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Journal Articles

Abstract 3118: IBI3026, a first-in-class anti-PD-1/IL-12 fusion protein, demonstrates the potential to be a new immuno-oncology therapy by releasing the break in immune response and strongly activating T and NK cells in the tumor microenvironment

Free
Xinran Liu, Fenggen Fu, Shuaixiang Zhou, Weiwei Wu, Haoyu Wen, Yang Liu, Min Wu, Meng Ni, Yan Liu, Enhong Zhong, Yayao Yan, Ying Zhang, Zhihai Wu, Yuting Wei, Kaijie He
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3118.
https://doi.org/10.1158/1538-7445.AM2025-3118
Published: 21 April 2025
View articletitled, Abstract 3118: IBI3026, a first-in-class anti-PD-1/IL-12 fusion protein, demonstrates the potential to be a new immuno-oncology therapy by releasing the break in immune response and strongly activating T and NK cells in the tumor microenvironment
Journal Articles

Abstract 3662: DNA-encoded chemical library screening and machine-learning for hit identification for WD40 repeat targets including oncology targets such as DCAF1, WDR5 and WDR12

Free
Anthony D. Keefe, Arrash J. Baghaie, Paolo A. Centrella, Matthew A. Clark, Marie-Aude Guié, John P. Guilinger, Jenny Liu, Ryan T. Walsh, Ying Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3662.
https://doi.org/10.1158/1538-7445.AM2025-3662
Published: 21 April 2025
View articletitled, Abstract 3662: DNA-encoded chemical library screening and machine-learning for hit identification for WD40 repeat targets including oncology targets such as DCAF1, WDR5 and WDR12
Journal Articles

Abstract 400: Preclinical development of TQB3019: A potent and selective oral BTK degrader leveraging the OAPD® platform to overcome acquired resistance mutations

Free
Jing Ren, Jinan Wang, Sheng Xu, Jin Liu, Ying Zhang, Xiaojin Wang, Baomin Liu, Wei Shi, Hongjiang Xu, Ling Yang, Wei Zhao, Xiquan Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 400.
https://doi.org/10.1158/1538-7445.AM2025-400
Published: 21 April 2025
View articletitled, Abstract 400: Preclinical development of TQB3019: A potent and selective oral BTK degrader leveraging the OAPD® platform to overcome acquired resistance mutations
Journal Articles

Abstract 3163: Discovery of highly selective ligands for the Bcl-2 family of proteins using DNA-encoded chemical libraries

Free
Ying Zhang, Sana Bazzaz, Corey Bienstock, Paolo A. Centrella, Marie-Aude Guié, John P. Guilinger, Anthony D. Keefe, Matthew A. Clark
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3163.
https://doi.org/10.1158/1538-7445.AM2025-3163
Published: 21 April 2025
View articletitled, Abstract 3163: Discovery of highly selective ligands for the Bcl-2 family of proteins using DNA-encoded chemical libraries
Journal Articles

Abstract 4249: IBI3019, a first-in-class EGFR/CDH17/CD16A tri-specific antibody, demonstrated potent efficacy against CRC and an excellent safety profile in preclinical studies

Free
Tiongsun Chia, Weiwei Wu, Li Li, Shuaixiang Zhou, Jia Lu, Shuming Lin, Ming Wu, Jia Liu, Feifei Wang, Ya Liu, Chenjuan Zhu, Ying Zhang, Yayao Yan, Huisi Liu, Jian Guan, Junjie Deng, Ninghuan Li, Zhihai Wu, Bin Li, Enhong Zhong, Bingliang Chen, Kaijie He
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4249.
https://doi.org/10.1158/1538-7445.AM2025-4249
Published: 21 April 2025
View articletitled, Abstract 4249: IBI3019, a first-in-class EGFR/CDH17/CD16A tri-specific antibody, demonstrated potent efficacy against CRC and an excellent safety profile in preclinical studies
Journal Articles

Abstract LB055: IBI3001: A potentially first-in-class site-specifically conjugated B7-H3/EGFR bispecific ADC for multiple solid tumors

Free
Jian Guan, Xiao Zhang, Weiwei Wu, Lei Cao, Zhengguang Liao, Tianyu Zhu, Chentao Liu, Shuaixiang Zhou, Jia Lu, Ninghuan Li, Nana Luo, Ying Zhang, Kang Dian, Tiong Sun Chia, Bingliang Chen, Kaijie He
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB055.
https://doi.org/10.1158/1538-7445.AM2024-LB055
Published: 05 April 2024
View articletitled, Abstract LB055: IBI3001: A potentially first-in-class site-specifically conjugated B7-H3/EGFR bispecific ADC for multiple solid tumors
Journal Articles

Abstract LB056: IBI334, a novel ADCC-enhanced B7-H3/EGFR bispecific antibody, demonstrated potent pre-clinical efficacy in solid tumors

Free
Jian Guan, Shuaixiang Zhou, Weiwei Wu, Tianyu Zhu, Lei Cao, Ming Wu, Ninghuan Li, Fenggen Fu, Zhengguan Liao, Shuming Lin, Zeyu Liu, Mengjia Zhu, Nana Luo, Ying Zhang, Tiong Sun Chia, Bingliang Chen, Kaijie He
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB056.
https://doi.org/10.1158/1538-7445.AM2024-LB056
Published: 05 April 2024
View articletitled, Abstract LB056: IBI334, a novel ADCC-enhanced B7-H3/EGFR bispecific antibody, demonstrated potent pre-clinical efficacy in solid tumors
Journal Articles

Abstract 5650: RNA regulatory disruption by 3’-dATP: A novel approach to inhibit ribosome biogenesis in cancer

Free
Mustafa Elshani, Ying Zhang, In Hwa Um, Ruth Plummer, Sarah P. Blagden, Stefan N. Symeonides, Natalie Cook, T.R. Jeffry Evans, Alison L. Dickson, David J. Harrison
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5650.
https://doi.org/10.1158/1538-7445.AM2024-5650
Published: 22 March 2024
View articletitled, Abstract 5650: RNA regulatory disruption by 3’-dATP: A novel approach to inhibit ribosome biogenesis in cancer
Journal Articles

Abstract 1826: New inhibitors of oncology targets discovered using the affinity-mediated selection of DNA-encoded chemical libraries followed by machine-learning

Free
Anthony D. Keefe, Mohamed AbouZleikha, AJ Baghaie, Matthew A. Clark, Marie-Aude Guie, John P. Guilinger, Ryan Walsh, Ying Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1826.
https://doi.org/10.1158/1538-7445.AM2024-1826
Published: 22 March 2024
View articletitled, Abstract 1826: New inhibitors of oncology targets discovered using the affinity-mediated selection of DNA-encoded chemical libraries followed by machine-learning
Journal Articles

Abstract 3091: Discovery of highly selective ligands with unique binding modes for challenging oncology targets using DNA-encoded chemical libraries

Free
Ying Zhang, Anthony Keefe, Matthew A. Clark
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3091.
https://doi.org/10.1158/1538-7445.AM2024-3091
Published: 22 March 2024
View articletitled, Abstract 3091: Discovery of highly selective ligands with unique binding modes for challenging oncology targets using DNA-encoded chemical libraries
Journal Articles

Abstract 6222: Exposing the heterogeneity of the lipidome in the TME of cutaneous melanoma following treatment with NUC-7738 in combination with anti-PD-1 therapy

Free
Alison L. Dickson, Greice M. Zickuhr, In Hwa Um, Ying Zhang, Ruth Plummer, Sarah P. Blagden, Stefan N. Symeonides, Natalie Cook, T.R. Jeffry Evans, Mustafa Elshani, David J. Harrison
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6222.
https://doi.org/10.1158/1538-7445.AM2024-6222
Published: 22 March 2024
View articletitled, Abstract 6222: Exposing the heterogeneity of the lipidome in the TME of cutaneous melanoma following treatment with NUC-7738 in combination with anti-PD-1 therapy
Journal Articles

Abstract 1033: Evaluation of autoantibodies to proteins encoded by cancer driver genes as biomarkers for prostate cancer

Free
Cuipeng Qiu, Xiao Wang, Carlos A. Casiano, Jian-Ying Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1033.
https://doi.org/10.1158/1538-7445.AM2024-1033
Published: 22 March 2024
View articletitled, Abstract 1033: Evaluation of autoantibodies to proteins encoded by cancer driver genes as biomarkers for prostate cancer
Journal Articles

Abstract 3328: Using Luminex approach to develop a panel of anti-TAA autoantibodies for the detection of prostate cancer

Free
Cuipeng Qiu, Xiao Wang, Serina Batson, Giulio Francia, Jian-Ying Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3328.
https://doi.org/10.1158/1538-7445.AM2023-3328
Published: 04 April 2023
View articletitled, Abstract 3328: Using Luminex approach to develop a panel of anti-TAA autoantibodies for the detection of prostate cancer
Journal Articles

