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Journal Articles

Abstract 2515: Aberrant expression of CSF1R in melanoma is driven through an endogenous viral promoter and it contributes to malignant growth and BRAF-inhibitor resistance

Orsolya Giricz, Yongkai Mo, Kimberly B. Dahlman, Xiomaris M. Cotto-Rios, Chiara Vardabasso, Hoa Nguyen, Bernice Matusow, Matthias Bartenstein, Veronika Polishchuck-Lee, Douglas B. Johnson, Tushar B. Bhagat, Rafe Shellooe, Elizabeth Burton, Gaston Habets, John M. Greally, Yiting Yu, Gideon Bollag, Paraic A. Kenny, Kith Pradhan, E. Richard Stanley, Emily Bernstein, Evripidis Gavathiotis, Brian L. West, Jeffrey A. Sosman, Amit Verma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2515.
https://doi.org/10.1158/1538-7445.AM2018-2515
Published: 01 July 2018
View article titled, Abstract 2515: Aberrant expression of CSF1R in melanoma is driven through an endogenous viral promoter and it contributes to malignant growth and BRAF-inhibitor resistance
Journal Articles

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Tushar D. Bhagat, Si Chen, Matthias Bartenstein, A. Trevor Barlowe, Dagny Von Ahrens, Gaurav S. Choudhary, Patrick Tivnan, Elianna Amin, A. Mario Marcondes, Mathijs A. Sanders, Remco M. Hoogenboezem, Suman Kambhampati, Nandini Ramachandra, Iaonnis Mantzaris, Vineeth Sukrithan, Remi Laurence, Robert Lopez, Prafulla Bhagat, Orsi Giricz, Davendra Sohal, Amittha Wickrema, Cecilia Yeung, Kira Gritsman, Peter Aplan, Konrad Hochedlinger, Yiting Yu, Kith Pradhan, Jinghang Zhang, John M. Greally, Siddhartha Mukherjee, Andrea Pellagatti, Jacqueline Boultwood, Britta Will, Ulrich Steidl, Marc H.G.P. Raaijmakers, H. Joachim Deeg, Michael G. Kharas, Amit Verma
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (18): 4846–4857.
https://doi.org/10.1158/0008-5472.CAN-17-0282
Published: 14 September 2017
View article titled, Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
Open the PDF for Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation in another window
Includes: Supplementary data
Journal Articles

Abstract 3332: Aberrant expression of CSF1R in melanoma is driven through an endogenous viral promoter and it contributes to malignant growth and the acquisition of resistance against BRAF inhibition

Orsolya Giricz, Yongkai Mo, Caroline Y. Hu, Yiting Yu, Kith Pradhan, Matthias Bartenstein, Nandini Ramachandra, Veronika Polishchuck, Kimberly B. Dahlman, Tushar Bhagat, Hoa Nguyen, Bernice Matusow, Rafe Shellooe, Elizabeth Burton, Paraic Kenny, John Greally, Jeffrey Sosman, Gideon Bollag, Brian West, Amit Verma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3332.
https://doi.org/10.1158/1538-7445.AM2017-3332
Published: 01 July 2017
View article titled, Abstract 3332: Aberrant expression of CSF1R in melanoma is driven through an endogenous viral promoter and it contributes to malignant growth and the acquisition of resistance against BRAF inhibition
Journal Articles

Abstract 1170: Notch pathway is overexpressed and is a therapeutic target in clear cell renal cancer

Tushar D. Bhagat, Yiyu Zou, Shizeng Huang, Jihwan Park, Matthew B. Palmer, Caroline Hu, Weijuan Li, Niraj Shenoy, Orsolya Giricz, Yiting Yu, Yi-An Ko, María Concepción Izquierdo, Esther Park, Nishanth Vallumsetla, Remi Laurence, Robert Lopez, Masako Suzuki, James Pullman, Justin Kaner, Benjamin Gartrell, A. Ari Hakimi, John Greally, Bharvin Patel, Karim Benhadji, Kith Pradhan, Amit Verma, Katalin Susztak
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1170.
https://doi.org/10.1158/1538-7445.AM2017-1170
Published: 01 July 2017
View article titled, Abstract 1170: Notch pathway is overexpressed and is a therapeutic target in clear cell renal cancer
Journal Articles

