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Yongkun Wei
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Journal Articles

Abstract 3921: Development of a KRAS-G12C-driven pancreatic cancer mouse model

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T. Nguyen, Xiaofei Wang, Zecheng Yang, Dean N. Pan, Jangho Park, Yiming Cai, Andrea Viale, Huamin Wang, Dan Zhao, Ronald A. DePinho, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3921.
https://doi.org/10.1158/1538-7445.AM2025-3921
Published: 21 April 2025
View articletitled, Abstract 3921: Development of a KRAS-G12C-driven pancreatic cancer mouse model
Journal Articles

Abstract C019: A novel SDC1-targeted therapeutic antibody inhibits macropinocytosis and induces anti-tumor immunity in pancreatic cancer

Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Xiaofei Wang, Jun Yao, Jennifer Li, Jangho Park, Yangxi Zheng, Long T Vien, Laura Bover, Haoqiang Ying, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C019.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C019
Published: 15 September 2024
View articletitled, Abstract C019: A novel SDC1-targeted therapeutic antibody inhibits macropinocytosis and induces anti-tumor immunity in pancreatic cancer
Journal Articles

Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T. Nguyen, Xiaofei Wang, Zecheng Yang, Abdelrahman Yousef, Dean Pan, Yanqing Jin, Madelaine S. Theady, Jangho Park, Yiming Cai, Mitsunobu Takeda, Matthew Vasquez, Yong Zhou, Hong Zhao, Andrea Viale, Huamin Wang, Dan Zhao, Ronald A. DePinho, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6532.
https://doi.org/10.1158/1538-7445.AM2024-6532
Published: 22 March 2024
View articletitled, Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors
Journal Articles

Abstract C097: KRASG12C exhibits allele-specific biology in pancreatic cancer and targeting CD24 sensitizes KRASG12C-driven tumors to sotorasib treatment

Yongkun Wei, Minghui Liu, Phuoc T. Nguyen, Dean N. Pan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C097.
https://doi.org/10.1158/1538-7445.PANCA2023-C097
Published: 16 January 2024
View articletitled, Abstract C097: KRASG12C exhibits allele-specific biology in pancreatic cancer and targeting CD24 sensitizes KRASG12C-driven tumors to sotorasib treatment
Journal Articles

Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance

MeiKuang Chen, Yuan Gao, Weiya Xia, Yu-Han Wang, Jennifer K. Litton, Yu-Yi Chu, Funda Meric-Bernstam, Helen Piwnica-Worms, Banu Arun, Jordi Rodon Ahnert, Yongkun Wei, Wei-Chao Chang, Hung-Ling Wang, Coya Tapia, Constance T. Albarracin, Shao-Chun Wang, Ying-Nai Wang, Gabriel N. Hortobagyi, Chunru Lin, Liuqing Yang, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1792.
https://doi.org/10.1158/1538-7445.AM2022-1792
Published: 15 June 2022
View articletitled, Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance
Journal Articles

Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function

Xixi Zhao, Yongkun Wei, Yu-Yi Chu, Yintao Li, Jung-Mao Hsu, Zhou Jiang, Chunxiao Liu, Jennifer L. Hsu, Wei-Chao Chang, Riyao Yang, Li-Chuan Chan, Jingkun Qu, Shuqun Zhang, Haoqiang Ying, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2185–2195.
https://doi.org/10.1158/0008-5472.CAN-21-2300
Published: 06 June 2022
View articletitled, Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
Open the PDF for Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function in another window
Includes: Supplementary data
Journal Articles

Abstract 5682: Synergism of PARP inhibitor and MET inhibitor in multiple cancer types with intrinsic and acquired PARP inhibitor resistances

