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TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma

Ryo Sato, Kosuke Imamura, Takashi Semba, Yusuke Tomita, Sho Saeki, Koei Ikeda, Yoshihiro Komohara, Makoto Suzuki, Takuro Sakagami, Hideyuki Saya, Yoshimi Arima

Cancer Res (2021) 81 (18): 4751–4765.

https://doi.org/10.1158/0008-5472.CAN-20-3941

Published: 15 September 2021

View articletitled, TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma

Includes: Supplementary data

Journal Articles

Abstract 5311: Establishment of neurofibroma cells and dedifferentiated fat (DFAT) cells from tumor tissues from patients diagnosed with NF1 (Neurofibromatosis type 1)

Yoshimi Arima, Hiroyuki Nobusue, Shigeki Sakai, Kazuo Kishi, Toshiki Takenouchi, Kenjiro Kosaki, Hideyuki Saya

Cancer Res (2019) 79 (13_Supplement): 5311.

https://doi.org/10.1158/1538-7445.AM2019-5311

Published: 01 July 2019

View articletitled, Abstract 5311: Establishment of neurofibroma cells and dedifferentiated fat (DFAT) cells from tumor tissues from patients diagnosed with NF1 (Neurofibromatosis type 1)

Journal Articles

Abstract 1983: Enriching EpCAM⁺/Sca-1⁺ mouse bronchioalveolar stem cells to generate lung adenocarcinoma

Takashi Semba, Ryo Sato, Akiyoshi Kasuga, Makoto Suzuki, Hideyuki Saya, Yoshimi Arima

Cancer Res (2018) 78 (13_Supplement): 1983.

https://doi.org/10.1158/1538-7445.AM2018-1983

Published: 01 July 2018

View articletitled, Abstract 1983: Enriching EpCAM+/Sca-1+ mouse bronchioalveolar stem cells to generate lung adenocarcinoma

Journal Articles

Abstract 4083: Intrahepatic cholangiocarcinoma and gallbladder carcinoma mouse model based on transplantation of syngeneic tumor-initiating cells

Akiyoshi Kasuga, Takashi Semba, Hiromasa Takaishi, Takanori Kanai, Hideyuki Saya, Yoshimi Arima

Cancer Res (2018) 78 (13_Supplement): 4083.

https://doi.org/10.1158/1538-7445.AM2018-4083

Published: 01 July 2018

View articletitled, Abstract 4083: Intrahepatic cholangiocarcinoma and gallbladder carcinoma mouse model based on transplantation of syngeneic tumor-initiating cells

Journal Articles

Abstract 3418: Additional mutation in PTPN11 gene promotes tumorigenesis of the NF1 gene mutated cells

Yoshimi Arima, Ritsuko Harigai, Ryo Sato, Toshiki Takenouchi, Kenjiro Kosaki, Hideyuki Saya

Cancer Res (2017) 77 (13_Supplement): 3418.

https://doi.org/10.1158/1538-7445.AM2017-3418

Published: 01 July 2017

View articletitled, Abstract 3418: Additional mutation in PTPN11 gene promotes tumorigenesis of the NF1 gene mutated cells

Journal Articles

Abstract 4192: The association between gastric Mucin 5AC (MUC5AC) expressions, transforming growth factor-β (TGF-β) signal, and histopathological phenotypes of lung cancer in xenograft models

Ryo Sato, Takashi Semba, Hirotsugu Kohrogi, Hideyuki Saya, Yoshimi Arima

Cancer Res (2016) 76 (14_Supplement): 4192.

https://doi.org/10.1158/1538-7445.AM2016-4192

Published: 15 July 2016

View articletitled, Abstract 4192: The association between gastric Mucin 5AC (MUC5AC) expressions, transforming growth factor-β (TGF-β) signal, and histopathological phenotypes of lung cancer in xenograft models

Journal Articles

Abstract 4255: EpCAM positive lung cells are involved in organoid formation

Takashi Semba, Ryo Sato, Makoto Suzuki, Hideyuki Saya, Yoshimi Arima

Cancer Res (2016) 76 (14_Supplement): 4255.

https://doi.org/10.1158/1538-7445.AM2016-4255

Published: 15 July 2016

View articletitled, Abstract 4255: EpCAM positive lung cells are involved in organoid formation

Journal Articles

Abstract 2730: Additional mutations in genes relevant to the Ras signaling pathway promote the malignant characteristics of NF1-associated malignant peripheral nerve sheath tumor (NF1-MPNST) cells

Yoshimi Arima, Kenjiro Kosaki, Chikako Hirose, Hideyuki Saya

Cancer Res (2015) 75 (15_Supplement): 2730.