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia

Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, Ioannis Mantzaris, Matthias Bartenstein, Nandini Ramachandra, Orsi Giricz, Vineeth Sukrithan, George Nwankwo, Samira Shahnaz, Tushar D. Bhagat, Sanchari Bhattacharyya, Amer Assal, Aditi Shastri, Shanisha Gordon-Mitchell, Andrea Pellagatti, Jacqueline Boultwood, Carolina Schinke, Yiting Yu, Chandan Guha, James Rizzi, Jennifer Garrus, Suzy Brown, Lance Wollenberg, Grant Hogeland, Dale Wright, Mark Munson, Mareli Rodriguez, Stefan Gross, David Chantry, Yiyu Zou, Leonidas C. Platanias, Laurence E. Burgess, Kith Pradhan, Ulrich Steidl, Amit Verma
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4841–4849.
https://doi.org/10.1158/0008-5472.CAN-15-3062
Published: 14 August 2016
View article titled, Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
Open the PDF for Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 1885: Integrated epigenomic profiling reveals widespread demethylation in melanoma and points to the role of CSF1R-RUNX1 axis in resistance against BRAF inhibition

Orsolya Giricz, Yongkai Mo, Caroline H. Hu, Kimberly Dahlman, Nandini Ramachandra, Matthias Bartenstein, Kith Pradhan, Tushar Bhagat, Yiting Yu, Hoa Nguyen, Elizabeth Burton, Bernice Matusow, Gaston Habets, Rafe Shellooe, Gideon Bollag, Brian West, John Greally, Jeffrey Sosman, Paraic Kenny, Amit Verma
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1885.
https://doi.org/10.1158/1538-7445.AM2016-1885
Published: 15 July 2016
View article titled, Abstract 1885: Integrated epigenomic profiling reveals widespread demethylation in melanoma and points to the role of CSF1R-RUNX1 axis in resistance against BRAF inhibition
Journal Articles

Abstract PR06: Integrated epigenomic profiling reveals widespread demethylation in melanoma and reveals CSF-1 Receptor as an aberrant regulator of malignant growth and invasion

Orsolya Giricz, Yongkai Mo, Caroline Hu, Kimberly Dahlman, Sanchari Bhattacharyya, Hoa Nguyen, Bernice Matusow, Tushar Bhagat, Yiting Yu, Rafe Shellooe, Elizabeth Burton, Gaston Habets, John Greally, Kenny Paraic, Jeffrey Sosman, Gideon Bollag, Brian West, Amit Verma
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): PR06.
https://doi.org/10.1158/1538-7445.MEL2014-PR06
Published: 16 July 2015
View article titled, Abstract PR06: Integrated epigenomic profiling reveals widespread demethylation in melanoma and reveals CSF-1 Receptor as an aberrant regulator of malignant growth and invasion
Journal Articles

Abstract 5224: MicroRNA mediated regulation of TGF-β signaling leads to stem cell alterations in myelodysplastic syndromes

Tushar D. Bhagat, Li Zhou, Lubomir Sokol, Ioannis Mantzaris, Sanchari Bhattacharyya, Shanisha A.K. Gordon, Yiting Yu, Krishna Gundabolu, Sangeeta Nischal, Rahul Polineni, Carolina Schinke, Grigorios Chrysofakis, Amittha Wickrema, Andrea Pellagatti, Jacqueline Boultwood, Ulrich Steidl, Gang Liu, Alan F. List, Markus Bitzer, Amit Verma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5224.
https://doi.org/10.1158/1538-7445.AM2014-5224
Published: 01 October 2014
View article titled, Abstract 5224: MicroRNA mediated regulation of TGF-β signaling leads to stem cell alterations in myelodysplastic syndromes
Journal Articles

Abstract 4781: Integrated epigenomic profiling reveals widespread demethylation in melanoma and reveals CSF-1 receptor as an aberrant regulator of malignant growth and invasion

Yongkai Mo, Orsolya Giricz, Caroline H. Hu, Kimberly B. Dahlman, Sanchari Bhattacharyya, Hoa Nguyen, Bernice Matusow, Tushar Bhagat, Rafe Shellooe, Elizabeth Burton, James Tsai, Chao Zhang, Gaston Habets, Yu Shyr, John Greally, Yiting Yu, Gideon E. Bollag, Richard Stanley, Jeffrey Trent, Paraic A. Kenny, Brian L. West, Jeffrey Sosman, Amit K. Verma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4781.
https://doi.org/10.1158/1538-7445.AM2014-4781
Published: 01 October 2014
View article titled, Abstract 4781: Integrated epigenomic profiling reveals widespread demethylation in melanoma and reveals CSF-1 receptor as an aberrant regulator of malignant growth and invasion
Journal Articles

Abstract A26: Integrated epigenomic profiling reveals widespread demethylation in melanoma, and reveals aberrant CSF-1 receptor expression as a regulator of malignant growth and invasion inhibited by PLX3397

