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Journal Articles

Abstract 6853: A standardized drug selectivity profiling platform with a proteome coverage of more than 5,000 proteins

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Tomas Friman, Tuomas Tolvanen, Tove Boström, Ying Sun, Alexey Chernobrovkin, Yasmin Andersson, Christina Velasco, Daniel Martinez Molina
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6853.
https://doi.org/10.1158/1538-7445.AM2025-6853
Published: 21 April 2025
View article titled, Abstract 6853: A standardized drug selectivity profiling platform with a proteome coverage of more than 5,000 proteins
Journal Articles

Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer

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Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao, Peng Gao
Journal: Cancer Research
Cancer Res (2022) 82 (5): 805–818.
https://doi.org/10.1158/0008-5472.CAN-21-1179
Published: 03 March 2022
View article titled, Low Glucose–Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer
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Includes: Supplementary data
Journal Articles

Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance

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Zi-Qi Zheng, Zhi-Xuan Li, Jia-Li Guan, Xu Liu, Jun-Yan Li, Yue Chen, Li Lin, Jia Kou, Jia-Wei Lv, Lu-Lu Zhang, Guan-Qun Zhou, Rui-Qi Liu, FoPing Chen, Xiao-Jun He, Ying-Qin Li, Feng Li, Si-Si Xu, Jun Ma, Na Liu, Ying Sun
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (23): 5174–5188.
https://doi.org/10.1158/0008-5472.CAN-19-3626
Published: 02 December 2020
View article titled, Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance
Open the PDF for Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance in another window
Includes: Supplementary data
Journal Articles

Abstract LB-109: Discovery of a highly potent and blood-brain barrier (BBB) penetrable second generation Pan-TRK/ROS1 dual inhibitor, XZP-5955

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Jun Sun, Shujin Bai, Bo Chen, Yuqi Dong, Yanwei Ding, Qian Hu, Xifeng Ma, Yanfang Nie, Chunmin Shi, Ying Sun, Zhaoqiang Wei, Xiping Yang, Peng Zhu, Chengkong Shi, Jiakui Li, Chongtie Shi, Zuliang Yao, Bin Liu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-109.
https://doi.org/10.1158/1538-7445.AM2020-LB-109
Published: 15 August 2020
View article titled, Abstract LB-109: Discovery of a highly potent and blood-brain barrier (BBB) penetrable second generation Pan-TRK/ROS1 dual inhibitor, XZP-5955
Journal Articles

Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma

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Rui You, You-Ping Liu, De-Chen Lin, Qing Li, Tao Yu, Xiong Zou, Mei Lin, Xiao-Long Zhang, Gui-Ping He, Qi Yang, Yi-Nuan Zhang, Yu-Long Xie, Rou Jiang, Chen-Yan Wu, Chao Zhang, Cheng Cui, Jing-Qi Wang, Yue Wang, Ai-Hua Zhuang, Gui-Fang Guo, Yi-Jun Hua, Rui Sun, Jing-Ping Yun, Zhi-Xiang Zuo, Ze-Xian Liu, Xiao-Feng Zhu, Tie-Bang Kang, Chao-Nan Qian, Hai-Qiang Mai, Ying Sun, Mu-Sheng Zeng, Lin Feng, Yi-Xin Zeng, Ming-Yuan Chen
Journal: Cancer Research
Cancer Res (2019) 79 (23): 5930–5943.
https://doi.org/10.1158/0008-5472.CAN-18-3845
Published: 02 December 2019
View article titled, Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3

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Zi-Qi Zheng, Zhi-Xuan Li, Guan-Qun Zhou, Li Lin, Lu-Lu Zhang, Jia-Wei Lv, Xiao-Dan Huang, Rui-Qi Liu, FoPing Chen, Xiao-Jun He, Jia Kou, Jian Zhang, Xin Wen, Ying-Qin Li, Jun Ma, Na Liu, Ying Sun
Journal: Cancer Research
Cancer Res (2019) 79 (18): 4612–4626.
https://doi.org/10.1158/0008-5472.CAN-19-0799
Published: 13 September 2019
View article titled, Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3
Open the PDF for Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3 in another window
Includes: Supplementary data
Journal Articles