https://doi.org/10.1158/1538-7445.AM2015-2730

Published: 01 August 2015

View articletitled, Abstract 2730: Additional mutations in genes relevant to the Ras signaling pathway promote the malignant characteristics of NF1-associated malignant peripheral nerve sheath tumor (NF1-MPNST) cells

Journal Articles

Abstract 3331: CD24 promotes HER2 signaling pathways and CD24 inhibition sensitizes anti-HER2 therapy in breast cancer

Yoshimi Arima, Mari Hosonaga, Hideyuki Saya

Cancer Res (2014) 74 (19_Supplement): 3331.

https://doi.org/10.1158/1538-7445.AM2014-3331

Published: 01 October 2014

View articletitled, Abstract 3331: CD24 promotes HER2 signaling pathways and CD24 inhibition sensitizes anti-HER2 therapy in breast cancer

Journal Articles

Abstract 522: The epithelial-mesenchymal transition-related transcription factor ZEB suppresses Claudin expression in breast cancer cells.

Yoshimi Arima, Mari Hosonaga, Hideyuki Saya

Cancer Res (2013) 73 (8_Supplement): 522.

https://doi.org/10.1158/1538-7445.AM2013-522

Published: 15 April 2013

View articletitled, Abstract 522: The epithelial-mesenchymal transition-related transcription factor ZEB suppresses Claudin expression in breast cancer cells.

Journal Articles

Abstract 562: The Hippo pathway component LATS1 phosphorylates MYPT1 to counteract PLK1 and regulate G2 DNA damage checkpoint.

Tatsuyuki Chiyoda, Shinji Kuninaka, Kenta Masuda, Takatsune Shimizu, Yoshimi Arima, Daisuke Aoki, Hideyuki Saya

Cancer Res (2013) 73 (8_Supplement): 562.

https://doi.org/10.1158/1538-7445.AM2013-562

Published: 15 April 2013

View articletitled, Abstract 562: The Hippo pathway component LATS1 phosphorylates MYPT1 to counteract PLK1 and regulate G2 DNA damage checkpoint.

Journal Articles

Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition

Yoshimi Arima, Yasumichi Inoue, Tatsuhiro Shibata, Hidemi Hayashi, Osamu Nagano, Hideyuki Saya, Yoichi Taya

Cancer Res (2008) 68 (13): 5104–5112.

https://doi.org/10.1158/0008-5472.CAN-07-5680

Published: 01 July 2008

View articletitled, Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition

Includes: Supplementary data

Journal Articles

Mouse model for mammary gland development and tumorigenesis through Cre/loxP controlled periodic Aurora-A overexpression

Dongwei Zhang, Toru Hirota, Tomotoshi Marumoto, Naoko Kunitoku, Takashi Sasayama, Yoshimi Arima, Liping Feng, Motohiro Takeya, Hideyuki Saya

Cancer Res (2004) 64 (7_Supplement): 912.

Published: 01 April 2004

View articletitled, Mouse model for mammary gland development and tumorigenesis through Cre/loxP controlled periodic Aurora-A overexpression

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TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma

Abstract 5311: Establishment of neurofibroma cells and dedifferentiated fat (DFAT) cells from tumor tissues from patients diagnosed with NF1 (Neurofibromatosis type 1)

Abstract 1983: Enriching EpCAM⁺/Sca-1⁺ mouse bronchioalveolar stem cells to generate lung adenocarcinoma

Abstract 4083: Intrahepatic cholangiocarcinoma and gallbladder carcinoma mouse model based on transplantation of syngeneic tumor-initiating cells

Abstract 3418: Additional mutation in PTPN11 gene promotes tumorigenesis of the NF1 gene mutated cells

Abstract 4192: The association between gastric Mucin 5AC (MUC5AC) expressions, transforming growth factor-β (TGF-β) signal, and histopathological phenotypes of lung cancer in xenograft models

Abstract 4255: EpCAM positive lung cells are involved in organoid formation

Abstract 2730: Additional mutations in genes relevant to the Ras signaling pathway promote the malignant characteristics of NF1-associated malignant peripheral nerve sheath tumor (NF1-MPNST) cells

Abstract 3331: CD24 promotes HER2 signaling pathways and CD24 inhibition sensitizes anti-HER2 therapy in breast cancer

Abstract 522: The epithelial-mesenchymal transition-related transcription factor ZEB suppresses Claudin expression in breast cancer cells.

Abstract 562: The Hippo pathway component LATS1 phosphorylates MYPT1 to counteract PLK1 and regulate G2 DNA damage checkpoint.

Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition

Mouse model for mammary gland development and tumorigenesis through Cre/loxP controlled periodic Aurora-A overexpression

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