Yongkai Mo, Orsolya Giricz, Caroline Hu, Kimberly Dahlman, Sanchari Bhattacharyya, Hoa Nguyen, Bernice Matusow, Tushar Bhagat, Yiting Yu, Rafe Shellooe, Elizabeth Burton, Gaston Habets, John Greally, Paraic Kenny, Jeffrey Sosman, Gideon Bollag, Brian L. West, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): A26.
https://doi.org/10.1158/1538-7445.TIM2013-A26
Published: 01 May 2014
View article titled, Abstract A26: Integrated epigenomic profiling reveals widespread demethylation in melanoma, and reveals aberrant CSF-1 receptor expression as a regulator of malignant growth and invasion inhibited by PLX3397
Journal Articles

Abstract 1504: Pancreatic cancer associated fibroblasts are characterized by widespread epigenetic reprogramming that leads to aberrant expression of druggable target CXCR4.

Tushar D. Bhagat, Yanique Rattigan, Brijesh Patel, Strepell Mirte, Yiting Yu, Davendra Sohal, Matthias Bartenstein, Orsolya Giricz, Shanisha AK Gordon, Nishanth Vallumsetla, Rahul Polineni, Meher Walia, Paraic Kenny, John Greally, Debabrata Banerjee, Anirban Maitra, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1504.
https://doi.org/10.1158/1538-7445.AM2013-1504
Published: 15 April 2013
View article titled, Abstract 1504: Pancreatic cancer associated fibroblasts are characterized by widespread epigenetic reprogramming that leads to aberrant expression of druggable target CXCR4.
Journal Articles

Abstract 1503: Myelodysplasia bone marrow stromal cells have widespread aberrant hypermethylation that is targeted by treatment with DNMT inhibitors.

Tushar D. Bhagat, Matthias Bartenstein, Yiting Yu, A. Mario Marcondes, Davendra Sohal, John Greally, H Joachim Deeg, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1503.
https://doi.org/10.1158/1538-7445.AM2013-1503
Published: 15 April 2013
View article titled, Abstract 1503: Myelodysplasia bone marrow stromal cells have widespread aberrant hypermethylation that is targeted by treatment with DNMT inhibitors.
Journal Articles

Abstract 3041: A tumor-suppressive role of the IL-21R/Jak/STAT3 pathway in the germinal center B cell subtype of diffuse large B cell lymphomas.

B. Hilda Ye, Enguang Bi, J. Jessica Yu, Yun Mai, B. Belinda Ding, Yiting Yu, Amit Verma, Rita Shaknovich, Wing C. Chan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3041.
https://doi.org/10.1158/1538-7445.AM2013-3041
Published: 15 April 2013
View article titled, Abstract 3041: A tumor-suppressive role of the IL-21R/Jak/STAT3 pathway in the germinal center B cell subtype of diffuse large B cell lymphomas.
Journal Articles

Abstract 4231: Genome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.

Sanchari Bhattacharyya, Yiting Yu, Masako Suzuki, Nathaniel Cambpell, Jozef Mazdo, Aparna Vasantkumar, Tushar D. Bhagat, Sangeeta Nischal, Ulrich Steidl, Lucy Godley, Anirban Maitra, John M. Greally, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4231.
https://doi.org/10.1158/1538-7445.AM2013-4231
Published: 15 April 2013
View article titled, Abstract 4231: Genome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
Journal Articles

Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms

Sangeeta Nischal, Sanchari Bhattacharyya, Maximilian Christopeit, Yiting Yu, Li Zhou, Tushar D. Bhagat, Davendra Sohal, Britta Will, Yongkai Mo, Masako Suzuki, Animesh Pardanani, Michael McDevitt, Jaroslaw P. Maciejewski, Ari M. Melnick, John M. Greally, Ulrich Steidl, Alison Moliterno, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1076–1085.
https://doi.org/10.1158/0008-5472.CAN-12-0735
Published: 31 January 2013
View article titled, Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms
Open the PDF for Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms in another window
Includes: Supplementary data
Journal Articles

Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Li Zhou, Christine McMahon, Tushar Bhagat, Cristina Alencar, Yiting Yu, Melissa Fazzari, Davendra Sohal, Christoph Heuck, Krishna Gundabolu, Chun Ng, Yongkai Mo, Wa Shen, Amittha Wickrema, Guanghui Kong, Ellen Friedman, Lubomir Sokol, Giannis Mantzaris, Andrea Pellagatti, Jacqueline Boultwood, Leonidas C. Platanias, Ulrich Steidl, Lei Yan, Jonathan M. Yingling, Michael M. Lahn, Alan List, Markus Bitzer, Amit Verma
Journal: Cancer Research
Cancer Res (2011) 71 (3): 955–963.
https://doi.org/10.1158/0008-5472.CAN-10-2933
Published: 01 February 2011
View article titled, Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase
Open the PDF for Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase in another window