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Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma

Yong Yean Kim, Girma Woldemichael, Berkley Gryder, Silvia Pomella, Ranuka Sinniah, Josh Kowalczyk, Young Song, Mehal Churiwal, Joseph Barchi, John Schneekloth, Xinyu Wen, Hsein-Chao Chou, Barry Okeefe, John Shern, Robert Hawley, Javed Khan

Cancer Res (2022) 82 (12_Supplement): 703.

DOI: https://doi.org/10.1158/1538-7445.AM2022-703

Published: 15 June 2022

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Journal Articles

Abstract 6061: Novel β-Apopicropodophyllin derivative, JNC-1043, exerts anti-cancer and radiosensitizing effects

Jong Kuk Park, A-Ram Kang, Jin-Hee Kwon, Jong-Ryoo Choi, Jie-Young Song, Sang-Gu Hwang

Cancer Res (2022) 82 (12_Supplement): 6061.

DOI: https://doi.org/10.1158/1538-7445.AM2022-6061

Published: 15 June 2022

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Abstract 1753: IKS014, a HER2-targeting antibody drug conjugate incorporating novel bioconjugation and tumor-selective linker technology with improved in vivo efficacy and tolerability

Jutta Deckert, Jenny Thirlway, Yun-Hee Park, Ho Young Song, Chul-Woong Chung, Xuesong Wang, Zhenshan Zhang, Robert J. Lutz

Cancer Res (2022) 82 (12_Supplement): 1753.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1753

Published: 15 June 2022

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Abstract 1755: IKS03, a CD19-targeted antibody drug conjugate with enhanced efficacy and tolerability for treatment of B-cell lymphomas

Jenny Thirlway, Adam Lodge, Daniel J. Williamson, Justyna Mysliwy, Jutta Deckert, Xavier Chauchet, Laura Cons, Yun-Hee Park, Hyun-Min Ryu, Na Ra Han, Ho Young Song, Chul-Woong Chung, Robert J. Lutz

Cancer Res (2022) 82 (12_Supplement): 1755.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1755

Published: 15 June 2022

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Abstract 47: Identification of first-in-class KDM3B inhibitors that suppress PAX3-FOXO1 oncogene activity in fusion positive rhabdomyosarcoma

Yong Yean Kim, Robert G. Hawley, Berkley Gryder, Silvia Pomella, Joshua Kowalczyk, Joseph Barchi, Young Song, Javed Khan

Cancer Res (2021) 81 (13_Supplement): 47.

DOI: https://doi.org/10.1158/1538-7445.AM2021-47

Published: 01 July 2021

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Abstract 1885: Potent tumoricidal activity of a FGFR4 CART in rhabdomyosarcoma

Adam Cheuk, Meijie Tian, Jeetendra Kumar, Peter Azorsa, Nityashree Shivaprasad, Dina Schneider, Berkley Gryder, Jun Wei, Young Song, Xinyu Wen, Sivasish Sindiri, Joon-Yong Chung, Zhongyu Zhu, Dimiter Dimitrov, Stephen Hewitt, Boro Dropulic, Rimas Orentas, Javed Khan

Cancer Res (2021) 81 (13_Supplement): 1885.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1885

Published: 01 July 2021

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Journal Articles

Abstract 4175: Identification of novel inhibitors of the PAX3-FOXO1 fusion oncogene in rhabdomyosarcoma

Yong Yean Kim, Robert Hawley, Berkley Gryder, Silvia Pomella, Josh Kowalczyk, Ranu Sinniah, Young Song, Javed Khan

Cancer Res (2020) 80 (16_Supplement): 4175.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4175

Published: 15 August 2020

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Abstract 6524: A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) shows potent anti-tumor effect through tumor-directed T cell activation

Cancer Res (2020) 80 (16_Supplement): 6524.