Mei-Kuang Chen, Weiya Xia, Qiongzhu Dong, Yi Du, Hung-Ling Wang, Coya Tapia, Yongkun Wei, Ye Han, Yu-Yi Chu, Clinton Yam, Yuan Gao, Yu-Han Wang, Funda Meric-Bernstam, Jinsong Liu, Shao-Chun Wang, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5682.
https://doi.org/10.1158/1538-7445.AM2020-5682
Published: 15 August 2020
View articletitled, Abstract 5682: Synergism of PARP inhibitor and MET inhibitor in multiple cancer types with intrinsic and acquired PARP inhibitor resistances
Journal Articles

Abstract LB-258: EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma

Qiongzhu Dong, Yi Du, Xixi Zhao, Hui Li, Chunxiao Liu, Yongkun Wei, Mien-chie Hung
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-258.
https://doi.org/10.1158/1538-7445.AM2019-LB-258
Published: 01 July 2019
View articletitled, Abstract LB-258: EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma
Journal Articles

Abstract 4122: The regulatory mechanism of PD-L1 level through ER-associated degradation

Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Chia-Wei Li, Heng-Huan Lee, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4122.
https://doi.org/10.1158/1538-7445.AM2019-4122
Published: 01 July 2019
View articletitled, Abstract 4122: The regulatory mechanism of PD-L1 level through ER-associated degradation
Journal Articles

EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma

Qiongzhu Dong, Yi Du, Hui Li, Chunxiao Liu, Yongkun Wei, Mei-Kuang Chen, Xixi Zhao, Yu-Yi Chu, Yufan Qiu, Lunxiu Qin, Hirohito Yamaguchi, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2019) 79 (4): 819–829.
https://doi.org/10.1158/0008-5472.CAN-18-1273
Published: 15 February 2019
View articletitled, EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma
Open the PDF for EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB-131: Targeting expression of EZH2 with increased H3K27 trimethylation activity drives and synergizes with oncogene to promote mammary tumorigenesis in genetically engineered mouse models

Lei Nie, Yongkun Wei, Hirohito Yamaguchi, Longfei Huo, Weiya Xia, Rong Deng, Jun Tang, Cihui Zhu, Baozhen Ke, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-131.
https://doi.org/10.1158/1538-7445.AM2017-LB-131
Published: 01 July 2017
View articletitled, Abstract LB-131: Targeting expression of EZH2 with increased H3K27 trimethylation activity drives and synergizes with oncogene to promote mammary tumorigenesis in genetically engineered mouse models
Journal Articles

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

Yan Wang, Jung-Mao Hsu, Ya'an Kang, Yongkun Wei, Pei-Chih Lee, Shing-Jyh Chang, Yi-Hsin Hsu, Jennifer L. Hsu, Hung-Ling Wang, Wei-Chao Chang, Chia-Wei Li, Hsin-Wei Liao, Shih-Shin Chang, Weiya Xia, How-Wen Ko, Chao-Kai Chou, Jason B. Fleming, Huamin Wang, Rosa F. Hwang, Yue Chen, Jun Qin, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2016) 76 (23): 7049–7058.
https://doi.org/10.1158/0008-5472.CAN-16-0715
Published: 30 November 2016
View articletitled, Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation
Open the PDF for Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation in another window
Includes: Supplementary data
Journal Articles

JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

Na Li, Shilpa S. Dhar, Tsai-Yu Chen, Pu-Yeh Kan, Yongkun Wei, Jae-Hwan Kim, Chia-Hsin Chan, Hui-Kuan Lin, Mien-Chie Hung, Min Gyu Lee
Journal: Cancer Research
Cancer Res (2016) 76 (4): 831–843.
https://doi.org/10.1158/0008-5472.CAN-15-0906
Published: 14 February 2016
View articletitled, JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis
Open the PDF for JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 2895: Phosphorylation of EZH2 at T416 by CDK2 promotes development of mammary tumors with basal-like phenotype

Lei Nie, Yongkun Wei, Adam LaBaff, Cheng-Chieh Yang, Weiya Xia, Longfei Huo, Dongping Liu, Yi-Hsin Hsu, Gabriel N. Hortobagyi, Jun Yao, Celina G. Kleer, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2895.
https://doi.org/10.1158/1538-7445.AM2015-2895
Published: 01 August 2015
View articletitled, Abstract 2895: Phosphorylation of EZH2 at T416 by CDK2 promotes development of mammary tumors with basal-like phenotype
Journal Articles

Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis

Alexey V. Sorokin, Binoj C. Nair, Yongkun Wei, Kathryn E. Aziz, Valentina Evdokimova, Mien-Chie Hung, Junjie Chen
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1846–1858.
https://doi.org/10.1158/0008-5472.CAN-14-2718
Published: 30 April 2015
View articletitled, Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis
Open the PDF for Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis in another window
Includes: Supplementary data
Journal Articles

Abstract 5146: The histone demethylase KDM2A is a new promoter of tumorigenesis, drug target and negative prognostic biomarker for non-small cell lung cancer

Klaus W. Wagner, Hunain Alam, Shilpa S. Dhar, Uma Giri, Na Li, Yongkun Wei, Tina Cascone, Dipak Giri, Jae-Hwan Kim, Yuanqing Ye, Asha Multani, Chia-Hsin Chan, Baruch Erez, Babita Saigal, Hui-Kuan Lin, Xifeng Wu, Mien-Chie Hung, John Heymach, MinGyu Lee
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5146.
https://doi.org/10.1158/1538-7445.AM2014-5146
Published: 01 October 2014
View articletitled, Abstract 5146: The histone demethylase KDM2A is a new promoter of tumorigenesis, drug target and negative prognostic biomarker for non-small cell lung cancer
Journal Articles

Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer

Yi-Hsin Hsu, Jun Yao, Li-Chuan Chan, Ting-Jung Wu, Jennifer L. Hsu, Yueh-Fu Fang, Yongkun Wei, Yun Wu, Wen-Chien Huang, Chien-Liang Liu, Yuan-Ching Chang, Ming-Yang Wang, Chia-Wei Li, Jia Shen, Mei-Kuang Chen, Aysegul A. Sahin, Anil Sood, Gordon B. Mills, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4822–4835.
https://doi.org/10.1158/0008-5472.CAN-14-0584
Published: 01 September 2014
View articletitled, Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
Open the PDF for Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5351: Phosphorylation of EZH2 at Thr487 is a marker for good prognosis in pancreatic cancer patients.

Yongkun Wei, Shih-Shin Chang, Huamin Wang, Weiya Xia, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5351.
https://doi.org/10.1158/1538-7445.AM2013-5351
Published: 15 April 2013
View articletitled, Abstract 5351: Phosphorylation of EZH2 at Thr487 is a marker for good prognosis in pancreatic cancer patients.
Journal Articles

Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer

Lyndsay V. Rhodes, Sarah P. Short, Nicole F. Neel, Virgilio A. Salvo, Yun Zhu, Steven Elliott, Yongkun Wei, Dihua Yu, Menghong Sun, Shannon E. Muir, Juan P. Fonseca, Melyssa R. Bratton, Chris Segar, Syreeta L. Tilghman, Tammy Sobolik-Delmaire, Linda W. Horton, Snjezana Zaja-Milatovic, Bridgette M. Collins-Burow, Scott Wadsworth, Barbara S. Beckman, Charles E. Wood, Suzanne A. Fuqua, Kenneth P. Nephew, Paul Dent, Rebecca A. Worthylake, Tyler J. Curiel, Mien-Chie Hung, Ann Richmond, Matthew E. Burow
Journal: Cancer Research
Cancer Res (2011) 71 (2): 603–613.
https://doi.org/10.1158/0008-5472.CAN-10-3185
Published: 13 January 2011
View articletitled, Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer
Open the PDF for Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract #LB-9: Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

Yong Liao, Yongkun Wei, Xiaoyan Zhou, Jer-Yen Yang, Chun Dai, Yun-Ju Chen, Nitin Agarwal, Dos Sarbassov, Daren Shi, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): LB-9.
Published: 01 May 2009
View articletitled, Abstract #LB-9: Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation