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Yinyin Yuan
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Journal Articles

Abstract PS03-07: Morphometric signature identifies ductal carcinoma in situ of the breast with low risk of progression to invasive breast cancer

Marcelo Sobral-Leite, Simon Castillo, Shiva Vonk, Xenia Melillo, Noomie Lam, Brandi de Bruijn, Yeman Hagos, Joyce Sanders, Mathilde Almekinders, Lindy Visser, Emilie Groen, Carolien Van der Borden, Petra Kristel, Ercan Caner, Leyla Azarang, Yinyin Yuan, Renee Menezes, Esther Lips, Jelle Wesseling, Grand Challenge PRECISION Consortium
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS03-07.
https://doi.org/10.1158/1538-7445.SABCS23-PS03-07
Published: 02 May 2024
View article titled, Abstract PS03-07: Morphometric signature identifies ductal carcinoma in situ of the breast with low risk of progression to invasive breast cancer
Journal Articles

Abstract 6184: A novel approach to Barrett's esophagus risk stratification: Whole-slide image analysis for aneuploidy detection

Caner Ercan, Xiaoxi Pan, Thomas G. Paulson, Matthew D. Stachler, Carlo C. Maley, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6184.
https://doi.org/10.1158/1538-7445.AM2024-6184
Published: 22 March 2024
View article titled, Abstract 6184: A novel approach to Barrett's esophagus risk stratification: Whole-slide image analysis for aneuploidy detection
Journal Articles

Abstract 6171: Evolution of the spatial myeloid-lymphoid engagement in glioblastoma under temozolomide treatment

Simon P. Castillo, Afrooz Jahedi, Pravesh Gupta, Jason T. Huse, Kasthuri Kannan, Yinyin Yuan, Krishna P. Bhat
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6171.
https://doi.org/10.1158/1538-7445.AM2024-6171
Published: 22 March 2024
View article titled, Abstract 6171: Evolution of the spatial myeloid-lymphoid engagement in glioblastoma under temozolomide treatment
Journal Articles

Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies

Yeman Brhane Hagos, Catherine S.Y. Lecat, Dominic Patel, Anna Mikolajczak, Simon P. Castillo, Emma J. Lyon, Kane Foster, Thien-An Tran, Lydia S.H. Lee, Manuel Rodriguez-Justo, Kwee L. Yong, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2024) 84 (3): 493–508.
https://doi.org/10.1158/0008-5472.CAN-22-2654
Published: 01 February 2024
View article titled, Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies
Open the PDF for Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies in another window
Includes: Supplementary data
Journal Articles

Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma

Hanyun Zhang, Khalid AbdulJabbar, David A. Moore, Ayse Akarca, Katey S.S. Enfield, Mariam Jamal-Hanjani, Shan E. Ahmed Raza, Selvaraju Veeriah, Roberto Salgado, Nicholas McGranahan, John Le Quesne, Charles Swanton, Teresa Marafioti, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2023) 83 (9): 1410–1425.
https://doi.org/10.1158/0008-5472.CAN-22-2589
Published: 02 May 2023
View article titled, Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma
Open the PDF for Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB064: B cells synergize with T cell regulation at immune hotspots in lung squamous cell carcinoma

Hanyun Zhang, Khalid AbdulJabbar, David A. Moore, Ayse Akarca, Katey Enfield, Mariam Jamal-Hanjani, Shan E Ahmed Raza, Selvaraju Veeriah, Dhruva Biswas, Roberto Salgado, Nicholas McGranahan, TRACERx Consortium, John Le Quesne, Charles Swanton, Teresa Marafioti, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB064.
https://doi.org/10.1158/1538-7445.AM2022-LB064
Published: 15 June 2022
View article titled, Abstract LB064: B cells synergize with T cell regulation at immune hotspots in lung squamous cell carcinoma
Journal Articles

Abstract LB504: Automated grading of growth patterns in lung adenocarcinoma-from TRACERx to LATTICe-A

Xiaoxi Pan, Khalid AbdulJabbar, Jose Coelho-Lima, Anca-Ioana Grapa, Hanyun Zhang, Ho Kwan Alvin Cheung, Sarah J. Aitken, David A. Moore, Charles Swanton, John Le Quesne, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB504.
https://doi.org/10.1158/1538-7445.AM2022-LB504
Published: 15 June 2022
View article titled, Abstract LB504: Automated grading of growth patterns in lung adenocarcinoma-from TRACERx to LATTICe-A
Journal Articles

Abstract LB153: Clinical relevance of spatial intermixing of growth patterns and immune infiltration in lung adenocarcinoma-from TRACERx to LATTICe-A

Anca-Ioana Grapa, Hanyun Zhang, Xiaoxi Pan, Khalid AbdulJabbar, Jose Coelho-Lima, Ho Kwan Alvin Cheung, Sarah J. Aitken, David A. Moore, Charles Swanton, John Le Quesne, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB153.
https://doi.org/10.1158/1538-7445.AM2022-LB153
Published: 15 June 2022
View article titled, Abstract LB153: Clinical relevance of spatial intermixing of growth patterns and immune infiltration in lung adenocarcinoma-from TRACERx to LATTICe-A
Journal Articles

