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Journal Articles

HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment

Yu-Wei Luo, Yang Fang, Hui-Xian Zeng, Yu-Chen Ji, Meng-Zhi Wu, Hui Li, Jie-Ying Chen, Li-Min Zheng, Jian-Hong Fang, Shi-Mei Zhuang
Journal: Cancer Research
Cancer Res (2025) 85 (1): 69–83.
https://doi.org/10.1158/0008-5472.CAN-24-2324
Published: 02 January 2025
View article titled, HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment
Open the PDF for HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer

Xiaohui Sun, Shiv P. Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xingyi Guo, Xiao-Ou Shu, Jianhong Chen, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H. Oh, Anne S. Reiner, Gordon P. Watt, Meghan Woods, Yaohua Yang, Christine B. Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A. Haiman, Jennifer J. Hu, Dezheng Huo, Esther M. John, Julia A. Knight, Christopher I. Li, Charles F. Lynch, Lene Mellemkjær, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Andrew F. Olshan, Tuya Pal, Julie R. Palmer, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Melissa A. Troester, Wei Zheng, Jonine L. Bernstein, Matthew F. Buas, Xiang Shu
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2533–2548.
https://doi.org/10.1158/0008-5472.CAN-23-3854
Published: 01 August 2024
View article titled, Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer
Open the PDF for Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer in another window
Includes: Supplementary data
Journal Articles

MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer

Si Min Zheng, Yu Chen Feng, Qin Zhu, Ruo Qi Li, Qian Qian Yan, Liu Teng, Yi Meng Yue, Man Man Han, Kaihong Ye, Sheng Nan Zhang, Teng Fei Qi, Cai Xia Tang, Xiao Hong Zhao, Yuan Yuan Zhang, Liang Xu, Ran Xu, Jun Xing, Mark Baker, Tao Liu, Rick F. Thorne, Lei Jin, Thomas Preiss, Xu Dong Zhang, Shundong Cang, Jin Nan Gao
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1460–1474.
https://doi.org/10.1158/0008-5472.CAN-23-3046
Published: 02 May 2024
View article titled, MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Open the PDF for MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PO1-15-07: Subtyping-directed precision treatment refines traditional one-size-fits-all therapy in HR+/HER2- breast cancer: a sub-study of the MULAN umbrella trial

Xiu-Zhi Zhu, Xi Jin, Hu-Yun-Long Zhang, Xiyu Liu, Yi-Fan Zhou, Yi-Yu Chen, Tong Fu, Ming-Liang Jin, Ya-Xin Zhao, Yi-Fan Xie, Ruo-Xi Wang, Zhong-Hua Wang, Lei Fan, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-15-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-15-07
Published: 02 May 2024
View article titled, Abstract PO1-15-07: Subtyping-directed precision treatment refines traditional one-size-fits-all therapy in HR+/HER2- breast cancer: a sub-study of the MULAN umbrella trial
Journal Articles

Abstract PO2-13-04: Single cell characterization of senescent CD8+ T cell promotes immunotherapy resistance in early-stage triple-negative breast cancer

Tong Fu, Yi-Yu Chen, Xi Jin, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-13-04.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-13-04
Published: 02 May 2024
View article titled, Abstract PO2-13-04: Single cell characterization of senescent CD8+ T cell promotes immunotherapy resistance in early-stage triple-negative breast cancer
Journal Articles

Abstract PO3-12-07: Utility of Volumetric Measurement for Clinical Diagnosis of Breast Cancer-Related Lymphedema

Fardeen Bhimani, Sheldon Feldman, Yu Chen, Anjuli Gupta, Jessica Pastoriza, Areej Shihabi, Maureen McEvoy
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-12-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-12-07
Published: 02 May 2024
View article titled, Abstract PO3-12-07: Utility of Volumetric Measurement for Clinical Diagnosis of Breast Cancer-Related Lymphedema
Journal Articles

Abstract PS10-09: Development of an absolute risk prediction model for premenopausal breast cancer in an international consortium

Kristen Brantley, Michael Jones, Minouk Schoemaker, Hazel Nichols, Anthony Swerdlow, Robert MacInnis, Roger Milne, Tess Clenenden, Yu Chen, Xiao-Ou Shu, Wei Zheng, Woon-Puay Koh, Jian-Min Yuan, Cari Kitahara, Martha Linet, Dale Sandler, Bernard A Rosner, Peter Kraft, A. Heather Eliassen
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS10-09.
https://doi.org/10.1158/1538-7445.SABCS23-PS10-09
Published: 02 May 2024
View article titled, Abstract PS10-09: Development of an absolute risk prediction model for premenopausal breast cancer in an international consortium
Journal Articles