Abstract 5962: NUC-7738 causes reduction of soluble and exosome-associated PD-L1 in melanoma cell lines and patients

Free
Mustafa Elshani, Ying Zhang, Boback Kaghazchi, Alison L. Dickson, Sarah P. Blagden, Stefan Symeonides, Ruth Plummer, David J. Harrison
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5962.
https://doi.org/10.1158/1538-7445.AM2023-5962
Published: 04 April 2023
View articletitled, Abstract 5962: NUC-7738 causes reduction of soluble and exosome-associated PD-L1 in melanoma cell lines and patients
Journal Articles

Abstract 5346: Discovery of new targeted protein degraders using DNA-encoded chemistry

Free
Anthony D. Keefe, Jeremy S. Disch, Jennifer Duffy, Esther C. Lee, Diana Gikunju, Betty Chan, Benjamin D. Levin, Michael I. Monteiro, Sarah A. Talcott, Anthony Lau, Fei Zhou, Anton Kozhushnyan, Neil E. Westlund, Patrick B. Mullins, Yan Yu, Moritz von Rechenberg, Junyi Zhang, Yelena Arnautova, Yanbin Liu, Ying Zhang, Andrew J. McRiner, Anna Kohlmann, Matthew A. Clark, John W. Cuozzo, Christelle Huguet, Shilpi Arora
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5346.
https://doi.org/10.1158/1538-7445.AM2023-5346
Published: 04 April 2023
View articletitled, Abstract 5346: Discovery of new targeted protein degraders using DNA-encoded chemistry
Journal Articles

Abstract 5331: DNA-encoded macrocyclic compound libraries for challenging targets

Free
Ying Zhang, Anthony Keefe, Paolo Centrella, John Cuozzo, Holly Soutter, Daniel Resnicow, Sevan Habeshian, Matt Clark
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5331.
https://doi.org/10.1158/1538-7445.AM2023-5331
Published: 04 April 2023
View articletitled, Abstract 5331: DNA-encoded macrocyclic compound libraries for challenging targets
Journal Articles

Abstract 277: NUC-7738 promotes alternative polyadenylation site usage and reduces glutaminase GAC isoform

Free
Mustafa Elshani, Ying Zhang, Tia Hawkins, Mary Kudsy, In Hwa Um, Greice Zickuhr, Alison L. Dickson, David J. Harrison
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 277.
https://doi.org/10.1158/1538-7445.AM2023-277
Published: 04 April 2023
View articletitled, Abstract 277: NUC-7738 promotes alternative polyadenylation site usage and reduces glutaminase GAC isoform
Journal Articles

Abstract PD15-03: PD15-03 Incorporation of Repeated Core Needle Biopsy and Targeted Fine Needle Aspiration to Optimize Axillary Surgery After Neoadjuvant Chemotherapy in Node-positive Breast Cancer: A Prospective Feasibility Study

Free
Siyu Wu, Jianwei Li, Ying Zhang, Na Hu, Guangyu Liu
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD15-03.
https://doi.org/10.1158/1538-7445.SABCS22-PD15-03
Published: 01 March 2023
View articletitled, Abstract PD15-03: PD15-03 Incorporation of Repeated Core Needle Biopsy and Targeted Fine Needle Aspiration to Optimize Axillary Surgery After Neoadjuvant Chemotherapy in Node-positive Breast Cancer: A Prospective Feasibility Study
Journal Articles

Abstract 5149: Autoantibodies to PAX5, PTCH1 and GNA11 as serological biomarkers in the detection of hepatocellular carcinoma in Hispanic Americans

Free
Cuipeng Qiu, Xiao Wang, Bofei Wang, Yangcheng Ma, Xiaojun Zhang, Jian-Ying Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5149.
https://doi.org/10.1158/1538-7445.AM2022-5149
Published: 15 June 2022
View articletitled, Abstract 5149: Autoantibodies to PAX5, PTCH1 and GNA11 as serological biomarkers in the detection of hepatocellular carcinoma in Hispanic Americans
Journal Articles

Abstract 1835: NUC-3373 targets the DNA-directed pathway more effectively than 5-FU

Free
Jennifer Bré, Alison L. Dickson, Oliver J. Read, Ying Zhang, Clarissa M. Czekster, David J. Harrison
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1835.
https://doi.org/10.1158/1538-7445.AM2022-1835
Published: 15 June 2022
View articletitled, Abstract 1835: NUC-3373 targets the DNA-directed pathway more effectively than 5-FU