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Journal Articles

Abstract 3965: Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis

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Verra Ngwa, Yoonha Hwang, Wenqiang Song, Deanna Edwards, Jin Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3965.
https://doi.org/10.1158/1538-7445.AM2025-3965
Published: 21 April 2025
View article titled, Abstract 3965: Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis
Journal Articles

Abstract 5555: Lung squamous cancer cell mTORC2 signaling suppresses antitumor immunity by up-regulation of PSGL-1, a ligand of VISTA/PD-1H checkpoint receptor

Free
Verra M. Ngwa, Yoonha Hwang, Deanna N. Edwards, Wenqiang Song, Jin Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5555.
https://doi.org/10.1158/1538-7445.AM2024-5555
Published: 22 March 2024
View article titled, Abstract 5555: Lung squamous cancer cell mTORC2 signaling suppresses antitumor immunity by up-regulation of PSGL-1, a ligand of VISTA/PD-1H checkpoint receptor
Journal Articles

Abstract 1490: Elucidating the effect of glutamine metabolism in breast to bone metastasis

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Breelyn A. Karno, Yoonha Hwang, Rachelle Johnson, Jin Chen, Deanna Edwards
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1490.
https://doi.org/10.1158/1538-7445.AM2024-1490
Published: 22 March 2024
View article titled, Abstract 1490: Elucidating the effect of glutamine metabolism in breast to bone metastasis
Journal Articles

Abstract 1275: In vivo functional CRISPR screens identifies metabolic dependencies mediating triple negative breast cancer lung metastasis

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Xiaoyong Wang, Shu-ting Chou, Verra Ngwa, Yoonha Hwang, Breelyn Karno, Deanna Edwards, Jin Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1275.
https://doi.org/10.1158/1538-7445.AM2024-1275
Published: 22 March 2024
View article titled, Abstract 1275: In vivo functional CRISPR screens identifies metabolic dependencies mediating triple negative breast cancer lung metastasis
Journal Articles

Abstract 198: Selective targeting of endothelial mTORC1 reduces transendothelial fatty acid delivery to improve anti-tumor immunity and suppress metastatic outgrowth

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Deanna N. Edwards, Shan Wang, Wenqiang Song, Laura C. Kim, Yoonha Hwang, Jin Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 198.
https://doi.org/10.1158/1538-7445.AM2024-198
Published: 22 March 2024
View article titled, Abstract 198: Selective targeting of endothelial mTORC1 reduces transendothelial fatty acid delivery to improve anti-tumor immunity and suppress metastatic outgrowth
Journal Articles

Abstract 3434: Selective inhibition of mTORC2 by disruption of mLST8 scaffolding function

Free
Laura C. Kim, Yoonha Hwang, Wenqiang Song, Rebecca S. Cook, Jin Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3434.
https://doi.org/10.1158/1538-7445.AM2019-3434
Published: 01 July 2019
View article titled, Abstract 3434: Selective inhibition of mTORC2 by disruption of mLST8 scaffolding function
Journal Articles

Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo

Free
Yoonha Hwang, Laura C. Kim, Wenqiang Song, Deanna N. Edwards, Rebecca S. Cook, Jin Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3178–3184.
https://doi.org/10.1158/0008-5472.CAN-18-3658
Published: 01 July 2019
View article titled, Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo
Open the PDF for Disruption of the Scaffolding Function of mLST8 Selectively Inhibits mTORC2 Assembly and Function and Suppresses mTORC2-Dependent Tumor Growth In Vivo in another window
Includes: Supplementary data
Journal Articles

The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer

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Victoria M. Youngblood, Laura C. Kim, Deanna N. Edwards, Yoonha Hwang, Pranav R. Santapuram, Steven M. Stirdivant, Pengcheng Lu, Fei Ye, Dana M. Brantley-Sieders, Jin Chen
Journal: Cancer Research
Cancer Res (2016) 76 (7): 1825–1836.
https://doi.org/10.1158/0008-5472.CAN-15-0847
Published: 31 March 2016
View article titled, The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer
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Journal Articles

Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium

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Dana M. Brantley-Sieders, Charlene M. Dunaway, Meghana Rao, Sarah Short, Yoonha Hwang, Yandong Gao, Deyu Li, Aixiang Jiang, Yu Shyr, Jane Y. Wu, Jin Chen
Journal: Cancer Research
Cancer Res (2011) 71 (3): 976–987.
https://doi.org/10.1158/0008-5472.CAN-10-3396
Published: 01 February 2011
View article titled, Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium
Open the PDF for Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium in another window
Includes: Supplementary data
Journal Articles

Interactions of EphA2 and HER2 promote tumor progression and anti-HER2 resistance

Free
Guanglei Zhuang, Dana Brantley-Sieders, Donna Hicks, Wei Fang, Yoonha Hwang, Jin Chen
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 122.
Published: 01 May 2008
View article titled, Interactions of EphA2 and HER2 promote tumor progression and anti-HER2 resistance
Journal Articles

Ephrin-A1 Facilitates Mammary Tumor Metastasis through an Angiogenesis-Dependent Mechanism Mediated by EphA Receptor and Vascular Endothelial Growth Factor in Mice

Free
Dana M. Brantley-Sieders, Wei Bin Fang, Yoonha Hwang, Donna Hicks, Jin Chen
Journal: Cancer Research
Cancer Res (2006) 66 (21): 10315–10324.
https://doi.org/10.1158/0008-5472.CAN-06-1560
Published: 01 November 2006
View article titled, Ephrin-A1 Facilitates Mammary Tumor Metastasis through an Angiogenesis-Dependent Mechanism Mediated by EphA Receptor and Vascular Endothelial Growth Factor in Mice
Open the PDF for Ephrin-A1 Facilitates Mammary Tumor Metastasis through an Angiogenesis-Dependent Mechanism Mediated by EphA Receptor and Vascular Endothelial Growth Factor in Mice in another window