Abstract CT189: A first-in-human, phase 1a, dose-escalation study of BGB-10188, a phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor, + tislelizumab (anti-PD-1) in patients with solid tumors

Rasha Cosman, Elizabeth Ahern, Jie Li, Hui K. Gan, Yu Chen, Bo Gao, Yongsheng Wang, Xiyan Mu, Huan Cheng, Yanrong Qian, Heather Zhang, Ke Cao
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT189.
https://doi.org/10.1158/1538-7445.AM2024-CT189
Published: 05 April 2024
View article titled, Abstract CT189: A first-in-human, phase 1a, dose-escalation study of BGB-10188, a phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor, + tislelizumab (anti-PD-1) in patients with solid tumors
Journal Articles

Abstract LB323: Deciphering the immunomodulatory role of IL-19 in glioblastoma-promoting ecosystem: Insights into glioblastoma stem cell-tumor-associated macrophage symbiosis

Gilbert Aaron Lee, Cheng-Yu Chen
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB323.
https://doi.org/10.1158/1538-7445.AM2024-LB323
Published: 05 April 2024
View article titled, Abstract LB323: Deciphering the immunomodulatory role of IL-19 in glioblastoma-promoting ecosystem: Insights into glioblastoma stem cell-tumor-associated macrophage symbiosis
Journal Articles

Abstract 6901: Paired colorectal and pancreatic cancer patient-derived tumor and organoids biobank

Juiling Wang, Wen-Hui Ma, Yun-Chi Lo, Hsiao-Chun Hsieh, Li-Ju Hsiao, Yu-Pin Bau, Nai-Chieh Yang, Shaw-Jenq Tsai, Yan-Shen Shan, Tzu-Yu Chen, Yu-Ling Chen, Pei-Ju Chiang, Tzu-Ling Chen, Hsiu-Ping Chang, Hsian-Jean Chin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6901.
https://doi.org/10.1158/1538-7445.AM2024-6901
Published: 22 March 2024
View article titled, Abstract 6901: Paired colorectal and pancreatic cancer patient-derived tumor and organoids biobank
Journal Articles

Abstract 660: OPN-6602, a potent dual EP300/CBP bromodomain inhibitor, targets multiple myeloma through concomitant suppression of IRF4 and c-MYC

Bernice Matusow, Wayne Spevak, Chao Zhang, Yan Ma, Rafe Shellooe, James Tsai, Pei Pei Li, Pan Yu Chen, Gaston Habets, Christine Nichols, Parmveer Singh, Kerry Inokuchi, Jackie Walling, Jason Halladay, Gideon Bollag
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 660.
https://doi.org/10.1158/1538-7445.AM2024-660
Published: 22 March 2024
View article titled, Abstract 660: OPN-6602, a potent dual EP300/CBP bromodomain inhibitor, targets multiple myeloma through concomitant suppression of IRF4 and c-MYC
Journal Articles

Abstract 3219: STAT3 inhibition synergizes with epigenetic therapy to suppress glutamine metabolism and clonogenic potential in non-small cell lung cancer

Julia An, Ying-Yu Chen, Jina Park, Stephen Baylin, Michael Topper
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3219.
https://doi.org/10.1158/1538-7445.AM2024-3219
Published: 22 March 2024
View article titled, Abstract 3219: STAT3 inhibition synergizes with epigenetic therapy to suppress glutamine metabolism and clonogenic potential in non-small cell lung cancer
Journal Articles

Abstract 7052: p53 underpins a dependence on oxidative phosphorylation in glycolysis-competent colorectal cancer

Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kai Hong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Tao Liu, Mark Baker, Rick F. Thorne, Xu Dong Zhang, Song Chen, Lei Jin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7052.
https://doi.org/10.1158/1538-7445.AM2024-7052
Published: 22 March 2024
View article titled, Abstract 7052: p53 underpins a dependence on oxidative phosphorylation in glycolysis-competent colorectal cancer
Journal Articles

Abstract 297: Role of purine metabolism in CLL cell pathobiology and CLL disease progression

