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Yogen Saunthararajah
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Journal Articles

Abstract 1088: Advancing non-cytotoxic DNMT1-targeting to treat chemorefractory pancreatic cancer

Rita Tohme, Francis Enane, Caroline Schuerger, Xiaorong Gu, Melissa Fishel, John Pink, Daniel Lindner, Davendra Sohal, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1088.
https://doi.org/10.1158/1538-7445.AM2021-1088
Published: 01 July 2021
View article titled, Abstract 1088: Advancing non-cytotoxic DNMT1-targeting to treat chemorefractory pancreatic cancer
Journal Articles

Abstract C58: p53/p16-independent cytoreduction of chemoresistant pancreatic adenocarcinoma by metabolically optimized epigenetic therapy

Rita Tohme, Xiaorong Gu, Asmaa El Desoky, Caroline Schuerger, Daniel Lindner, Davendra Sohal, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C58.
https://doi.org/10.1158/1538-7445.PANCA19-C58
Published: 13 December 2019
View article titled, Abstract C58: p53/p16-independent cytoreduction of chemoresistant pancreatic adenocarcinoma by metabolically optimized epigenetic therapy
Journal Articles

Abstract 2917: Differentiation therapy and the mechanisms that terminate malignant proliferation

Francis O. Enane, Xiaorong Gu, Murray Korc, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2917.
https://doi.org/10.1158/1538-7445.AM2018-2917
Published: 01 July 2018
View article titled, Abstract 2917: Differentiation therapy and the mechanisms that terminate malignant proliferation
Journal Articles

Abstract 4316: Disruption and restoration of pioneer transcription factor hub function in bladder cancer

Caroline Schuerger, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4316.
https://doi.org/10.1158/1538-7445.AM2018-4316
Published: 01 July 2018
View article titled, Abstract 4316: Disruption and restoration of pioneer transcription factor hub function in bladder cancer
Journal Articles

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo

Hien Anh Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic, Michael Caffrey, Amanda M. Schalk, Li Liu, Damiano Rondelli, Annie Oh, Dolores L. Mahmud, Maarten C. Bosland, Andre Kajdacsy-Balla, Sofie Peirs, Tim Lammens, Veerle Mondelaers, Barbara De Moerloose, Steven Goossens, Michael J. Schlicht, Kasim K. Kabirov, Alexander V. Lyubimov, Bradley J. Merrill, Yogen Saunthararajah, Pieter Van Vlierberghe, Arnon Lavie
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1549–1560.
https://doi.org/10.1158/0008-5472.CAN-17-2106
Published: 14 March 2018
View article titled, A Novel <sc>l</sc>-Asparaginase with low <sc>l</sc>-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias <em>In Vivo</em>
Open the PDF for A Novel <sc>l</sc>-Asparaginase with low <sc>l</sc>-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias <em>In Vivo</em> in another window
Includes: Supplementary data
Journal Articles

Abstract 3520: PBRM1 inactivation in renal cell cancer alters master transcription factor hub composition to repress instead of activate epithelial-differentiation

Xiaorong Gu, Francis Enane, Reda Mahfouz, Tomas Radivoyevitch, Bartlomiej Przychodzen, Yvonne Parker, Daniel Lindner, Brian Rini, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3520.
https://doi.org/10.1158/1538-7445.AM2017-3520
Published: 01 July 2017
View article titled, Abstract 3520: PBRM1 inactivation in renal cell cancer alters master transcription factor hub composition to repress instead of activate epithelial-differentiation
Journal Articles

Abstract 2872: Cytoplasmic localization of PU.1 with mutated NPM1 causes myeloid differentiation arrest

Xiaorong Gu, Reda Mahfouz, Ji Zhang, Francis Enane, Zhenbo Hu, Tomas Radivoyevitch, David Wald, Maria Paola Martelli, Brunangelo Falini, Yosef Landesman, Jaroslaw Maciejewski, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2872.
https://doi.org/10.1158/1538-7445.AM2016-2872
Published: 15 July 2016
View article titled, Abstract 2872: Cytoplasmic localization of PU.1 with mutated NPM1 causes myeloid differentiation arrest
Journal Articles

GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation

Kalpana Gupta, Tammy Stefan, James Ignatz-Hoover, Stephen Moreton, Gary Parizher, Yogen Saunthararajah, David N. Wald
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2743–2753.
https://doi.org/10.1158/0008-5472.CAN-15-2290
Published: 01 May 2016
View article titled, GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation
Open the PDF for GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation in another window
Includes: Supplementary data
Journal Articles

Abstract 3518: Frequent mutation and deletion of GATA4 in hepatocellular carcinoma represses proliferation terminating late-maturation genes CEBPD and HNF4A by reversible epigenetic mechanisms.

Francis O. Enane, Marissa Teo, Hideki Makishima, Zhenbo Hu, Han Chong Toh, Yogen Saunthararajah, Joanna Ng, Chit Lai, Soo Fan Ang, Lim Kiat Hon
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3518.
https://doi.org/10.1158/1538-7445.AM2013-3518
Published: 15 April 2013
View article titled, Abstract 3518: Frequent mutation and deletion of GATA4 in hepatocellular carcinoma represses proliferation terminating late-maturation genes CEBPD and HNF4A by reversible epigenetic mechanisms.
Journal Articles

Noncytotoxic Differentiation Treatment of Renal Cell Cancer

Soledad Negrotto, Zhenbo Hu, Oscar Alcazar, Kwok Peng Ng, Pierre Triozzi, Daniel Lindner, Brian Rini, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2011) 71 (4): 1431–1441.
https://doi.org/10.1158/0008-5472.CAN-10-2422
Published: 14 February 2011
View article titled, Noncytotoxic Differentiation Treatment of Renal Cell Cancer
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Includes: Supplementary data
Journal Articles

AML1-ETO Decreases ETO-2 (MTG16) Interactions with Nuclear Receptor Corepressor, an Effect That Impairs Granulocyte Differentiation

Vinzon Ibañez, Arun Sharma, Silvia Buonamici, Amit Verma, Sudhakar Kalakonda, Jianxiang Wang, ShriHari Kadkol, Yogen Saunthararajah
Journal: Cancer Research
Cancer Res (2004) 64 (13): 4547–4554.
https://doi.org/10.1158/0008-5472.CAN-03-3689
Published: 01 July 2004
View article titled, AML1-ETO Decreases ETO-2 (MTG16) Interactions with Nuclear Receptor Corepressor, an Effect That Impairs Granulocyte Differentiation
Open the PDF for AML1-ETO Decreases ETO-2 (MTG16) Interactions with Nuclear Receptor Corepressor, an Effect That Impairs Granulocyte Differentiation in another window
Journal Articles

Inhibitors of Histone Deacetylase Relieve ETO-mediated Repression and Induce Differentiation of AML1-ETO Leukemia Cells

Jianxiang Wang, Yogen Saunthararajah, Robert L. Redner, Johnson M. Liu
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2766–2769.
Published: 15 June 1999
View article titled, Inhibitors of Histone Deacetylase Relieve ETO-mediated Repression and Induce Differentiation of AML1-ETO Leukemia Cells
Open the PDF for Inhibitors of Histone Deacetylase Relieve ETO-mediated Repression and Induce Differentiation of AML1-ETO Leukemia Cells in another window