Abstract 4006: Effect of Prior Cancer on Trial Eligibility and Treatment Outcomes in Nasopharyngeal Carcinoma: Implications for Clinical Trial Accrual

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Ya-Qin Wang, Jia-Wei Lv, Ling-Long Tang, Xiao-Jing Du, Lei Chen, Wen-Fei Li, Xu Liu, Ying Guo, Ai-Hua Lin, Yan-Ping Mao, Ying Sun, Yu-Pei Chen, Jun Ma
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4006.
https://doi.org/10.1158/1538-7445.AM2019-4006
Published: 01 July 2019
View article titled, Abstract 4006: Effect of Prior Cancer on Trial Eligibility and Treatment Outcomes in Nasopharyngeal Carcinoma: Implications for Clinical Trial Accrual
Journal Articles

Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability

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Jian Zhang, Ying-Qin Li, Rui Guo, Ya-Qin Wang, Pan-Pan Zhang, Xin-Ran Tang, Xin Wen, Xiao-Hong Hong, Yuan Lei, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Jun Ma, Na Liu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (4): 747–759.
https://doi.org/10.1158/0008-5472.CAN-18-1754
Published: 15 February 2019
View article titled, Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability
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Includes: Supplementary data
Journal Articles

Abstract LB-222: Optimization and preclinical characterization of highly potent and stable anti-CD70 ADCs for the potential treatment of CD70 positive cancers

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Lillian Skidmore, Kari Cox, Jessica Kirtley, Tiep Le, Juhi Firdos, Anthony Manibusan, Shiao-Yan Fang, Andy Beck, Shiva Bhowmik, Nick Knudsen, Jianing Wang, Ying Sun, Armando Ayala, Alyssa Powell, Alan Wahl, Feng Tian, Robin Humphreys
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-222.
https://doi.org/10.1158/1538-7445.AM2016-LB-222
Published: 15 July 2016
View article titled, Abstract LB-222: Optimization and preclinical characterization of highly potent and stable anti-CD70 ADCs for the potential treatment of CD70 positive cancers
Journal Articles

Abstract 2614: Targeting heat shock protein 90 with Ganetespib for the treatment of lymphoma

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Zhigang Tu, Hanqing Liu, Jingjing Zhao, Peishan Zhang, Zhiquan Liang, Lingling Ruan, Yongjin Lu, Dongsheng Shang, Ying Sun, Lili Xu, Keping Chen, Quji Danzeng
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2614.
https://doi.org/10.1158/1538-7445.AM2015-2614
Published: 01 August 2015
View article titled, Abstract 2614: Targeting heat shock protein 90 with Ganetespib for the treatment of lymphoma
Journal Articles

Abstract 668: Folate conjugated site-specifically to anti-human-CD3-Fab is efficacious in mouse models of ovarian cancer

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Sandra L. Biroc, Marco Gymnopoulos, Shailaja Srinagesh, Brad Hayes, Nick Knudsen, Anthony Manibusan, Jason Pinkstaff, Tim Buss, Kari Cox, Robin Marsden, Lillian Skidmore, Jinming Xia, Ying Sun, Ning Zou, Tsotne Javahishvili
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 668.
https://doi.org/10.1158/1538-7445.AM2014-668
Published: 01 October 2014
View article titled, Abstract 668: Folate conjugated site-specifically to anti-human-CD3-Fab is efficacious in mouse models of ovarian cancer
Journal Articles

Abstract 1810: PI-1840, a novel non-covalent and rapidly reversible proteasome inhibitor with anti-tumor activity

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Said M. Sebti, Aslamuzzaman Kazi, Sevil Ozcan, Awet G. Tecleab, Ying Sun, Harshani Lawrence
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1810.
https://doi.org/10.1158/1538-7445.AM2014-1810
Published: 01 October 2014
View article titled, Abstract 1810: PI-1840, a novel non-covalent and rapidly reversible proteasome inhibitor with anti-tumor activity
Journal Articles

Abstract 3254: Discovery of S3I-1757, a STAT3-STAT3 dimerization disruptor that inhibits STAT3 activity, tumor survival, migration and invasion.

