View articletitled, Abstract 4626: A machine learning model for predicting hyperprogressive disease risk in cancer immunotherapy: Integrating clinical and molecular data
Journal Articles

Abstract 6070: A novel epitope specific TIM-3 antibody significantly enhanced anti-tumor activities with bispecific format, not with combination strategy

Free
Xin Dong, Bu Tining, Bishnu Nayak, Jinyu Dong, Meiguang Xiong, Binbin Wang, Dong Wang, Haojie Wang, Yu Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6070.
https://doi.org/10.1158/1538-7445.AM2025-6070
Published: 21 April 2025
View articletitled, Abstract 6070: A novel epitope specific TIM-3 antibody significantly enhanced anti-tumor activities with bispecific format, not with combination strategy
Journal Articles

Abstract 7317: A novel LY6G6D x CD3 bispecific T-cell engager demonstrates better tumor killing and minimal cytokine release than a benchmark molecule

Free
Lini Huang, Mengting Chen, Yu Zhang, Dong Wu, Shiyong Gong, Xuan Wu, Danqing Wu, Chengbin Wu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7317.
https://doi.org/10.1158/1538-7445.AM2025-7317
Published: 21 April 2025
View articletitled, Abstract 7317: A novel LY6G6D x CD3 bispecific T-cell engager demonstrates better tumor killing and minimal cytokine release than a benchmark molecule
Journal Articles

Abstract 5444: ImmuMab® mice enable efficient development of antibody therapeutics by unparalleled diversity across multiple formats

Free
Yuan Li, Wenbao Wu, Yu Wei, Yingjun Zhao, Yu Zhang, Jiwei Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5444.
https://doi.org/10.1158/1538-7445.AM2025-5444
Published: 21 April 2025
View articletitled, Abstract 5444: ImmuMab® mice enable efficient development of antibody therapeutics by unparalleled diversity across multiple formats
Journal Articles

Abstract 3128: Nonclinical efficacy and safety evaluation of IL-12 mRNA delivered by a novel lipid nanoparticle

Free
Qing He, Chunyan Dong, Dejiang Tan, Huimin Sun, Yiyang Zheng, Zhuang Li, Linyu Zhang, Sihan Liu, Yu Zhang, Jijun Yuan, Peng Gao, Liang Du, Huayuan Yan, Bo Ying
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3128.
https://doi.org/10.1158/1538-7445.AM2025-3128
Published: 21 April 2025
View articletitled, Abstract 3128: Nonclinical efficacy and safety evaluation of IL-12 mRNA delivered by a novel lipid nanoparticle
Journal Articles

Abstract 6035: The role of EBV+ nasopharyngeal carcinoma in shaping double-negative B cells to form a pro-metastatic niche

Free
Michael King Yung Chung, Ngar Woon Kam, Yingpei Zhang, Zhaozheng Hou, Kazi Anisha Islam, Yu Zhang, Gong Lanqi, Xin-Yuan Guan, Wei Dai
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6035.
https://doi.org/10.1158/1538-7445.AM2025-6035
Published: 21 April 2025
View articletitled, Abstract 6035: The role of EBV+ nasopharyngeal carcinoma in shaping double-negative B cells to form a pro-metastatic niche
Journal Articles

Abstract 5454: DB-1325, a BCMA-targeting antibody-drug conjugate with a Duality Unique Payload, exhibits promising efficacy and safety in preclinical multiple myeloma treatment

Free
Shengchao Lin, Bing Li, Yu Zhang, Jun Yao, Rong Shi, Yang Qiu, Haiqing Hua
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5454.
https://doi.org/10.1158/1538-7445.AM2025-5454
Published: 21 April 2025
View articletitled, Abstract 5454: DB-1325, a BCMA-targeting antibody-drug conjugate with a Duality Unique Payload, exhibits promising efficacy and safety in preclinical multiple myeloma treatment
Journal Articles

DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma

Available to Purchase
Jiayi Zhang, Zihui Ni, Yu Zhang, Yan Guo, Rundong Zhai, Mengqi Wang, Zizhen Gong, Mengyao Wang, Fanrui Zeng, Ziyue Gu, Qianming Chen, Laikui Liu, Zhiyong Wang, Weiwen Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (22): 3818–3833.
https://doi.org/10.1158/0008-5472.CAN-24-0067
Published: 15 November 2024
View articletitled, DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma
Open the PDF for DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract PO4-16-03: Ectopic expression of lineage-specific transcription factors in Breast Cancer

Free
Sunil Badve, Jian Hu, Yu Zhang, Yesim Gokmen-Polar
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-16-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-16-03
Published: 02 May 2024
View articletitled, Abstract PO4-16-03: Ectopic expression of lineage-specific transcription factors in Breast Cancer
Journal Articles

Abstract PO4-13-11: Epigenetically defined sub-clonal heterogeneity drives therapy resistance in triple-negative breast cancer

Free
Fatemeh Ahmadimoghari, Yu Zhang, Ioanna Mavrommati, Shefali Thakur, Chris Starling, Ioannis Roxanis, Syed Haider, Rachael Natrajan
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-13-11.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-13-11
Published: 02 May 2024
View articletitled, Abstract PO4-13-11: Epigenetically defined sub-clonal heterogeneity drives therapy resistance in triple-negative breast cancer
Journal Articles

Abstract 2733: NB202: A bispecific anti-PD1/TIM-3 antibody for cancer immunotherapy

Free
Jinyu Dong, Yu Zhang, Binbin Wang, Dong Wang, Tingting Bu, Jie Ni, Bishnu Nayak, Xin Dong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2733.
https://doi.org/10.1158/1538-7445.AM2024-2733
Published: 22 March 2024
View articletitled, Abstract 2733: NB202: A bispecific anti-PD1/TIM-3 antibody for cancer immunotherapy
Journal Articles