Sutapa Sinha, Weiguo Han, Zhiquan Wang, Kari G. Rabe, Susan L. Slager, Chantal E. McCabe, Daniel R. O'Brien, Sameer A. Parikh, Esteban Braggio, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Bing Dai, Yue Shen, Neil E. Kay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 297.
https://doi.org/10.1158/1538-7445.AM2024-297
Published: 22 March 2024
View article titled, Abstract 297: Role of purine metabolism in CLL cell pathobiology and CLL disease progression
Journal Articles

Abstract 285: Targeting TXNDC5 in stromal fibroblasts resolves desmoplasia and resistance to immune checkpoint blockade in mesenchymal-type colorectal cancer

Kai-Lin Cheng, Chih-I Chen, Shu-Han Yu, Huai-Wen Liang, Yi-Wei Tsai, Chen-Ting Hung, Yu-Shan Lin, Yi-Shiuan Tzeng, Sung-Jan Lin, Yueh-Feng Wu, Jen-Kuang Lee, Chia-Hui Yu, Shuei-Liong Lin, Shih-Yu Chen, Tzu-Tang Wei, Yun-Ju Huang, Ruey-Hwa Chen, Ching-Chow Chen, Kai-Chien Yang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 285.
https://doi.org/10.1158/1538-7445.AM2024-285
Published: 22 March 2024
View article titled, Abstract 285: Targeting TXNDC5 in stromal fibroblasts resolves desmoplasia and resistance to immune checkpoint blockade in mesenchymal-type colorectal cancer
Journal Articles

Abstract 3513: A CNN-based approach with efficient transfer learning improves microRNA-mRNA prediction

Chen-Hao Peng, Hui-Yu Chen, Da-Chuan Cheng, Eric Y. Chuang, Chien-Yueh Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3513.
https://doi.org/10.1158/1538-7445.AM2024-3513
Published: 22 March 2024
View article titled, Abstract 3513: A CNN-based approach with efficient transfer learning improves microRNA-mRNA prediction
Journal Articles

Abstract 1017: Characterizing immune cell infiltration in colorectal cancer tumor microenvironment among Native Hawaiians

Yuanyuan Fu, Gino Quintal, Masaki Nasu, Mayumi Jijiwa, Sudhir K. Rai, Isam Mohd-Ibrahim, Yu Chen, Hua Yang, Zhanwei Wang, Christina Wai, Owen Chan, Brenda Y. Hernandez, Youping Deng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1017.
https://doi.org/10.1158/1538-7445.AM2024-1017
Published: 22 March 2024
View article titled, Abstract 1017: Characterizing immune cell infiltration in colorectal cancer tumor microenvironment among Native Hawaiians
Journal Articles

Abstract 5113: Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma

Zi-Lu Huang, Zhi-Gang Liu, Qi Lin, Ya-Lan Tao, Xinzhuoyun Li, Patricia Baxter, Jack MF Su, Adekunle M. Adesina, Chris Man, Murali Chintagumpala, Wan Yee Teo, Yu-Chen Du, Yun-Fei Xia, Xiao-Nan Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5113.
https://doi.org/10.1158/1538-7445.AM2024-5113
Published: 22 March 2024
View article titled, Abstract 5113: Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma
Journal Articles

Abstract 437: Hydrogen sulfide switches the glucose metabolism through sulfhydration on pyruvate kinase M2

Po-Chen Chien, Rong-Hsuan Wang, Pin-Ru Chen, Yue-Ting Chen, Yi-Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Shao-Yun Lo, Zhong-Liang Wang, Min-Chen Tsou, Ssu-Yu Chen, Guang-Shen Chiu, Wen-Ling Chen, Yi-Hsuan Wu, Hui-Ching Wang, Shu-Yi Lin, Wen-Ching Wang, Hsing-Jien Kung, Lu-Hai Wang, Hui-Chun Cheng, Kai-Ti Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 437.
https://doi.org/10.1158/1538-7445.AM2024-437
Published: 22 March 2024
View article titled, Abstract 437: Hydrogen sulfide switches the glucose metabolism through sulfhydration on pyruvate kinase M2
Journal Articles

Abstract 5874: Phenotypic plasticity of TKI resistance reprograms cytoskeleton organization through cadherin-catenin and integrin pathways

Chun Ma, Jerry Chieh-Yu Chen, Mong-Lien Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5874.
https://doi.org/10.1158/1538-7445.AM2024-5874
Published: 22 March 2024
View article titled, Abstract 5874: Phenotypic plasticity of TKI resistance reprograms cytoskeleton organization through cadherin-catenin and integrin pathways