Free
Xiaolei Zhang, Ying Sun, Roberta Pireddu, Hua Yang, Murali K. Urlam, Harshani R. Lawrence, Wayne C. Guida, Nicholas J. Lawrence, Said M. Sebti
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3254.
https://doi.org/10.1158/1538-7445.AM2013-3254
Published: 15 April 2013
View article titled, Abstract 3254: Discovery of S3I-1757, a STAT3-STAT3 dimerization disruptor that inhibits STAT3 activity, tumor survival, migration and invasion.
Journal Articles

Abstract 2467: Development of new N-Arylbenzamides as STAT3 dimerization inhibitors.

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Nicholas J. Lawrence, Roberta Pireddu, Yiyu Ge, Murali K. Urlam, Xiaolei Zhang, Ying Sun, Harshani R. Lawrence, Wayne C. Guida, Said Sebti
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2467.
https://doi.org/10.1158/1538-7445.AM2013-2467
Published: 15 April 2013
View article titled, Abstract 2467: Development of new N-Arylbenzamides as STAT3 dimerization inhibitors.
Journal Articles

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

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Xiaolei Zhang, Ying Sun, Roberta Pireddu, Hua Yang, Murali K. Urlam, Harshani R. Lawrence, Wayne C. Guida, Nicholas J. Lawrence, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (2013) 73 (6): 1922–1933.
https://doi.org/10.1158/0008-5472.CAN-12-3175
Published: 14 March 2013
View article titled, A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
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Includes: Supplementary data
Journal Articles

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

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Ronil A. Patel, Kara D. Forinash, Roberta Pireddu, Ying Sun, Nan Sun, Mathew P. Martin, Ernst Schönbrunn, Nicholas J. Lawrence, Saïd M. Sebti
Journal: Cancer Research
Cancer Res (2012) 72 (19): 5025–5034.
https://doi.org/10.1158/0008-5472.CAN-12-0954
Published: 30 September 2012
View article titled, RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Open the PDF for RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody drug conjugates

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Puja Sapra Sapra, Lioudmila Tchistiakova, Russell Dushin, Mauricio Leal, John DiJoseph, Robert Veneziale, Eric Feyfant, HansPeter Gerber, Ying Sun, Anthony Manibusan, Yingchun Lu, Aaron Sellers, Trung Phuong, Michael DeGuzman, Semsi Ensari, Barney Barnett, Ho Cho, Feng Tian
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5691.
https://doi.org/10.1158/1538-7445.AM2012-5691
Published: 15 April 2012
View article titled, Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody drug conjugates
Journal Articles

Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer

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Ronil A. Patel, Kara D. Forinash, Roberta Pireddu, Ying Sun, Mathew P. Martin, Jin-Yi Zhu, Brian G. Alexander, Ernst Schonbrunn, Nicholas J. Lawrence, Said M. Sebti
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2942.
https://doi.org/10.1158/1538-7445.AM2012-2942
Published: 15 April 2012
View article titled, Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer
Journal Articles

Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth

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Nina S. Funa, Vitezslav Kriz, Guangxiang Zang, Gabriela Calounova, Björn Åkerblom, Jaroslav Mares, Erik Larsson, Ying Sun, Christer Betsholtz, Michael Welsh
Journal: Cancer Research
Cancer Res (2009) 69 (5): 2141–2148.
https://doi.org/10.1158/0008-5472.CAN-08-3797
Published: 02 March 2009
View article titled, Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth
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Includes: Supplementary data
Journal Articles

Differential induction of prosaposin promoter by androgen and serum in human prostate cancer and stromal cells

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Tae-Jin Lee, Oliver Sartor, Ardalan Minokadeh, David Y. Patten, Ying Sun, Gregory A. Grabowski, Shahriar Koochekpour
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 219–220.
Published: 01 April 2004
View article titled, Differential induction of prosaposin promoter by androgen and serum in human prostate cancer and stromal cells