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Journal Articles

HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment

Yu-Wei Luo, Yang Fang, Hui-Xian Zeng, Yu-Chen Ji, Meng-Zhi Wu, Hui Li, Jie-Ying Chen, Li-Min Zheng, Jian-Hong Fang, Shi-Mei Zhuang
Journal: Cancer Research
Cancer Res (2024)
https://doi.org/10.1158/0008-5472.CAN-24-2324
Published: 02 October 2024
View article titled, HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment
Open the PDF for HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Abstract 6021: Lutetium-177 (177Lu) radiolabeled engineered antibody fragment against human prostate stem cell antigen (hPSCA) demonstrates targeting and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)

Bao Ying Chen, Masoud Farshbaf, Felix B. Salazar, Saad N. Ahmed, Sunidhi Jaiswal, Jennifer Chean, Anakim Sherman, Teresa Hong, Paul J. Yazaki, Tove Olafsen, Kirstin A. Zettlitz, Anna M. Wu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6021.
https://doi.org/10.1158/1538-7445.AM2024-6021
Published: 22 March 2024
View article titled, Abstract 6021: Lutetium-177 (<sup>177</sup>Lu) radiolabeled engineered antibody fragment against human prostate stem cell antigen (hPSCA) demonstrates targeting and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)
Journal Articles

Abstract A088: Radiopharmaceutical therapy for pancreatic cancer: Engineered anti-prostate stem cell antigen (PSCA) antibody demonstrates targeted imaging and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)

Bao Ying Chen, Saad N. Ahmed, Felix Salazar, Sunidhi Jaiswal, Masoud Farshbaf, Jennifer Chean, Anakim Sherman, Teresa Hong, Paul J. Yazaki, Tove Olafsen, Kirstin A. Zettlitz, Anna M. Wu
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A088.
https://doi.org/10.1158/1538-7445.PANCA2023-A088
Published: 16 January 2024
View article titled, Abstract A088: Radiopharmaceutical therapy for pancreatic cancer: Engineered anti-prostate stem cell antigen (PSCA) antibody demonstrates targeted imaging and antitumor effects in a syngeneic mouse model of pancreatic ductal adenocarcinoma (PDAC)
Journal Articles

Fructose Metabolism in Tumor Endothelial Cells Promotes Angiogenesis by Activating AMPK Signaling and Mitochondrial Respiration

Jian-Hong Fang, Jie-Ying Chen, Jia-Lin Zheng, Hui-Xian Zeng, Jun-Guang Chen, Chen-Hui Wu, Jia-Li Cai, Zhi-Yong Wang, Shi-Mei Zhuang
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1249–1263.
https://doi.org/10.1158/0008-5472.CAN-22-1844
Published: 14 April 2023
View article titled, Fructose Metabolism in Tumor Endothelial Cells Promotes Angiogenesis by Activating AMPK Signaling and Mitochondrial Respiration
Open the PDF for Fructose Metabolism in Tumor Endothelial Cells Promotes Angiogenesis by Activating AMPK Signaling and Mitochondrial Respiration in another window
Includes: Supplementary data
Journal Articles

Abstract 3420: Tgfbm3b is a natural germline genetic variant that modifies anti-tumor responses to anti-PD-1 immunotherapy through its action on the tumor microenvironment

Szu-Ying Chen, Ons Mamai, Rosemary Akhurst
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3420.
https://doi.org/10.1158/1538-7445.AM2022-3420
Published: 15 June 2022
View article titled, Abstract 3420: Tgfbm3b is a natural germline genetic variant that modifies anti-tumor responses to anti-PD-1 immunotherapy through its action on the tumor microenvironment
Journal Articles

Abstract P5-13-08: Identification of PD-L1+ status as a candidate predictive biomarker of response to talazoparib (TALA) in the phase 3 EMBRACA study

Hope S. Rugo, Joanne L. Blum, A. Douglas Laird, Sara A. Hurvitz, Johannes Ettl, Lida A. Mina, Kyung-Hun Lee, Anthony Gonçalves, Rinat Yerushalmi, Young-Hyuck Im, Miguel Martin, Louis Fehrenbacher, Henri H. Roché, Ying Chen, Silvana Lanzalone, Jijumon Chelliserry, Wolfgang Eiermann, Jennifer K. Litton
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-08.
https://doi.org/10.1158/1538-7445.SABCS21-P5-13-08
Published: 15 February 2022
View article titled, Abstract P5-13-08: Identification of PD-L1+ status as a candidate predictive biomarker of response to talazoparib (TALA) in the phase 3 EMBRACA study
Journal Articles

Abstract 2291: A novel TGF-βRI inhibitor ASKC852, possessing antitumor and PD-L1 synergistic effect activities

Tingting Song, Min Sun, Hongyu Chen, Xiangyu Fu, Lihong Hu, Shuhua Han, Haijun Tong, Yuanfeng Xia, Jian Zuo, Shaohua Qin, Ying Chen, Charles Ding, Chichung Chan, Shuhui Chen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2291.
https://doi.org/10.1158/1538-7445.AM2021-2291
Published: 01 July 2021
View article titled, Abstract 2291: A novel TGF-βRI inhibitor ASKC852, possessing antitumor and PD-L1 synergistic effect activities
Journal Articles

Abstract 6141: Role of aldehyde dehydrogenase 1B1 in colon carcinogenesis in a newly developed mouse model

Wan Ying Tan, David. J. Orlicky, Ying Chen, Yatrik M. Shah, David C. Thompson, Vasilis Vasiliou
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6141.
https://doi.org/10.1158/1538-7445.AM2020-6141
Published: 15 August 2020
View article titled, Abstract 6141: Role of aldehyde dehydrogenase 1B1 in colon carcinogenesis in a newly developed mouse model
Journal Articles

Abstract 846: Microsatellite instability determined by clinical targeted next generation sequencing

Ya-Chi Yeh, Chien-Hung Chen, Kuan-Ying Chen, Ying-Ja Chen, Shu-Jen Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 846.
https://doi.org/10.1158/1538-7445.AM2020-846
Published: 15 August 2020
View article titled, Abstract 846: Microsatellite instability determined by clinical targeted next generation sequencing
Journal Articles

Abstract 2890: IMGN151 - A next generation folate receptor alpha targeting antibody drug conjugate active against tumors with low, medium and high receptor expression

Olga Ab, Laura M. Bartle, Leanne Lanieri, Jose F. Ponte, Qifeng Qiu, Surina Sikka, Juliet A. Costoplus, Wayne Deats, Nicholas C. Yoder, Wayne C. Widdison, Katherine Mucciarone, Kate Selvitelli, Ying Chen, Neeraj Kohli, Thomas Chittenden, Richard Gregory, Yulius Setiady, Eric H. Westin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2890.
https://doi.org/10.1158/1538-7445.AM2020-2890
Published: 15 August 2020
View article titled, Abstract 2890: IMGN151 - A next generation folate receptor alpha targeting antibody drug conjugate active against tumors with low, medium and high receptor expression
Journal Articles

Abstract 3766: Development of new FLT3/AXL dual inhibitor JRF104 with potent FLT3-TKD inhibition

yuquan wei, Xiawei Wei, Yanzhong Zhang, Wanru Qin, Xiangyu Fu, Lihong Hu, Yuanfeng Xia, Jian Zuo, Zhong Xiong, Shanshan Yin, Shaohua Qin, Ge Dong, Ying Chen, Charles Ding, Chichung Chan, Shuhui Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3766.
https://doi.org/10.1158/1538-7445.AM2020-3766
Published: 15 August 2020
View article titled, Abstract 3766: Development of new FLT3/AXL dual inhibitor JRF104 with potent FLT3-TKD inhibition
Journal Articles

Abstract CT072: Exploration of impact of tumor BRCA zygosity and genomic loss-of-heterozygosity (gLOH) on efficacy in Phase 3 EMBRACA study of talazoparib in patients (pts) with HER2-negative (HER2−) advanced breast cancer (ABC) and a germline BRCA1/2 (gBRCA1/2) mutation

Jennifer K. Litton, A. Douglas Laird, Hope S. Rugo, Johannes Ettl, Sara A. Hurvitz, Miguel Martin, Henri Roché, Young-Hyuck Im, Annabel Goodwin, Joanne L. Blum, Wolfgang Eiermann, Ying Chen, Silvana Lanzalone, Jijumon Chelliserry, Akos Czibere, Lee A. Albacker, Garrett M. Frampton, Lida A. Mina
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT072.
https://doi.org/10.1158/1538-7445.AM2020-CT072
Published: 15 August 2020
View article titled, Abstract CT072: Exploration of impact of tumor <em>BRCA</em> zygosity and genomic loss-of-heterozygosity (gLOH) on efficacy in Phase 3 EMBRACA study of talazoparib in patients (pts) with HER2-negative (HER2−) advanced breast cancer (ABC) and a germline <em>BRCA1/2</em> (g<em>BRCA1/2</em>) mutation
Journal Articles

Abstract 3072: GFH018, a novel TGF-βRI inhibitor, for the treatment of advanced solid tumors