Abstract 5055: Precise segmentation of growth patterns in TRACERx lung adenocarcinoma

Xiaoxi Pan, Hanyun Zhang, Anca-Ioana Grapa, Khalid AbdulJabbar, Shan E. Ahmed Raza, HO KWAN ALVIN CHEUNG, Takahiro Karasaki, John Le Quesne, David A. Moore, Charles Swanton, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5055.
https://doi.org/10.1158/1538-7445.AM2022-5055
Published: 15 June 2022
View article titled, Abstract 5055: Precise segmentation of growth patterns in TRACERx lung adenocarcinoma
Journal Articles

Abstract IA05: Deciphering the immune microenvironment with spatial histology

Yinyin Yuan
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): IA05.
https://doi.org/10.1158/1538-7445.TUMHET2020-IA05
Published: 03 November 2020
View article titled, Abstract IA05: Deciphering the immune microenvironment with spatial histology
Journal Articles

Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma

Konstantinos Zormpas-Petridis, Evon Poon, Matthew Clarke, Neil P. Jerome, Jessica K.R. Boult, Matthew D. Blackledge, Fernando Carceller, Alexander Koers, Giuseppe Barone, Andrew D.J. Pearson, Lucas Moreno, John Anderson, Neil Sebire, Kieran McHugh, Dow-Mu Koh, Louis Chesler, Yinyin Yuan, Simon P. Robinson, Yann Jamin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (16): 3424–3435.
https://doi.org/10.1158/0008-5472.CAN-20-0133
Published: 14 August 2020
View article titled, Noninvasive MRI Native T<sub>1</sub> Mapping Detects Response to <em>MYCN</em>-targeted Therapies in the Th-<em>MYCN</em> Model of Neuroblastoma
Open the PDF for Noninvasive MRI Native T<sub>1</sub> Mapping Detects Response to <em>MYCN</em>-targeted Therapies in the Th-<em>MYCN</em> Model of Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Topological Tumor Graphs: A Graph-Based Spatial Model to Infer Stromal Recruitment for Immunosuppression in Melanoma Histology

Henrik Failmezger, Sathya Muralidhar, Antonio Rullan, Carlos E. de Andrea, Erik Sahai, Yinyin Yuan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (5): 1199–1209.
https://doi.org/10.1158/0008-5472.CAN-19-2268
Published: 02 March 2020
View article titled, Topological Tumor Graphs: A Graph-Based Spatial Model to Infer Stromal Recruitment for Immunosuppression in Melanoma Histology
Open the PDF for Topological Tumor Graphs: A Graph-Based Spatial Model to Infer Stromal Recruitment for Immunosuppression in Melanoma Histology in another window
Includes: Supplementary data
Journal Articles

Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography

Jin Li, Konstantinos Zormpas-Petridis, Jessica K.R. Boult, Emma L. Reeves, Andreas Heindl, Maria Vinci, Filipa Lopes, Craig Cummings, Caroline J. Springer, Louis Chesler, Chris Jones, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (22): 5874–5883.
https://doi.org/10.1158/0008-5472.CAN-19-1595
Published: 15 November 2019
View article titled, Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography
Open the PDF for Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography in another window
Includes: Supplementary data
Journal Articles

MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment

Konstantinos Zormpas-Petridis, Neil P. Jerome, Matthew D. Blackledge, Fernando Carceller, Evon Poon, Matthew Clarke, Ciara M. McErlean, Giuseppe Barone, Alexander Koers, Sucheta J. Vaidya, Lynley V. Marshall, Andrew D.J. Pearson, Lucas Moreno, John Anderson, Neil Sebire, Kieran McHugh, Dow-Mu Koh, Yinyin Yuan, Louis Chesler, Simon P. Robinson, Yann Jamin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (11): 2978–2991.
https://doi.org/10.1158/0008-5472.CAN-18-3412
Published: 03 June 2019
View article titled, MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment
Open the PDF for MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment in another window
Includes: Supplementary data
Journal Articles

Abstract B2-55: Critical role of immune spatial heterogeneity and the molecular scaffold in estrogen receptor-negative breast cancer

Sidra Nawaz, Andreas Heindl, Andrea Agostinelli, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B2-55.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B2-55
Published: 15 November 2015
View article titled, Abstract B2-55: Critical role of immune spatial heterogeneity and the molecular scaffold in estrogen receptor-negative breast cancer
Journal Articles

Abstract B2-51: SpEeCH: Quantifying Spatial Expression of Clonal Heterogeneity in breast cancer

Andreas Heindl, Adnan Mujahid Khan, Yinyin Yuan
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B2-51.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B2-51
Published: 15 November 2015
View article titled, Abstract B2-51: SpEeCH: Quantifying Spatial Expression of Clonal Heterogeneity in breast cancer