Abstract 2732: NB203: A Novel therapeutic bispecific antibody targeting CEACAM1/VEGF for tumor immunity and angiogenesis modulation in the tumor microenvironment

Free
Jinyu Dong, Binbin Wang, Dong Wang, Jie Ni, Tingting Bu, Haojie Wang, Bishnu Nayak, Baiyang Wang, Xin Dong, Yu Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2732.
https://doi.org/10.1158/1538-7445.AM2024-2732
Published: 22 March 2024
View articletitled, Abstract 2732: NB203: A Novel therapeutic bispecific antibody targeting CEACAM1/VEGF for tumor immunity and angiogenesis modulation in the tumor microenvironment
Journal Articles

Abstract 1969: Off-target autophagy inhibition by SHP2 allosteric inhibitors and therapeutic implications for aberrant RAS-driven cancers

Free
Yiming Miao, Yunpeng Bai, Jinmin Miao, Allison A. Murray, Jianping Lin, Jiajun Dong, Zihan Qu, Ruo-Yu Zhang, Quyen Nguyen, Shaomeng Wang, Zhong-Yin Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1969.
https://doi.org/10.1158/1538-7445.AM2024-1969
Published: 22 March 2024
View articletitled, Abstract 1969: Off-target autophagy inhibition by SHP2 allosteric inhibitors and therapeutic implications for aberrant RAS-driven cancers
Journal Articles

Abstract 7532: NB005.1, a fully humanized anti-KLRG1 blocking mAb enhances effector function of human CD8 T-cells

Free
Bishnu P. Nayak, Meiguang Xiong, Yajuan Xue, Binbin Wang, Shahrzad Lighvani, Shilpi Sharma, Dong Wang, Haojai Wang, Baiyang Wang, Yu Zhang, Xin Dong
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7532.
https://doi.org/10.1158/1538-7445.AM2024-7532
Published: 22 March 2024
View articletitled, Abstract 7532: NB005.1, a fully humanized anti-KLRG1 blocking mAb enhances effector function of human CD8 T-cells
Journal Articles

FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma

Available to Purchase
Jiao Huang, Wai Ying Tsang, Xiao-Na Fang, Yu Zhang, Jie Luo, Lan-Qi Gong, Bai-Feng Zhang, Ching Ngar Wong, Zhi-Hong Li, Bei-Lei Liu, Jin-Lin Huang, Yu-Ma Yang, Shan Liu, Liu-Xian Ban, Yiu Hong Chan, Xin-Yuan Guan
Journal: Cancer Research
Cancer Res (2024) 84 (6): 855–871.
https://doi.org/10.1158/0008-5472.CAN-23-0966
Published: 15 March 2024
View articletitled, FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Open the PDF for FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract B059: Epigenetically defined sub-clonal heterogeneity drives therapy resistance in triple-negative breast cancer

Free
Fatemeh Ahmadimoghari, Yu Zhang, Ioanna Mavrommatis, Shafali Thakur, Chris Starling, Ioannis Roxanis, Syed Haider, Rachael Natrajan
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B059.
https://doi.org/10.1158/1538-7445.ADVBC23-B059
Published: 01 February 2024
View articletitled, Abstract B059: Epigenetically defined sub-clonal heterogeneity drives therapy resistance in triple-negative breast cancer
Journal Articles

Abstract B058: Deconvoluting the intra-tumour heterogeneity and subclonal evolution of CDK4/6 inhibitor resistance in ER+ breast cancer

Free
Ioanna Mavrommati, Fatemeh Ahmadi Moughari, Shefali Thakur, Yu Zhang, Lesley-Ann Martin, Syed Haider, Rachael Natrajan
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B058.
https://doi.org/10.1158/1538-7445.ADVBC23-B058
Published: 01 February 2024
View articletitled, Abstract B058: Deconvoluting the intra-tumour heterogeneity and subclonal evolution of CDK4/6 inhibitor resistance in ER+ breast cancer
Journal Articles

Abstract LB163: A microfluidic platform for developing circulating tumor cells (CTCs) organoids for precision medicine in pancreatic cancer

Free
Yu Zhang, Scott Smith, Minal Nenwani, Valerie Gunchick, Vaibhav Sahai, Sunitha Nagrath, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB163.
https://doi.org/10.1158/1538-7445.AM2023-LB163
Published: 14 April 2023
View articletitled, Abstract LB163: A microfluidic platform for developing circulating tumor cells (CTCs) organoids for precision medicine in pancreatic cancer
Journal Articles

Abstract LB151: Exploring the tumor microenvironment in a spatial context with SpaCET

Free
Beibei Ru, Jinlin Huang, Yu Zhang, Kenneth Aldape, Peng Jiang
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB151.
https://doi.org/10.1158/1538-7445.AM2023-LB151
Published: 14 April 2023
View articletitled, Abstract LB151: Exploring the tumor microenvironment in a spatial context with SpaCET
Journal Articles

Abstract 6006: RNA m6A methylation relay the oncogenic flow from DNA methylationto gene expression of ANKRD13B

Free
JingRong Weng, JinXin Lin, YuMo Xie, GuanNan Tang, LiangLiang Bai, JinHua Chen, ZengHong Huang, ZhuoKai Zhuang, ShaoYong Peng, Heng Wang, GaoPo Xu, Yu Zhang, XiaoXia Liu, MeiJin Huang, YanXin Luo, XiaoLin Wang, Huichuan Yu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6006.
https://doi.org/10.1158/1538-7445.AM2023-6006
Published: 04 April 2023
View articletitled, Abstract 6006: RNA m6A methylation relay the oncogenic flow from DNA methylationto gene expression of ANKRD13B