DOI: https://doi.org/10.1158/1538-7445.AM2020-6524

Published: 15 August 2020

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Journal Articles

Abstract 6394: Combined FLT3 and PARP inhibition induces synthetic lethality in non-small cell lung cancer cells

Hwani Ryu, Hyo Jeong Kim, Jie-Young Song, Sang-Gu Hwang, Jiyeon Ahn

Cancer Res (2020) 80 (16_Supplement): 6394.

DOI: https://doi.org/10.1158/1538-7445.AM2020-6394

Published: 15 August 2020

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Abstract 6613: Identification of targetable HLA*A2:01 restricted peptides in osteosarcoma

David Milewski, Sivasish Sindiri, Jun S. Wei, Andrew Brohl, Young Song, Xinyu Wen, Andrew Qi, Udayan Guha, Javed Khan

Cancer Res (2020) 80 (16_Supplement): 6613.

DOI: https://doi.org/10.1158/1538-7445.AM2020-6613

Published: 15 August 2020

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Abstract B12: PAX3 translocations co-opt super enhancers and intrinsically disordered fusion partners in rhabdomyosarcoma

Berkley E. Gryder, Marco Wachtel, Winston Ewert, Kenneth Chang, Osama El Demerdash, Young Song, Beat W Schäfer, Christopher R. Vakoc, Javed Khan

Cancer Res (2020) 80 (14_Supplement): B12.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B12

Published: 15 July 2020

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Abstract B35: Liaison between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in fusion-negative rhabdomyosarcoma

Cancer Res (2020) 80 (14_Supplement): B35.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B35

Published: 15 July 2020

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Abstract B15: Genomic classification and prognosis in rhabdomyosarcoma: A report from the Children’s Oncology Group, the Institute of Cancer Research, and the National Cancer Institute

Cancer Res (2020) 80 (14_Supplement): B15.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B15

Published: 15 July 2020

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Abstract A08: Development of FGFR4-specific chimeric antibody receptor (CAR) T cell and bispecific T cell engager (BiTE) for rhabdomyosarcoma (RMS) immunotherapy

Cancer Res (2020) 80 (14_Supplement): A08.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-A08

Published: 15 July 2020

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Abstract B17: IKKα/STAT3 antagonistic signaling regulates fungi-bacteria endosymbiosis-associated carcinogenesis

Na-Young Song, Xin Li, Jonathan H. Badger, Jami Willette Brown, Xhonghe Sun, Gongping Shi, Feng Zhu, Chengfei Jiang, Colum O'hUigin, Xiaolin Wu, Giorgio Trinchieri, Yinling Hu

Cancer Res (2020) 80 (8_Supplement): B17.

DOI: https://doi.org/10.1158/1538-7445.MVC2020-B17

Published: 15 April 2020

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Abstract P2-09-08: Breast cancer tumor sequencing coupled with germline genetic testing aids the identification of at-risk individuals for hereditary breast cancer disorders

Daniel E Pineda-Alvarez, Scott T Michalski, Meaghan Russell, Shan Yang, Ihn Young Song, Robert L Nussbaum, Edward D. Esplin

Cancer Res (2020) 80 (4_Supplement): P2-09-08.

DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-09-08

Published: 15 February 2020

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Journal Articles

Abstract 287: A novel class III receptor tyrosine kinase inhibitor synergizes with olaparib by inhibition of DNA repair-related genes in non-small cell lung cancer cells

Hwani Ryu, Jie-young Song, Sang-Gu Hwang, Jiyeon Ahn

Cancer Res (2019) 79 (13_Supplement): 287.

DOI: https://doi.org/10.1158/1538-7445.AM2019-287

Published: 01 July 2019

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Journal Articles

Abstract LB-056: An integrated genomic, epigenetic, proteomic, and single cell analysis of pediatric B cell acute lymphoblastic leukemia to elucidate resistance mechanisms to CD19 CAR T cell therapy

Katherine E. Masih, Rebecca Gardner, Berkley E. Gryder, Justin Lack, Benjamin Z. Stanton, Ashley Wilson, Olivia Finney, Sivasish Sindiri, Young Song, Zachary Rae, Michael Kelly, Chaoyu Wang, Xinyu Wen, Adam Cheuk, Jun S. Wei, Michael Jensen, Rimas Orentas, Javed Khan

Cancer Res (2019) 79 (13_Supplement): LB-056.

DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-056

Published: 01 July 2019

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Abstract LB-243: Curcumin suppresses oncogenicity of human colon cancer cells through covalent modification of oncogenic SIRT1

Yeon-Hwa Lee, Na-Young Song, Do-Hee Kim, Hye-Kyung Na, Young-Joon Surh

Cancer Res (2019) 79 (13_Supplement): LB-243.

DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-243

Published: 01 July 2019

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Journal Articles

Abstract 4687: Gastric cancer stem cell-related marker LINGO2 is associated with cancer phenotype and poor patient survival

Soo Been Park, Jung Hyun Jo, Chanyang Kim, Hee Seung Lee, Dawoon E. Jung, Si Young Song

Cancer Res (2019) 79 (13_Supplement): 4687.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4687

Published: 01 July 2019

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2 3 4 5

NARROW

Abstract 703: Novel histone lysine demethylase inhibitors disrupt PAX3-FOXO1-driven transcriptional output in fusion-positive rhabdomyosarcoma

Abstract 6061: Novel β-Apopicropodophyllin derivative, JNC-1043, exerts anti-cancer and radiosensitizing effects

Abstract 1753: IKS014, a HER2-targeting antibody drug conjugate incorporating novel bioconjugation and tumor-selective linker technology with improved in vivo efficacy and tolerability

Abstract 1755: IKS03, a CD19-targeted antibody drug conjugate with enhanced efficacy and tolerability for treatment of B-cell lymphomas

Abstract 47: Identification of first-in-class KDM3B inhibitors that suppress PAX3-FOXO1 oncogene activity in fusion positive rhabdomyosarcoma

Abstract 1885: Potent tumoricidal activity of a FGFR4 CART in rhabdomyosarcoma

Abstract 4175: Identification of novel inhibitors of the PAX3-FOXO1 fusion oncogene in rhabdomyosarcoma

Abstract 6524: A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) shows potent anti-tumor effect through tumor-directed T cell activation

Abstract 6394: Combined FLT3 and PARP inhibition induces synthetic lethality in non-small cell lung cancer cells

Abstract 6613: Identification of targetable HLA*A2:01 restricted peptides in osteosarcoma

Abstract B12: PAX3 translocations co-opt super enhancers and intrinsically disordered fusion partners in rhabdomyosarcoma

Abstract B35: Liaison between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in fusion-negative rhabdomyosarcoma

Abstract B15: Genomic classification and prognosis in rhabdomyosarcoma: A report from the Children’s Oncology Group, the Institute of Cancer Research, and the National Cancer Institute

Abstract A08: Development of FGFR4-specific chimeric antibody receptor (CAR) T cell and bispecific T cell engager (BiTE) for rhabdomyosarcoma (RMS) immunotherapy

Abstract B17: IKKα/STAT3 antagonistic signaling regulates fungi-bacteria endosymbiosis-associated carcinogenesis

Abstract P2-09-08: Breast cancer tumor sequencing coupled with germline genetic testing aids the identification of at-risk individuals for hereditary breast cancer disorders

Abstract 287: A novel class III receptor tyrosine kinase inhibitor synergizes with olaparib by inhibition of DNA repair-related genes in non-small cell lung cancer cells

Abstract LB-056: An integrated genomic, epigenetic, proteomic, and single cell analysis of pediatric B cell acute lymphoblastic leukemia to elucidate resistance mechanisms to CD19 CAR T cell therapy

Abstract LB-243: Curcumin suppresses oncogenicity of human colon cancer cells through covalent modification of oncogenic SIRT1

Abstract 4687: Gastric cancer stem cell-related marker LINGO2 is associated with cancer phenotype and poor patient survival

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