Gang Hu, Rong Zhao, Fusheng Zhou, Jiong Lan, Biao Zheng, Qiang LU, Jianyu Lu, Lifang Wu, Fei Sun, Lihong Hu, Shuhua Han, Haijun Tong, Yuanfeng Xia, Wei Li, Liping Ma, Ying Chen, Charles Ding, Chichung Chan, Shuhui Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3072.
https://doi.org/10.1158/1538-7445.AM2019-3072
Published: 01 July 2019
View article titled, Abstract 3072: GFH018, a novel TGF-βRI inhibitor, for the treatment of advanced solid tumors
Journal Articles

Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis

Hong Zhu, Dan-Dan Wang, Tao Yuan, Fang-Jie Yan, Chen-Ming Zeng, Xiao-Yang Dai, Zi-bo Chen, Ying Chen, Tianyi Zhou, Guang-Han Fan, Meidan Ying, Ji Cao, Peihua Luo, Xi-Jie Liu, Yuandong Hu, Yong Peng, Qiaojun He, Bo Yang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (14): 3995–4006.
https://doi.org/10.1158/0008-5472.CAN-17-1548
Published: 15 July 2018
View article titled, Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis
Open the PDF for Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis in another window
Includes: Supplementary data
Journal Articles

STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α

Fanyang Kong, Xiangyu Kong, Yiqi Du, Ying Chen, Xuan Deng, Jianwei Zhu, Jiawei Du, Lei Li, Zhiliang Jia, Dacheng Xie, Zhaoshen Li, Keping Xie
Journal: Cancer Research
Cancer Res (2017) 77 (24): 6851–6862.
https://doi.org/10.1158/0008-5472.CAN-17-0067
Published: 14 December 2017
View article titled, STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α
Open the PDF for STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α in another window
Includes: Supplementary data
Journal Articles

Abstract 3933: Characterization of oncogenic activity of interferon-induced protein with tetratricopeptide repeats 1 and 3 in human oral squamous cell carcinoma progression

Vijaya Kumar Pidugu, Ai-Hsin Yen, Ying-Chen Chen, Mei-Maan Wu, Chung-Ji Liu, Te-Chang Lee
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3933.
https://doi.org/10.1158/1538-7445.AM2017-3933
Published: 01 July 2017
View article titled, Abstract 3933: Characterization of oncogenic activity of interferon-induced protein with tetratricopeptide repeats 1 and 3 in human oral squamous cell carcinoma progression
Journal Articles

Abstract 2415: Genome-wide alterations in gene expression of prostate cancer (PC) cells surviving neo-adjuvant androgen deprivation therapy

Anna C. Ferrari, Hatem Sabaawy, Mark Stein, David Foran, Ying Chen, Srinivasan Yegnasubramanian
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2415.
https://doi.org/10.1158/1538-7445.AM2017-2415
Published: 01 July 2017
View article titled, Abstract 2415: Genome-wide alterations in gene expression of prostate cancer (PC) cells surviving neo-adjuvant androgen deprivation therapy
Journal Articles

Abstract LB-268: Androgen signaling in cancer-associated fibroblasts contributes to progression of prostate cancer

Chun-Peng Liao, Leng-Ying Chen, Andrea Luethy, Youngsoo Kim, Robert MacLeod, Mitchell Gross
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-268.
https://doi.org/10.1158/1538-7445.AM2016-LB-268
Published: 15 July 2016
View article titled, Abstract LB-268: Androgen signaling in cancer-associated fibroblasts contributes to progression of prostate cancer
Journal Articles

Abstract 3937: Nestin expression is associated with a basal-like phenotype and poor prognosis in breast cancer

Kristi Krüger, Elisabeth Wik, Tor Audun Klingen, Ying Chen, Turid Aas, Lars A. Akslen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3937.
https://doi.org/10.1158/1538-7445.AM2016-3937
Published: 15 July 2016
View article titled, Abstract 3937: Nestin expression is associated with a basal-like phenotype and poor prognosis in breast cancer
Journal Articles

Abstract 5079: Sunitinib suppresses ovarian cancer metastasis through the negative modulation of TGF-β-mediated epithelial-mesenchymal transition

Zibo Chen, Lin-lin Chang, Tian-yi Zhou, Dan-dan Wang, Ying Chen, Hong Zhu, Meidan Ying, Bo Yang, Qiao-jun He
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5079.
https://doi.org/10.1158/1538-7445.AM2016-5079
Published: 15 July 2016
View article titled, Abstract 5079: Sunitinib suppresses ovarian cancer metastasis through the negative modulation of TGF-β-mediated epithelial-mesenchymal transition